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제암성물질의 합성 및 항종양시험에 관한 연구 IV N-치환, p-Arsanilic Acid 유도체의 합성 및 항종양시험
정원근(Won Kun Chung),정문우(Moon Woo Chung),김정협(Chung Hyup Kim),이남복(Nam Bock Lee) 대한약학회 1971 약학회지 Vol.15 No.1
Seven organic arsine compounds are synthesized as potential anti-tumor agents are subjected to the screening test of activity against SN-36 Leukemia, Sarcoma 180 and Ehrlich ascites carcinoma. Three compounds, namely N-(5-Nitrofroyl)-p-arsanilic acid. N-(2,4-Dihydroxybenzoethyl)-p-arsanilic acid and N-alpha(p-arsanilide)acetyl thiourea of the all synthesized compounds showed comparatively potential activities against experimental ascitic tumors both through cytological findings and survival duration.
정원근(WK Chung),이문옥(MO Lee),이만선(MS Lee) 대한산부인과학회 1967 Obstetrics & Gynecology Science Vol.10 No.12
A case of ovarian pregnancy in a 37 year-old, mltiparous woman is presented with a brief review of literature available.
제암성물질의 합성 및 항종양시험에 관한 연구III. 수종한국산식물의 Ethanol Extract의 항종양시험
정보섭(Bo Sup Chung),정원근(Won Keun Chung),김중협(Choong Hyp Kim),천문우(Moon Woo Chun) 대한약학회 1970 약학회지 Vol.14 No.3,4
Alcohol extracts of six plant namely Coix agrestis L>OUREIRO, Chloranthus Japonicus (Siebi) NAKAI, Ajuga Spectabilis NAKAI, Juglans mandsuria Max,, Cirsium Macki var Ussuriense KITA and Sasamorpha Purpurascense (Hack) NAKAI were subjected to the screening tests for anti-tumor activities against SN-36 Leukemia, Sarcoma 180 and Ehrlich ascites carcinoma. Of the six extracts, Ajuga Spectabilis NAKAI and Coix agrestis LOUREIRO were found to be potential in survival effect of tumor transplanted mice.
제암성물질의 합성에 관한 연구 VI. 2,4-Dihydroxy-5-nitropropiophenone 유도체의 합성 및 항종양시험
정원근(Won Keun Chung),이남복(Nam Bok Lee) 대한약학회 1973 약학회지 Vol.17 No.2
Seven beta-substituted-2, 4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the synthesized compounds, beta-(1-methyl-1-hydroxymethyl) ethylamino-2,4-dihydroxy-5-nitropropiophenone, beta-(1,1-dihydroxymethyl) ethylamino-2, 4-dihydroxy-5-nitropropiophenone and beta-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.
Benzoxazolin-2-thione과 PAS의 Alkyl Ester과의 Mannich Base 합성 및 항균력에 관한 연구
정원근(Won Keun Chung),정상헌(Sang Hun Chung),정필근(Pil Keun Chung),윤원영(Won Yung Yoon),이남복(Nam Bok Lee) 대한약학회 1974 약학회지 Vol.18 No.4
Nine benzoxazolin-2-thione derivatives were synthesized as the potential antimicrobial substances. These compounds were tested for the antimicrobial activities using Staphylococcus aureus and Escherichia coli by way of tube dilution method. The three compounds of 1, II and VII inhibited the growth of S. aureus at the concentration of 1mcg/ml, and III, VI, VIII and IX exhibited considerable antimicrobial activities against S. aureus at the concentration of l0mcg/ml. As to the growth of E. Coli, VII VII and VIII inhibited at the concentration of 1mcg/ml. II,III and IV exhibited considerable antimicrobial activities against E. coli at the concentration of 10mcg/ml.
CdSe 나노입자 형광층 구조에 따른 백색 LED 발광 특성 연구
정원근 ( Won Keun Chung ),유홍정 ( Hong Jeong Yu ),박선희 ( Sun Hee Park ),전병희 ( Byung Hee Chun ),김성현 ( Sung Hyun Kim ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.3
TOPO/TOP capped CdSe nanoparticles were synthesized via thermal-solvent method. The 540nm green and 620 nm red emitting CdSe nanoparticles were obtained by controlling the reaction time and temperature. Phosphor conversion white LED was produced combining a 460 nm emitting InGaN LED chip as an excitation source with 540 and 620 nm CdSe nanoparticles as phosphors. The single or double phosphor layer was fabricated by mixing with epoxy, and investigated the effects on the luminous properties of the white LED. The single phosphor layer white LED showed 5.78 lm/W with CIE of (0.36, 0.45) in reddish white, and the double phosphor layer white LED showed 7.28 lm/W with that of (0.32, 0.34) in pure white at 20 mA. When the 400 nm near-UV LED was applied to optical pumping source, the luminous efficiency of white LED was enhanced to 8.76 lm/W.
