http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 조현장 ( Hyun Jang Cho ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Chloroquine 내성 유입 말라리아 14 예에 대한 Halofantrine 의 치료효과
조현장(Hyun Jang Cho),노성민(Sung Min Noh),이상도(Sang Do Lee),부철수(Cheol Su Poo),김성일(Sung Il Kim),김두형(Du Hyeong Kim),김승영(Seung Young Kim),박병엽(Byeung Yeub Park) 대한내과학회 1997 대한내과학회지 Vol.53 No.4
N/A Objectives: The prevalence of malaria is increasing in recent years and also multidrug resistant malaria is increasing around the world and there is an increasing concern about imported malaria in nonendemic areas. Now many drugs are tried to find out effect on multidrug resistant malaria. We performed this study to investigate the thrapeutic effect of halofantrine in the treatment of chloroquine resistant imported malaria. Methods: From Feb. 1992 to May 1995, we experienced 35 patients infected with malaria and treated 14 patients among 35 patients with halofantrine. Results: 1) All 14 patients were sailor with a mean age of 39.4 years and infected with malaria. 2) The majority of patients were infected with malaria at Africa. 3) 10 patients were infected with Plasmodium falciparum and the remainder were undetermined. 4) In the 11 cases of chloroquine resistant malaria treated with quinine plus tetracycline combination therapy or Fansidar, 4 cases could not be tolerable due to side effects and resistance to the therapy, we substituted halofantrine for above regimens. 5) In the 10 cases, treated after May 1994, halofantrine was the first choice of treatment because they were the cases of malaria infected in the mid-Africa where the prevalence of chloroquine resistant malaria is high. 6) With halofantrine, all 14 cases were treated with minimal side effects suc4 as nausea, vomiting, anorexia, abdominal pain and fatigue. Conclusion: We think halofantrine is a simple and effective regimen against chloroquine resistant malaria and consider this agent as an alternative therapeutic regimen on chloroquine resistant malaria.
-
류마티스 관절염, 골 관절염, 강직성 척추염, 통풍성 관절염 환자의 활액내 Adenosine deaminase 활성도
김승영 ( Seung Young Kim ),김지수 ( Ji Soo Kim ),김태범 ( Tae Bum Kim ),부철수 ( Chul Su Poo ),조현장 ( Hyun Jang Cho ),노성민 ( Sung Min Noh ),김병국 ( Byoung Kuk Kim ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.1
Adenosine deaminase는 체내의 핵을 가진 모든 세포에 존재하는데, T 임파구, 대식세포, 또는 단핵구의 활동이 증가되어 있는 곳에 활성도가 증가되어 있다. 그러므로 관절염이 있는 환자의 활액에서 이 효소의 활성도를 측정함으로서 관절종창의 감별진단과 질환의 활동도 판단에 유용한지 알아보았다. 대상 및 방법: 1996년 3월부터 1997년 1월까지 해동병원 류마티스 크리닉을 방문한 환자중 활액 천자가 가능하였던 류마티스 관절염 21명, 퇴행성 관절염 11명, 강직성 척추염 3명, 통풍성 관절염 2명을 대상으로 채취된 활액을 hyaluronidase로 처리하고 상층액에서 ADA을 측정하였다. 결과: 류마티스 관절염 환자의 adenosine deaminase의 활성도가 골관절염 환자에 비해 유의하게 증가되어 있었으나, 강직성 척추염이나 통풍성관절염 환자에서도 비슷한 정도로 증가되어 있었다. 1) 환자 활액내 ADA 활성도가 류마티스 관절염은 39.5±9.3 U/L, 골 관절염은 13.3±9.7 U/L로 유의한 차이를 보였다(p<0.001). 강직성 척추염과 통풍성 관절염에서는 44.7±10.7 U/L과 42±18.4 U/L 이었다. 2) ESR과 활액 ADA 활성도 사이에는 약한 상관관계를 보였으나(r=0.4061, p<0.1), 혈청 CRP와 활액 ADA는 유의한 상관관계를 보이지 않았다(r=0.1315). 3) 전 환자의 활액내 백혈구 수와 ADA 활성도는 유의한 상관관계를 보였으나(r=0.697, p<0.05), 임파구 수와 ADA 활성도는 유의한 상관관계를 보이지 않았다(r=-0.1181). 결론: 혈액내 ADA 활성도는 류마티스 관절염 환자에서 골관절염 환자에 비해 유의하게 증가되어 있었다. 하지만 염증성 질환인 강직성 척추염 및 통풍성 관절염 환자와는 유의한 차이가 없어, 원인질환의 감별에는 도움이 되지 못하였다. 