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메포르민사용에 의한 유산산증 (Lactic Acidosis)
최혜숙 ( Choe Hye Sug ),정경환 ( Jeong Gyeong Hwan ),심재준 ( Sim Jae Jun ),채명종 ( Chae Myeong Jong ),이상호 ( Lee Sang Ho ),이태원 ( Lee Tae Won ),임천규 ( Im Cheon Gyu ),김명재 ( Kim Myeong Jae ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.1
A 76-year-old female admitted with nausea, anorexia, vague dbdominal pain, and malaise. Her past medical history included an 15-year history of type 2 diabetes mellitus and hypertension. She had been taking mctformin, glipizid, and amolodipine for past 2 years. One week previously, she underwent gastroscopy to evaluate epigastic pain, and she was diagnosed Helicobacter pylori positive duodenal ulcer, for which she was treated with amoxicillin, clarithromycin, and omeprazole. At admission, laboratory test revealed lactic acidosis (pH 7.23, bicarbonate 8.3 mEq/L, and lactate 5.51 mmol/L) and acute renal failure with a serum creatinine of 7.4 mg/dL. We diagnosed meformin-associated lactic acidosis and the patient made a complete recovery following therapy with bicarbonate-based hemodialysis and supportive care. It is the first report of metformin-associated lactic acidosis in Korea. (Korean J Nephrol 2004;23(1):143-146)