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3개 침제조회사 침구(鍼具)에 대한 침감지표 비교 - 이중 맹검 무작위 배정법 -
임성철,서정철,김경운,서보명,김성웅,이세연,정태영,한상원,이현,Lim, Seong-chul,Seo, Jung-chul,Kim, Kyung-un,Seo, Bo-myung,Kim, Sung-woong,Lee, Se-youn,Jung, Tae-young,Han, Sang-won,Lee, Hyun 대한침구의학회 2004 대한침구의학회지 Vol.21 No.6
Objective : This study was designed to compare acupuncture sensation index among three different acupuncture devices. Methods : A, B and C acupuncture devices were inserted into Quchi(LI 11) of the subjects. After 5 minutes the subjects completed a questionnaire rating the intensity of 21 kinds of acupuncture sensation; hurting, penetrating, sharp, aching, intense, spreading, radiating, tingling, pricking, stinging, pulling, heavy, dull, numb, electric, shocking, hot, burning, cool, pulsing, and throbbing. We compared subjective evaluations of acupuncture sensation among the groups. Results : The acupuncture sensation index when administrated among three different acupuncture devices(A, B and C) was not significantly different. The acupuncture sensation of B acupuncture devices showed significant difference than A or C in Spreading, Dull, Numb item. But, the other items of acupuncture sensation were not significantly different among three acupuncture devices. Conclusions : We found that acupuncture sensation index when administrated among three different acupuncture devices. Further study is needed to know different acupuncture sensation among acupuncture devices.
Estradiol valerate와 Letrozole에 의해 유발되는 다낭성난소증후군의 난소변화 비교
임성철 ( Sung Chul Lim ),정문진 ( Moon Jin Jeong ),김세은 ( Se Eun Kim ),김승현 ( Seung Hyun Kim ),김삼철 ( Sam Cheol Kim ),서승용 ( Seung Yong Seo ),김탁 ( Tak Kim ),강성수 ( Seong Soo Kang ),배춘식 ( Chun Sik Bae ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.6
목적: 다낭성난소증후군(polycystic ovary syndrome, PCOS)을 estradiol valerate (EV)와 letrozole (LE)로 유발할 수 있는데 인간의 다낭성난소증후군과 가장 유사한 질환동물 모델이 무엇인가를 알아보고자 하였다. 연구방법: EV와 LE를 각각 랫드에 처리하여 PCOS를 유발시킨 후 희생시켜 난소를 적출하였다. 난소를 조직학적으로 관찰하여 다낭성 난소 변화 유발유무, 난소의 크기, 난포낭의 크기 및 수를 측정하고 난포 및 간질세포의 황체화 등을 비교 관찰하였다. 결과: LE처리군은 EV처리군에 비하여 난소의 크기 및 난포낭의 수가 유의하게 증가하고 난포막세포의 황체화가 뚜렷하여 인간의 PCOS와 더유사한 소견을 보였다. 결론: 랫드에서 LE처리에 의한 PCOS는 PCOS질환유발 동물 모델로 더 적합한 것으로 평가된다. Objective: To compare ovarian morphology of the estradiol valerate (EV)-and the letrozole (LE)-induced polycystic ovary syndrome (PCOS) in rat models. Methods: EV were injected (IM) to 10 Sprague-Dawley rats and LE were administered (PO) to the other 10 Sprague-Dawley rats for 21 days. Sixty days after single injection of EV and 21 days after LE administration, the animals were sacrifi ced and the ovaries were sectioned, measured and analyzed histopathologically. Results: LE-treated group showed larger ovary bearing more abundant cystic follicles with luteinized theca cells. These fi ndings were more similar to human PCOS ovarian morphology. Conclusion: LE-induced PCOS model is recommended to conduct PCOS-related animal experiments.
자하거(紫河車), 봉약침(蜂藥鍼)을 가미한 한방치료로 호전된 악관절장애 치험 1예(例)
서보명,임성철,정태영,한상원,서정철,Seo, Bo-Myung,Lim, Seong-Chul,Jung, Tae-Young,Han, Sang-Won,Seo, Jung-Chul 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.3
Objectives : The purpose of this study is to analyze the functional and clinical improvement effect on temporomandibular disorder by additional Hominis Placenta and bee venom herbal acupuncture treatment. Methods : A patient was treated with Hominis Placenta, bee venom herbal acupuncture, simple acupuncture, chiropractic therapy, and herbal medicine. We evaluated the improvement by visual analogue scale(VAS) score, mouth opening range, and X-ray image. Results : The VAS score was significantly decreased and mouth opening range was increased after treatment. X-ray image showed improved change after treatments. Conclusions : We think Hominis Placenta and bee venom herbal acupuncture treatment mainly contributed to the improvement of temporomandibular disorders. Further study is needed for the confirmation of this effect of on temporomandibular disorders.
