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장윤정 ( Yun Jung Chang ),변관수 ( Kwan Soo Byun ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.6
Chronic infection with HCV represents second most common cause of end-stage liver diseases and hepatocellular carcinoma in Korea. The introduction of new agents and regimens for the treatment of chronic hepatitis C, such as pegylated forms of interferon-α
장윤정 ( Yun Jung Chang ),백수정 ( Soo Jung Baek ),오성남 ( Sung Nam Oh ),안수현 ( Soo Hyun Ahn ),김윤홍 ( Yoon Hong Kim ),정길만 ( Gil Man Gung ),연종은 ( Jong Eun Yeon ),변관수 ( Kwan Soo Byun ),이창홍 ( Chang Hong Lee ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 우리나라 청소년충의 B형간염바이러스(HBV) 보유율은 과거에 비해 현저히 감소하였는데 (20세 이하 1.6%, 중고생 1.9%) 이는 B형간염예방백신 도입과 전신생아 예방접종 시행의 결과이며 우리나라 5-6세 아동의 백신접종율이 98.5% 이상으로 보고되고 있다. 이에 따라 우리나라에서 근래 급성B형간염의 발생빈도가 청소년층에서는 급격히 감소되었을 것과 백신접종 전세대인 30대 전후에서 주로 발생될 것이 예상된다. 우리나라의 HBV 보유자들은
장윤정 ( Yoon Jeong Jang ),김송백 ( Song Baek Kim ),최창민 ( Chang Min Choi ),서윤정 ( Yun Jung Seo ),조한백 ( Han Baek Ch ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.4
Samul-tang and Rhizome of Cyperus rotundus L. have been frequently used in gynecologic disease. The purpose of the present study is to explore the behavioral and neurobiological effects of Samul-tanggahyangbuja (SGH) on ovariectomized rats and to form a basis for clinical treatment. Methods: Ovariectomized rats were repeatedly stressed for over 2 weeks. After orally medicated with SGH (200 or 400 mg/kg/day), the anxiety response was tested using the Elevated Plus Maze (EPM) in rats. The serum levels of estradiol and IL-4, and immunohistochemical changes of IL-4 in the Locus coeruleus (LC) and Paraventricular Nucleus (PVN) were measured. Results:1. In the EPM, SGH 400 mg significantly increased time spent on the open arms and decreased time spent on the closed arms, compared with the control group (p<0.05). 2. SGH tended to increase numbers of crossings in the open and closed arms in the EPM. However, it did not reach statistical significance. 3. SGH significantly increased the serum levels of estradiol compared with the control group (p<0.05). 4. SGH 400 mg significantly increased the serum levels of IL-4 compared with the control group (p<0.05). 5. IL-4 immunoreactivity was reduced in the control group compared with the normal group (p<0.05). However, SGH groups (200 and 400 mg) did not produce any significant effects on levels of IL-4 in the LC and PVN. Conclusions: These results suggest that SGH possesses the anti-depressant and immuno-modulatory effects on ovariectomized rats.
