건물데이터를 통한 건물에너지 절감 가능성에 대한 연구

조수연(Soo Youn Cho),이승복(Seung-Bok Leigh) 대한설비공학회 2017 설비공학 논문집 Vol.29 No.11

In accordance with 2015 Paris agreement, each individual country around the world should voluntarily propose not only its (individual) reduction target, but also actively develop and present expansion targets of its scope and concrete reduction goals exceeding the previous ones. Accordingly, it is necessary to prepare a macroscopic, long-range strategy for reducing energy consumption and greenhouse gas emissions, which can cover a single building, town, city and eventually even a province. The purpose of this research is to gather and compile government-acquired data from various sources and (in accordance with contents and specificity), combine building data by stages by using multi-variable matrix and then analyze the significance of combined data for each stage. The first order data presents the probability and the cost effectiveness of energy saving on the scale of a city or a province, based only upon general information, size and power consumption of buildings. The second order data can identify a pattern of energy consumption for a building of a specific purpose and which tends to consume a larger amount of energy during one particular season (than others). Finally, the third order data can derive influential factors (base load, humidity) from the energy consumption pattern of a building, and thus propose an informed and practical energy-saving method to be applied in real time.

고강도 운동 시 성별에 따른 혈장 MDA, SOD 및 임파구 DNA 손상 변화

Su-Youn Cho(조수연),Young-Soo Chung(정영수),Yi-Sub Kwak(곽이섭),Hee-Tae Roh(노희태) 한국생명과학회 2011 생명과학회지 Vol.21 No.6

본 연구는 고강도 1회성 운동 시 혈장 MDA와 SOD의 농도변화와 임파구 DNA 손상에 대한 성별의 차이를 평가하는데 목적이 있었다. 본 연구의 목적을 달성하기 위하여 남자 대학생과 여자 대학생을 대상으로 85%VO2max all-out 운동수행에 따른 혈장 MDA와 SOD 그리고 임파구 DNA 손상에 대한 분석을 실시하였으며, 연구 결과에 대한 결론은 다음과 같다. 85%VO2max all-out 운동에 따른 혈장 MDA와 SOD는 운동 종료 시 유의하게 증가하였으며, 통계적으로 유의한 차이는 나타나지 않았으나 남성이 여성에 비해 MDA는 높고 SOD는 낮은 경향을 보였다. 반면 85%VO2max all-out 운동에 따른 임파구 DNA 손상을 알아보기 위해 실시한 comet assay 결과 세 가지 parameter (%DNA in the tail, tail length, tail moment) 모두 운동 종료 시 유의하게 증가하였으며 남성의 %DNA in the tail과 tail length가 여성에 비해 통계적으로 유의하게 높게 나타났다. 따라서 본 연구 결과를 종합해보면 1회성 고강도 운동은 산화적 스트레스를 유발할 수 있으며 남성이 여성에 비해 산화적 손상이 더 크다고 보여진다. 그러나, DNA 손상에는 산화적 스트레스 외에도 체력, 호르몬 수치, 생활습관, 운동 강도 및 지속시간 등 여러 가지 요인들이 영향을 줄 수 있다고 보고되고 있어, 성별에 따른 DNA 손상에 대한 명확한 기전을 제시하기 위해서는 DNA 손상에 영향을 줄 수 있는 여러 요인들과의 관계를 고려한 지속적인 연구들이 필요하다고 생각된다. The purpose of this study was to investigate gender-specific changes of plasma MDA, SOD, and lymphocyte DNA damage during high intensity exercise. In this study, 17 healthy male and 18 healthy female college students ran on a treadmill at 85%VO2max until the point of all-out. Blood-collecting was carried out five times (Rest, Ex-Exha, R0.5h, R4h and R24h), and with the collected blood, plasma malondialdehyde (MDA), superoxide dismutase (SOD), and lymphocyte DNA damage were analyzed. Plasma MDA and SOD concentration increased significantly at the Ex-Exha (p<0.05), and there were no significant differences in gender. For the degree of lymphocyte DNA damage, all %DNA in the tail, tail length and tail moment increased significantly at the Ex-Exha (p<0.05), and %DNA in the tail and tail length were significantly higher in the male group than in the female group (p<0.05). These results suggest that acute high intensity exercise not only causes oxidative stress but also brings about lymphocyte DNA damage. In addition, it was found that males showed higher DNA damage than females in terms of oxidative stress subject to high intensity exercise. Nevertheless, further subsequent studies are required in order to better understand the mechanism behind DNA damage varying with gender, in a way that takes into consideration physical fitness, hormonal level, exercise intensity and duration ? additional factors which might affect DNA damage.

