A Clinical Study and assays of P53 expression in 43 Cases of Uterine Sarcomas

최수희 ( Soo Hee Choi ),( Jae Weon Kim ),( Sang Young Ryu ),( Su Yeon Kim ),( Noh Hyun Park ),( Yong Sang Song ),( Soon Beon Kang ),( Hyo Pyo Lee ) 대한산부인과학회 1997 대한산부인과학회 학술대회 Vol.80 No.-

탄소나노튜브로 강화시킨 Poly(ethylene terephthalate) 나노복합재료

최수희(Soo Hee Choi),정영진(Young Jin Jeong) 한국고분자학회 2014 폴리머 Vol.38 No.2

다중벽 탄소나노튜브(MWNT)로 보강된 폴리에스터(PET) 복합재료에 관한 연구를 수행하였다. PET와 MWNT간의 계면결합력을 향상시키기 위하여, MWNT 표면에 bishydroxyethylene-terephthalate(BHET)를 도입하였다. 이렇게 기능화된 MWNT를 0.5~2.0 wt% 범위에서 이축압출기를 이용하여 PET와 용융 혼합하였다. MWNT/PET 복합재료를 필라멘트로 방사하고, 이를 연신 및 열처리하여 특성 분석을 하였다. 이로부터 복합섬유의 결정화 온도와 열분해 온도가 MWNT로 인하여 증가함을 알 수 있었으며, 항복응력과 인성은 MWNT의 1 wt%의 첨가만으로도 30%이상 증가함을 알 수 있었다. 따라서 MWNT를 BHET로 기능화하는 방법은 폴리에스터에 탄소나노튜브를 효과적으로 분산시키고 계면결합력을 증가시키는데 매우 효과적임을 알 수 있었다. Multi-walled carbon nanotube (MWNT) reinforced poly(ethylene terephthalate) (PET) composites are studied. To increase the interfacial interactions between PET and MWNTs, the MWNTs are functionalized with bishydroxy-ethylene-terephthalate (BHET). The functionalized MWNTs are melt blended into PET matrix using a twin screw extruder. The amount of MWNTs loaded in PET matrix ranges from 0.5 to 2.0 wt%. After compounding and spinning, the filaments are post-drawn and annealed. To verify the chemical modifications of carbon nanotubes, Raman, 1H NMR, XPS, TGA and FE-SEM are used. The nanocomposites are also analyzed with DSC, TGA, and UTM. These tests show that crystallization temperature and thermal degradation temperature increase due to the functionalized MWNTs. Also, tensile test shows that yield strength and toughness increase more than 30% with addition of only 1 wt% of MWNTs. These results show that the introduction of BHET onto the MWNTs is a very effective way in manufacturing MWNT/PET composite.

조현병 환자에서 다감각적 되먹임에 의한 원격현존감 특성 및 관련 신경 기전 : 기능자기공명영상 연구

한기완,최수희,박일호,이형래,김선일,김재진,Han, Ki-Wan,Choi, Soo-Hee,Park, Il-Ho,Lee, Hyeong-Rae,Kim, Sun-I.,Kim, Jae-Jin 대한생물정신의학회 2012 생물정신의학 Vol.19 No.3

Objectives : The multimodal telepresence systems have been adopted in a variety of applications, such as telemedicine, space or underwater teleoperation and videoconference. Multimedia, one of the telepresence systems, has been used in various fields including entertainment, education and communication. The degree of subjective telepresence is defined as the probability that a person perceives to be physically in the remote place when he/she experiences a multisensory feedback from the multimedia. The current study aimed to explore the neural mechanism of telepresence related to multisensory feedback in patients with schizophrenia. Methods : Brain activity was measured using functional magnetic resonance imaging while fifteen healthy controls and fifteen patients with schizophrenia were experiencing filmed referential conversation at various distances (1 m, 5 m and 10 m). Correlations between the image contrast values and the telepresence scores were analyzed. Results : Subjective telepresence was not significantly different between the two groups. Some significant correlations of brain activities with the telepresence scores were found in the left postcentral gyrus, bilateral inferior frontal gyri, right fusiform gyrus, and left superior temporal sulcus. There were no main effects of group and distance. Conclusion : These results suggest that patients with schizophrenia experience telepresence as appropriately as healthy people do when exposed to multimedia. Therefore, patients with schizophrenia would have no difficulty in immersing themselves in multimedia which may be used in clinical training therapies.

