두부외상 후 동반 발생한 경동맥해면정맥동루와 내경동맥박리증 1례

조진성 ( Jin Seong Cho ),양혁준 ( Hyuk Jun Yang ),이근 ( Gun Lee ),유찬종 ( Chan Jong Yoo ),진욱 ( Wook Jin ),이재관 ( Jae Gwan Lee ) 대한외상학회 2003 大韓外傷學會誌 Vol.16 No.2

A carotid-cavernous fistula (CCF) is a pathologic arteriovenous communication between the carotid artery and the cavernous sinus, and the incidence of CCF as a result of craniofacial trauma is less than 0.2%. Traumatic internal carotid artery dissection (TICAD) is a rare phenomenon, occurring in 0.02 to 0.67% of cervical blunt trauma cases. We report a rare case of CCF associated with ICAD after craniofacial trauma injury, which is very rare. A 23-year-old woman presented with left ptosis on 21 days after a car crash accident. She had suffered from headaches, diplopia, tinnitus, and dizziness. Brain MRI revealed no mass or aneurysmal sac or intracranial hemorrhage, but cerebral angiography showed CCF with ICAD. She was treated with a ICAD percutaneous transarterial stent and endovascular embolization, 1 months after cerebral angiography. clinicians treating patients with craniofacial injuries should have a complete understanding of these patients` entity, because urgent intervention may improve outcome.

3세 소아에서 토혈을 주소로 내원한 위식도 탈출증 1례

조진성,류일,이근,김재광,Cho, Jin-Seong,Ryoo, Eell,Lee, Gun,Kim, Jae-Kwang 대한소아소화기영양학회 2003 Pediatric gastroenterology, hepatology & nutrition Vol.6 No.2

저자들은 반복적인 구토와 복통이 발생한 후 토혈을 주소로 내원한 3세 된 남아에서 상부소화관 내시경으로 진단된 위식도 탈출증 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Prolapse gastropathy is not uncommon in adult, but is not reported yet in previously healthy children. A 3-year-old child came to our emergency room after a 1-day history of emesis episodes with coffee-ground hematemesis. During the endoscopic procedure, and the process of retching and vomiting was observed and a tense knuckle of gastric mucosa was seen to be forcefully and repeated prolapsed into the distal esophageal mucosa, and mucosal hematoma was found in the gastric fundus. Upper gastrointestinal study revealed no abnormality and 24 hour pH monitoring revealed no pathologic gastroesophageal reflux. Retching is thought to cause the forceful prolapse and induce subsequent trauma of gastric mucosa. This case illustrates that the episodes of vigorous retching and resultant gastric mucosa are now considered to be the cause of the hematemesis and epigastric pain in children.

의도적 중독으로 응급센터에 내원한 환자에 대한 연령별 비교 분석

김진현 ( Jin Hyun Kim ),조진성 ( Jin Seong Cho ),김진주 ( Jin Joo Kim ),임용수 ( Yong Su Lim ),양혁준 ( Hyuk Jun Yang ),이근 ( Geun Lee ) 대한임상독성학회 2016 대한임상독성학회지 Vol.14 No.2

Purpose: This study was conducted to compare demographic and characteristic differences in self-poisoned patients by age groups using a comprehensive trauma database. Methods: This study included 1,823 patients who were admitted to the emergency room following self-poisoning. Three age groups were defined: young patients (less than 19 years), adult patients (19 to 64 years) and elderly patients (65 years and old). From January 2011 to December 2015, data were obtained from in a single emergency medical center. We investigated the materials of poisoning, ingestion time, GCS, systolic blood pressure, heart rate, and outcomes of patients. Results: A total of 1,823 self-poisoned patients visited the hospital during 5 years. Among these, 130 (7.1%) were categorized as young, 1,460 (80.1%) were adults and 233 (12.8%) were elderly. The most common drug of self-poisoning substances was antipyretics (50.0%) for those in the young group, sedative drugs (45.0%) for adults, and pesticides (41.2%) for the elderly. Mortality was 2.7% in the adult group and 14.6% in the elderly group. After adjusting for all factors related to mortality, the odds ratio (OR) of mortality was 2.63 in the elderly group (95% confidence interval [CI]: 1.44-4.81). Conclusion: There were definite differences in the characteristics of three groups. The younger patients used drugs that could be easily obtained while older patients used more lethal drugs.

