운동의 항암효과와 암 치료를 위한 보조요법으로서 운동처치

정일규(Il Gyu Jeong),오명진(Myung Jin Oh) 한국사회체육학회 2010 한국사회체육학회지 Vol.0 No.40

It has been reported that regular exercise has the effect to reduce the risk of cancer and exercise intervention help the cancer patient to be able to get through the hard treatment procedure. In this study, the author summarized the proposed mechanisms of anti-cancer and anti-fatigue effects of exercise and introduce the exercise intervention researches so for. For the proposed anti-cancer effect of exercise, three major mechanism have been suggested as follows. The first, exercise-induced reactive oxygen species(ROS) might cause the apoptosis of pre-stage of cancer cells. The second, ROS or pro-inflammatory cytokines like IL-1 and TNF-α which can be induced by exercise might activate the signaling pathway to promote the transcription of endogenous anti-oxidant enzymes such as SOD, CAT, GPX and HSP70 and in turn increase the protective capability of our body against various carcinogenic factors. The third, Regular exercise can increase the phase Ⅱ enzymes such as GST and UDP-GT associating with DNA repair system and also increase the activities of proteasome and OGG1 which have the role of eliminating the misfolding protein or oxidized base of DNA, respectively. It also has been reported that cancer-related fatigue(CRF) might be the most common and painful side effect of cancer itself and cancer treatment such as chemical and radiation therapy or transplantation surgery. The increase of pro-inflammatory cytokines during the cancer treatment has been suggested as the most plausible etiology of CRF. The anemia induced by the decreased function of erythropoiesis in red bone marrow and deregulation of HPA axis and the abnormal change of synaptic serotonin level in central nerve system might be caused by chronically increased pro-inflammatory cytokines. Many researches which have investigated the effects of exercise intervention for cancer patients and survivors suggested that exercise might be one of the most effective way to alleviate the cancer-related fatigue and prevent the change of body composition and the decrease of muscle mass and strength, cardiovascular function and improve the pain index and quality of life(QOL). Therefore we need to encourage the cancer specialist to use the exercise intervention for cancer treatment as the most evidence-based intervention and cooperate to improve the treatment effect and quality of life(QOL) of cancer patients and survivors.

척수 편측절단 손상 후 일회성 운동량에 따른 neurotrophins 단백질발현 및 수용체 활성

오명진 ( Myung Jin Oh ),한재덕 ( Jae Duk Han ),서태범 ( Tae Beom Seo ),김종오 ( Jong Oh Kim ),정일규 ( Il Gyu Jeong ) 한국운동생리학회(구 한국운동과학회) 2011 운동과학 Vol.20 No.4

오명진, 한재덕, 서태범, 김종오, 정일규. 척수 편측절단 손상 후 일회성 운동량에 따른 neurotrophins 단백질발현 및 수용체 활성. 운동과학, 제20권 제4호. 475-486, 2011. 본 연구는 흰쥐의 흉추 9번을 반측절단 손상을 유발시키고, 1주 동안의 휴식 후 저강도 운동 처치를 15분, 30분, 60분, 90분으로 나누어 1회 실시하였으며, 운동직후 손상신경조직을 적출하여 형태적 변화와 신경성장관련 인자들의 발현정도를 분석하였다. 실험동물은 7주령된 SD계열 수컷 흰쥐 60마리를 실험대상으로 normal 그룹, 척수손상(SCI) 대조군, SCI+운동15분그룹, SCI+운동30분그룹, SCI+운동60분그룹, SCI+운동90분그룹으로 총 6그룹으로 설정하였다. 운동처치는 저강도운동으로 1회 실시하였다. 그 결과 BDNF 단백질의 발현량은 운동 60분 > 30분 > 90분 > 15분순으로 60분에서 가장 많이 발현되었으며, 수용체인 TrkB mRNA의 발현량은 30분 운동그룹에서만 높게 발현되었다. NGF 단백질 발현량은 손상 후 운동그룹 모두가 손상그룹보다 높게 나타났으며, 수용체인 TrkA mRNA의 발현량은 운동 15분 > 60분 > 30분, 90분순으로 운동 15분에 가장 높게 발현되었다. NT3 단백질 발현량에서는 운동 30분, 60분 > 90분 > 15분순으로 운동 30분과 60분에서 높게 나타났으며, 수용체인 TrkC mRNA의 발현량은 운동 30분 > 60분, 90분 > 15분순으로 운동 30분에서 가장 높게 발현되었다. 형태학적인 변화로 반응성 별아교세포의 변화는 일회적인 운동량만으로는 변화가 나타나지 않는 것을 확인하였다. 이상의 결과를 종합한 결론은 척수손상 후 운동처치에 따른 신경성장관련 인자들의 발현량은 운동약 30분~60분정도에서 높게 나타나는 것을 확인하였다. Oh, M. J., Han, J. D., Seo, T. B., Kim, J. O., Jeong, I. G. The effects of quantity of treadmill exercise on expression of neurotrophins and receptor after spinal cord hemisection in the rats. Exercise Science. 20(4): 475-486, 2011. Sixty male Sprague-Dawley rats (230±10 g; 7 week in age) were assigned equally to six different groups; Normal (n=10), Spinal cord injury (SCI)(n=10), SCI+15m treadmill training (TMT)(n=10), SCI+30 mTMT (n=10), SCI+60 mTMT (n=10), SCI+90 mTMT (n=10). Every rat in SCI and SCI+TMT groups underwent laminectomy at thoracic vertebra ninth(T9) level and then hemisection the exposed spinal cord site in the anesthetized condition. After one week-recovery from injury, rats in SCI+TMT group exercised on a motorized treadmill for 15, 30, 60, 90 min/d. All tissues were used for H&E, immunofluorescence staining, Western blot and RT-PCR. The data obtained were analyzed by one-way ANOVA and Tukey`s post-hoc. and presented as mean±standard deviation. BDNF induction levels in the injured spinal cord significantly showed more increases in exercise group with SCI and were highly correlated with time of exercise, but NGF did not differ from another groups. TrkB mRNA which is receptor for BDNF was increased in only exercise group for 30 minutes and TrkA mRNA which is receptor for NGF was upregulated in two exercise group for 15 and 60 minutes. Also, TrkC mRNA, activated by NT-3, was significantly enhanced in exercise group for 30 minutes. Thus present data suggest that exercise plays a important role for axonal regeneration and functional recovery after SCI.