미세수술적 난관복원술을 시행받은 36세 이상 환자에서의 임신율에 관한 연구

김석현,이규창,최수희,최영민,신창재,김정구,문신용,이진용,장윤석,Kim, Seok-Hyun,Lee, Gyu-Chang,Choi, Soo-Hee,Choi, Young-Min,Shin, Chang-Jae,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Young,Chang, Yoon-Seok 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.3

Objective: To determine the reproductive outcomes of women undergoing microsurgical reversal of tubal sterilization at age 36 years or older. Materials and Methods: A series of 133 patients who received microsurgical reversal of the previously sterilized fallopian tubes at Seoul National University Hospital from July, 1980 to January, 1992 was reviewed and evaluated for clinical characteristics, pregnancy rates, and factors influencing the outcome of tubal reversal. Results: Of 133 patients, 78 (58.6%) had been sterilized by laparoscopic cautery. Loss of children was a leading cause for tubal reversal. The mean interval from tubal sterilization to tubal reversal was 65.0 months. The overall pregnancy rate was 52.6% (70/133), and the mean interval was 9.4 months from tubal reversal to pregnancy. Excluding 7 patients who were lost to follow-up, 76 pregnancies were confirmed in 63 patients with the delivery rate per patient of 66.7% (42/63). There were no significant differences in age, duration of tubal sterilization, postoperative tubal length between pregnant and non-pregnant groups. Conclusions: Microsurgical reversal of tubal sterilization could be a justifiable method in women 36 years age or older.

만다라 미술치료의 음양오행적 해석과 한의학적 이용

오미영 ( Mi Young Oh ),최수희 ( Soo Hee Choi ),장현호 ( Hyun Ho Jang ),강형원 ( Hyung Won Kang ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.3

Objective : The Mandala art therapy is used as a clinical method for helping patients to perceive their internal existence and to maintain harmonious between body and mind. Despite the fact that Mandala is congruous with the oriental philosophy, there are few studies that approach Mandala from the view point of the oriental medicine. Method : This study looks into the Mandala art therapy from the perspective of Yin-Yang Wuxing(陰陽五行) and examines the possibility of using Mandala art therapy in the oriental medical practice. Results : In Analyzing the symbols of Mandala, the lines can be interpreted in terms of Yin and Yang, and the preferences for colors and the style of expression can be interpreted in terms of the body organs associated with colors and emotions in Wuxing. In addition, the clinical effects of Mandala, such as body-mind harmony and self-examination, are congruous with the Suncheondo(先天圖) of the oriental medicine primer. Conclusion : The Mandala art therapy has a potential to be used for medical diagnosis and treatment in the oriental medicine. Therefore, it is necessary to research and develop various Mandala art programs and assess their effectiveness through applications to medical cases.

강박장애 및 조현병 환자에서의 정량뇌파 소견과 신경인지기능 간의 연관성

김서영,신정은,김민주,권준수,최수희,Kim, Seoyoung,Shin, Jung Eun,Kim, Min Joo,Kwon, Jun Soo,Choi, Soo-Hee 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4