유방암의 뇌 전이 환자에 대한 감마나이프 방사선수술

최은진(Eun Jin Choi),노혜원(Hye Won Ro),조진성(Jin Seong Cho),박민호(Min Ho Park),윤정한(Jung Han Yoon),제갈영종(Young Jong Jegal) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.2

Purpose: This study was performed to evaluate the feasibility of the Gamma Knife Surgery on the symptomatic control of brain metastasis from breast carcinoma. Methods: We retrospectively reviewed patients with brain metastases from breast cancer who underwent Gamma Knife Surgery at our hospital, between May 2004 and November 2007. Total 82 metastases were treated with 26 cycles of Leksell gamma knife. Freedom from local recurrence and survival time were analyzed by the Kaplan-Meier method. Results: 17 patients with 82 metastases were treated over 26 Gamma Knife Surgery sessions. The mean time to brain metastases was 41.7 months (8∼84), median number was 2.0 (1∼10), and median volume was 7.4 ㎤ (0.6∼25.4). Radiologic response occurred in 84.6%, and the rate of symptom relief was 73.1%. Local brain tumor recurrences were observed in 15.3% and intracranial distant recurrence occurred in 57.7% that occurred within 3.2 months. The median length of survival for all patients was 9.3 months (95% confidence interval, 4.23∼9.37 months). Conclusion: Gamma Knife Surgery is an effective and feasible treatment for symptomatic control of brain metastases from breast cancer patients who have severe extracranial metastases and short life expectancy.

현사시나무에서 MYC2 유전자의 분리 및 노화 지연에 관한 특성 구명

최현모,배은경,조진성,이효신,최영임,Choi, Hyunmo,Bae, Eun-Kyung,Cho, Jin Seong,Lee, Hyoshin,Choi, Young-Im 한국식물생명공학회 2017 식물생명공학회지 Vol.44 No.4

The vegetation period of trees might be prolonged by the delay of the leaf senescence in autumn. Thus, we focused on the generation of senescence-delayed transgenic trees to enhance biomass production. The PagMYC2, a gene containing the basic helix-loop-helix domain, was selected as a candidate for a senescence-delayed transgenic tree. The PagMYC2 gene was specifically induced after treatment with phytohormone jasmonic acid, and upregulated by abiotic stresses such as salinity, osmotic pressure and a low temperature. The constitutive overexpression of the PagMYC2 delayed the leaf senescence and inhibited chlorophyll degradation in the transgenic poplars. Leaf senescence analysis was performed in the leaf tissues of the PagMYC2-over-expression transgenic poplars. The transgenic poplars exhibited higher photochemical efficiency than did a wild type plant under a short-day condition (6 hours light/18 hours darkness) or a low temperature condition ($15^{\circ}C$) that was similar to the weather conditions of autumn. These results suggest that the PagMYC2 is a useful genetic resource to improve biomass production, which is able to sustain growth with senescence-delayed leaves for a long time in autumn. JA는 병원균과 곤충에 대한 방어기작 뿐만 아니라 식물 노화에도 관여하는 식물 호르몬이다. Basic helix-loop-helix 전사인자인 MYC2는 JA의 신호전달반응의 핵심조절자 역할을 하는 것으로 알려져 있다. 본 연구에서는 현사시나무에서 MYC2 유전자를 분리하고 발현특성을 조사하였으며, 다양한 환경 스트레스에 대한 내성을 갖는 임목을 생산하기 위하여 MYC2를 과발현시킨 현사시나무를 개발하였다. 포트에 식재된 MYC2 과발현 현사시나무는 대조구에 비해 잎 노화 표현형이 지연되는 특징을 보였으며, 엽록소 손실이 적은 것으로 나타났다. 또한 가을의 온도 및 광 주기 조건에서 MYC2 과발현 현사시나무의 광화학 효율을 측정한 결과 대조구보다 높은 특징을 보였다. 따라서 현사시나무의 MYC2 유전자가 낙엽이 지는 가을 동안에도 지속적인 생장을 가능하게 하여 임목의 바이오매스를 증진시키는데 기여할 수 있을 것으로 판단된다.

5 mm 이하의 유두 갑상선 미세암에서 림프절 전이와 관련된 예측인자

류희선,노혜원,조진성,박민호,윤정한,제갈영종,Hee-Seon Ryu,M.D.,Hye-Won Ro,M.D.,Jin-Seong Cho,M.D.,Min-Ho Park,M.D.,Jung-Han Yoon,M.D. and Young-Jong Jegal,M.D. 대한갑상선-내분비외과학회 2007 The Koreran journal of Endocrine Surgery Vol.7 No.4

Purpose: Papillary thyroid cancer is the most common histological type of malignancy that originates from the thyroid. The disease has an excellent prognosis, despite characteristically being associated with lymph node metastases. According to the World Health Organization, a papillary thyroid microcarcinoma (PTMC) is defined as papillary carcinoma measuring ≤1 cm in the greatest dimension. We present the clinico-pathological features and investigate predictive factors related with lymph node metastases in patients with papillary thyroid microcarcinomas less than 5 mm in size. Methods: Between January 2003 and June 2005, 75 patients underwent surgical treatment for thyroid papillary cancer less than 5 mm in size at the Department of Endocrine Surgery at our hospital. We analyzed the age of patients, gender, presence of symptoms, multifocality, combined thyroid disease, tumor size, capsular invasion, presence of a lymph node metastasis, tumor location, operative method and postoperative complications by use of Pearson's chi-squared test. Results: Lymph node metastases most frequently occurred in patients with a lateral neck mass at presentation (p= 0.004). Patients with capsular invasion of the thyroid showed a high rate of lymph node metastases (p=0.027). In patients with combined thyroid disease such as thyroiditis, more lymph node metastases were observed (p= 0.018). Conclusion: Preoperative symptoms at presentation (especially a lateral neck mass) and tumors with capsular invasion had a high potential to cause lymph node metastases. Factors such as a lateral neck mass, capsular invasion, and combined thyroiditis may be predictive of a lymph node metastasis and are helpful in the determination of proper treatment. (Korean J Endocrine Surg 2007;7: 242-245)

