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패장(敗醬) 물 추출물의 LPS로 유도된 RAW 264.7 세포와 mouse 염증모델에서 cytokine 및 NF-κB의 활성에 미치는 효과
류익한,조해중,송미화,최창민,Ryu, Ik-Han,Cho, Hae-Joong,Song, Mi-Hwa,Choi, Chang-Min 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.18 No.4
Objectives: The object of this study was to identify the anti-inflammatory effects of Patrinia scabiosaefolia aqueous extract (PSE). Methods: RAW 264.7 cells were pre-treated with PSE and then incubated with or without lipopolysaccharide (LPS). Cell viability, production of nitric oxide (NO), secretion of pro-inflammatory cytokine, activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-${\kappa}B$) were measured. In addition, we observed mice survival rate after LPS and their cytokine levels of serum. We also observed inflammatory and hemorrhagic change on the histological sections of the liver. Results: PSE inhibited LPS-induced NO production, interleukin (IL)-6 secretion, c-Jun NH2-terminal kinase (JNK) and NF-${\kappa}B$ activation. In addition, PSE reduced the death rate of LPS-induced mice and IL-6 production on the serum of mice. PSE inhibited inflammation and hemorrhage on liver tissue as well. Conclusions: The results suggest that PSE have anti-inflammatory effects by inhibited NF-${\kappa}B$ and JNK activation, IL-6 secretion, and NO production. So PSE may be effective treatment for the inflammatory disease.
정상 임신여성과 질염을 가진 임신여성에서 아스코르빈산을 함유한 질정(바지-씨(R) 질정) 투여 시 나타나는 질내 pH 변화 및 질염치료 효과
호정규 ( Jeong Kyu Hoh ),조해중 ( Hae Joong Cho ),정성로 ( Sung Ro Chung ),문형 ( Hyung Moon ),박문일 ( Moon Il Park ) 대한주산의학회 2006 Perinatology Vol.17 No.1
목적 : 임신 여성에서 아스코르빈산을 함유한 비타민-C 질정(바지-C(R) 질정) 투여 후 질내 pH 변화 및 질염치료의 효과와 안전성을 평가하기 위하여 본 연구를 실시하였다. 방법 : 90명의 임신여성(평균 임신주수 : 32±0.5주, range : 28~36주)으로 부터 연구 동의서를 받은 후, 6일간 연속으로 질 내에 비타민-C 질정(250 mg, Vagi-C(R), Taurus Pharma GmbH, Germany)을 투여하였다. 질 pH는 질정투여직전 및 투여 종료 1주일 후에 측정되었다. 90명중 10명은 추적이 안되어 연구대상에서 제외하였다. 연구대상 80명중 10명(12.5%)은 질정 투여 후 질 자극감 등의 부작용으로 투여를 자가중단 하였으며 결국 70명이 최종 연구대상에 포함되었다. 질정 투여 전의 기본적인 세균검사에서 39명은 정상이었으며 나머지 31명은 질염으로 분류되었는데. 15명은 캔디다 질염, 10명은 세균성 질증, 67명은 트리코모나스 질염으로 각각 분류되었으며 중복된 경우는 없었다. 세균성 질증의 진단은 특징적인 clue cell의 발견, 우유 같은 백색 질 분비물, KOH 검사(+), 질 pH> 4.5의 소견중 적어도 3개의 소견이 있는 경우로 하였다. 결과 : 질 pH는 질염군(N=31)에서 바지-씨(R) 투여전의 평균 4.9±0.5이었는데, 질정투여후 4.2±0.2로 의미 있게 감소하였다( p<.05). 한편 각 질염의 증상도 완화되었는데, 실제로 세균성질증에서는 10명중 8명에서 증상의 완화가 있었다(80%). 그러나 캔디다질염에서는 15명중 5명(33.3%), 트리코모나스질염에서는 6명중 2명(33.3%)에서만 원인균의 소실이 있었다. 질염이 없는 정상여성군(n=39)에서는 바지-씨(R) 투여전 평균 질 pH가 4.4±0.3에서 4.2±0.1로 감소하였으나 통계적인 차이를 보이지는 않았다. 결론 : 임신중 질염이 있는 여성에서 아스코르빈산을 함유한 비타민-C 질정(바지-씨(R) 질정) 투여는 질 pH를 의미 있게 감소시키며, 특히 세균성 질증에서는 80.0%의 증상개선효과가 있었다. Objective : The purpose of this study is to evaluate the effect of Vitamin-C vaginal tablets on vaginal pH and vaginitis symptoms of pregnant women. Methods : Ninety pregnant women who visited the antenatal clinic were included in this study after giving their informed consent. The treatment regimen of the vitamin-C vaginal tablets (250 mg, Vagi-C(R), Taurus Pharma GmbH, Germany) was one tablet given once a day for 6 consecutive days. Vaginal pH was measured the day before and the day after the Vit-C vaginal treatment. Ninety women of initial, ten failed to follow-up (participate). After routine screening using microscopic analysis of the vaginal smears, 31 of the 80 participating women fell into one of 3 pathologic groups (15 monilial infection, 10 bacterial vaginosis, 6 trichomonial infection) and leaving 49 pathogen-free pregnant women. 