외상이 경추 후종인대 골화증 환자의 수술결과에 미치는 영향

진동규,진병호,조용은,윤도흠,김영수,Chin, Dong-Kyu,Jin, Byung-Ho,Cho, Yong-Eun,Yoon, Do-Heum,Kim, Young-Soo 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.7

Objectives : Most cases of cervical ossification of the posterior longitudinal ligament(OPLL) present with myelopathy or myeloradiculopathy, which sometimes is further complicated by minor trauma to the spinal cord. The main purpose of surgery in these patients is the alleviation symptoms but also as protection against further deterioration. The purpose of this study is to analyze the influence of trauma on the surgical outcome in patients with cervical OPLL. Methods : Over the past 13 years, we have operated on 123 patients with myelopathy associated with cevical OPLL. Among these, thirty patients had cervical cord injury associated with major or minor trauma and their clinical and radiographic data were reviewed retrosepctively. Results : As to cause of trauma, seventeen were related with traffic accident and 13 were related with minor slipping injury. The pre- and post-operative motor power were significantly weaker in the patients with trauma, but the degree of motor improvement was significantly higher(trauma group : $0.90{\pm}1.49$, non-trauma group : $0.41{\pm}0.80$). Conclusion : These results indicate that even indirect minor trauma to the cervical spine can cause irreversible changes to the spinal cord if this is associated with underlying cervical stenosis with OPLL. Although less favorable results may be anticipated in patients with trauma, operative decompression could improve motor power and protect further deterioration.

스케줄링 알고리즘에 따른 협업 시스템의 성능 분석

진동규 ( Dong-kyu Jin ),조성우 ( Sung-woo Cho ),조용연 ( Yong-yeon Jo ),김상욱 ( Sang-wook Kim ),오현옥 한국정보처리학회 2014 한국정보처리학회 학술대회논문집 Vol.21 No.2

대량의 정보를 효과적으로 처리하기 위한 기술로 CPU 뿐만 아니라 iSSD 와 GPGPU 를 개별적으로 이용하는 연구가 진행되고 있다. 본 논문에서는 더 나아가 CPU, iSSD 와 GPU 를 협업시켜 프로그램 수행 성능을 향상시키는 방법을 연구한다. 이러한 이질 시스템의 협업을 위해 이질 스케줄링 알고리즘을 적용하고, 스케줄링 알고리즘에 따른 협업 시스템의 성능을 분석한다.

유전성대사질환의 치료 - 효소보충요법

진동규(Jin Dong Kyu) 대한의학유전학회 2014 대한의학유전학회 학술대회 논문집 Vol.1 No.1

Mechanism of ERT in LSD -Most Iysosomal enzymes can be interanalized by cells through mannose-6-phosphate receptor to delivered to the Iysosomes -Placental extraction enzyme > Recombinant enzymes

뮤코다당증 진단과 치료의 최신 지견

맹세현,진동규,Maeng, Se-Hyun,Jin, Dong Kyu 대한유전성대사질환학회 2012 대한유전성대사질환학회지 Vol.12 No.2

동아시아 지역 뮤코다당증 환자의 분포와 치료에 대한 현황과 전망

조성윤,진동규,Cho, Sung Yoon,Jin, Dong-Kyu 대한유전성대사질환학회 2013 대한유전성대사질환학회지 Vol.13 No.2

경추에 발생한 멜라닌 신경초종 - 증례보고 -

이성,진동규,진병호,조용은,김영수,Yi, Seong,Chin, Dong Kyu,Jin, Byung Ho,Cho, Yong Eun,Kim, Young Soo 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.7

Primary melanotic schwannoma in spinal cord is a very uncommon disorder, eight cases of melanotic schwannoma in spinal cord have been found in the literature. We present a case report of a patient with an intradural, extramadullary melanotic schwannoma in cervical spine and the literature on melanotic schwannoma is reviewed. The proposed theories on the origin of these tumors and treatment are discussed.

척수종양 수술 후 발생한 척추 불안정 : 추궁성형술과 추궁제거술의 비교 연구

김상현,진동규,윤영설,진병호,조용은,김영수,Kim, Sang Hyun,Chin, Dong kyu,Yoon, Young Sul,Jin, Byung Ho,Cho, Yong Eun,Kim, Young Soo 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objectives : To demonstrate the preventive effect on post-operative spinal deformity of the laminoplasty compared with laminectomy for spinal cord tumor. Methods : Sixteen patients who underwent laminoplasty and 89 patients who underwent lamenectomy were reviewed retrospectively after removal of spinal cord tumors between February 1981 and December 1999. The mean follow-up period after laminoplasty and laminectomy were 29 months(range, 12-49 months) and 66 months(range, 6-120 months) respectively. Patients were observed neurologically and radiologically. Results : Postoperative kyphosis was observed 17 patients(19%) in the laminectomy group, but was not observed in the laminoplasty group. Postoperative slipping was observed 16 patients(18%) in the laminectomy group, but was not observed in the laminoplasty group. Complications such as postoperative scoliosis, rotation, and swan-neck deformity were observed in the laminectomy group, but were not observed in the laminoplasty group. Conclusions : Laminoplasty prevented postoperative spinal deformities after removal of spinal cord tumors, and afforded anatomic reconstruction of the vertebral arch. Additionally, appropriate patient selection maximizes the chance of optimal neurologic outcomes and minimizes complications. Laminoplasty appears to warrant further evaluation as an alternative to wide laminectomies for exposure of intraspinal tumors.

