복령감초탕(茯?甘草湯)과 영계출감탕(?桂朮甘湯)으로 치료한 화폐상습진 환자 치험 1례

정종길,이숭인,Jeong, Jong-Kil,Lee, Soong-In 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1

Objectives : The purpose of this study is to report the clinical effectiveness of herbal remedies (Bokryeongkamcho -tang. Yeongkyechulkam-tang.) on nummular eczema. Methods : The 49 year-old male patient has been suffered from nummular eczema for 8 months. At first, he was treated with Bokryeongkamcho-tang for 56 days. And then he was treated with Yeongkyechulkam-tang for last 40 days. During the treatment we checked pruritis degree changes and extent changes by asking. And we checked how prulent exudates, crusts, scratch marks are changes by taking photos. First evaluation was performed before treatment, second evaluation was performed after taking Bokryeongkamcho-tang 56 days, third evaluation was performed after taking Yeongkyechulkam-tang 40 days. Results : After taking Bokryeongkamcho-tang 56 days, pruritus was decreased and prulent exudents were stopped, and crusts were disappeared. Nummular eczema on trunk, arm, thigh was disappeared. But light pruritis was still going on, and small circle-shaped vesicles groups were lagged on forearm and shin, ankle. So we found other symptoms from the patient, and administered Yeongkyechulkam-tang. After taking Yeongkyechulkam-tang 40 days, pruritus was almost decreased and nummular eczema on fore arm, shin was disappeared. Conclusions : This clinical case indicates that herbal remedies(Bokryeongkamcho-tang. Yeongkyechulkam-tang.) are effective on nummular eczema.

동의보감(東醫寶鑑)에 수록(收錄)된 인삼(人蔘)이 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)범위, 병증, 주치(主治), 병리(病理) 및 구성내용(構成內容) 조사(調査)

조대연,정종길,윤용갑,Cho, Dae-Yeon,Jeong, Jong-Kil,Yun, Young-Gab 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1

In the Encyclopedia Medica Koreana(Dongeuibogam), I have researched 245 prescriptions in which Panax Ginseng plays an important role. And I have got the following results. The healing scope and frequency of ginseng-mainly-included prescriptions are Child Part 29(11.83%), Violent Cough Part 23(9.38%), Sick-by-Cold Part 21(8.57%), Oncosis Part 16(6.53%), Overwork Part 14(5.71%), Gynecologic Part 14(5.71%), Internal Part 13(5.3%), Apoplexy Part 11(4.48%), Mind Part 10(4.08%) and Fecal Part 10(4.08%) prescriptions. And also each of Nausea Part, Anger Part, and Spirit parts has the same 5 (2.04%) prescriptions. And each of Qi Part, Diabetes Meatus Part, Malaria Part, and Humoral Part has 4(1.63%) prescriptions. And each of Foot Part, Choleraic Part, Genital Part, Blood Part, and Voice Part has 3 (1.2%). All of these prescriptions cover 88.88%. And besides listed parts above, Panax Ginseng is all used in 48 Parts: Body-Mind Part. Mouth-Tongue Part, Breast Part, Muscle Part, Swelling Part, Urine Part, Epidermis Part, Heat Part, Anus Part, Stomach Part, Eye Part, Laryngopharynx Part. Uterus Part" Heavy Stomach Part, Head Part, Pulse Part, Hair Part, Navel Part, Emetic Part, Costal Part, Edema Part, Vomiting Part, Superstitious Part, and Cardiac Part, etc. Of the prescriptions in which Panax Ginseng plays an important role, the most representative diseases, which more than 86.8% prescriptions cure, are shock, numbness from cold, Taeeum disease, oncosis, overwork, sick from eating, numbness of extremities, diarrhea, tachycardia, forgetfulness, nausea, heat from kidney, nocturnal emission, short breath, diabetes meatus, malaria, sweating, sweating overnight, beriberi, cholera, insomnia from enervation, sialitis, navel pain, hemorrhage, and loss of voice. The pathology of the prescriptions in which Panax Ginseng plays an important role is divided into the organ problems, six natural factors, seven extreme feelings, unbalanced humoral status, overwork, and, unbalance of qi and blood. Spleen, heart, and uterus is the main cause of organ problems; wind and cold are the main cause of six natural factors; heavy humors are the main cause of unbalanced humoral status; the stasis of seven feelings are the main cause of seven extreme feelings; the lack of stamina and overwork are the main cause of the overwork; the lack of qi, the lack of blood, and, the lack of qi and blood are the main cause of the unbalance of qi and blood. After I have researched the contents of the prescriptions in which Panax Ginseng plays an important role, I could understand the addition of the different prescriptions, combination of medicines, and the role of medicine groups associated with Panax Ginseng. So from now on, the results I have got could be used as the data which show the theoretical basis on the prescriptions.