Objectives Obsessive-compulsive disorder (OCD) and schizophrenia have many common clinical and neurocognitive features. However, not all of them share the same underlying mechanism. The aim of this study was to discover evidences that indicate a pathophysiological mechanism specific to OCD by comparing correlations of quantitative electroencephalography (QEEG) patterns and neurocognitive function in patients with OCD and schizophrenia. Methods Resting-state QEEG data of total 265 patients were acquired retrospectively and parameters such as absolute power, relative power and peak frequency were analyzed from the data. Stroop test and Trail Making Test results as well as demographic features were reviewed for this study. The correlation of neurocognitive functions and brain electrical activities in each group were assessed and compared by correlation analysis. Results Compared with the OCD group, the schizophrenia group performed poorly in neurocognitive tests. Mean values of QEEG parameters in patients with OCD and schizophrenia did not show significant differences. Both absolute and relative power of alpha rhythm in central and frontal regions showed significant positive correlation with Stroop test results in OCD patients. Conclusions Findings in this study shows distinctive correlations between frontal executive dysfunction and frontal alpha rhythm in the OCD patients, both of which might be a candidate for endophenotype underlying obsessive rumination.

정신질환에서 뇌영상의 이해와 전망

김재진,한기완,이정석,최수희,Kim, Jae-Jin,Han, Ki-Wan,Lee, Jung-Suk,Choi, Soo-Hee 대한생물정신의학회 2011 생물정신의학 Vol.18 No.1

Neuroimaging in psychiatry encompasses the powerful tools available for the in vivo study of brain structure and function. MRI including the volumetry, voxel-base morphometry(VBM) and diffusion tensor imaging (DTI) are useful for assessing brain structure, whereas function MRI, positron emission tomography(PET) and magnetoencephalography(MEG) are well established for probing brain function. These tools are well tolerated by the vast majority of psychiatric patients because they provide a powerful but noninvasive means to directly evaluate the brain. Although neuroimaging technology is currently used only to rule in or rule out general medical conditions as opposed to diagnosing primary mental disorders, it may be used to confirm or make psychiatric diagnoses in the future. In addition, neuroimaging may be valuable for predicting the natural course of psychiatric illness as well as treatment response.

선천성 자궁 기형 환자에서 자궁성형술 후 임신 예후에 관한 연구

문신용(Shin Yong Moon),최영민(Young Min Choi),김석현(Seok Hyun Kim),서창석(Chang Suk Suh),이진용(Jin Yong Lee),김정구(Jung Gu Kim),최수희(Soo Hee Choi),이규창(Gyu Chang Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2

N/A Objective: Metroplasty has been shown to improve the reproductive outcomes in patients with congenital uterine anomalies, especially for those suffering from multiple fetal losses. This study was performed to evaluate the impact of abdominal metroplasty on the reproductive outcomes in patients with infertility or recurrent abortions. Methods: Among fifty cases diagnosed as Mullerian anornalies at SNUH from Oct. 1988 to Dec. 1996, only 26 cases were included in this retrospective study. Inclusion criteria was the patients with primary infertility(n=7) or recurrent spontaneous abortions(n 19) who underwent abdominal metroplasty for the correction of uterine anomalies. Statistical analysis was carried out by chi-square test using SPSS ver 7.0. Results: Bicornuate uterus was the most common uterine anomaly as 53.9%(14/26). After metroplaty, the overall live birth rate was increased from 0% to 57.7%(15/26), and the live birth rate in patients with recurrent abortions, 68.4%(13/19), was significantly higher than that in patients with primary infertility, 28.6%(2/7). The rate of fetal wastage was dropped from 96.0%(48/50) to 41.7%(10/24) after metroplasty in 19 patients with recurrent abortions. Pelvic pathologic lesions associated with uterine anomalies were diagnosed in 11(42.3%) patients, and 45.5%(5/11) of them succeeded in live births postoperatively. Conclusion: These data showed that metroplasty may improve the reproductive outcomes definitely in patients with recurrent abortions. Although the impact of metroplasty on the fertility in infertile patients was not definite, it seems better to perform metroplasty in infertile patients with uterine anomaly, which offers the opportunity to correct the combined pelvic lesions such as myoma, ovarian cyst or endometriosis, and to avoid the chance of abortion after ART(assisted reproductive technology) such as 1VF-ET.