원발성 폐암 치료 중 발생한 Henoch-Schonlein Purpura

강민수 ( Min Soo Kang ),노금엽 ( Geum Yeub Noh ),장영주 ( Young Joo Jang ),조수연 ( Soo Youn Cho ),임경진 ( Kyung Jin Rhim ),노희선 ( Hee Sun Noh ),김혜련 ( Hye Ryoun Kim ),김철현 ( Cheol Hyeon Kim ),이재철 ( Jae Cheol Lee ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.3

Henoch-Schonlein Purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA and C3, which is characterized by associated skin, joint, renal, and gastrointestinal manifestations. Although there were several causes such as autoimmunity, infection, and drugs, it also can be presented as a form of vasculitidies associated with malignancies. We report a case of HSP developed during treatment for non-small cell lung cancer in a 66-year-old man. Multiple purpuric skin lesions occurred in both legs after the first cycle of chemotherapy, which was diagnosed as HSP by clinical and pathologic examinations. Due to the itching sensation, topical steroid was applied and the patient was improved 3 weeks later without a scheduled change in chemotherapy.

The Effect of Cancer Associated Fibroblasts(CAFs) and CD44 of CAFs on the Motility of Cancer Cells in Head and Neck Squamous Cell Carcinoma

심선희,하정훈,조수연,김태민,고영일,김동완,이춘택,허대석,성명훈,Shim, Seon-Hui,Hah, J. Hun,Cho, Soo Youn,Kim, Tae-Min,Koh, Young-Il,Kim, Dong-Wan,Lee, Choon-Taek,Heo, Dae Seog,Sung, Myung-Whun The Korean Society for Head and Neck Oncology 2014 대한두경부 종양학회지 Vol.30 No.2

배경 및 목적 암-연관 섬유아세포(Cancer-associated fibroblasts, CAF)는 종양미세환경의 가장 중요한 요소의 하나다. 그래서 두경부편평세포암에 대해 CAF가 암세포의 운동성에 미치는 영향을 평가하고, CAF에 과발현되는 CD44의 역할에 대해 평가하고자 하였다. 재료 및 방법 두경부암환자의 종양조직에서 CAF를 분리하고, 비종양성 조직으로부터 정상 섬유아세포(NHF)를 분리하였다. 창상치유분석과 상하 챔버를 이용한 3차원 세포 이동 분석을 이용하여, CAF가 암세포의 이동에 미치는 영향을 분석하고, CAF에서 과발현되는 CD44를 중화항체로 CAF를 차단했을 때 암세포 이동의 변화를 관찰하였다. 결과 NHF에 비해 CAF에서 CD44가 과발현되는 것을 관찰하였다. 창상치유분석에서 CAF와 같이 배양된 암세포는 NHF와 같이 배양된 암세포에 비해 더 빠른 이동을 보였다. CD44 중화 항체를 처리했을 때는 암세포의 이동성이 저해되었다. 결론 CAF는 종양미세환경에서 암세포의 운동성을 조절하는 중요한 인자의 하나일 것으로 사료된다. CD44는 CAF의 기능을 매개하는 중요한 표지자 중 하나로 생각된다.