초음파 합성법을 이용한 이리듐계 인광 물질 합성과 합성된 인광 물질의 전계 발광 특성 분석
유홍정 ( Hong Jeong Yu ),정원근 ( Won Keun Chung ),전병희 ( Byung Hee Chun ),김성현 ( Sung Hyun Kim ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.3
Ir(pmb)3 (Iridium(III)Tri(1-phenyl-3-methylbenzimidazolin-2-ylidene-C,C2) was synthesized to develop a deep blue-emitting Ir(III) complex. We suggested the ultrasonic reactor to enhance the poor reaction yield of Ir(pmb)3. The ultrasonic wave enhanced the reaction yield of Ir(pmb)3 because the ultrasound helped non-soluble reactants disperse efficiently and produced free radial during the reaction. The maximum yield of Ir(pmb)3 was 42.5%, which was 4 times higher than conventional method. Organic light emitting devices were fabricated with the synthesized mer-Ir(pmb)3 which emitted at 405 nm. A range of host materials with large bandgaps (UGH2, mCP and CBP) were tested for developing a deep blue emitting device. In case of the device with mCP as the host material, it emitted deep blue and performed quite well relative to the other host materials tested.
이만선(MS Lee),정원근(WK Chung) 대한산부인과학회 1967 Obstetrics & Gynecology Science Vol.10 No.12
A clinical observation on 33 cases of gynecologic tumor (cervical carcinoma, myoma and serous cystadenoma of ovary) during the period of June 1965 to May 1966 was made with statistical analysis. The following results were obtained: 1) The number of gynecologic tumor was 33 cases out of 1633 cases of the out patients. The incidence was 2 per cent. 2)Subdivision of 33 cases was made according to the each tumor; Cervical carcinoma; 17 cases Myoma; 8 cases Serous cytadenoma of ovary; 8 cases. 3)Age distribution of tumor patient was ranged between 17 to 70. 4)Gravidity between 0 to 10 were 33 cases and average 5 times. Parity between 0-9 were 33 cases and average 4 times. 5)Papanicolaou`s smear was done: Class I,II; 39% Class III;9% Class VI,V;51%
추출방법에 따른 감귤 과피 유래 Flavonoid의 추출효율 및 항산화 효과에 대한 비교
최찬익 ( Chan Ick Cheigh ),정원근 ( Won Guen Jung ),정은영 ( Eun Young Chung ),고민정 ( Min Jung Ko ),조상우 ( Sang Woo Cho ),이재환 ( Jae Hwan Lee ),장판식 ( Pahn Shick Chang ),박영서 ( Young Seo Park ),백현동 ( Hyun Dong Paik 한국산업식품공학회 2010 산업 식품공학 Vol.14 No.2
본 연구에서는 감귤 과피 가공부산물로부터 기능성 polyphenol 및 flavonoid가 새로운 추출방법인 아임계 추출법을 통해 추출되었고, 열수(80oC), 에탄올, 설탕용액을 이용한 기존 추출법과의 추출효율이 비교 분석되었다. 건조된 감귤 과피로부터 총 polyphenol(27.25±1.33mg QE/g DCP) 및 flavonoid(7.31±0.41mg QE/g DCP)에 대한 최대수율이 아임계 추출법(190°C, 1300 psi, 10 min)을 통해 획득되었으며, 이것은 기존 추출법 가운데 가장 높은 수율을 보인 에탄올 추출법을 통한 총 polyphenol(3.79±0.73mg QE/g DCP) 및 flavonoid(0.86±0.27mg QE/g DCP) 수율 대비 7.2배와 8.5배 이상 더 높은 것이었다. 추출방법에 따른 감귤 과피 추출물의 항산화 활성은 큰 차이를 나타내지 않았으나, 이러한 결과는 건조 감귤 과피 1g 당 아임계 추출법(190oC, 1300 psi, 10 min)에 의한 항산화 성분의 상대 수율(relative yield, %)이 다른 추출방법을 통해 획득된 것보다 대략 9.5배 이상 더 높다는 것을 설명하는 결과로, 아임계 추출법이 기존의 전통적 추출법에 비하여 감귤 과피의 기능성 polyphenol 및 flavonoid를 추출하는데 매우 적합한 방법임을 제시하고 있다. The extraction of polyphenol and flavonoid from citrus peel was performed by the ethanol, sugar, hot water (80oC), and subcritical water extraction methods. The maximum yields of total polyphenolic compounds (27.25±1.33mg QE/g DCP, QE and DCP indicate quercetin equivalent and dried citrus peel, respectively) and flavonoids (7.31±0.41mg QE/g DCP) were obtained by subcritical water extraction (SWE) with operating conditions of 190oC, 1300 psi, and 10 min. The yields by SWE were over 7.2-, and 8.5-fold higher than those of total polyphenols (3.79±0.73mg QE/g DCP) and flavonoids (0.86±0.27mg QE/g DCP) obtained using the ethanol extraction, which showed the highest extraction efficiency among tested conventional methods, respectively. Antioxidant activities of extracts obtained by different methods showed no significant differences. However, the relative antioxidant yield per 1 g dried citrus peel by SWE (190oC, 10 min) was over 9.5-fold higher than that by the ethanol extraction.