Oligonucleotide chip을 이용한 홍화자약침액(紅花子藥鍼液)이 위암세포주(胃癌細胞柱)의 유전자(遺傳子) 발현(發顯)에 미치는 영향(影響)
이경민,임성철,정태영,서정철,한상원,Lee, Kyung-Min,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul,Han, Sang-Won 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.1
Objectives : It has long been known about the osteogenic effect of CTF-HAS on bone tissues. However, it has not been determined the effect of CTF-HAS on cancer cells. The purpose of this study is to screen the CTF-HAS mediated differentially expressed genes in cancer cells such as SNU484 gastric cancer cell lines. Oligonucleotide microarray approach were employed to screen the differential expression genes. Methods : CTF-HAS was prepared by boiling and stored at $-70^{\circ}C$ until use. Cells were treated with various concentrations of CTF-HAS(0.1, 0.5, 1.5, 10, 20mg/ml) for 24 h. Cytotoxicity was tested by MTT assay. To screen the differentially expressed genes in cancer cells, cells were treated with 1.5mg/ml of CTF-HAS. For oligonucleotide microarry assay, total RNA was used for gene expression analysis using oligonucleotide genechip (Human genome U133 Plus 2.0., Affimatrix Co.). Results : It has no cytotoxic effects on HepG2 cells in all concentration (0.1, 0.5, 1.5, 10,20mg/ml). More than twofold up-regulated genes were 5 genes. The number of more than twofold down-regulated genes was 10. Discussion : This study showed the screening of CTF-HAS mediated differentially regulated genes using combined approaches of oligonucleotide microarray. The screened genes will be used for the better understanding in therapeutic effect of CTF-HAS on cancer field.
이세민,임성철,이윤규,김재수,Lee, Se-Min,Lim, Seong-Chul,Lee, Yun-Kyu,Kim, Jae-Soo The Korean Acupuncture Moxibustion Medicine Societ 2011 대한침구의학회지 Vol.28 No.6
목적 : Elastin 섬유는 피부, 폐, 동맥, 정맥 등 조직에서 발견된다. Elastin 섬유의 손실은 대동맥, 동맥, 세동맥의 탄력 등과 연관되어 폐기종, 혈액순환 부전 및 폐동맥 고혈압을 악화시킬 수 있다. 본 연구는 당귀약침액의 elastase 효소활성에 대한 효과와 항산화 효과에 대하여 연구하고자 계획되었다. 방법 : 당귀약침액의 elastase 억제효과와 DPPH, 및 NO 소거능을 측정하여 항산화 효과를 측정하였다. 결과 : 당귀약침액에서 통계적으로 유의한 elastase 활성 억제효과를 관찰할 수 있었다. 또한 통계적으로 강한 DPPH free radical 소거 효과가 관찰되었다. 그리고 NO 소거효과를 관찰할 수 있었으며, 그 효능은 pH 6.0에서 가장 강한 효능을 보였다. 결론 : 본 연구 결과에 의하면, 당귀약침액에는 유효한 elastase 활성 억제효과와 강한 항산화 효과가 있어, 폐기종 및 폐동맥 고혈압 치료에 유효한 작용이 있을 것으로 사료된다.
오공(蜈蚣) 약침(藥鍼)을 병행한 요골신경마비 치험 1례(例)
이윤경,임성철,정태영,한상원,서정철,Lee, Yoon-Kyung,Lim, Seong-Chul,Jung, Tae-Young,Han, Sang-Won,Seo, Jung-Chul 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.2
Objective : The purpose of this study is to report the patient with radial nerve palsy, who improved by Scolopendrae Corpus Herbal-Acupuncture and other Oriental medical treatments. Methods : The patient was managed by Scolopendrae Corpus Herbal-Acupuncture, body acupuncture, physical theraphy and herbal medicine. We took picture of the patient's wrist and checked the power of muscles. Result : After 4 week treatment, the movement and power of wrist was restored to nearly normal range. Conclusions : The results suggest that combination of Scolopendrae Corpus Herbal-Acupuncture and other Oriental medical treatments is good method for treatment of radial nerve palsy. But further studies are required to concretely prove the effectiveness of this methods.
척수 경막하 출혈로 인한 하지마비 환자의 한방치료를 통한 근력 및 감각 호전 1례
오세정,임성철,이윤규,김재수,이현종,Oh, Se Jung,Lim, Seong Chul,Lee, Yun Kyu,Kim, Jae Soo,Lee, Hyun Jong 대한침구의학회 2014 대한침구의학회지 Vol.31 No.3
Objectives : The objective of this study is to report the clinical effects of Korean medical treatment for spinal subdural hematoma associated with anticoagulant drug. Methods : The patients were treated using acupuncture, electroacupuncture, herbal medication, moxibustion and physical treatment. And we checked American Spinal Injury Association scale, Spinal Cord Independence Measure Version III. Results : Motor score on the American Spinal Injury Association scale is increased 50 to 72. Sensory score on the American Spinal Injury Association scale is increased 124 to 170. Spinal Cord Independence Measure Version III is increased 18 to 26. Conclusions : This study suggest that Korean medical treatments are effective to spinal subdural hematoma patient.
