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크론병에서 Infliximab 치료에 의해 발생한 건선
좌윤정 ( Yoon Jung Jwa ),김남훈 ( Nam Hoon Kim ),박혜진 ( Hai Jin Park ),박준섭 ( Jun Sup Park ),배원기 ( Won Ki Bae ),김경아 ( Kyung Ah Kim ),이준성 ( June Sung Lee ),문영수 ( Young Soo Moon ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.5
Infliximab, the monoclonal antibody to tumor necrosis factor, is indicated for refractory luminal and fistulizing Crohn`s disease and rheumatoid arthritis. Infliximab treatment has adverse events including infusion reactions, opportunistic infections, and the potential for the event such as reactivation of latent tuberculosis. Cutaneous adverse reactions of TNF-α agents include skin rash, urticaria, pruritus, lupus-like eruption, and injection site reactions. Most of all, psoriasis or psoriasiform dermatitis induced by infliximab treatment for Crohn`s disease is rarely reported in Korea. We report a case of psoriasis induced by infliximab treatment for Crohn`s disease with a review of world literature. (Korean J Gastroenterol 2010;56:324-328)
원 저 : 대장내시경 숙련자와 비숙련자 간의 대장회수시간에 따른 선종발견율의 차이
김영두 ( Young Doo Kim ),배원기 ( Won Ki Bae ),최윤호 ( Yun Ho Choi ),좌윤정 ( Yoon Jung Jwa ),정상경 ( Sang Kyung Jung ),이부현 ( Bu Hyun Lee ),백우현 ( Woo Hyun Paik ),김정욱 ( Jong Wook Kim ),김남훈 ( Nam Hoon Kim ),김경아 ( Ky 대한소화기학회 2014 대한소화기학회지 Vol.64 No.5
Background/Aims: Adequate screening colonoscopy in the general population decreases the mortality associated with colorectal cancer through detection and removal of adenomatous polyps. Prolonged colonoscopic withdrawal times (>6 min) are reportedly beneficial for adenoma detection rates (ADRs). However, the quality of the endoscopist compared with colonoscopic withdrawal times is not known. The aims of this study were to investigate the difference in ADRs between trainees and experienced examiners. Methods: A total of 967 consecutive patients who underwent screening colonoscopy in a single University hospital from June 2010 to November 2011 were enrolled in this prospective observational study. Colonoscopy was performed by four experienced staff and seven gastroenterology fellows. Results: Seven gastroenterology fellows performed 633 colonoscopies and four experienced staff performed 334 colonoscopies. The overall detection rates of colorectal adenoma were 31.5% with ADRs of fellows and staff of 29.4% and 35.6%, respectively (p=0.047). Fellows also showed lower advanced ADRs (5.7% vs. 9.9%, p=0.016), and fellows had longer mean withdrawal times than staff (12.4±4.9 min vs. 8.2±4.1 min, p<0.001). Multivariate analysis showed significantly increased ADRs and advanced ADRs for staff compared with fellows (adjusted OR 2.41, 95% CI 1.70-3.43; adjusted OR 2.55, 95% CI 1.47 4.45, respectively). Conclusions: ADRs were significantly lower when colonoscopy was performed by trainees, although withdrawal times were longer than those of staff. Our results demonstrated that the quality of colonoscopy, as measured by ADRs, may be improved by experienced examiners. (Korean J Gastroenterol 2014;64:278-283)