지구성 운동 중 산소수 섭취가 운동수행력 및 피로회복에 미치는 영향

정일규(Jeong Il-Gyu),오명진(Oh Myung-Jin),김종오(Kim Jong-Oh),백만수(Baek Man-Su),이수철(Lee Su-Chul) 한국코칭능력개발원 2006 코칭능력개발지 Vol.8 No.4

암 관련 피로(CRF: Cancer-related Fatigue)에 미치는 운동의 효과

정일규(Il Gyu Jeong) 한국사회체육학회 2010 한국사회체육학회지 Vol.0 No.41

It has been well known that the cancer-related fatigue(CRF) is one of the most common and distressing side-effects of cancer or/and cancer treatment. In this study, the author reviewed the epidemical, experimental or pilot studies on the prevalence of CRF, the etiology of CRF as well as the effects of exercise intervention for cancer patients with CRF. This study also tried to find any updated exercise guideline of exercise prescription for cancer patients and cancer survivors. To date, it seems that increased pro-inflammatory cytokine activity might be the most potential underlying mechanism of CRF. However, to elucidate the correct etiology of CRF, further controlled and well designed researches are required. Through the review about the effects of exercise intervention for CRF, the author also suggest strongly that exercise should be considered as the most effective approach to deal with CRF and other side effects as well as to improve the patient`s physical function and the quality of life. There are also very important task of developing the relevant and effective exercise program for cancer patients through the cooperation among the oncologists, exercise physiologists, fitness specialists.

단기간 체중감량이 체내철분과 적혈구용혈지표, 적혈구 형태에 미치는 영향

정일규(Il Gyu Jeong),오명진(Myung Jin Oh),이장희(Jang Hee Lee) 한국사회체육학회 2006 한국사회체육학회지 Vol.0 No.28

월경전증후군(Premenstrual syndrome: PMS)과 운동

정일규(Il Gyu Jeong) 한국사회체육학회 2012 한국사회체육학회지 Vol.0 No.48

There have been very few studies which gave the clear mechanical explanation about the effects of exercise on premenstrual syndrome(PMS) or premenstrual dysphoric disorder because of very extensive symptoms of PMS and limitation of invasive human studies. One persuasive me chanism suggested to explain the exercise effect of alleviating PMS was that exercise might stimulate the release of endogenous opiate hormones which might lessen the pain itself and thereafter alleviate various symptoms of PMS related to ovulation cycle through the inhibition of GnRH or stimulation of prolaction secretion. Another underlying mechanism is that exercise might normalize the too sensitive response of neurotransmitters such as serotonin and GABA in central nerve system to cyclic hormone release in PMS women. Besides, the increase of serotonin synthesis caused by increased uptake of tryptophan through blood-brain barrier(BBB) in brain tissue stimulated by exercise can be suggested as one of the possible mechanisms. The researcher also suggest that the changes of inflammatory or anti-inflammatory cytokines according to acute or chronic exercise might provide the clue to explain the underlying mechanism. So far three times a week and about 20 or 30 minutes of anaerobic exercise has been recommended for PMS. More evidence-based exercise intensity and exercise prescription guideline for PMS have to be suggested through further studies in this area.