2000년대 초기의 국내 급성 B형 간염 발생 양상의 변화
임형준 ( Hyung Joon Yim ),장윤정 ( Yun Jung Chang ),변관수 ( Kwan Soo Byun ),서연석 ( Yeon Seok Suh ),김지훈 ( Ji Hoon Kim ),김진용 ( Jin Yong Kim ),연종은 ( Jong Eun Yeon ),박종재 ( Jong Jae Park ),김재선 ( Jae Seon Kim ),박영태 대한내과학회 2005 대한내과학회지 Vol.69 No.6
목적 : 우리나라 청소년층의 B형 간염바이러스(HBV) 보유율은 과거에 비해 현저히 감소하였는데(20세 이하 1.6%, 중고생 1.9%) 이는 B형 간염 예방 백신 도입과 전신생아 예방 접종 시행의 결과이며 우리나라 5~6세 아동의 백신 접종율이 98.5% 이상으로 보고되고 있다. 이에 따라 우리나라에서 근래 급성 B형 간염의 발생빈도가 청소년층에서는 급격히 감소되었을 가능성이 높으므로 전반적인 급성 B형 간염의 발생 양상에 변화가 있으리라 추정된다. 이번 연구의 목적은 근래 우리나라의 급성 B형 간염의 호발연령을 조사하여 성인에서의 catch-up vaccination의 필요성을 연구하고 급성 B형 간염과 만성 B형 간염의 급성 악화를 감별하는데 있어서 IgM anti-HBc의 진단적 가치를 재평가하기 위함이다. 방법 : 1999년 2월부터 2002년 2월까지 급성 B형 간염을 진단받은 57명과 만성 B형 간염의 급성 악화예 중 IgM anti-HBc를 측정하였던 99명을 대상으로 IgM anti-HBc양성 여부를 측정하고 간염을 최초로 진단받은 시기의 평균연령 및 연령별 분포를 후향적으로 분석하였다. 결과 : 급성 B형 간염이 발생하였던 57명 중 30대가 20명(35%)으로 가장 많은 분포를 차지하였고, 그 다음으로 20대(19명, 33%)에서 호발함을 알 수 있었다. IgM anti-HBc 양성인 만성 B형 간염의 급성 악화예는 25.3%(25명)였고, 30대가 11명(44%)로 가장 많은 분포를 차지하였다. 또한 IgM anti-HBc 양성인 만성 B형 간염의 급성 악화 예에서 S/CO ratio를 구한 결과 43.6%에서 3 이상의 역가를 보였고, 급성 B형 간염에서는 90%에서 3 이상의 역가를 보였다. 결론 : 현재의 우리나라 급성 B형 간염의 호발연령은 30대로 이전보다 성인에서 호발하므로, 성인에서의 catch-up vaccination이 필요하다. 또한 급성 B형 간염의 호발연령과 IgM anti-HBc 양성인 만성 B형 간염의 급성 악화예의 호발연령이 일치하므로 두 군의 감별에 좀 더 주의가 필요하고 이에 IgM anti-HBc 단독 검사만으로 감별이 어려운 경우가 있음을 주지하여야 하겠다. Background : The prevalence of the hepatitis B virus (HBV) carrier state in Korean children is markedly reduced after the introduction of routine HBV vaccination program. The aims of this study were to evaluate the recent changing patterns of acute HBV infection, and to elucidate the diagnostic value of IgM anti-HBc in distinguishing acute hepatitis B from acute exacerbation in chronic HBV infection (CHB). Methods : Fifty seven patients with acute hepatitis B and ninety nine patients with acute exacerbation in CHB were included. The titer of IgM anti-HBc was measured and the distribution of age was analyzed retrospectively. Signal to cut off ratio (S/CO ratio) of IgM anti-HBc was calculated in each IgM anti-HBc positive cases. Results : The peak age of acute hepatitis B was 30~39 years old in 2000`s. IgM anti-HBc was positive in 25.3% of CHB with acute exacerbation and the peak age of this group was also 30-39 years old. Mean(±SD) value of S/CO ratio was 8.3±9.1 in CHB group, while 22.9±18.7 in acute hepatitis group. The difference was significant between two groups (p value=0.001). However, S/CO ratio in 43.6% of CHB group was greater than 3. Conclusions : The incidence of acute hepatitis in Korea was highest in 30-39 years old recently. Therefore, catch-up vaccination is better to be recommended in adults. As the peak age of distribution of acute hepatitis B and CHB with acute exacerbation overlaps, much more caution is needed to differentiate these two conditions from each other by IgM anti-HBc only.(Korean J Med 69:601-607, 2005)
말기 암 환자 가족의 전화상담을 통한 정보요구와 만족도 조사
권경은,김분한,장윤정,김희정,정연,Kwon, Kyeung-Eun,Kim, Boon-Han,Chang, Yoon-Jung,Kim, Hee-Jung,Jung, Yun 한국호스피스완화의료학회 2009 한국호스피스.완화의료학회지 Vol.12 No.1