실측 데이터를 활용한 겨울철 오피스 건물의 최적 난방시점 예측에 대한 연구

장지훈(Jang, Ji-Hoon),조수연(Cho, Soo-Youn),이승복(Leigh, Seung-Bok) 대한건축학회 2017 대한건축학회 학술발표대회 논문집 Vol.37 No.1

세침흡인 세포검사에서 폐의 소세포암종과 샘암종의 감별진단

최영희,고재수,박선후,김민석,조수연,김정순,하화정,이승숙,Choi, Young-Hee,Koh, Jae-Soo,Park, Sun-Hoo,Kim, Min-Suk,Cho, Soo-Youn,Kim, Jung-Soon,Ha, Hwa-Jung,Lee, Seung-Sook 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.2

Distinguishing small cell carcinoma from other lung malignancies is of great clinico-therapeutic significance. Small cell carcinoma is an aggressive tumor with a tendency to metastasize early. Survival time if untreated is low but this tumor is highly responsive to chemotherapy. We have occasionally experienced difficulties in differentiation between adenocarcinoma and small cell carcinoma of the lung in fine needle aspiration cytology (FNAC). The aim of this study was to investigate the possibility of distinguishing small cell carcinoma from adenocarcinoma of the lung in FNAC. We evaluated cytomorphological features of FNAC specimens from 62 small cell carcinomas and 57 adenocarcinomas from the lung that were confirmed by biopsy and/or immunohistochemistry on cell block. Cytomorphological details of the two tumors were compared. Nuclear smearing and nearly absent cytoplasm were the most distinct findings in small cell carcinoma compared to adenocarcinoma (p<0.05). Necrotic background, architecture and chromatin pattern, nuclear molding and nucleoli were significantly different (p<0.05). Nuclear size, nuclear membrane nature and nuclear size variation however were not helpful in distinguishing the two tumors. Combining several features described above, small cell carcinoma can be properly differentiated from adenocarcinoma on FNAC. FNAC is proposed as a diagnostic tool of small cell carcinoma of the lung in the case of inaccessibility to biopsy, and so may allow the proper therapeutic strategies to be determined in such cases

고층 건축물의 수평진동에 대한 사용자의 지각임계가속도

조강표,신성우,정승환,조수연,Cho, Kang-Pyo,Shin, Sung-Woo,Jeong, Seung-Hwan,Cho, Soo-Youn 한국전산구조공학회 2007 한국전산구조공학회논문집 Vol.20 No.3

본 논문에서는 진동대를 이용하여 고층 건축물의 수평진동에 대한 지각임계가속도를 측정하였다. 바람에 의한 초고층 건축물의 과도한 진동은 거주자들에게 시각차와 현기증 같은 불쾌감을 줄 수 있다. 초고층 건축물 거주자들에게 쾌적한 환경을 제공하기 위해서는 가속도를 제한할 필요가 있다. 초고층 건축물은 1차 고유주기에 지배적이다 본 연구진은 1차 고유주기를 재연하기 위해 진동대를 사용하여 사인파진동에서 실험을 수행하였다. 실험은 진동하우스를 제작하고, 건장한 40명의 피험자를 대상으로 실시하였다 40명의 피험자를 8명씩 5개조로 나누고, 특정주파수범위$(0.2Hz{\sim}1.2Hz)$에서 가속도를 증가시키면서 수평진동에 대한 인지도를 측정하였다. 수평진동실험으로 피험자들의 진동에 대한 인지도를 누적분포표로 만들고, $0{\sim}20%,\;21{\sim}40%,\;41{\sim}60%,\;61{\sim}80%,\;81{\sim}100%$의 누적분포에 대해 추세선을 그려서 성능평가곡선을 작성하였다. In this paper, acceleration threshold of perception for the horizontal vibration of tall buildings was estimated. Excessive vibration of tall buildings by wind can give displeasure, such as giddiness and visual insecurity. To provide comfortable environment to residents of tall buildings, acceleration needs to be limited. For tall buildings the first mode of vibration is dominant. To reproduce the first mode of vibration, experiments were performed by generating sine waves by a shaking table. A nitration house was made and forty persons were employed for experiments. The forty persons were organized into five experimental groups, each of which was composed of eight persons, and the threshold of perception for horizontal vibration was measured by increasing acceleration in the range of 0.2Hz through 1.2Hz of frequency, Performance curves were obtained by dividing the distribution of perception for horizontal vibration into the range of $0{\sim}20%,\;21{\sim}40%,\;41{\sim}60%,\;61{\sim}80%\;and\;81{\sim}100%$ and by fitting curves.