상하지의 등속성 굴근력과 신근력, 그리고 근육량과 골밀도의 상관관계

정일규 ( Jeong Il Gyu ),윤진환 ( Yun Jin Hwan ),김종오 ( Kim Jong O ),김영표 ( Kim Yeong Pyo ),이미숙 ( Lee Mi Sug ),윤재석 ( Yun Jae Seog ),변재종 ( Byeon Jae Jong ) 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.2

The purpose of this study was to investigate the relationship among Isokinetic Muscle Strength, Muscle Mass and Bone Mineral Density in Body Segments. The subjects in this study were 12 males (age, 19.66±1.72yr; height, 172.66±4.92cm; weight, 66.45±8.22kg

스쿼시 선수들의 스포츠 상해 요인과 처치방법 실태에 대한 연령 집단별 분석

정일규(Il Gyu Jeong),이근수(Kun Su Lee),최덕구(Duk Gu Choi),윤진환(Jin Hwan Yoon),김영표(Young Pyo Kim) 한국사회체육학회 2004 한국사회체육학회지 Vol.0 No.21

The Morphological Changes of Erythrocytes and Blood Indexes of Footstrike Hemolysis after 8km Distance Competitive Running

Il Gyu Jeong(정일규),Jin Hwan Yoon(윤진환),Young Pyo Kim(김영표),Kyung Hwun Chung(정경훈),Jong Oh Kim(김종오),Jae Jong Byun(변재종) 한국발육발달학회 2004 한국발육발달학회지 Vol.12 No.1

사전운동이 알쯔하이머병 흰쥐에서 기억력과 해마 신경세포 생성에 미치는 영향

정일규(Il-Gyu Jeong),윤진환(Jin-Hwan Yoon),이희혁(Hee-Hyuk Lee) 한국생명과학회 2008 생명과학회지 Vol.18 No.5

본 연구는 ICV STZ 투여로 유도한 알쯔하이머형 치매동물에서 사전 운동이 기억력 및 해마 신경세포생성에 미치는 영향을 조사하기 위하여 수행되었다. 먼저 ICV STZ 투여가 기억력에 미치는 효과를 step-down avoidance에서 검사한 결과 retention latency가 정상 대조군에 비해 유의하게 감소 하였으나, ICV STZ 투여 전에 운동을 실시했던 흰쥐의 경우 retention latency가 ICV STZ 투여군에 비해 유의하게 증가됨을 확인하였다. 이것은 사전 운동이 ICV STZ 투여로 유발되는 기억력 손상을 완화시킬 수 있음을 보여주는 것이다. 또한 ICV STZ 투여가 해마의 신경세포생성에 미치는 영향을 조사한 결과에서도 정상 대조군에 비해 ICV STZ 투여군에서 유의하게 감소하였다. 하지만 사전 운동 후 ICV STZ 투여를 받은 흰쥐의 신경세포생성율이 ICV STZ 투여군보다 유의하게 증가된 것으로 나타났다. 이러한 결과는 ICV STZ 투여로 유발되는 알쯔하이며형 치매에서 기억력 손상이 해마의 신경세포생성의 감소로 인해 유발될 수 있음을 보여주는 것이다. 게다가 2주간의 사전 운동이 ICV STZ 투여로 유발된 해마 신경세포생성의 감소를 완화시킴으로써 기억력 손상을 유의하게 억제시키는 효과를 나타내었다. Physical activity is known to slow the onset and progression of Alzheimer disease. In the present study, we investigated the effects of exercise pre-conditioning on hippocampal cell proliferation and memory in intracerebroventricular streptozotocin-induced Alzheimer's disease rats. Male (8 weeks old) Sprague-Dawley rats were used in the present study. Rats in the exercise pre-conditioning group were forced to run on a treadmill for 30 min daily for 14 days before lesioning. Rat model for Alzheimer's disease was made by injection of streptozotocin (STZ) (1.5 mg/kg) into a bilateral intracerebroventricular (ICV). Passive avoidance test was performed in order to evaluate the memory ability. After memory testing, the rat brains were removed, and 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry for the detection of cell proliferation were then performed. ICV STZ-injected rats showed a severe deficit in memory associated with decreased cell proliferation in the hippocampus. In contrast, exercise pre-conditioning demonstrated significantly enhanced hippocampal cell proliferation and improved memory performance in ICV STZ-injected rats. These results suggest that exercise pre-conditioning may enhance memory function by increasing cell proliferation in Alzheimer's type dementia.