Interleukin 4 Receptor (IL-4R) Gene Polymorphism in Korean Stroke Patients by Using Pyrosequencing
한상원,임성철,정태영,신동훈,김민정,서정철,Han, Sang-won,Lim, Seong-chul,Jung, Tae-young,Shin, Dong-hoon,Kim, Min-jung,Seo, Jung-chul The Korean AcupunctureMoxibustion Medicine Society 2004 대한침구의학회지 Vol.21 No.2
목적 : 본 연구는 Interleukin 4 Receptor (IL-4R) 유전자 다형성이 중풍의 발병과 관련이 있는지 알아보기 위해 수행되었다. 대상: 대구한의대학교부속 한방병원에 입원한 중풍환자 56명과 종합건진센터에 내원한 중풍 기왕력이 없는 건강인 83명을 대상으로 하였다. 방법 : 각 그룹에서 개개인마다 DNA를 분리 정제한 후 Taq polymerase로 증폭하여 한천 겔에서 전기영동을 하여 PCR 산물을 확인하였다. PCR 산물은 Pyrosequencing 과정을 통하여 IL4R의 유전형이 자동으로 판정되었다. 결과 : A/A, A/G, G/G의 세가지 유전자형이 검출되었으며 중풍군과 대조군 사이에 유의성 있는 차이가 발견되었다(p=0.005). 그러나 개별 allele 빈도에 있어서는 중풍군과 건강인 사이에 통계적인 유의성이 나타나지 않았다(p=0.995). 결론 : 이상의 결과를 통하여 IL4R 유전자 다형성은 중풍의 발병과는 관련성이 있는 것으로 사려되지만 더 많은 환자를 대상으로 다른 환경요인 또는 유전자와의 연관성에 대한 심도있는 연구가 필요하다고 하겠다.
고삼이 항암제 cisplatin의 췌$\cdot$심장 부작용 감소에 미치는 영향
김진철,임성철,정태영,서정철,한상원,Kim, Jin-Cheo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul,Han, Sang-Won 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
The objective of this study is to investigate the inhibitor effects of an traditional oriental herb, Sophora flavescens on the pancreatic & cardiac side effects of chemotherapy were studied by using Bl6-BL6 melanoma-injected C57BL6 mouse tumor model. In this study, the effects of an traditional oriental herb, Sophora flavescens, on the side effects of chemotherapy were studied using B16 melanoma-injected C57BL6 mouse tumor model. Anticancer drugs widely used in clinical situation. Sophora flavescen has significant effect on the reduction of the side effects of chemotherapy. Water extract of Sophora flavescens significantly inhibited cisplatin-induced increase of amylase (AMY) which is a good indicator of pancreatic toxicity. Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effect. Theses results suggest a possibility that Sophora flavescens extract can be used for cancer patients for the reduction of the side effects and improving the quality of life during chemotherapy of cancer patients.
Oligonucleotide chip를 이용한 홍화자약침액(紅花子藥鍼液)이 간암세포주(肝癌細胞柱)의 유전자(遺傳子) 발현(發顯)에 미치는 영향(影響)
이경민,임성철,정태영,서정철,한상원,Lee, Kyung-min,Lim, Seong-chul,Jung, Tae-young,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2005 대한침구의학회지 Vol.22 No.3
Objective : It has long been known about the osteogenic effect of CTF-HAS on bone tissues. However, it has not been determined the effect of CTF-HAS on cancer cells. The purpose of this study is to screen the CTF-HAS mediated differentially expressed genes in cancer cells such as HepG2 hepatoma cells lines. Oligonucleotide microarray approach were employed to screen the differential expression genes. Methods : CTF-HAS was prepared by boiling and stored at $-70^{\circ}C$ until use. Cells were treated with various concentrations of CTF-HAS(0.1, 0.5, 1.5, 10, $20mg/m{\ell}$) for 24 h. Cytotoxicity was tested by MTT assay. To screen the differentially expressed genes in cancer cells, cells were treated with $1.5mg/m{\ell}$ of CTF-HAS. For oligonucleotide microarray assay, total RNA was used for gene expression analysis using oligonucleotide genechip (Human genome U133 Plus 2.0., Affimatrix Co.). ResuIts : It has no cytotoxic effects on HepG2 cells in all concentrations (0.1, 0.5, 1.5, 10, $20mg/m{\ell}$). More than twofold up-regulated genes were 19 genes. The number of more than twofold down-regulated genes was 13. Discussion : This study showed the screening of CTF-HAS mediated differentially regulated genes using combined approaches of oligonucleotide microarray. The screened genes will be used for the better understanding in therapeutic effect of CTF-HAS on cancer field.