10 of the pathogen- free pregnant women were excluded during the study because they did not complete the treatment period due to vaginal irritation such as itching or burning sensations. The diagnosis of each vaginal infection was made by specific pathologic findings. Result : Mean vaginal pH values for the pathology group decreased significantly from 4.9 to 4.2. Pathologic findings of each infection were also improved without specific treatment. Bacterial vaginosis disappeared in 80.0% (8/10) of patients. The specific pathogens of the remained two vaginitis types were not detected in 33.3% (5/15) of monilial infection and 33.3% (2/6) trichomonial infection 1 week after discontinuation of Vitamin-C vaginal tablets Although it is not significant, mean vaginal pH values decreased from 4.4 to 4.2 in the pathogen-free pregnant women. Conclusion : Vitamin-C, when vaginally applied, is effective in lowering vaginal pH and in the treatment of vaginitis in pregnant women.
패장(敗醬) 물 추출물의 LPS로 유도된 RAW 264.7 세포와 mouse 염증모델에서 cytokine 및 NF-κB의 활성에 미치는 효과
류익한 ( Ik-han Ryu ),조해중 ( Hae-joong Cho ),송미화 ( Mi-hwa Song ),최창민 ( Chang-min Choi ) 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.2
Objectives: The object of this study was to identify the anti-inflammatory effects of Patrinia scabiosaefolia aqueous extract (PSE). Methods: RAW 264.7 cells were pre-treated with PSE and then incubated with or without lipopolysaccharide (LPS). Cell viability, production of nitric oxide (NO), secretion of pro-inflammatory cytokine, activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) were measured. In addition, we observed mice survival rate after LPS and their cytokine levels of serum. We also observed inflammatory and hemorrhagic change on the histological sections of the liver. Results: PSE inhibited LPS-induced NO production, interleukin (IL)-6 secretion, c-Jun NH2-terminal kinase (JNK) and NF-κB activation. In addition, PSE reduced the death rate of LPS-induced mice and IL-6 production on the serum of mice. PSE inhibited inflammation and hemorrhage on liver tissue as well. Conclusions: The results suggest that PSE have anti-inflammatory effects by inhibited NF-κB and JNK activation, IL-6 secretion, and NO production. So PSE may be effective treatment for the inflammatory disease.
임법인 ( Beob In Lim ),조해중 ( Hae Joong Cho ),이제중 ( Je Jung Lee ),이해창 ( Hae Chang Lee ),홍기연 ( Gi Youn Hong ),김병륜 ( Byoung Ryun Kim ),문형배 ( Hyung Bae Moon ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10
Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine adenomyoma is a rare entity. Cystic degeneration of adenomyoma is also very rare case. We report a case of huge extrauterine endometrioid-type adenomyoma with cystic change with brief review of literature.
이영진 ( Young Jin Lee ),김아리 ( Ari Kim ),조해중 ( Hae Joong Cho ),박성남 ( Seong Nam Park ),홍성남 ( Sung Nam Hong ),김흥열 ( Heung Yeol Kim ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.5
Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia, which grows rapidly and metastasizes to the lung, liver, and, less frequently, brain. This tumor is known for its association with molar pregnancy, rapid hematogenous spread to multiple organs, high human chorionic gonadotropin levels, and good response to chemotherapy. Metastases to the brain are responsible for most of the deaths from choriocarcinoma. Its prognosis is generally good when treated. We report a rare case of metastatic gestational choriocarcinoma as an initial presentation of intracerebral hemorrhage.
