임상간호사의 뇌사자 장기기증에 대한 지식과 태도에 영향을 미치는 요인

이현아,허유진,이영규,송가람,이은지,신수진,Lee, Hyun Ah,Hur, Yujin,Lee, Young Gew,Song, Garam,Lee, Eunji,Shin, Sujin 한국중환자간호학회 2017 중환자간호학회지 Vol.10 No.3

Purpose : This study investigated factors affecting the knowledge and attitude of organ procurement from brain dead patients in nurse clinicians. Methods : A survey was conducted with 160 clinical nurses from a university hospital in Seoul. Descriptive statistics, t-tests, an ANOVA, $Scheff{\acute{e}}^{\prime}s$ test, Pearson's correlation coefficient, and a multiple regression analysis were used. Results : The mean score for knowledge of organ procurement from brain dead patients was $12.41{\pm}2.16$ (mean correct answers = 62.1). Factors influencing the knowledge of organ procurement among nurse clinicians were working department (${\beta}=.454$, p < .001), a recent family death (${\beta}=.187$, p = .014), experience recognizing potential brain dead patients (${\beta}=.182$, p = .033), and experience referring to potential brain dead patients (${\beta}=-.192$, p = .048). Conclusion : To ensure effective organ procurement from brain dead patients, it is necessary to continually educate nurse clinicians to improve their attitude and knowledge concerning organ donation.

중등도 이상의 위험 수술을 받은 환자에서 수술 전후 항혈전제 약물 사용 평가

이현아,조윤희,조윤숙,한현주,이주연,정근화,이상건,Lee, Hyeon-Ah,Jo, Yun Hee,Cho, Yoonsook,Hahn, Hyeon Joo,Lee, Ju-Yeun,Jung, Keun-Hwa,Lee, Sang Kun 한국임상약학회 2017 한국임상약학회지 Vol.27 No.1

Objective: The perioperative management of antithrombotic therapy is often challenging and it requires a fine balance between the risk of hemorrhage and thrombosis. We aimed to evaluate the antithrombotic management for moderate to high risk patients in real world setting. Methods: Among the patients who were consulted to the neurologist for the evaluation of perioperative risk from 2010 to 2012, patients undergoing moderate to high risk surgery and taking antithrombotics within 30 days were identified. We analyzed the timing of discontinuation and reinitiation of antithrombotic drugs before or after surgery as well as the status of bridging therapy. In addition, the conformity with the guideline suggested by American College of Chest Physicians was assessed. The rate of thromboembolic event and major hemorrhage were also investigated. Results: A total of 329 patients were included. The concordance rate of warfarin stop and restart time with guideline was 23.4% and 10.3%, respectively. Continuing aspirin in patients undergoing coronary artery bypass surgery or non-cardiac surgery in patients with high risk for cardiovascular events were 59.2% and 2.6%, respectively. Bridging therapy was adopted in 92.9% and 81.2% in patients who had received anticoagulant before surgery and who were at high and low risk thromboembolism, respectively. In entire cohorts, 30-day incidence of major bleeding and thromboembolic event were 31.9% and 3.0%. Co-morbid renal disease were shown as independent predictor for major bleeding (adjusted OR 2.65. 95% CI 1.33-5.28). Conclusion: The concordance rate with guideline regarding perioperative antithrombotic use was low and bridging therapy was prevalent in patients undergoing moderate to high risk surgery.

영작문 자동 채점 시스템에서의 중복 보고 오류 제거를 통한 성능 향상

이현아,김지은,이공주,Lee, Hyun-Ah,Kim, Jee-Eun,Lee, Kong-Joo 한국정보처리학회 2009 정보처리학회논문지B Vol.16 No.2

The purpose of developing an automated scoring system for English composition is to score English writing tests and to give diagnostic feedback to the test-takers without human's efforts. The system developed through our research detects grammatical errors of a single sentence on morphological, syntactic and semantic stages, respectively, and those errors are calculated into the final score. The error detecting stages are independent from one another, which causes duplicating the identical errors with different labels at different stages. These duplicated errors become a hindering factor to calculating an accurate score. This paper presents a solution to detecting the duplicated errors and improving an accuracy in calculating the final score by eliminating one of the errors. 영어 작문 자동 채점 시스템은 수험자가 작성한 영작문을 사람의 개입 없이 시스템이 처리하여 점수나 피드백을 줄 수 있는 시스템이다. 본 논문에서 개발한 영작문 자동 채점 시스템은 단어 단계, 구문 단계, 의미 단계의 세 단계 처리 과정을 통해서 오류를 탐지하고 탐지된 오류 개수를 기반으로 채점 점수를 결정한다. 이와 같이 독립적인 세 단계의 처리 과정에서 오류를 탐지하므로 동일한 오류 현상에 대해 서로 다른 단계에서 서로 다른 이름으로 오류를 탐지하는 경우가 발생할 수 있다. 이는 결과적으로 전체 시스템의 채점 점수의 정확도를 저하시키는 원인이 된다. 본 논문에서는 동일한 오류 현상에 대해 서로 다른 단계에서 탐지된 오류 쌍을 '중복 보고 오류'라고 정의한다. 본 논문에서는 중복 보고 오류를 찾는 방법을 제안하고 중복 보고 오류 제거를 통해 영작문 자동 채점 시스템의 채점 점수를 향상시킬 수 있음을 보인다.

