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RISS 인기검색어
- 검색키워드
- 저자 : 최선미 ( Seung Uoo Shin ) (검색결과 3 건)
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Peroxisome Proliferator-Activated Receptor-γ 2 (PPARγ2) Pro12Ala (P12A) 유전자 다형성이 한국여성의 체지방분포에 미치는 영향
김길수 ( Kil Soo Kim ),최선미 ( Sun Mi Choi ),신승우 ( Seung Uoo Shin ),양현성 ( Hyun Sung Yang ),윤유식 ( Yoo Sik Yoon ) 한방비만학회 2004 한방비만학회지 Vol.4 No.1
Objectives : The effects of peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala (P12A) polymorphism on body mass index (BMI) and type 2 diabetes are well documented; however, until now, only a few studies have evaluated the effects of this polymorphism on body fat distribution. This study was conducted to elucidate the effects of this polymorphism on computed tomography (CT)-measured body fat distribution and other obesity-related parameters in Korean female subjects. Methods & Results : The frequencies of PPARγ2 genotypes were: PP type, 93.0%; PA type, 6.8%; and AA type, 0.2%. The frequency of the A allele was 0.035. Body weight (P .012), BMI (P .012), and waist-to-hip ratio (WHR) (P .001) were significantly higher in subjects with PA/AA compared with subjects with PP. When body composition was analyzed by bioimpedance analysis, lean body mass and body water content were similar between the 2 groups. However, body fat mass (P .003) and body fat percent (P .025) were significantly higher in subjects with PA/AA compared with subjects with PP. Among overweight subjects with BMI of greater than 25, PA/AA was associated with significantly higher abdominal subcutaneous fat (P .000), abdominal visceral fat (P .031), and subcutaneous upper and lower thigh adipose tissue (P .010 and .013). However, among lean subjects with BMI of less than 25, no significant differences associated with PPARγ2 genotype were found, suggesting that the fat-accumulating effects of the PA/AA genotype were evident only among overweight subjects, but not among lean subjects. When serum lipid profiles, glucose, and liver function indicators were compared among overweight subjects, no significant difference associated with PPARγ2 genotype was found. Changes in body weight, BMI, WHR, and body fat mass were measured among overweight subjects who finished a 1-month weight lose program of a hypocaloric diet and exercise; no significant differences associated with PPARγ2 genotype were found. Conclusions : The results of this study suggest that the PPARγ2 PA/AA genotype is associated with increased subcutaneous and visceral fat areas in overweight Korean female subjects, but does not significantly affect serum biochemical parameters and outcomes of weight loss programs.1)
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UCP-2, 3 단일염기다형성이 한국인 여성의 체중감량에 미치는 영향
심우진 ( Woo Jin Shim ),문진석 ( Jin Seok Moon ),최선미 ( Sun Mi Choi ),신승우 ( Seung Uoo Shin ),김길수 ( Kil Soo Kim ) 한방비만학회 2006 한방비만학회지 Vol.6 No.2
This study was conducted to investigate the effects of Uncoupling protein (UCP) polymorphisms on weight loss. We analyzed associations between polymorphisms of UCP-2, 3 and changes in percentage of obesity phenotypes (Body mass index and percent body fat) after treatment. Materials and Methods: A total of 207 Korean women (BMI over 25) were recruited from the obesity clinic in Kirin Oriental Medical Hospital (Seoul, Korea). All patients were treated with a very low calorie diet and oriental medical therapy for one month. The effect of UCP polymorphisms on changes in obesity-phenotypes were analyzed. For the genotyping of a single nucleotide polymorphism (SNPs), genomic DNA from each subject was extracted from whole blood and genotyped using the TaqMan Method. Associations between changes in percentage of obesity phenotypes (BMI and percent body fat) and UCP polymorphisms were analyzed using age-adjusted general linear model. Results and Conclusions: In this study, AG, GG type of UCP-2 -866A>G, CC, CT type of UCP-2 +4787C>T, CG, GG type of UCP-3 +2564C>G, AG, GG type of UCP-3 +3106A>G, and TC, CC type of UCP-3 +4589T>C played a role as a resistance gene to weight loss.
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비만환자의 담음변증(痰飮辨證)과 복부내장지방과의 연관성에 관한 연구
이형철 ( Hyung Chul Lee ),최영민 ( Young Min Choi ),심우진 ( Woo Jin Sim ),김길수 ( Kil Soo Kim ),최선미 ( Seung Uoo Shin ),강병갑 ( Sun Mi Choi ),신승우 ( Byeong Kab Kang ) 한방비만학회 2006 한방비만학회지 Vol.6 No.1
This study was designed to evaluate the relationship with abdominal visceral fat area in obese patients identified as phlegm type. Methods : This research were performed in 201 cases, visited Kirin Oriental Hospital from March 2005 to February 2006 for weight loss. We measured body mass index(BMI), abdominal CT, and classified all patients into two groups, normal and obesity group. And then we differentiated patients with phlegm-retention symptom from patients without it through questionnaire made by Korea Institute of Oriental Medicine. Results and Conclusions : Phlegm type was significantly higher than them of no symptom of phlegm in the abdominal visceral areas(P=0.036) and ratio(P=0.007), in obesity group(BMI≥25). On the other hand, there is little difference between abdominal visceral fat areas of phlegm type and no symptom of phlegm in normal group. According to the above results, if obese patients are diagnosed as identification of phlegm type there is good chance of abdominal visceral obesity.
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