다발성 요추간반 탈출증에서 추간반조영술의 진단적 의의

이상원,김긍년,진동규,김영수,조용은,진병호,Lee, Sang-Won,Kim, Keung-Nyun,Chin, Dong-Kyu,Kim, Young-Soo,Cho, Yong-Eun,Jin, Byung Ho 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.5

Objective : The introduction of MRI makes it easy to detect multiple lumbar disc herniation. However, MRI is not a physiologic test for detecting the symptomatic level. For the surgical plan, it is very important to determine the symtomatic level among the multiple lumbar disc herniation. In this regard, we studied diagnostic significance of discography on multiple lumbar disc herniation in determining the symptomatic level. Method and Material : We retrospectvely analyzed the discographic and clinical findings of 121 patients with multiple lumbar disc herniation for investigating the diagnostic availability of discography. All were surgically treated from January 1995 through May 1998. Result : Discography provocated the same pain as usual symptom in 99 out of 121 patients(81.8%). Compared with surgical findings, the diagnostic accuracy of the discography in multiple lumbar disc herniation was 75.6%, sensitivity was 64.6%, and specificity 87.2%. There was no correlation between the pain provocation of discography and the extent of annular degeneration on CT/discogram. The pain provocation showed good correlation with the extent of annular disruption on CT/discogram. The rate of same result(correlation rate) between the discography and D.I.T.I was 81.4% in multiple lumbar disc herniation patients with unilateral leg pain. Conclusion : These results indicate that in multiple lumbar disc herniation, the discography is considered useful diagnostic tool to determine the symptomatic level and to decide the surgical plan.

증가된 글루타민에 의해 초래되는 뇌신경질환의 초파리 모델에 대한 연구

신상민,백경훈,진동규,Shin, Sang Min,Paik, Kyung Hoon,Jin, Dong Kyu The Korean Pediatric Society 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.4

목 적 : 폴리글루타민 질환은 해당 발현단백질의 연속되는 글루타민 아미노산 서열이 신장되기 때문에 일어나는 질환군이다. 현 연구는 폴리글루타민 질환 형질전환 초파리 모델들이 환자들 에서와 유사한 장애를 나타내는지 확인하기 위해 수행되었다. 방 법 : 폴리글루타민 질환 (SCA3) 형질전환 초파리를 대상으로 벽을 기어오르는 운동 능력을 검사하였다. 또한 유전학적인 방법을 통해서 아폽토시스를 억제하는 bcl-2 유전자와 화학적 샤페론이 뇌신경의 퇴행에 어떤 영향을 미치는지 확인하였으며 향후의 연구를 위해 척수소뇌 운동실조증 타입 2 (SCA2) 질환을 발현하는 형질전환 초파리를 생산하였다. 결 과 : SCA3 형질전환 초파리에서 신장된 폴리글루타민 배열을 지니는 질환성 초파리의 경우 신경계에서 해당 단백질을 발현하였을 경우 전형적인 운동 능력 상실을 나타냈다. 아폽토시스를 억제하는 유전자인 bcl-2를 함께 발현했을 경우, 신장된 단백질의 유독한 영향을 약화시키지 못했지만, 화학적 샤페론인글리세롤의 경우 적어도 눈에서의 유독한 영향은 억제하는 것으로 보인다. 본 연구진에 의해 개발된 SCA2 형질전환 초파리의 경우 유해 단백질의 발현 정도가 낮아서 정확한 분석이 어려웠다. 결 론 : SCA3 형질전환 초파리는 환자들에서 발견되는 운동실조증을 보였다. 글리세롤과 같은 화학적 샤페론이 현재 치료가 전무한 이 종류의 질환군의 치료에 효과적일 것으로 사료된다. Purpose : Polyglutamine diseases are a group of diseases caused by the expansion of a polyglutamine tract in the protein. The present study was performed to verify if polyglutamine disease transgenic Drosophila models show similar dysfunctions as are seen in human patients. Methods : Polyglutamine disease transgenic Drosophila were tested for their climbing ability. And using genetic methods, the effects of anti-apoptotic gene bcl-2 and chemical chaperones on neurodegeneration were observed. Also, spinocerebellar ataxia 2 (SCA2) transgenic Drosophila lines were generated for future studies. Results : Expanded forms of spinocerebellar ataxia 3 (SCA3) transgenic protein causes characteristic locomotor dysfunction when expressed in the nervous system of Drosophila but the anti-apoptotic gene bcl-2 shows no evidence of ameliorating the deleterious effect of the expanded protein. However, Glycerol, a chemical chaperone, seemed to reduce the toxicity, at least in the eyes of the transgenic flies. The level SCA2 expression is too weak in the transgenic SCA2 Drosophila for evaluation. Conclusion : SCA3 transgenic Drosophila show ataxic behavior as observed in human patients. Chemical chaperones such as glycerol may prove beneficial in this class of genetic disease, which has no current method of cure.

