위기협상 훈련프로그램의 효과성 평가

최성재(Choi Seong Jae),황세웅(Hwang Se Woong) 경찰대학 경찰학연구편집위원회 2011 경찰학연구 Vol.11 No.2

This study has evaluated the effectiveness of ‘Active listening skills' in the 'crisis negotiation specialization course' of National Police University. Crisis negotiation course, which was transformed from the 'open-education course' in 2009, covers various issues like containment․isolation, hostage, suicide, kidnap situations, techniques and tactics to resolve these situations, and has role-play trainings with professional actors for 2 weeks period of time. The frequencies of 8 active listening techniques were measured, and the result shows that the increases of the usage of emotion labeling, mirroring, summarizing, open-ended question were statistically significant, but those of ''I message', effective pause, rapid problem solving were not. And, overall response time has significantly decreased. The average frequency of emotion labeling has almost doubled from 3.14 to 6.61 (t=-4.495, α=0.00), paraphrasing from 2.04 to 3.79(t=-2,660, α=0.13), mirroring from 1.68 to 2.79(t=-2.585, α=0.15), summery from 0.23 to 1.26(t=-2.753, α=0.01), and open-ended question from 2.11 to 5.04(t=-4.813, α=0.00), which was the highest increase of all.

전신성 홍반성 루푸스(SLE) 환자에서 한약 복용후 발생한 Stevens-Johnson 증후군 1례

최성재 ( Seong Jae Choi ),권성대 ( Sung Dae Kwon ),이주한 ( Ju Han Lee ),김애리 ( Ae Ree Kim ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.1

Stevens-Johnson syndrome is an acute devastating condition which is related to certain drugs or infections. This syndrome involves multiple organs such as mucocutaneous, respiratory, occular and gastrointestinal systems. Patients who have underlying immunologic diseases are thought to be more susceptible. In lots of case reports and studies, more than 100 drugs have been implicated as causes of Stevens-Johnson syndrome or toxic epidermal necrolysis, but not so much as in Chinese Herb medications. Recently, we have experienced a patient with Stevens-Johnson syndrome after taking herb medicine and diagnosed as SLE during evaluation and treatment. We report this patient with a brief review of literatures.

전신성 홍반성 루푸스 환자에서 Fas Promoter 유전자 다형성에 대한 연구

최성재 ( Seong Jae Choi ),김예리 ( Ye Ree Kim ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.4

Objective: To investigate whether the polymorphism of Fas promoter gene is associated with susceptibility to systemic lupus erythematosus (SLE) and its clinical features. Methods: Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism using MvaI was used to determine genotypes of the Fas promoter in 87 SLE patients and 87 healthy control subjects. Clinical manifestations were analyzed in each patient and correlated with the genotypes. Results: The genotype distribution of the Fas promoter did not differ between SLE patients and control subjects (AA, GA, GG genotypes 31.0%, 54.0%, 14.9% in SLE patients vs. 29.9%, 55.2%, 14.9% in controls respectively, χ2=0.03, 2 degrees of freedom, p=0.99). No significant differences were also found in allele frequencies between the groups. Clinically in the lupus patients according to the Fas promoter polymorphism, there were no significant differences in age at onset, anti-ds DNA titer, C3, C4 level, renal involvement, number of ACR (American College of Rheumatology) criteria presented, SLE Disease Activity Index, SLICC/ACR (The Systemic Lupus international Collaborating Clinics/American College of Rheumatology) damage index, and autoantibody profiles except for anti-RNP antibody. The frequency of anti-RNP antibody in the lupus patients was increased in AA group (71.4%) compared to GA and GG groups (26.2% and 30.0%, p=0.007). Conclusion: The Fas promoter polymorphism does not seem to confer susceptibility to SLE, but seems to have some influence on the development of certain autoantibody like anti-RNP antibody, suggesting that the Fas promoter polymorphism is functional.