갈근, 갈화, 갈근과죽력의 추출물이 알코올을 투여한 생쥐에 미치는 영향

김경수,정종길,나창수,김정상,Kim Kyung-Soo,Jung Jong-Kil,Na Chang-Su,Kim Jeong-Sang 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.1

This study was performed to investigate the effects of Radix Puerariae (RP), Flos Puerariae (FP) and Caules in Liquamen Phyllostachyos+Radix Puerariae water extracts on the alcohol dehydrogenase (ADH). transaminase (GOT, GPT) activities, and two hepatic antioxidant enzyme (SOD, catalase) activities in acute ethanol administered mice, and we have investigated the morphological changes that occur in hepatocytes of the experimental mice. The activities of ADH decreased compared with control group in the A1(66%), C1(57%), C2(54%) groups. The transaminase activites increased in the control groups compared with experimental groups. Ethanol treatment group without the RP or FP administration significantly lowered the activities of hepatic SOD and catalase, whereas MnSOD increased in the A1(27%) and B2(43%)groups, CuZnSOD increased in the B2(25%) and C2 groups. The catalase activites were increased in the A1(270%), A2(478%), B2(487%) and B1(770%) compared with control group, A lot of PAS-positive granules were observed in the A1, A2, C1 and C2 groups compared with the other groups. These results suggested that RP, FP and RP+Bamboo extracts administration may be prevent from liver damage in the alcohol treatment mice.

D-Galactosamine으로 유발된 흰쥐의 간손상에 대한 치자와 두시 추출액이 미치는 영향

김정상,정종길,Kim, Jeong-Sang,Jeong, Jong-Kil 대한상한금궤의학회 2012 대한상한금궤의학회지 Vol.4 No.1

Aim : To investigate the hepatotective effect of Gardenia jsaminodes and Glycine max aqueous extract against D-galactosamine (d-GalN, 300mg/kg body weight) was administered to the male Sprague Dawley (SD) rats. Materials and Methods : The study was carried out on male SD rats (age matched, weight $250{\pm}10g$). Experimental groups divided four: Normal group (Nor) was administered saline, Control (Con) group was administered saline after d-GalN treatment. Experimental group (Exp) was administered Gardenia jsaminodes (200 mg/kg; Ga group), Glycine max (700 mg/kg; Gl group), and Gardenia jsaminodes+Glycine max (200 mg/kg+700 mg/kg, GG group) during 14 days(n=5). Results : d-GalN administration induced hepatotoxicity in rats which was manifested by increased levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase but decreased total cholesterol and triglyceride. Treatment with Gardenia jsaminodes extract significantly protected the liver in d-GalN administered rats. Conclusion : Gardenia jsaminodes aqueous extract and Gardenia jsaminodes+Glycine max extract possesses hepatoprotective potential, thus validating its use in alleviating toxic effects of d-GalN.

쪽 니람의 DNCB 유발 생쥐의 아토피 피부염에 미치는 효과

추한나,박은혜,정종길,백윤웅,김정상,Choo, Han-Na,Park, Eun-Hye,Jeong, Jong-Kil,Paek, Yun-Woong,Kim, Jeong-Sang 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.1

Objectives : The purpose of this study was to investigate the effects of Polygonum tinctoria Niram(PTN) on atopic dermatitis(AD) in hairless mice induced by 2,4-dinitrochlorobenzene(DNCB). Method : They were divided into four group, Nor, Con, 1X and 5X, for evaluating the change of appearance of skin surface, skin hydration, thickness of epidermis and mast cell numbers during 30 days. Results : PTN suppressed symptoms of AD in appearance of skin and increased skin hydration for 1X and 5X. In histopathological examination, 1X and 5X significantly reduced the thickness of epidermis and number of mast cell in dermis. These results suggested that the PTN improved the AD-like symptoms of hairless Mice.