주산기에 발견된 수신증의 자연 경과와 치료 방침

채수호,이지혁,진동규,박관현,백경훈,Chae Soo-Ho,Lee Ji-Hyuk,Jin Dong-Kyu,Park Kwan-Hyun,Paik Kyung-Hoon 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.1

목적 :신생아 수신증은 임신의 약 4.5-7% 정도로 흔하게 나타날 뿐 아니라 산전 초음파의 발달과 함께 조기진단이 가능한 질환이다. 그러나 그 자연 경과에 대한 이해 부족으로, 수술적 중재술의 적절한 시기에 대한 합의가 이루어지지 않은 상태이다. 저자들은 신생아 수신증의 자연경과에 대한 이해와 수술의 위험요소를 분석함으로써, 적절한 치료지침을 제시하고자 하였다. 방법 : 2001년 4월부터 2005년 4월까지 본원에서 태어난 신생아 중, 주산기에 시행한 신 초음파 검사에서 신생아 수신증으로 진단된 환아를 대상으로 하였다. 총 2회 이상의 초음파 검사를 통한 경과 관찰을 하였던 환아들 중, 6개월 이상 추적관찰된 총 69명의 환자를 대상으로 하였다. 환자군은 주산기 신장 초음파에서 신우전후경 길이를 기준으로 분류하였다 각각 환자의 신장 초음파 검사에서 신우전후경 길이 및 SFU 지수를 측정하였고, $^{99m}Tc-MAG3$ 검사 결과를 바탕으로 분석하였다. 수술은 정해진 기준에 따라 시행하였다. 결과 : 신우전후경의 길이가 10 mm 이상인 환자군에서, 10 mm 미만인 환자군에 비해 수술적 중재술을 필요한 경우가 많았다. 또한 SFU 지수가 3 이상인 경우에서, 수술의 빈도가 높아, SFU 지수 3 미만인 환자군과 유의한 차이를 두었다. MAG3 검사 중, 상대 신기능은 수술과의 연관성을 찾기 어려웠으나, 신장 폐색의 정도와 수술 여부와 상호 관계가 있는 것으로 나타났다. 결론 : 신생아 수신증에서 주산기 신장 초음파 검사 상, 신우전후경의 길이가 10 mm가 넘거나, SFU 지수가 3 이상이거나, MAG3 검사 결과 상 폐색이 의심되는 경우에는 수술적 중재술을 통한 적극적인 치료를 고려하는 것이 추천된다. 그리고 신우전후경의 길이가 10 mm 미만이거나 SFU 지수가 2 이하인 경우, 신생아 수신증의 자연 경과를 관찰할 수 있으나 정기적인 경과 관찰이 필요하다. Purpose : Neonatal hydronephrosis is diagnosed with an incidence of 4.5-7% of pregnancies. Recently, early detection of neonatal hydroneprosis with antenatal ultrasonography has be-come possible. But consensus about its management has not been reached, especially concerning surgical intervention. The purpose of this study is to analyze the natural course of neonatal hydronephrosis and to determine the guideline of surgical intervention and follow up study. Methods : Sixty nine hydronephrotic kidneys were confirmed from April 2001 to April 2005. All cases were rechecked by ultrasonography once at least and had a minimum follow-up of 6 months. We classified the patients into 4 groups according to the anterior posterior pelvic diameter(APPD) on perinatal ultrasonography. Ultrasonography to measure the APPD diameter and Society for Fetal Urology(SFU) grade, $^{99m}Tc-MAG3$ scan were done to a set protocol. Pyeloplasty was peformed according to the protocol. Results : Pyeloplasty was not needed in most cases where the APPD was below 10 mm and where the SFU grade were less than grade 3. Many cases with APPD 10 mm above or SFU grade III above had undergone pyeloplasty. We found a correlation between obstruction grade on MAG3 scan and whether surgery was performed or not. Conclusion : If APPD is above 10 mm, SFU grade is above grade 3 or urinary tract obstruction is suspected by MAG3 scan, pyeloplasty must be considered. In cases where APPD is below 10mm and SFU grade is less than grade 3, we can observe the natural course of neonatal hydronephrosis with consecutive follow-up. (J Korean Soc Pediatr Nephrol 2006;10:33-39)