유방의 악성 림프종으로 발현된 경피증

최성재 ( Seong Jae Choi ),노영희 ( Young Hee Rho ),이영호 ( Young Ho Lee ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ),김애리 ( Ae Ree Kim ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2

We report a patient with scleroderma who had the unusual development of an anaplastic large/null cell malignant lymphoma of her breast at the time of diagnosis of scleroderma. It is well known that patients with scleroderma have malignant neoplasms such as lung cancer, breast cancer, and lymphoproliferative diseases more frequently than normal population. Although it is not well known about disease process of underlying cancer in patients with scleroderma, there must be some possible explanations. In brief, one disease may increase the risk of the other as a direct complication or as a result of the treatment given. Alternatively, the two disorders may share common risk factors. So it seems very important to emphasize that associated malignancy might be validated properly on rapidly developing scleroderma.

한국형발사체 1단 추력벡터제어용 유압 구동기의 진폭별 주파수 응답에 따른 엔진 배치 방법

최성재(Seong-Jae Choi),배종진(Jong-Jin Bae),정호락(Ho-Lac Jung),박현종(Hyun-Jong Park),박문수(Moonsu Park) 한국항공우주학회 2022 한국항공우주학회 학술발표회 논문집 Vol.2022 No.11

한국형발사체 1단 연료-유압식 추력벡터제어 구동장치시스템 Slew Test

최성재(Seong-Jae Choi),정호락(Ho-Lac Jung),배종진(Jong-Jin Bae),박문수(Moonsu Park),민병주(Byeong-Joo Min) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.11

충남 공주지역 문화유적의 지리적 입지 연구

최성재 ( Seong Jae Choi ),박지훈 ( Ji Hoon Park ),이애진 ( Aejin Lee ) 한국지리학회 2016 한국지리학회지 Vol.5 No.3

본 연구에서는 충남 공주지역에 분포하는 삼국시대~근대 문화유적의 지리적 입지 특성을 밝히고자 정량분석이 가능한 67개소의 문화유적(예: 고분, 관방, 불교, 유교)을 대상으로 지형분석과 GIS분석(표고 분석, 경사도 분석, 사면향 분석)을 실시하였다. 그 결과는 다음과 같다. 불교유적의 경우, `통일신라시대 이전 시기`의 불교유적은 백제도성(또는 제민천) 주변에 주로 분포하며 지형장 측면에서는 구릉과 선상지, 표고 120m 이하, 경사도 4~10°, 사면향 동향과 북동향이 각각 50%로 나타난다. 그러나 `통일신라시대 말 이후`의 불교유적은 계룡산지와 차령산맥에 주로 분포하며 지형장 측면에서는 산지의 선상지(또는 곡저평야), 표고 120m이상, 경사도 3~32° 구간 중 주로 평탄지 또는 완경사지, 사면향은 남향(47%)과 서향(43.8%)이 우세하게 나타나는 것으로 확인되었다. 그 외 고분유적의 경우, 지형장 측면에서는 구릉, 표고 40~50m, 경사도 5~16°, 사면향은 남향계열(67%)이 우세하게 나타난다. 관방유적의 경우, 삼국시대 산성은 지형장 측면에서는 구릉, 표고 50~70m, 경사도 15~21°에 입지하며, 조선시대 봉수대는 지형장 측면에서는 산지, 표고 200~330m, 경사도 0~10°(주로 평탄지 또는 완경사지), 사면향은 모든 사면향이 두루 분포한다. 유교유적의 경우, 관청과 향교는 지형장 측면에서는 선상지(또는 곡저평야), 표고 30m 이하, 경사도 0~10°에 입지하며, 사면향은 동향계열(75%)이 우세하게 나타난다. 정각유적은 지형장 측면에서는 구릉, 표고 30~50m, 경사도 4~20°, 북향계열(63%)이 우세하게 나타난다. The purpose of this study is to reveal the topographical characteristics of cultural relics from the Three Kingdoms Period to modern times distributed in the Gongju area of Chungnam. For this, 67 relics (i.e.: tomb, fortress, Buddhist, and Confucian relics) for which quantitative analysis can be carried out on were extracted to carry out topographic analysis and GIS analysis. The results are as follows. In the case of Buddhist relics, they were distributed in hills and alluvial fans standing less than 120 m high and slopes of 3.3-10° (especially in flatlands and soft slopes) around the Baekje capital (or Jemincheon) prior to the Unified Silla Period. But after the Goryeo Period, they were distributed alluvial fans and valley plains with gradients between 2.8-32° (especially in flatlands and soft slopes) at over 120 m in the Charyeong Mountain Range and Gyeryong Mountain area reflecting the social aspect of the Zen doctrine and Pro-Confucianism/Anti-Buddhism of the Chosun Dynasty. In the case of tomb relics, they are located in 40-50 m hills with slopes of 5-16° (especially in flatlands and soft slopes). In the case of fortress relics, in the Three Kingdoms Period they are located in 50-70m hills with slopes of 15-21° (especially in slope areas) and in the Chosun Dynasty, beacon fire stations were mainly distributed in mountain areas of 200-330 m altitude and gradients of 0-10° (especially in flatlands and soft slopes). In the case of Confucian relics, pavilion relics are located on the upper flatlands river cliffs of meandering rivers advantageous for viewing the scenery, while official buildings and Confucian schools are located on alluvial fans or valley plains.