고혈압 환자에서 좌심실 중벽 기능과 경동맥 내막-중막 두께와의 상관관계

이경헌 ( Kyung Hun Lee ),최여원 ( Yeo Won Choi ),최수희 ( Soo Hee Choi ),이광호 ( Kwang Ho Lee ),서기우 ( Ki Woo Seo ),김은영 ( Eun Young Kim ),이광제 ( Kwang Je Lee ),김상욱 ( Sang Wook Kim ),김태호 ( Tae Ho Kim ),김치정 ( Chee J 대한내과학회 2008 대한내과학회지 Vol.74 No.4

목적: 심혈관 질환의 가장 큰 부분을 차지하고 있는 고혈압 환자에서는 좌심실 박출률이 정상이거나 오히려 높은 경우도 있어 예후를 판정하는데 많은 제한점이 있기 때문에 좌심실 중벽의 구획 단축률(midwall fractional shortening)을 이용하는 연구가 점차 많아지고 있다. 본 연구에서는 고혈압 환자에서 좌심실 midwall 기능을 평가하고, 고혈압의 표적장기 손상 지표 중 하나로 가능성이 있는 경동맥 IMT와의 상관관계를 조사하였다. 방법: 주요 합병증이 없는 고혈압 환자(n=136) 및 대조군(n=48)을 대상으로 심초음파와 경동맥 초음파를 실시하였다. 좌심실 midwall shortening (MWS)은 two cylindrical model을 이용해서 산출하였으며, 같은 환자에서 총경동맥, 경동맥 분지 위치 및 내경동맥 각각의 원벽 6부위에서 내막-중막 두께를 측정하였다. 결과: 1. 대상 고혈압 환자와 대조군의 평균 나이는 각각 61.1세, 62.4세였으며, 평균 혈압은 각각 167/99 mmHg, 107/69 mmHg였다. LV mass index는 평균 135.5 g/M2, 97.5 g/M2이었으며, 혈청 총 콜레스테롤치는 평균 188 mg/dL, 198 mg/dL였다. 2. 좌심실의 midwall shortening은 정상 혈압군에 비해서 stage 1 고혈압군이 약 16% 감소하였으며, stage 2 고혈압군은 약 20% 감소하였다(p<0.05). 3. 경동맥 최대 내막-중막 두께는 stage 1 고혈압군이 평균 1.12 mm, stage 2 고혈압군이 평균 1.43 mm 로서 정상 혈압군의 0.71 mm보다 유의하게 두터웠다(p<0.05). 4. 고혈압 환자에서 좌심실 MWS와 경동맥 6부위 평균 내막-중막 두께와의 상관관계를 분석한 결과 r=-0.41 (p<0.001)의 유의한 상관관계가 있었으며, 최대 내막-중막 두께(r=-0.40), 좌심실질량지수(r=-0.32), 연령(r=-0.31), 수축기 혈압(r=-0.22)과도 미약하지만 유의한 음의 상관관계가 있었다. 5. 경동맥 죽상반의 유병률은 stage 1 고혈압군이 16.7%, stage 2 고혈압군이 32.9%로 대조군의 4.2%보다 훨씬 높게 나타났다. 결론: 본 연구 결과 고혈압 환자의 좌심실 MWS은 정상 혈압군보다 유의하게 감소해 있으며, 좌심실 MWS과 경동맥 IMT와의 상관관계가 일반적인 혈압 지수의 경우보다 높은 것으로 나타났다. 좌심실 MWS는 다른 위험인자와 함께 고혈압 환자의 예후 판정 지표로 이용 가능할 것으로 생각된다. Background/Aims: In hypertensive patients, LV ejection fraction may be normal or high, thus limiting assessment of prognosis. This has led to a growing body of research using LV midwall fractional shortening (MWS) instead. The current study aims to assess LV midwall function in hypertension patients and to study its correlation with the intima-media thickness (IMT) of the carotid artery. Methods: Echocardiography and ultrasonography of the carotid artery were conducted to establish a group of hypertension patients without major complications (n=136) and a control group (n=48). LV MWS was determined using two cylindrical models, and the IMT was measured. Results: Compared with normotensive subjects, hypertensive adults exhibited higher LV mass index and lower LV MWS. A statistically significant correlation was found between the LV MWS and the average IMT in hypertension patients (r=-0.41). There was also a significant negative correlation among the maximum IMT (r=-0.40), LV mass index (r=-0.32), age (r=-0.31), and systolic blood pressure (r=-0.22). Regarding the prevalence of plaque in the carotid artery, the stage 1 hypertension group exhibited 16.7% prevalence, and the stage 2 hypertension group 32.9% prevalence, thereby showing far higher figures than the control group`s 4.2%. Conclusions: The LV MWS in hypertension patients underwent a statistically significant decrease, and the correlation between LV MWS and the IMT of the carotid artery was found to be high compared with the general blood pressure index. LV MWS can be used as an indicator to assess the prognosis of hypertension patients.(Korean J Med 74:376-384, 2008)

