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- 저자 : 정상경 ( Sang Kyung Jung ) (검색결과 2 건)
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증례 : 류마티스 ; Etanercept으로 치료한 류마티스관절염 환자에서 발생한 악성 림프종 1예
정상경 ( Sang Kyung Jung ),이주현 ( Ju Hyun Lee ),이준성 ( June Sung Lee ),이혜란 ( Hye Ran Lee ),장선희 ( Sun Hee Chang ),윤보영 ( Bo Young Yoon ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
1998년 이래로 TNF-α 길항제는 중증 류마티스 관절염의 치료에 탁월한 치료 효과와 함께 비교적 안전하게 널리 치료제로 이용되고 있다. 그러나 악성 림프종 발생 위험을 높인다는 많은 보고들과 함께, 악성 림프종 발생이 치료제 자체보다는 류마티스관절염의 질병 활성도와 더 큰 상관관계가 있다는 주장도 제기되고 있는 상태이다. 본 저자들은 아직까지 국내에 보고가 드문 etanercept로 치료한 류마티스관절염 환자에서 발생한 악성 림프종을 경험하여 참고문헌과 함께 보고하는 바이다. Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis that is associated with an increased risk of coronary artery disease, infection, lymphoma, and life expectancy. Several studies have shown that patients with RA have a 2~3x increased risk of developing lymphomas as compared with the general population. TNF-α antagonist therapy might be independently associated with an increased risk of lymphoma; however, other studies have shown that the risk of lymphoma is increased in RA patients with severe disease activity rather than the treatment per se. We experienced a 65-year-old woman who developed Etanercept-associated malignant lymphoma with rheumatoid arthritis. (Korean J Med 77:S1342-S1346, 2009)
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원 저 : 대장내시경 숙련자와 비숙련자 간의 대장회수시간에 따른 선종발견율의 차이
김영두 ( Young Doo Kim ),배원기 ( Won Ki Bae ),최윤호 ( Yun Ho Choi ),좌윤정 ( Yoon Jung Jwa ),정상경 ( Sang Kyung Jung ),이부현 ( Bu Hyun Lee ),백우현 ( Woo Hyun Paik ),김정욱 ( Jong Wook Kim ),김남훈 ( Nam Hoon Kim ),김경아 ( Ky 대한소화기학회 2014 대한소화기학회지 Vol.64 No.5
Background/Aims: Adequate screening colonoscopy in the general population decreases the mortality associated with colorectal cancer through detection and removal of adenomatous polyps. Prolonged colonoscopic withdrawal times (>6 min) are reportedly beneficial for adenoma detection rates (ADRs). However, the quality of the endoscopist compared with colonoscopic withdrawal times is not known. The aims of this study were to investigate the difference in ADRs between trainees and experienced examiners. Methods: A total of 967 consecutive patients who underwent screening colonoscopy in a single University hospital from June 2010 to November 2011 were enrolled in this prospective observational study. Colonoscopy was performed by four experienced staff and seven gastroenterology fellows. Results: Seven gastroenterology fellows performed 633 colonoscopies and four experienced staff performed 334 colonoscopies. The overall detection rates of colorectal adenoma were 31.5% with ADRs of fellows and staff of 29.4% and 35.6%, respectively (p=0.047). Fellows also showed lower advanced ADRs (5.7% vs. 9.9%, p=0.016), and fellows had longer mean withdrawal times than staff (12.4±4.9 min vs. 8.2±4.1 min, p<0.001). Multivariate analysis showed significantly increased ADRs and advanced ADRs for staff compared with fellows (adjusted OR 2.41, 95% CI 1.70-3.43; adjusted OR 2.55, 95% CI 1.47 4.45, respectively). Conclusions: ADRs were significantly lower when colonoscopy was performed by trainees, although withdrawal times were longer than those of staff. Our results demonstrated that the quality of colonoscopy, as measured by ADRs, may be improved by experienced examiners. (Korean J Gastroenterol 2014;64:278-283)
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