원발성 위 소세포암 2예

서윤석,박도중,이혁준,조수연,김우호,박성희,양한광,이건욱,최국진,Seo Yun-Seock,Park Do Joong,Lee Hyuk-Joon,Cho Soo Youn,Kim Woo Ho,Park Seong Hoe,Yang Han-Kwang,Lee Kuhn Uk,Choe Kuk Jin 대한위암학회 2004 대한위암학회지 Vol.4 No.3

Primary small-cell carcinomas of the stomach are rare and aggressive malignancies with poor survival rates. Preoperative diagnosis is difficult and a standard treatment is not yet established. We have recently experienced two cases of a primary small-cell carcinoma of the stomach. The first case was a 65-year-old man with epigastric soreness. Endoscopic biopsy showed an adenocarcinoma. He underwent a radical subtotal gastrectomy with D2 lymph-node dissection. Pathology revealed a collision tumor of a smallcell carcinoma and an adenocarcinoma with submucosal invasion and with metastasis in 20 out of 48 lymph nodes (T1N3M0). The second case was a 64-year-old man with epigastric soreness. Endoscopic biopsy revealed a small-cell carcinoma. There was no evidence of a primary tumor in the lung. A radical subtotal gastrectomy with D2 lymph-node dissection was performed. Pathology showed a pure smallcell carcinoma with proper muscle invasion and with metastasis in 1 out of 36 lymph nodes (T2aN1M0).

호지킨 림프종과 역형성 대세포 림프종의 세침흡인 세포소견 비교

고재수,박선후,김민석,조수연,정수영,유한석,김정순,하화정,류백렬,이승숙,Koh, Jae-Soo,Park, Sun-Hoo,Kim, Min-Suk,Cho, Soo-Youn,Chung, Soo-Young,Ryu, Han-Suk,Kim, Jung-Soon,Ha, Hwa-Jung,Ryoo, Baek-Youl,Lee, Seung-Sook 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.2

To study the differentiating cytomorphological features of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) using fine needle aspiration cytology (FNAC), cytomorphological features of 16 patients with HL (n=8) or ALCL (n=8) were analyzed. In the initial cytological diagnosis prior to biopsy, HLs were properly diagnosed in 4 out of 8 cases (4 HL, 2 atypical, 2 benign), whereas all ALCL were diagnosed as malignancies. However, correct diagnosis of non-Hodgkin lymphoma (NHL) was made in only two ALCL patients (2 NHL, 1 HL, 1 sarcoma, 4 malignancy without specific type). Overall, the percentage of large abnormal cells ranged from 30% to 90% in ALCL except for one case, whereas it was less than 5% in all 8 HL. A spectrum of atypical cells was more characteristic of ALCL. In contrast, HL showed an sharp difference between reactive lymphoid cells and neoplastic ones (bimorphic pattern). Moreover, the emergence of kidney-shaped abnormal cells or wreath-like multinucleated cells was helpful in diagnosing ALCL. The combination of thesefeatures would be useful in differentiating HL and ALCL. Nevertheless, these two types of lymphomas cannot be definitely distinguished based on cytomorphological features alone. Therefore, the aim of FNAC would be to suggest a specific diagnosis and indicate the need for a biopsy.