CTLA4 exon 1 and promotor polymorphisms in systemic Lupus erythematosus

이용호 ( Young Ho Lee ),최성재 ( Seong Jae Choi ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

Dupuytren 연축에서 콜키신의 치료효과: 예비연구

이영호 ( Young Ho Lee ),최성재 ( Seong Jae Choi ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.2

목적: 콜키신은 섬유아세포의 증식을 억제하고, 콜라게나제 활성도를 증가시키고 콜라겐 합성을 억제하는 것으로 알려져있어 이론적으로 Dupuytren 연축 치료에 효과적일 수 있지만 콜키신의 실제 치료효과에 대해서는 아직 확실하지 않다. 저자들은 Dupuytren 연축에서 콜키신의 치료 효과를 알아보고자 하였다. 방법: 비대조군 예비 연구로서 전에 치료를 받은 적이 없는 Dupuytren 연축 환자 10명을 대상으로 하여 2-12개월간 콜키신을 경구 투여하였다. 콜키신의 치료효과는 통증, 손가락 운동정도, 결절 또는 대(band) 크기, 수지 위축, 피부 오무라짐(tethering) 등을 처음과 비교하여 악화(-1), 변화 없음(0), 호전(1), 정상화(2)로 판정하였다. 결과: 1. 콜키신 치료후 5명에서 Dupuytren 연축으로 인한 통증의 호전을 보였으며, 손가락 운동 정도, 결절 또는 대(band) 크기, 수지 위축 및 피부 오무라짐(tethering) 등도 호전을 보였다. 2. 콜키신 치료후 4명은 통증의 소실 및 손가락 운동장애, 결절 또는 대(band) 크기, 수지 위축, 피부 오무라짐(tethering) 등이 모두 소실되어 정상화되었다. 이들중 최대 12개월간 치료 및 추적기간 중 Dupuytren 연축이 소실된 후 재발된 경우는 없었다. 3. 한 환자는 콜키신을 5개월간 투여한 후에도 병변 및 통증의 호전이 없어 트리암시놀론 20mg을 병변 부위에 국소 주사한 후 증상의 호전을 보였으나 5개월후 재발하여 다시 콜키신을 2개월간 투여하였고 통증 및 손가락 운동정도, 결절 또는 대(band) 크기, 수지 위축, 피부 오무라짐 등에서 호전을 보였다. 4. 콜키신 치료중 콜키신으로 인한 부작용은 임상증상이나 검사상 한 예에서도 관찰되지 않았다. 결론: 비록 비대조군 예비연구이기는 하지만 콜키신은 Dupuytren 연축 치료에 효과적인 것으로 생각된다. 향후 Dupuytren 연축에서 콜키신의 치료효과에 대한 전향적인 대조군 연구가 필요할 것으로 생각된다. Objective: The treatment of Dupuytren`s contracture has not been entirely satisfactory. We investigated the effectiveness of colchicine, known to inhibit fibroblastic activity, induce collagenase activity and decrease collagen synthesis, in the treatment of Dupuytren`s contracture. Methods: Colchicine was administered orally for 2-12 months to 10 previously untreated patients with Dupuyten`s contracture. We evaluated the effectiveness of the treatment based on subjective(pain) and objective(finger movement, nodule or band size, digital contracture, skin tethering) criteria. Results: 1) Pain and more than one of objective criteria improved in 5 of the 10 patients after colchicine therapy. 2) Dupuytren`s contracture disappeared in 4 of the 10 patients after colchicine therapy. 3) As one patient had no improvement of Dupuytren`s contracture 5 months after colchicine treatment, she was injected with steroid. But she experienced recurrence of the disease 5 months after steroid injection and she was retreated with colchicine. She finally showed the improvement of the disease 2 months after colchicine therapy. 4) Side effect due to colchicine was not found in any of the patients. Conclusion: Although this is a pilot study, colchicine seems to be effective in the treatment of Dupuytren`s contracture. Hereafter a prospective controlled double-blind study is needed to verify this effectiveness of colchicine treatment in Dupuytren`s contracture.