활액 ADA 활성도는 ESR, 혈청 CRP와 유의한 상관관계를 보이지 않아 질환의 활동도 반영에는 미흡한 결과가 나왔으나, 향후 더 많은 환자를 대상으로 한 조사가 필요할 것으로 생각된다. 혈액내 ADA 활성도는 활액의 백혈구 수가 많을수록 증가되어 나타나 국소 관절 부위의 염증 정도를 나타내는 지표로 이용될 수 있으리라 생각되며, 활액 ADA 활성도와 질환 경과의 관계는 앞으로 더 연구해 보아야 하겠다. Objective: To investigate whether synovial fluid adenosine deaminase activity is useful in the differential diagnosis of joint swelling and in estimating the disease activity. Method: Adenosine deaminase activity was determined in the synovial fluid taken from patients with rheumatoid arthritis (n=21), osteoarthritis (n=l1), ankylosing spondylitis (n=3), and gouty arthritis (n=2). This enzyme activity was compared with the laboratory indices (ESR, CRP) in the blood and the other parameters in the synovial fluid. Result: More increased adenosine deaminase activity was found in the synovial fluid taken from patients with rheumatoid arthritis, ankylosing spondylitis, and gouty arthritis, as compared with that of osteoarthritis patients. Synovial fluid ADA activity was significantly corelated with the WBC count in the synovial fluid, but there was no statistical corelation between other synovial parameters and adenosine deaminase activity. Conclusion: Adenosine deaminase activity is useful in the differential diagnosis of joint swelling between inflammatory joint disease and osteoarthritis, but not useful in estimating the disease activity.
-
김지수,양용석,김승영,부철수,이헌직,박병엽,조현장,양승호,김두형 대한내과학회 1998 대한내과학회지 Vol.55 No.5
Autoimmune neutropenia is characterized by severe neutropenia with cell-bound neutrophil antibodies or circulating antibodies for neutrophils. Diagnosis of disease is made of the basis of the presence of antibodies for neutrophil. Corticosteroid or rhG-CSF have been reported to be effective in some patients. Recently we experienced one case of autoimmune neutropenia patient who was admitted to our hospital in 1997 because of stomach cancer and degenerative joint disease. She had severe neutropenia without underlying autoimmune disease. And cell-bound neutrophil antibodies were detected by indirect immunofluorescence test. Treatments with rhG-CSF and steroid result in transient improvement of neutropenia and subtotal gastrectomy was done successfully. We herein report one case of autoimmune neutropenia patient, to our best knowledge, the first report in Korea, with a brief review of literature.
-
이재홍,이상도,이일두,정주섭,노성민,박병엽,조현장,김승영 대한내과학회 1996 대한내과학회지 Vol.51 No.1
Actinomycosis is chronic suppurative and granulomatous disease caused by anaerobic, gram positive filamentous bacterium, The most common sites of involvement are the cervicofascial area, thorax, abdomen and pelvis. Primary hepatic actinomycosis is rare and presents a diagnostic challenge. A 57-year old man was admitted because of right upper quadrant abdominal pain and fever for 1 month. abdominal ultrasonography, computed tomography examination showed mass lesion in liver. Primary hepatic actinomycosis was confirmed by identification of sulfur granule, ultrasonography-guided percutaneous needle aspiration. We report a case of primary hepatic actinomycosis, emphasizing the role of imaging study followed by percutaneous liver biopsy in a condition which frequently requires laparotomy for diagnosis.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