세대별 기혼남성의 가사노동시간 연구: 베이비붐세대, X세대, Y세대를 중심으로

이현아,김주희,Lee, hyunah,Kim, Joohee 한국가족자원경영학회 2021 가족자원경영과 정책 Vol.25 No.4

The purpose of this study is to identify the influencing factors of married men's household labor time by generation to understand the changes in male participation in household labor. To this end, married men were classified into Baby Boomers, Generation X, and Generation Y, and the factors of participation in household labor for each generation were analyzed by applying the hypothesis of participation in household labor. As for the data, the original data of the National Statistical Office's "2019 Time Use Survey" were used. Multinomial logistic analysis was conducted to analyze the factors affecting married men's household labor time. As a result of the analysis, household labor time for Baby Boomers can be explained by the hypothesis of economic efficiency, gender role attitude, and the demand/response capability, while household labor time for Generation X can be explained by economic efficiency hypothesis, gender role attitude hypothesis, time-availability hypothesis, and demand/response capability hypothesis. It was found that the household labor time for Generation Y can be explained by the time-availability hypothesis and demand/response capability hypothesis. The fact that each generation has different factors of participation in household labor suggests that the characteristics of each generation should be considered in establishing policies to support the work and family balance for men.

충격과 마모를 고려한 원자로 핵연료봉 지지격자의 설계

이현아,김종기,송기남,박경진,Lee, Hyun-Ah,Kim, Chong-Ki,Song, Kee-Nam,Park, Gyung-Jin 대한기계학회 2007 大韓機械學會論文集A Vol.31 No.10

The spacer grid set is a component in the nuclear fuel assembly. The set supports the fuel rods safely. Therefore, the spacer grid set should have sufficient strength for the external impact forces such as earthquake. The fretting wear occurs between the spring of the fuel rod and the spacer grid due to flow-induced vibration. Conceptual design of the spacer grid set is performed based on the Independence Axiom of axiomatic design. Two functional requirements are defined for the impact load and the fretting wear, and corresponding design parameters are selected. The overall flow of design is defined according to the application of axiomatic design. Design for the impact load is carried out by using nonlinear dynamic analysis to determine the length of the dimple. Topology optimization is carried out to determine a new configuration of the spring. The fretting wear is reduced by shape optimization using the homology theory. The deformation of a structure is called homologous if a given geometrical relationship holds before, during, and after the deformation. In the design to reduce the fretting wear, the deformed shape of the spring should be the same as that of the fuel rod. This condition is transformed to a function and considered as a constraint in the shape optimization process. The fretting wear is expected to be reduced due to the homology constraint. The objective function is minimizing the maximum stress to allow a slight plastic deformation. Shape optimization results are confirmed through nonlinear static analysis.

홍삼 성분의 혈당강하작용 연구 (I) :쥐의 배양 간세포의 당대사 관련 효소 활성에 미치는 홍삼 사포닌 성분의 영향 조사

이현아,권상옥,이희봉,Lee, Hyeon-A,Gwon, Sang-Ok,Lee, Hui-Bong 고려인삼학회 1997 Journal of Ginseng Research Vol.21 No.3

In this study, rat hepatocytes known to have active carbohydrate metabolism were obtained by using the liver perfusion technique to examine the hypoglycemic action of red ginseng saponin components [ginsenoside (mixture, $Rb_1$, and $Rg_1$)] and incubated in two different media-one containing insulin and glucagon (control group), and the other containing glucagon only, The specific activities of some regulatory enzymes such as glucokinase, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glucose 6-phosphatase, in main pathways which were directly related to the glucose metabolism were compared between these two kinds of hepatocytes cultured in two different media. The effects of red ginseng saponin components [ginsenoside (mixture, $Rb_1$, and $Rg_1$)] under the concentration of $10^3$~$10^6$% on these enzymes In hepatocytes were also investigated, when they were added to these two media. The results were as follows. The specific activity of enzymes such as glucokinase, glucose 6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase related to glucose-consuming pathways of insulin-deficient group was much less than control one, however, their decreased activity was recovered after the addition of ginseng components at all range of concentrations. The increased specific activity of these on - zymes was shown by the addition of ginseng components to the control group. On the other hand, the specific activity of glucose 6-phosphatase related to glucose-producing pathway of insulin-deficient group was much higher than control one, but their Increased activity was decreased after the addition of ginseng components at all range of concentrations. The same results were obtained after the addition of ginseng components to the control group. These results suggest that the red ginseng saponin components might better diabetic hyperglycemia by regulating the activity of enzymes related to glucose metabolism directly and/or Indirectly though more detailed studies were needed.