전신성 홍반성 루푸스와 류마티스 관절염에서 CTLA-4 exon 1과 promoter 유전자 다형성에 대한 연구

이영호 ( Young Ho Lee ),최성재 ( Seong Jae Choi ),김예리 ( Ye Ree Kim ),지종대 ( Jong Dae Ji ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.1

Objective: Strong genetic evidence has shown an association between cytotoxic T lymphocyte associated antigen-4 (CTLA-4) and autoimmune diseases. This study was set out to determine whether the polymorphisms of the CTLA-4 exon 1 and promoter are associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and their clinical features. Methods: Polymerase chain reaction of genomic DNA-restriction fragment length polymorphism using Bst E II and Tru9 I was used to determine genotypes of the CTLA-4 exon 1 and promoter in 80 SLE, 86 RA patients and 86 healthy control subjects. Clinical manifestations were analyzed in each patient and correlated with the genotypes. Results: The genotype frequency of the CTLA-4 exon 1 differed between SLE patients and controls (chi-squared=6.74, 2 degrees of freedom (df), p=0.03). The CTLA-4 AG genotype occurred more frequently in patients with SLE (46.3% vs. 33.7% controls). On the other hand, the CTLA-4 AA genotype as well as the CTLA-4 GG genotype was less frequent among SLE patients than among control subjects (1.3% vs. 9.3% and 52.5% vs. 57.0% respectively). The genotype distribution of the CTLA-4 promoter differed between SLE patients and control subjects (CT, TT, CC genotypes 27.5%, 0%, 72.5% vs. 16.3%, 4.7%, 79.1% controls respectively, chi-squared=6.36, 2 df, p=0.04). When the association was analyzed with respect to sex, the distribution of the CTLA-4 exon 1-promotor genotypes was significantly different between female SLE patients and females in the control group (chi-squared=8.16, 3 df, p=0.04). The frequencies of the CTLA-4 exon 1 and promoter genotypes, allele and phenotypes and exon 1-promotor genotypes were not significantly different between RA patients and control subjects. Clinically, there were no significant differences in patients with SLE and RA according to the CTLA-4 polymorphisms. Conclusion: The polymorphisms within the CTLA-4 exon 1 and promoter appear to play a role in susceptibility to SLE, but not to be associated with clinical features of SLE, susceptibility to RA and its clinical features.