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- 저자 : 천기태 ( Ki Tae Cheon ) (검색결과 6 건)
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기관지천식 환자에서 angiotesin converting enxyme과 endothelial nitric oxide synthase 유전자의 다형성에 관한 연구
전현순(Hyun Sun Jeon),천기태(Ki Tae Cheon),이홍범(Heung Bum Lee),이양근(Yang Keun Lee),김달식(Dal Sik Kim),이용철(Yong Chul Lee) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.4
N/A Background: Angiotensin converting enzyme (ACE) is heavily expressed in the lung and plays a role in the metabolism of angiotensin II, bradykinin and substance P. Nitric oxides. including those produced by endothelial nitric oxide synthase (ecNOS). may regulate vascular and airway tone in the lung and influence various aspects of airway homeostasis. They are potentially involved in the pathogenesis of asthma, but the role of ACE and ecNOS gene in bronchial asthma is not completely understood, Objective To examine the possible involvement of ACE and ecNOS genes in the genetic basis for bronchial asthma. we investigated the association between genetic polymorphism and bronchial asthma, and its severity. Method: We determined the ACE and ecNOS genotypes by the polyrnerase chain reaction in 160 patients with bronchial asthma and 121 healthy subjects. Severity of asthma was classified by the guideline of NHLBI/WHO workshop. Results: The frequency of the ID genotypes of ACE and bb genotype of ecNOS was highest in both groups, respectively. The distribution of ACE genotypes did not differ between the two groups (p=0.27). There was a higher frequency of the bb genotype of ecNOS in the asthma group than in the control population (p=0.004). In asthmatic patients, there were no differences in the distribution of ACE and ecNOS genotypes in different severity groups (p= 0.17, 0.06), Conclusion: These results suggest that the polymorphism of the ecNOS gene. not ACE gene. may be associated with develop>ment of asthma. But, the severity of asthma may not be influenced by polymorphisms of the ecNOS and ACE genes. (J Asthma Allergy Clin Immunol 20: 609-618, 2000)
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간 혈관종의 진단과정에서 임상적 및 방사선 형태학적 특징에 대한 연구
천기태,송정선,이수택,김대곤,안득수 의과학연구소 1996 全北醫大論文集 Vol.20 No.2
Objective : Hemangioma is the most common benign neoplasm of the liver and the second most common hepatic tumor, exceeded only by metastatic tumor. Fifty to 20 per cent of patients with hemagiomas are asymptomatic, and the lesions are discovered incidentally, usually by ultrasonography or CT performed for some other reason. Despite their usual benign behavior, hepatic hemagiomas frequently cause difficult diagnostic problems because they can be confused with a malignant neoplasm. Numerous methods are commonly applied to making this decision, including CT, ultrasound, MRI, radionuclide scintigram, angiography, and percutaneous fine needle biopsy. But, the specific diagnostic criteria for hemangioma cannot be reliably demonstrated in every classes. This study was done to evaluate the characteristics and problems of each clinical and radiological method for identifying hemangioma. We can find occasionally very huge sized hemangioma, so has to differenciate from hepatocellular carcinoma. Methods : We considered for symptoms, laboratory results, characteristic findings and problems of above diagnostic methods in 26 patients diagnosed as hepatic hemangioma between March, 1990 and October, 1994 at Chonbuk and Chonnam National University. Results : Hemangiomas occur predominantly in women and seen more commonly in forth and fifth decade. For the most cases the liver function tests are within normal limit or mildly increased. Especially the value of alpha-fetoprotein(AFP) is normal except for one case. Although ultrasound has low sensitivity, it has many advantages as screening test. We can discover that ^(99m)Tc-RBC SPECT and the fine needle aspiration biopsy are safe diagnostic method but has risks such as bleeding and shock. Conclusion : IF the lesion is well marginated and hyperechoic and the patient has normal liver function costs and normal AFP, we recommend only a follow-up sonogram in 3 to 6 months to assess lesion Patients with an atypical sonographic pattern(hypoechoic or mixed) or those with abnormal liver function test or elevated AFP, should have a technetium ^(99m)Tc erythrocyte scan. If the radionuclide scan is negative, MRI should be performed. Needle biopsy of hemangioma should be reserved for those cases in which a confident diagnosis cannot be reached by other means. (Key Words : Hepatic Hemangioma, Radiology)
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천기태,김현중,송정선,권철,이수택,김대곤,안득수 의과학연구소 1994 全北醫大論文集 Vol.18 No.2
Eosinophilic gastroenteritis is a rare disease of gastrointestinal tract and includes three major clinical patterns of mucosal, muscle layer, and subserosal disease. A 53-year-man was presented with bloody diarrhea, tenesmus and marked eosinophilia in peripheral blood. The mucosal type of eosinophilic gastroenteritis was confirmed by mucosal biopsy on the sigmoid and descending colon. The patient was rapidly improved with oral prednisolone administration. We report this case with the review of relevant literature.
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통상형 간질성 폐렴 환자의 기관지세척액 및 혈청의 Cytokine 농도에 관한 연구
황진수,천기태,이흥범,이용철,박태선,이수택,이양근 의과학연구소 1999 全北醫大論文集 Vol.23 No.2
There are increasing evidences that the proinflammatory cytokines such as interleukin-1, tumor necrosis factor-α and transforming growth factor-β are involved in the pathogenesis of the idiopathic pulmonary fibrosis. In this study, we investigated the concentration of the cytokines using ELISA method in the bronchoalveolar lavage (BAL) fluids and serum of the patients with usual interstitial pneumonia (UIP) and normal healthy control (n=10). With the exception of TNF-α in the serum, there was no significant difference of the cytokine concentration between the patients with UIP and controls in both BAL fluid and serum. The concentration of TNF-α was significantly increased in the serum of the patients with UIP compared to the controls(p=0.002). However, IL-1 has a tendency to be released with higher level in the sera of UIP patients than controls without significance (p=0.08). So, we carefully demonstrated that IL-1 and TNF-α were increased in the serum of UIP, and that these cytokines may have pivotal roles in the pathogenesis of UIP. (Key word : IL-1, TNF-α , TGF-β, interstitial pneumonia)
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이동근,이양근,이용철,천기태,인병현,이성중,고정곤 대한내과학회 1996 대한내과학회지 Vol.50 No.3
We desceribe a case of pulmonary capillary hemangiomatosis in a 52-year-old woman with history of hemoptysis. Pulmonary capillary hemangiomatosis is a locally aggressive benign neoplasm of the lung characterized by the presence of numerous cytologically benign thin walled capillary-sized blood vessel proliferating diffusely through the pulmonary interstitium, in and around pulmonary vessels and airway. Pulmonary capillary hemangiomatosis is characterized by a slow progressive clinical course with sign and symptom of pulmonary hypertension, hemoptysis and right heart failure. The cause of capillary hemangimatosis is as yet unknown. Definitive diagnosis can only be made histologically. Complication may occur in the form of necrosis, shunting, inflammatory process, and local compression or obstruction leading to respiratory failure. We experienced a case of pedunculated capillary hemagioma of the bronchus, and report with review of literatures.
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