취오동(臭梧桐)의 국내, 외 연구동향과『본초학』, 한국표준질병사인분류의 상관관계에 대한 체계적 문헌고찰

김현석 ( Hyun-seok Kim ),정종길 ( Jong-kil Jeong ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.6

Objectives : The study was aimed to analyze the correlation between Herbology and contemporary research results, KCD-codes, and terms. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology. Methods : Papers were searched in PubMed, ScienceDirect, and KISS. Papers were then categorized as “medicine and pharmacy articles” or “articles unrelated to medicine and pharmacy.” Medicine or pharmacy articles about Clerodendri Trichotomi Folium were matched with treatments in Herbology and KCD-codes. Medicine and pharmacy articles not researching Clerodendri Trichotomi Folium mainly, and articles unrelated to medicine and pharmacy were categorized and analyzed. KCD-codes and terms were arranged by treatments in Herbology. Research types, the number of papers, and the citation count were arranged by each treatment in Herbology. Degrees of Herbology research were represented as a number and a graph. Results : There were 25 Medicine and pharmacy articles about Clerodendri Trichotomi Folium, 6 medicine and pharmacy articles which did not studied Clerodendri Trichotomi Folium mainly. Among in vivo researched herbology treatments, Hypertension scored 47, migraine scored 47, and abscess and scabies scored 53. Conclusions : The category `Abscess and scabies` was the most researched treatment in Herbology. Of the medicine and pharmacy articles that did not match treatments in Herbology, there were in vivo researching on reflux oesophagitis, Malignant neoplasm of bronchus and lung, and that of breast which can be used in the Herbology education field.

D-Galactosamine으로 유발된 흰쥐의 간손상에 대한 치자두시탕 추출액이 미치는 영향

김진호 ( Jin Ho Kim ),정종길 ( Jong Kil Jeong ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.2

Objectives: To investigate the hepatoprotective effect of Gardeniae Fructus (Ga) and Glycine semen preparatum (Gl) aqueous extract against D-galactosamine (D-GalN, 300㎎/㎏ body weight) was administered to the male Sprague Dawley (SD) rats. Materials and Methods : The study was carried out on male SD rats (age matched, weight 250±10 g). Experimental groups (Exp) divided four : Normal group (Nor) was administered saline, Control (Con) group was only received D-GalN (300 ㎎/㎏) intraperitoneally. Exp was orally administered Ga (200 mg/kg; Ga group), Gl (700 mg/kg; Gl group), and Chizadochi-Tang (200 mg/kg+700 mg/kg, GG group) after D-GalN treatment during 14 days (n=6). Results: D-GalN administration induced hepatotoxicity in rats which was manifested by increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) but decreased total cholesterol (HDL C) and triglyceride (TG). The serum TG concentrations were significantly increased (#p<0.05) in the Ga group compared with Con. AST and ALP activities were significantly decreased (#p<0.05) in the all experimental groups compared with Con. ALT activities were significantly decreased (#p<0.05) in the Ga group compared with Con. LDH activities were significantly decreased (#p<0.05) in the GG group compared with Con. On the light microscopic study, a number of vacuole were observed in the Con, but decreased in experimental groups. Conclusion: Ga aqueous extract and Chizadochi-Tang extract possesses hepatoprotective potential, thus validating its use in alleviating toxic effects of D-GalN.