반회후두신경을 침윤한 갑상선 유두상암에 대한 처치

김충영,노혜원,조진성,박민호,윤정한,제갈영종,Choong Young Kim,Hye Won Ro,Jin Seong Cho,Min Ho Park,Jung Han Yoon and Young Jong Jegal 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.2

전원된 외상성 뇌 손상환자에서 중증도에 따른 일상적인 반복CT의 유용성

황정인 ( Jeong In Hwang ),조진성 ( Jin Seong Cho ),이승철 ( Seung Chul Lee ),이정훈 ( Jeong Hun Lee ) 대한외상학회 2009 大韓外傷學會誌 Vol.22 No.2

Purpose: Patients with traumatic brain injury (TBI) were referred from other hospitals for further management. In addition, patients routinely underwent computed tomography examinations of the head (HCT) in the referral hospitals. The purpose of this study was to evaluate retrospectively the utility of routine HCT scans according to the severity of TBI. Methods: Patients with TBI referred to our hospital between December 2005 and July 2008 were included in this study. We investigated HCT findings, indications for repeat HCT examinations (routine versus a neurological change), and neurosurgical interventions. The head injury severity was divided into three categories according to the Glasgow Coma Scale (GCS) score, including mild, moderate, and severe TBI. The use of neurosurgical interventions between patients who underwent routine HCT scans and patients who underwent HCT scans for a neurological change were compared according to the severity of TBI. Results: A total of 81 patients met the entry criteria for this study. Among these patients, 67%(n=54) of the patients underwent HCT scans on a routine basis, whereas 33%(n=27) of the patients underwent HCT scans for a neurological change. A total of 21 patients showed signs of a worsening condition on the HCT scans. Neurosurgical intervention was required for 23(28.4%) patients. For patients who underwent routine HCT examinations, no patient with mild TBI underwent a neurosurgical intervention. However, one patient with moderate TBI and three(13%) patients with severe TBI underwent neurosurgical interventions. The kappa index, the level of agreement for HCT indications of intervention and referral reasons for intervention, was 0.65 for high hierarchy hospitals and 0.06 for low hierarchy hospitals. Conclusion: Routine serial HCT examinations in the referred hospitals would be useful for patients with severe head injury and for patients from low hierarchy hospitals where no emergency physicians or neurosurgeons are available. (J Korean Soc Traumatol 2009;22:134-41)

두개저 골절과 동반된 외상성 양측성 외전신경 마비 1례

황정인 ( Jeong In Hwang ),조진성 ( Jin Seong Cho ),이승철 ( Seung Chul Lee ),이정훈 ( Jeong Hun Lee ) 대한외상학회 2008 大韓外傷學會誌 Vol.21 No.1

Traumatic bilateral abducens nerve palsy is rare and is associated with intracranial, skull and cervical spine injuries. We report a case of bilateral abducens nerve palsy in a 40-month-old patient with a skull base fracture. The injury mechanism was associated with direct nerve injury caused by a right petrous bone fracture and indirect injury by frontal impact on the abducens nerve at the point of fixation to the petrous portion and Dorello`s canal. The emergency physician should be aware of injuries and the mechanism of abducens nerve palsy in head trauma.

Stochastic Simulated 아닐링을 이용한 다중 죠인 최적화

허철구(Cheol Ku Her),신동조(Dong Cho Shin),조철권(Cheol Kwon Cho),진성일(Seong Il Jin),이만호(Mann Ho Lee) 한국정보과학회 1994 한국정보과학회 학술발표논문집 Vol.21 No.2A

본 논문에서는 size가 큰 다중 질의 문제에서 효과적인 죠인을 위한 최적화 방법을 구현하였다. 현재 Shared Nothing(SN) Multiprocessor 구조는 매우 큰 Data Base를 지원하는데 높은 scalability를 효율적으로 지원한다고 알려져 있다. 그러나 이 하드웨어 구조는 자료 편중 현상과 load balancing 문제를 가지고 있다. 그리고 매우 많은 자료(릴레이션)를 가진 DB에서 효과적인 죠인을 위한 질의 최적화 방법은 거의 지역 최적(local optimization)으로 처리하고 있다. 그러나 본 논문에서는 SN구조를 가진 시스템에서 자료 편중 현상과 load balancing 문제를 고려한 다중 죠인 질의 최적화 문제를 효율적으로 개선한 Stochastic Simulated Annealing(SSA) 기법을 사용하여 전역 최적(global optimization)으로 처리 할 수 있음을 보였다. 또한 릴레이션수에 관계없이 동작하는 자동화된 SSA 프로그램을 구현하였다.