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직장-항문의 원발성 악성 흑색종은 드물며, 직장 항문악성 종양의 1%를 차지하고 있으며, 한국에는 1예가 보고되어 있다. 저자들은 설사와 배변 장애를 주소로 내원한 여자 환자에서 대장 촬영, 북부 CT 촬영, 복부 초음파검사, 흉부 X-선 등으로 간, 비장, 폐, 난소, 임파선에 전이된, 직장암으로 진단하고 조직 검사상에 원발성 악성 흑색종으로 확인된 예를 경험하였기에 이를 보고하는 바이다. Primary malignant melanoma of anorectum is rare, comprising approximately 1% of anal canal tumors, and reported only one case in Korea. A case of primary malignant melanoma of rectum is reported. This 57-year-old female patient was admitted to the hospital because of diarrhea & defication difficulty. She was revealed rectal mass on barium enema & abdominal CT scan and demonstrated malignant melanoma in histopathologic examination of rectal biopsy. Loop sigmoid colostomy was performed and she died of respiratory failure, hapatic failure from lung & liver metastasis.
To investigate possible relationship between depression and chronic decrease of serotonin, immobility time during forced swimming test(IT) and motor activity(ACT) in open field test weremeasured in mice raised with 4 weeks of tryptophan-free or control diet. The results were 1) IT was not affected by tryptophan depletion neither gender, 2) forced swim-induced behavioral inhibition was not observed in tryptophan depleted male mice, 3) muricidal behavior was increased in tryptophan depleted male mice. It was suggested that chronic decrease in serotonin level affected stress-related animal behavior gender dependently, and it might be related with a certain type of depression, agitated depression in males, for an example.
This study reports the psychometric peroperties and factorial structure of a Korean version of the Padua Inventory (PI) in clinical (35 patients withobsessive-compulsive disorder and 66 with other psychiatric disorders) and non-clinical (458 including 120 undergraduate medical students) samples. The PI total and subscales showed good internal consistency, convergent and known-group validity. Test-retest reliability with interval of one year was superior to that of obsessive-compulsive subscale of SCL-90R. PI scores of non-clinical sample were lower than those reported in western countries, apart from Dutch sample. Principal component analysis on data from whole sample suggested four-factor solutions, which was comparable to that found in other versions of the PI developed in the western cultures. Items asking urges or worries of breaking or stealing things were separated from the factor 'urges and worries of losing control over motor behavior'. Factor analysis on data from non-clinical sample revealed five-factor solution: being contaminated, checking behaviors, doubting, worries of disasters, and ruminations. The first two factors were very same as the western reports, the other three were comparable to 'impaired control over mental activities', but 'urges and worries of losing control over motor behavior' was not extracted as a separate factor in this study. Needs for cross-cultural study including other Asian countries arise to confirm lower PI scores and different factor structures in this sample reflects Korean-specific or Asian-specific culture.