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조경자(kyung Ja Cho),최진(Jene Choi),김상윤(Sang Yoon Kim),남순열(Soon Yuhl Nam),최승호(Seung Ho Choi),김성배(Sung Bae Kim) 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.2
Objectives: To document the incidence and pattern of c-kit protein expression & mutation in adenoid cystic carcinomas. Materials and Methods: Twenty-five cases of adenoid cystic carcinomas of the major and minor salivary glands and the upper and lower respiratory tract were subjected to the immunohistochemical study for ckit(CD117 ; Dako). Nineteen cases of them were analyzed for mutations in exon 11 and exon 17 by PCR-SSCP, and in cases of need, by DNA sequencing. Results: Twenty-three cases (92%) showed c-kit expression, but none showed mutations in exon 11 and exon 17. The expression was restricted to the inner luminal cells in all tubular types and most of cribriform adenoid cystic carcinomas, while the staining was diffuse in all solid variants and two cribriform types. Conclusion: C-kit expression was common in adenoid cystic carcinomas, regardless of their origins. Although genetic bases await further studies, a clinical trial of tyrosine kinase inhibitors in adenoid cystic carcinomas, especially in solid variants, is considered encouraging.
위 점막연관림프조직 림프종에서 헬리코박터 치료 후 발견된 림프구 위염 -2 증례 보고-
송동은 ( Dong Eun Song ),김정선 ( Jung-Sun Kim ),허주령 ( Joo Ryung Huh ),최진 ( Jene Choi ),장세진 ( Se Jin Jang ),유은실 ( Eunsil Yu ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5
Both lymphocytic gastritis and gastric mucosa associated lymphoid tissue (MALT) lymphoma are associated with Helicobacter pylori (H. pylori) infection. However, this association has not been fully elucidated. We report two cases of lymphocytic gastritis i