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Objectives : The purpose of this study was to examine the changes in metabolic parameters and Positive and Negative Syndrome Scale (PANSS) scores of patients previously treated with atypical antipsychotic drugs other than paliperidone, after 8 weeks of treatment with paliperidone. Methods : Changes in body weight, body mass index, leptin, lipid levels, fasting glucose, and PANSS scores of patients who switched from other atypical antipsychotic drugs to paliperidone were measured after 8 weeks of treatment with paliperidone. We compared these results with those of patients who had not been treated with antipsychotic drugs for at least 2 weeks prior to treatment with paliperidone (antipsychotic drug-free patients). Results : The antipsychotic drug-free group (n = 9) did not show significant changes in metabolic parameters, but showed a significant improvement in total and subscale scores of PANSS. In the group that switched from other atypical antipsychotic drugs to paliperidone (n = 13), body weight, body mass index and fasting glucose level significantly increased, while total and subscale scores of PANSS significantly improved. Conclusions : Paliperidone treatment will benefit patients with schizophrenia who have been antipsychotic drug-free or who have had difficulty with other atypical antipsychotic drugs, with regard to their psychopathological state. However, if patients have been treated with other atypical antipsychotic drugs before switching to paliperidone, they could gain body weight or their fasting glucose level could increase over a short period because of a change in receptor number and sensitivity caused by the previously prescribed antipsychotic drugs, and hence, paliperidone should be prescribed with caution for these patients.
Objective: To investigate a clinical effect of Taichichuan training focussing on improvement of quality of life in cancer patients. Methods: The subject of study consisted of 10 cancer patients at the East-West Cancer Center of Dunsan Oriental hospital. The survey method of this study is Functional Assessment of Cancer Therapy-General (FACT-G) korean version. Patients performed Taichichuan twice a week and filled out FACT-G questionnaire before and after training. Results: Although total FACT-G score decreased 0.7 point after training, emotional well-being score increased 1.0 point after training. Male improved FACT-G score better than female. Over 50 age improved FACT-G score better than under 50 age. Over stage Ⅲ improved FACT-G score better than Under Stage II. Patients who were treated integrative treatment improved FACT-G score better than patients who were only treated conventional treatment. But all results were not significant statistically. Conclusions: Emotional well-being tends to improve after training, but this study cannot proved Taichichuan training improve quality of life in cancer patients. Well designed advanced study will be needed to prove its benefits.
Recently a case of liver injury from ingestion of Taeyeumjowi-tang containing Ma-huang(Ephedra sinica stapf) arose. The patient, a 30 year-old woman, was diagnosed with asthenia and anorexia after 6 weeks of ingesting Taeyeumjowi-tang containing Ma-huang(Ephedra sinica stapf) as a treatment for her obesity. Tests showed elevated levels of serum transaminase(ALT 903 IU/L, AST 716 IU/L), alkaline phosphatase (229 IU/L), total bilirubin (1.4 mg/dl). Other possible causes of liver injury were excluded by laboratory test and medical history, so the liver injury was taken to be drug-induced. Saenggangeonbi-tang was administered. After 2 weeks of treatment with this medication, the clinical symptoms and liver function improved. This case is reported with a call for further accumulation of objective data on drug-induced liver injury, and to bring more attention to the relative levels of safety and toxicity of herbal medicines.
Objective : This study was aimed to obtain epidemiological information of cancer patients treated with Oriental medicine. Methods :The medical records of 899 cancer patients treated at the East-West Cancer Center of Dunsan Oriental Hospital from January to December 2008 were analyzed. Careful investigations were done by categorizing these patients by their sex, origin, stage, treatment duration, conventional treatment type, etc. Results : 61.7% of the patients had stage IV tumor. 53.1% of patients visited Oriental hospital for combination treatment with conventional medicine. In the tumor origin, lung cancer showed the largest proportion (21.6%). Of the two genders, lung cancer was the most frequent cause (31%) in male patients, and breast cancer in females (21.2%). In inpatients, thyroid cancer resulted in the highest percentage (24.0%). Lung, colon, stomach cancer patients were mostly in stage III or IV. Thyroid cancer patients were mostly in stage I. Conclusions : This study presented the characteristics of cancer patients treated by Oriental medicine. Based on this study, further advanced study of Oriental medical cancer treatments is needed.
본 논문은 문자열 기반 패스워드 인증에서 키보드 감시 문제를 유발하는 하드웨어 취약점에 대한 효과적인 대응방안을 제안한다. 악의적인 공격자가 해당 취약점을 이용하면 기존의 보안 소프트웨어가 실행되고 있는 상황에서도 키보드로부터 입력되는 사용자의 모든 문자열을 탈취할 수 있었으나 본 논문에서 제시하는 방안을 활용하면 공격자가 키보드 감시에 성공한다 하더라도 사용자의 입력 문자열을 온전히 탈취할 수 없다. 따라서 제안한 방안을 구현하여 적용하면 보다 안전한 인터넷 기반 금융거래가 가능해질 것으로 사료된다. This paper proposes an effective countermeasure to an intrinsic hardware vulnerability of the keyboard controller that causes sniffing problem on the password authentication system based on the keyboard input string. Through the vulnerability, some possible attacker is able to snoop whole the password string input from the keyboard even when any of the existing keyboard protection software is running. However, it will be impossible for attackers to gather the exact password strings if the proposed policy is applied to the authentication system though they can sniff the keyboard hardware protocol. It is expected that people can use secure Internet commerce after implementing and applying the proposed policy to the real environment.
This study examines the rustling sound characteristics of electrospun nanofiber web laminates according to layer structures. This study assesses mechanical properties and frictional sounds (such as SPL); in addition, Zwicker`s psychoacoustic parameters (such as Loudness (Z), Sharpness (Z), Roughness (Z), and Fluctuation strength (Z)) were calculated using the Sound Quality Program (ver.3.2, B&K, Denmark). The result determined how to control these characteristics and minimize rustling sounds. A total of 3 specimens` frictional sound (generated at 0.63 m/s) was recorded using a Simulator for Frictional Sound of Fabrics (Korea Patent No. 10-2008-0105524) and SPLs were analyzed with a Fast Fourier Transformation (FFT). The mechanical properties of fabrics were measured with a KES-FB system. The SPL value of the sound spectrum showed 6.84~58.47dB at 0~17,500Hz. The SPL value was 61.2dB for the 2-layer PU nanofiber web laminates layered on densely woven PET(C1) and was the highest at 65.1dB for the 3-layer PU nanofiber web laminates (C3). Based on SPSS 18.0, it was shown that there is a correlation between mechanical properties and psychoacoustic characteristics. Tensile properties (LT), weight (T), and bending properties (2HB) showed a high correlation with psychoacoustic characteristics. Tensile linearity (LT) with Loudness (Z) showed a negative correlation coefficient; however, weight (T) with Sharpness (Z) and Roughness (Z), and bending hysteresis (2HB) with Roughness (Z) indicated positive correlation coefficients, respectively.