Purpose: This exploratory study was undertaken to analyze the information needs of family members of terminal cancer patients, collected through the telephone counselling service by National Cancer Information Center. Methods: The study included 113 family members of terminal cancer patients who had enrolled at the National Cancer Information Center for the period from June, 2007 through March, 2008 and had agreed to the survey. Results: The subjects (n=113) consisted of grown-up children (n=82) and spouses (n=8) of patients'. Those in their 40's (n=40) and 30's (n=36) accounted for the majority of the sample. The questions raised most were about the information on treatment methods (n=117), management of terminal cancer patients (n=46), terminal cancer patients' life (n=27), deathbed and prediction of remaining life (n=18), hospitalization (n=16), and financial support (n=15). Most of the subjects were satisfied with the telephone counseling services, and 69% of the subjects had come to know about the telephone counseling service via Internet, and 10.6% of them stated that the PR for the service was poor. Conclusion: It is deemed essential for the government to use the mass media for PR of the hospice services, since family members of terminal cancer patients' are less aware of the hospice conducive to enhancement of patients' remaining quality of life, being involued too deeply in their treatment. 목적: 본 연구는 국가암정보센터의 전화상담을 통해 말기 암 환자가족의 정보요구와 만족도 조사를 통해 말기 암 환자 간호의 질을 향상하고자 시도되었다. 방법: 2007년 6월부터 2008년 3월까지 국가암정보센터를 통해 문의한 말기 암 환자 가족 중 만족도 조사에 동의하고 실제 통화된 113명을 대상하였다. 결과: 1. 정보를 요구한 말기 암 환자 가족은 113명으로 가족 중 자녀(82명)와 배우자(8명)가 주로 이용하였고, 연령은 40대(40명)와 30대(36명)의 이용이 많았다. 가장 많은 질문은 치료방법 117건, 말기 암 환자의 관리 46건, 말기 암 환자의 생활은 27건, 임종과 수명예측 18건, 입원기관에 관한 정보 16건, 경제적 지원은 15건 으로 나타났다. 전화상담 서비스에 대해 전반적으로 높은 만족을 보였다. 전화상담 서비스를 알게 된 경위는 인터넷이 69%로 가장 많았고 상담 후 개선사항을 묻는 질문에 홍보가 부족하다는 대답이 10.6%로 가장 많았다. 결론: 이 연구의 결과를 통해 말기 암 환자 가족은 치료방법에 매여 있어 남은 삶의 질을 높일 수 있는 호스피스에 대한 인식이 적은 만큼 국가적 차원에서 매스미디어를 활용한 호스피스 홍보방안을 모색해야 한다.
단지특성에 따른 국민임대주택 커뮤니티시설의 거주자 이용 실태에 관한 연구
황연숙(Hwang, Yeon-Sook),장윤정(Chang, Yun-Jung),손여림(Son, Yeo-Rym),장아리(Chang, Ari) 한국실내디자인학회 2009 한국실내디자인학회논문집 Vol.18 No.5
The purpose of this study is to examine the residents’ preference to community facilities in national rental apartment complexes. Twelve housing complexes were sampled and researched with questionnaire and field-survey methods. The data from the questionnaire survey were processed with SPSS 14 and analyzed by regional group, size of complex, and arrangement plan of facilities. The complexes are located in two regions, Seoul and Gyounggi province. They were also sorted into three groups by size: less than 500 households, 500 to 1,000, and more than 1,000. Lastly, the complexes were categorized into three types: those where facilities are concentrated in or around a single building, dispersed into several places, and located in residential buildings. The results are as follows: Majority of the community facilities are established outdoor and, therefore, the indoor facilities are relatively more insufficient. Especially, there is a shortage of indoor gymnasium while the demand is increasing. It is partly because there is no regulatory guideline on indoor gym requirements in housing complexes. The resident satisfaction measurement shows significant comparison according to region and complex size. The level of satisfaction with garden/kitchen-garden, pond/fountain/streamlet is higher at the complexes in Gyunggi. The residents of larger complexes give positive feedback about sports facilities while those of smaller complexes are more satisfied with education-related facilities such as library and study. The measurement of resident needs shows significant comparison according to complex size and facility arrangement plan. The residents of smaller complexes are more in need of community facilities. In both regulatory standards and actual condition, community facilities are more insufficient at small complexes with less than 500 households.