트레이닝 형태의 차이가 3차원 공간상의 회전운동 시 혈중 산화질소, 근 손상지표 및 피로물질에 미치는 영향

노희택 ( Hee Tae Roh ),정영수 ( Young Soo Chung ),조수연 ( Su Youn Cho ) 한국운동생리학회(구-한국운동과학회) 2012 운동과학 Vol.21 No.1

본 연구는 트레이닝 행태의 차이가 3차원 공간상의 회전운동 시 혈중 nitric oxide(NO) 생성, 근 손상지표 및 피로물질에 미치는 영향을 규명하는데 목적이 있다. 연구 대상은 건강한 공군사관학교 남성 생도 15명으로 하였으며, 웨이트 트레이닝 그룹(WT), 런닝 트레이닝 그룹(RT), 오보트론 트레이닝 그룹(OT)에 각각 5명씩 무선 배정하였다. 9주간의 트레이닝 시 WT는 l-RM의 80% 무게로 11종목의 저항성 트레이닝을 circuit weight training 방법으로 실시하였으며, RT는 HRmax의 80% 운동 강도로 30분간 달리기를 실시하였다. OT는 orbotron을 이용하여 분당 35회전 내외의 속도로 3분간 5세트를 질시하였다. 트레이닝 전, 후 3차원 공간상의 회전운동 테스트 방법은 orbotron을 이용하여 분당 30회전의 속도로 각 세트 당 3분씩 5세트를 실시하여 총 운동 시간은 15분으로 하였다. 연구 결과, 혈중 NO는 WT와 RT에서 트레이닝 후 유의하게 증가하였다(p<.05). 혈중 CK는 모든 그룹에서 트레이 닝 전, 후 유의한 차이가 나타나지 않았으나, LDH는 운동직후 시점에서 트레이닝 후 유의하게 감소하였다(p<05). 혈중 NH3는 운동직후 시점을 기준으로 RT와 OT에서 트레이닝 후 유의하게 감소하였다(p<.05). 이상의 결과를 종합해 보면, RT는 다른 두 가지 트레이닝 형태(RT, OT)보다 유산소적 대사와 관련된 효소, 혈류량, shear stress 증가 동 유산소성 트레이닝에 의해 일어나는 대사적 적응을 유도하여 3차원 공간상의 회전운동 시 혈중 NO 농도를 증가시킬 수 있을 뿐만 아니라, 근 손상지표인 LDH와 피로물질인 NH3 농도를 감소시킬 수 있는 것으로 나타내 근 손상 및 피로 정도의 경감에도 가장 효과적인 트레이닝 형태로 판단된다. The purpose of this study was investigate the effect of training types on blood nitric oxide (NO) concentration, indices of muscle damage and fatigue factors during 3-dimensional rotation exercise. As study subjects, 15 healthy male cadets of Air Force Academy were selected, and each 5 cadets were assigned to weight training group (WT), running training group (RT), and orbotron training group (OT) randomly. During training for 9 weeks, WT resistance training of 11 events was conducted with 80% of l-RM by circuit weight training method, RT conducted running for 30 minutes by 80% exercise intensity of HRmax. OT conducted 5 sets for 3 minutes at a speed of around 35 rotations per minute using orbotron. Regarding the protocol of the 3-dimensional rotation exercise, 5 sets were carried out for 3 minutes per set at 30 rotations a minutes. Plasma NO increased in WT and RT after training compared to before training significantly (p<.05). Serum creatine kinase (CK) didn`t appear significant difference before and after training, lactate dehydrogenase (LDH) decreased significantly in all groups after training by on the basis of the time immediately after exercise (p<.05), Plasma ammonia (LDH) decreased significantly in RT and OT after training at a time immediately after exercise (p<.05), These results suggested that the aerobic training is considered as most effective for increasing concentration of NO and reducing muscle damage and fatigue lass during 3-dimensional rotation exercise.