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- 저자 : 장운하(Woon Ha Chang) (검색결과 4 건)
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고콜레스테롤식이가 Wister계와 자생고혈압 흰쥐에서 대동경맥화 초기변화에 미치는 영향
장운하,유재형,송계용,류왕성,유언호 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.2
Atherosclerosis refers to a group of disorders that have common thickening and loss of elasticity of arterial walls. Of the various risk factors, hyperlipidemia and hypertension are most important. So, the scanning electron microscopic observation was carried out to evaluate the effects of high cholesterol diet on the early altheroscleotic changes of the aorta both in Wistar and spontaneously hypertensive rat(SHR) for a 8 months. The blood pressure of SHR rised gradually from 3.5months after birth and reached nearly 190 mmHg from the 5.5 to 9.5months. blood cholesterol levels were remarkably increased in rats fed high cholesterol diet from 67.0+-㎎/㎗ to 403.0+-43.8㎎/㎗ in Wistar rat and 117.80+-36.00㎎/㎗ in SHR, respectively. Until 3.5 months, adhesion of a few platelets and fibrin were noted in Wister rats fed with hypercholesterol diet while focal injury on the endothelial surface were noted in SHR in 3.5 months. Later on, adhesion of platelets, fibrin and white blood cells as well as demage of inner wall revealed as multiple small holes wer more marked, resulted in marked atherosclerosis at 9.5month. Atherosclerotic changes were more marked in the condition of hypertension with hypercholesterolemia. With above results, it is suggested that hypercholesterolemia induce endothelial damage by adhesion of platelets and white blood cells in SHR at the beginning of the atherogenesis.
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장운하,박영관,송계용 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.3
The pathogenesis of the idiopathic hypertrophic subaortic stenosis was proved to be the disarray of microfilament of myocardial muscle fibers. But pathogenesis of myocardial hypertrophy of infundibulum in Tetralogy of Fallot (TOF) is still unknown. So, we thought that light microscopic and ultrastructural observation would be helpful to understand the pathogenesis of the thickening of myocardium of infundibulum in TOF. This pathology observation were carried out in the myocardium of myocardial infundibulum on the consecutive open heart surgery in 20 cases of TOF. 1. Moderate to severe myocardial hypertrophy with interstitial fibrosis was observed, accompanied by lymphocyte infiltration and moderate to severe intimal fibrosis of endocardium while in some cases show infundibular mass composed by small sized muscular bundles. 2. Arrangement of myocardial muscular bundles were within normal limits except for focal suggestive disarray in three out of 20 cases. 3. Arrangement of microfilament were well developed and organized with abundant mitochondria accompanied by mitochondrial swelling and vacuolar degeneration & increased lipofuscin pigment. No disorganized microfilaments was noted. 4. Therefore, mass of myocardial infundibulum consists of both small sized or hypertrophied muscular bundles induced mainly by hypertrophy and with or without intimal fibrosis secondary to the increased ventricular pressure.
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김상훈,심대중,금주섭,서원태,임시영,이승세,장운하,오태윤,국신호 대한내과학회 1999 대한내과학회지 Vol.57 No.1
Epithelioid hemangioendothelioma(EH) is a rare vascular tumor of low-grade malignancy. It was previously described as intravascular bronchioloalveolar tumor (IVBAT). But electron microscopic study and immunohistochemical staining results have proved endothelial origin. Patients are usually asymptomatic and the tumors are found incidentally on routine chest X-rays. Most patients show a slowly progressive clinical course, even though some patients occasionally die as results of respiratory failure or extrathoracic complications. Confirmative diagnosis is made through thoracoscopic or open-lung biopsy. There is still no effective therapeutic modality for pulmonary EH. We have experienced a 55-year-old woman whose simple chest x-ray film revealed bilateral multiple small nodules. The nodules were histopathologically and immunohistochemically diagnosed as primary epithelioid hemangioendothelioma of the lung. The possibility of metastatic disease was excluded thorough clinical, laboratory and radiological studies. Comparison of radiographic chest film taken 3 years ago showed no significant progression of the pulmonary nodular lesions. Conservative management was instituted and careful 4 months follow-up showed no significant changes.
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박성민,김범수,이만호,전우규,이상종,김명숙,손봉준,임병훈,장운하 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.4
Leiomyoma is the most common benign tumor of the esophagus, but it still occurs rarely as compared with the incidence of carcinoma in this area. Most of leiomyomas may manifest itself with unusual and inconsistent symptoms, and found incidentally during endoscopic or radiographic examination. Those who menifested symptoms are included as dysphagia and vague pain mostly. We experienced recently two cases with esophageal leiomyoma who underwent successful surgical resection and endoscopic enucleation, respectively.
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