건강 검진에서 발견된 단엽성 대동맥판막 질환 1례 보고

류정(Ryu Jung),이현복(Lee Hyun Bok),구혜정(Koo Hye Jung),최수희(Choi Soo Hee) 대한초음파의료영상학회 2012 대한초음파의료영상학회지 Vol.3 No.1

목적 : 건강 검진을 위해 본원에 방문한 수진자에게서 우연히 발견된 선천성 심장 질환인 단엽성 대동맥판막 (unicuspid aortic valve)질환의 동반 질환 및 치료 계획에 대한 보고이다. 증례보고: 운동 중 호흡 곤란 증상을 호소하고, 심장병 가족력이 있는 49세 여자 환자로 건강 검진상 시행한 경흉부 심장초음파 검사상 이엽성 대동맥 판막으로 의심되었으며, 중등도의 대동맥판막 협착증을 동반하였고, 상행대동맥 확장 소견도 관찰되었다. 이 후 경식도 심장초음파, 심장 컴퓨터 단층촬영, 자기공명영상 검사를 추가로 시행하였다. 경식도 심장초음파 검사상 중등도의 대동맥판막 협착증을 동반한 단엽 대동맥판막, 경증의 대동맥판막 폐쇄부 전증, 상행대동맥 확장 소견이 관찰되었으며, 심장 컴퓨터 단층촬영과 자기공명영상 검사에서는 경흉부 심장 초음파 검사 및 경식도 심장초음파에서 관찰되었던 소견 외에 대동맥 축착 소견이 관찰되었다. 환자는 Atenolol 25mg 투약을 처방 받았고, 3개월 간격으로 외래 추적검사 예정이며, 상행대동맥의 확장이 더 진행 될 경우 수술 예정에 있다. Objective : During a routine medical check-up, a unicuspid aortic valve which is a kind of congenital heart disease was accidentally discovered in the patient. This is a report on the treatment plan for the patient. Casuistics : A 49-year-old female patient who has a family history of heart disease complained of Dyspnea On Exercise. A Bicuspid aortic valve was suspected in the Transthoracic echocardiography, with moderate Aortic stenosis and ascending aorta dilatation. Additionally, Transesophageal echocardiography, Cardiac CT, and Cardiac MRI were carried out. In the Transesophageal echocardiography, a unicuspid aortic valve was accompanied by moderate Aortic stenosis, with a diagnosis of mild Aortic regurgitation and ascending aorta dilatation. In addition, coarctation of aorta has been diagnosed in the Cardiac CT and Cardiac MRI. For the patient, 25mg of Atenol was prescribed, and monitoring treatment is going to be carried out at intervals of 3 months. In the event that ascending aorta dilatation worsens, operation will be performed.