김신호 ( Shin Ho Kim ),최기욱 ( Gee Uook Choi ),최정호 ( Jeong Ho Choi ),조해중 ( Hae Joong Cho ),박성남 ( Seong Nam Park ),홍기연 ( Gi Youn Hong ),김흥곤 ( Heung Gon Kim ),민부기 ( Boo Kee Min ) 대한주산의학회 2004 Perinatology Vol.15 No.3
목적 : 진단 기준에 따른 경증 전자간증과 중증 전자간증 임신부에서 혈관 내피 성장 인자가 전자간증의 중등도에 미치는 영향을 평가하기 위해서 본 연구을 실시하였다. 방법 : 1999년 1월 1일부터 2001년 6월 30일까지, 임신 28~40주 사이의 경증 전자간증 46명과 28명의 중증 전자간증 임신부를 대상으로 하였다. 각각의 경증과 중증 전자간증 임신부에서 혈청 내 간 효소치, 혈소판 수, 크리아티닌를 측정하였고, 태아의 제대동맥에서 수축/이완 비와 혈관 내피세포의 손상을 확인하기 위해 혈청 혈관 내피 성장인자의 농도를 측정하였다. 결과 : 간 효소치 상승, 혈수판 수 감소, 고크레아티닌은 경증 전자간증에 비해 중증 전자간증에서 보다 높은 비율을 보였다. HELLP증후군의 빈도는 중증 전자간증에서만 높은 비율을 보였다. 제대 동맥의 수축/이완의 비는 경증 전자간증 임신부의 4/46 (8.7%)에서 >3.0 이상이고, 중증 전자간증 임신부는 15/28 (53.6%)에서 3.0~4.5로 중증 전자간증에서 높은 빈도의 태반 혈류 저항을 보였다. 혈청 내에 혈관 내피 성장인자의 농도는 경증 전자간증에서 7.5±4.9 ng/mL, 중증 전자간증에서는 19.3±8.8 ng/mL로 경증 전자간증에 비해 중증 전자간증에서 통계적으로 유의한 차이를 보였다(p<0.05). 결론 : 제대 동맥의 수축/이완 비가 증가하는 것과 미세 혈관 투과성 및 혈액 응고성을 증가시키는 혈청 혈관 내피 성장인자 농도는 경증 전자간증에 비해 중증 전자간증 임신부에서 높게 측정 되었다. 따라서 혈청 혈관 내피 성장인자 농도 변화는 전자간증 임신부의 예후와 태아 발육부전을 예측하는 지표가 된다. Objective : The purpose of this study was to assess the impact of vascular endothelial growth factor (VEGF) in pregnancies with mild and severe preeclampsia. Methods : From January 1999 to June 2001, we studied the severity for pregnant women with pregnancy induced hypertension between 28 and 40 weeks gestation. In the mild (n=46) and severe preeclamptic women (n=28), the laboratory evaluation included liver function test, platelet counts, and serum creatinine. The systolic/diastolic (S/D) ratio of the fetal umbilical artery flow for placental resistance was measured by ultrasonographic doppler velocimetry. To detect the damage of vascular endothelial cells in all preeclamptic women, serum concentrations of VEGF were measured. Results : Severe preeclampsia had more elevated liver enzymes, thrombocytopenia, high creatinine than mild preeclampsia. HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) was encountered in 8/28 (28.6%) of severe preeclampsia. Fifteen out of twenty-eight cases (53.6%) in severe preeclampsia had elevated S/D ratio from 3.0 to 4.5 including 6 cases with absent end diastolic velocity, whereas 4/46 (8.7%) was elevated SD ratio (>3.0) in mild preeclampsia. Serum concentrations of VEGF were elevated in both mild (7.5±4.9 ng/mL, p<0.05) and severe preeclampsia (19.3±8.8 ng/mL, p<0.05) compared to normal pregnancy (0.5~2.1 ng/mL). Conclusion : The higher serum concentration of VEGF and elevated S/D ratio of umbilical artery were responsible for the changes of the resistance of placental blood flow in severe preeclampsia. Furthermore, elevated S/D ratio of umbilical artery velocity was essential as a surveillance method of fetal health status with IUGR (Intrauterine growth restriction) by vascular declination of placenta.