Effects of cold stress as a pathogenic factor on fatal disease progression of canine herpesvirus

이현아,홍선화,이윤성,김동우,권혜영,Cheol-Yong Lee,김옥진 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.3

Canine herpesvirus (CHV) is a member of the alphaher- pesvirus subfamily, which can cause severe hemorrhagic diseases in neonatal pups as well as mild or subclinical respi- ratory infections in adult dogs. We examined the effects of cold stress on disease progression of CHV, an alphaherpes- virus, in neonatal puppies. Eight puppies were challenged intranasally with CHV suspension and divided into a cold stress treatment group and a hyperthermal group. Four pups were left uninoculated as controls and divided into cold and hyperthermal groups. In the challenged cold treatment group, all pups showed CHV-related disease within 5 days; pathological changes were observed in organs of puppies showing clinical symptoms. Grossly, numerous petechial red foci were scattered throughout lungs, kidneys, livers, and intestines of all CHV-infected puppies exposed to cold stress. Most puppies showed typical clinical signs and macroscopic lesions, and CHV infection was confirmed by isolation of the virus. However, in the challenged hyperthermal group, only one of the pups showed mild symptoms of CHV-induced disease. None of the puppies in the uninoculated group showed abnormal signs, although they were exposed to cold stress. These findings indicate that cold stress can cause rapid disease progression of CHV, an alphaherpesvirus.

국내 지진 감시·예측을 위한 지하수관측망의 활용 방안

이현아,함세영,우남칠,Lee, Hyun A,Hamm, Se-Yeong,Woo, Nam C. 대한자원환경지질학회 2017 자원환경지질 Vol.50 No.5

To prevent the damages from earthquakes, various researches have been conducted around the world focusing on earthquake prediction and forecasting for several decades. Among various precursory phenomena, changes in groundwater level and quality are considered to be reliable for estimating the time of earthquake occurrence and its magnitude. In effects, some countries impacted by frequent earthquakes have established and operated the groundwater monitoring network for earthquake surveillance and prediction. In Korea, recently researches have begun for using groundwater monitoring techniques for earthquake prediction. In this paper, the groundwater monitoring networks of China, Japan, and the United States were reviewed focusing on the facilities and results of researches to deduce the tasks for earthquake prediction researches using groundwater monitoring techniques in Korea. In results, research needs are suggested in the implementation of groundwater monitoring networks for specifically earthquake surveillance with the real-time monitoring and the measures to quantify the degrees of abnormal changes in the relationship of distance from the earthquake epicenter. 지진에 의한 피해를 방지하기 위하여 지진 예측과 예보를 위한 다양한 연구가 전 세계적으로 시도되어 왔다. 지진예측지표 중, 지하수 수위 및 수질의 장기관측자료에서 지진 전에 나타나는 이상변동은 지질매체에 가해지는 압력의 변화와 매체 내 균열의 발달에 의한 것으로 지진의 발생 시기와 규모를 추측할 수 있는 것으로 평가되고 있다. 따라서 국외에서는 지하수 관측시스템을 지진감시 관측망의 보조관측망으로 활용하고 있으며, 실제 지진 예측에 활용되고 있다. 우리나라는 최근에서야 지하수를 활용한 지진예측연구가 시작되었으며, 그 가운데 발생한 2016년 9월의 경주지진 전후로 나타난 지하수의 변동은 많은 관심을 불러왔다. 이 연구는 지진감시 및 예측을 위해 적극적으로 지하수관측시설을 운용하고 있는 중국, 일본, 미국의 관측시설 현황 및 연구 사례를 분석, 검토하고 최근 우리나라에서 수행되기 시작한 지진예측 연구의 연구방향과 과제를 제시하고자 수행되었다. 그 결과, 앞으로 고품질의 자료를 생산할 수 있는 지진감시 전용의 단층대 지하수관측시설 구축과 주요 관측인자의 실시간 감시, 이상변동의 폭과 관측되는 거리에 대한 정밀한 평가 및 연구가 필요할 것으로 사료된다.

Helicobacter pylori에 대한 천련자 추출물의 in vitro와 in vivo 실험에서의 항균활성

이현아,김옥진,Lee, Hyun-A,Kim, Okjin 대한수의학회 2012 大韓獸醫學會誌 Vol.52 No.2

In this study, a medicinal herbal plant, Meliae fructus, was examined and screened for anti-Helicobacter (H.) pylori activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Meliae fructus extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Meliae fructus demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Meliae fructus extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Meliae fructus. It could be a promising native herbal treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.

Helicobacter pylori에 대한 항균활성을 가진 천연물의 검색과 항균력 비교 연구

이현아,김옥진,Lee, Hyun-A,Kim, Okjin 대한수의학회 2013 大韓獸醫學會誌 Vol.53 No.2

Infection with Helicobacter (H.) pylori is strongly associated with duodenal and gastric ulcers. Substantial epidemiological data has revealed that high rates of H. pylori infection might be related to high rates of gastric cancer. In this study, a medicinal herbal extracts were examined and screened for anti-H. pylori activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity study, the inhibitory zone tests with 74 herbal compounds were conducted. As the results, thirteen compounds including Cinnamomi Cortex, Magnoliae Cortex and Meliae Fructus were revealed strong anti-H. pylori activities.