8년 동안 진행된 만성치열(Chronic anal fissure) 환자에게 치자시탕과 상담요법을 사용하여 호전된 치험 1례

이숭인,조민석,이성준,정종길,Lee, Soong-in,Cho, Min-seok,Lee, Sung-jun,Jeong, Jong-kil 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : This study is aimed to report the outcomes of the treatment of a patient with chronic anal fissure during a 8-year period. Methods : Basic patient’s data was analyzed as a CARE guideline. And related psychological state was measured with BAI, STAI-X-II test. Results : The treatment is based on Shanghanlun and the patient reported better outcomes. The main symptoms of the patient were chronic constipation, blood in the stool. The main clinical findings were that the patient’s symptoms got worse during the examination period because of the anxiety of the exam. And loss of appetite and digestive disorders are due to Jue-Yin-Bing(厥陰病) and the clue of bleeding can be found in article 375 in Shanghanlun. The main diagnoses was chronic anal fissure and main interventions were Chijasi-tang according to article 375 in Shanghanlun and counseling on anxiety. As a results bleeding has stopped after taking herbal medicine and constipation has been treated at the same time. After 6 months, the patient performed BAI, STAI-X-II test and scores got lowered indicating decreasing anxiety level. Conclusion : Chijasi-tang with counseling achieved valid positive results to the patient with chronic anal fissure.

택사(澤瀉)의 국내,외 연구동향과 『본초학』, 한국표준질병사인분류의 상관관계에 대한 연구

장일웅 ( Il-woong Jang ),정종길 ( Jong-kil Jeong ),김현석 ( Hyun-seok Kim ),이숭인 ( Soong-in Lee ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.2

Objectives : This study was aimed to analyze the correlation between the Herbology and contemporary research results, KCD and terms of Alismatis Rhizoma. The study will present information that can be used to find the direction of further researches and be applied to the education of Herbology. Methods : Papers were searched in Riss4U and PubMed, and categorized. Medicine or pharmacy articles about Alismatis Rhizoma were matched with the Herbology treatment and KCD. KCD-codes and terms were arranged by the Herbology treatment. The Degree of Herbology research (HDR) was calculated by numbers of papers, study method, citation rates. Results : There were 392 articles about Alismatis Rhizoma. Among these there were 141 medicine and pharmacy articles about Alismatis Rhizoma, and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness was more active than others. Analysis of other articles showed that studies about anti-cancer, anti-biotic effect, anti-diabetes mellitus, anti-oxidant effect, anti-inflammation, hepatoprotective effect were active, too. In HDR, Phlegm-Fluid Retention and Dizziness was scored by 181, Edema- Distention and Fullness by 173, Hyperlipidemia by 83, Dysuria 64, Heat strangury pain by 18, Diarrhea and decreased urine volum by 0. Conclusions : 141 articles about Alismatis Rhizoma were analyzed and 51 articles were matched to the Herbology treatment. Studies about Phlegm-Fluid Retention and Dizziness, Edema and Distention and Fullness were more active than others. And studies about anti-cancer, anti-biotic effect, anti-oxidant effect, anti-inflammation, Osteoporosis should be more studied and be more discussed among Herbology researchers.

논문(論文) : 『강평상한론(康平傷寒論)』내 "상한(傷寒)" 개념의 다양성에 대한 고찰

이숭인 ( Soong In Lee ),정종길 ( Jong Kil Jeong ) 대한한의학원전학회(구 대한원전의사학회) 2015 대한한의학원전학회지 Vol.28 No.1

Objectives : Usually medical terminology of oriental mecidine has a multiple meaning. But concept of Shanghan(傷寒) should be simple, because Shanghanlun(傷寒論) is a clinical guideline book. So I researched to suggest many concept of Shanghan, which are suitable for each chapter of Shanghanlun. Methods : I enumerated provisions including Shnaghan from the original texts of Gangpyeong-Shanghanlun(康平傷寒論). And I translated and reviewed them. Results : 1. Shanghan of Preface(序文) means a disease of high fatality. 2. Shanghan of Shanghanrye(傷寒例) means diseases due to physical damage of cold weather. 3. Shanghan of Diagnosis of Daeyang Disease(辨大陽病) - Neck stiffness(痙), Dampness(濕), Sun stroke(□) means certain disease names accompanying fever, chill. 4. Shanghan used in Diagnosis of Diseases is a premise of many provisions of Shanghanlun. And Shanghan is made up of finished fever, expected fever, chill, body pain, loss of appetite, image of tension. Conclusions : We can use a appropriate translation on Shanghan of each chapter of Gangpyeong-Sanghanlun. Especially Shanghan used in 「Diagnosis of Diseases」should have more accurate meaning.