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      • KCI등재

        파골세포 분화에 미치는 蘆會추출물의 효과

        이정휴(Jeong Hugh Lee), 이명수(Myeung Su Lee), 채수욱(Soo Uk Chae), 김하영(Ha Young Kim), 문서영(Seo Young Moon), 전병훈(Byung Hoon Jeon), 조해중(Hae Joong Cho) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.6

        Osteoporosis is the leading underlying cause of fractures, particularly in postmenopausal women, due to the loss of estrogen-mediated suppression of bone resorption. More than 50% of adults 50 years of age or older are estimated to have osteoporosis. Osteoclast which is main target for treatment of osteoporosis is originated from hematopoietic cell line. Aloe has been widely used in worldwide country as a coadjuvant medicine. Extracts of the leaves of Aloe have been used in condition to improve dermatologic problem such as seborrheic dermatitis, aphthous stomatitis, xerosis, lichen planus and has been known to exert anti-inflammatory, anti-oxidant and anti-tumor effects. However, despite the popularity of aloe as a plant food supplements, the evaluation of its efficacy as a possible therapeutic option for osteoporosis remains scarce. Thus, we evaluated the effect of Aloe on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. Here we found that Aloe significantly inhibited osteoclast differentiation induced by RANKL. Aloe suppressed the activation of p38 pathway and NFκB in bone marrow macrophages (BMMs) treated with RANKL. Also, Aloe significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase (TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Aloe greatly inhibited the protein expression of c-fos and NFATc1. Taken together, our results suggested that Aloe may be useful tool for treatment of osteoporosis by inhibition of osteoclast differentiation.

      • KCI등재

        파골세포 분화에 목향 물 추출물의 효과

        이명수(Myeung Su Lee), 김정중(Jeong Joong Kim), 오재민(Jae Min Oh), 최민규(Min Kyu Choi), 송미진(Mi Jin Song), 안용환(Yong Hwan Ahn), 이정휴(Jeong Hugh Lee), 전병훈(Byung Hoon Jeon), 박기인(Kie-In Park), 장성조(Sung Jo Jang) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.3

        Osteoporosis is social problem around the world, because fracture of old age may lead to critical medical condition. Osteoclast is a main target for prevention and treatment of osteoporosis due to their responsibility for bone resorption. Saussureae Radix has been known that has gastro-protective, bronchodilatory effect and has a anti-biotic effect. Saussureae Radix has been widely used in Oriental medicine. However, the effect of extract of Saussureae Radix in osteoclast differentiation remains unknown. Thus, we examined the effect of Saussureae Radix in receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. From the results of our study, Here we found that Saussureae Radix significantly inhibited osteoclast differentiation induced by RANKL. Saussureae Radix suppressed the activation of NFκB in bone marrow macrophages (BMMs) treated with RANKL. Also, Saussureae Radix significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase (TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Saussureae Radix greatly inhibited the protein expression of c-fos and NFATc1. especially in the case of NFATc1 expression, a master transcription factor of the differentiation of osteoclasts is very important step for osteoclastogenesis. These results demonstrate that Saussureae Radix may be useful treatment option of bone-related disease such as osteoporosis and rheumatoid arthritis.

      • KCI등재

        파골세포 분화에 미치는 복분자 물 추출물의 효과

        오재민(Jae Min Oh), 이명수(Myeung Su Lee), 김정중(Jeong Joong Kim), 이정휴(Jeong Hugh Lee), 채수욱(Soo Uk Chae), 김하영(Ha Young Kim), 전병훈(Byung Hoon Jeon), 박기인(Kie In Park), 문서영(Seo Young Moon), 조해중(Hae Joong Cho) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.4

        To prevent and treat the osteoporotic fracture, more attention should be paid in old age patients. Osteoclast which has ability to bone resorption is originated from hematopoietic cell line and plays a key role osteoporotic bone loss. Rubi Fructus has been widely used in Oriental medicine. Extracts of the leaves and fruit of Rubus species have been used in various countries as natural remedies to treat diabetes, infections, colic, and burns. However, the effect of extract of Rubi Fructus (fruit of Rubus coreanus Miq.) in osteoclast differentiation remains unknown. Thus, we evaluated the effect of Rubi Fructus on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. Here we found that Rubi Fructus significantly inhibited osteoclast differentiation induced by RANKL. Rubi Fructus suppressed the activation of p38 pathway and NFκB in bone marrow macrophages (BMMs) treated with RANKL. Also, Rubi Fructus significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase(TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Rubi Fructus greatly inhibited the protein expression of c-fos and NFATc1. especially in the case of NFATc1 expression, a master transcription factor of the differentiation of osteoclasts is very important step for osteoclastogenesis. Taken together, our results demonstrated that Rubi Fructus may be useful treatment option of bone-related disease such as osteoporosis and rheumatoid arthritis.

      • KCI등재

        Inhibitory Effects of 1',2'-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo

        Kwang-Jin Kim(김광진), Han Bok Kwak(곽한복), Eun-Yong Choi(최은영), Jaemin Oh(오재민), Min-Kyu Choi(최민규), Jeong Hugh Lee(이정휴), Mi-Jin Song(송미진), Yong Hwan Ahn(안용환), Myeung Su Lee(이명수), Chang Hoon Lee(이창훈), Seong Hoon Park() 대한체질인류학회 2011 대한체질인류학회지 Vol.24 No.3

        뼈 관련 질환을 앓고 있는 환자에게 부작용이 없는 치료제의 발견은 중요하다. 따라서 본 연구의 목적은 뼈 파괴세포의 분화와 뼈 흡수를 억제할 수 있는 새로운 물질을 발견하는 것이다. 본 연구에서 뼈 파괴세포의 분화 및 뼈 흡수에 1',2'-dihydrorotenone의 효과를 세포수준과 마우스 생체 내에서 검증하였다. 1',2'-dihydrorotenone은 농도 증감에 따라 receptor activator of NF-κB ligand (RANKL)에 의해 대식세포에서 뼈 파괴세포로의 분화를 억제하였다. 그러나 1',2'-dihydrorotenone은 대식세포에 독성을 나타내지 않았다. 이들의 결과로 1',2'-dihydrorotenone이 대식세포로부터 뼈 파괴세포로 분화에 특이적으로 작용한다고 할 수 있다. 1',2'-dihydrorotenone은 RANKL에 의한 뼈 파괴세포 특이 유전자 뿐만 아니라 c-Fos와 NFATc1의 발현을 억제하였다. RANKL는 inhibitors of differentiation/DNA binding (Id)1, 2, 3의 발현을 억제하였지만, 1',2'-dihydrorotenone가 Id1과 Id2의 발현을 촉진하였다. 더욱이, 1',2'-dihydrorotenone은 뼈 파괴세포의 뼈 흡수를 억제하였고 마우스 생체 내 lipopolysaccharide에 의한 뼈 흡수를 억제하였다. 이 모든 결과로 1',2'-dihydrorotenone이 뼈 질환 치료제로 가능성을 가진다고 할 수 있다. It is important to identify therapeutic compounds with no adverse effects for use in the chemotherapy of patients with bone-related diseases. The aim of this study was to identify a new compound that inhibits osteoclast differentiation and bone resorption. Herein, we examined the effects of 1',2'-dihydrorotenone on osteoclast differentiation and bone resorption in vitro and in vivo. 1',2'-dihydrorotenone inhibited receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation of cultured bone marrow macrophages (BMMs) in a dosedependent manner. However, 1',2'-dihydrorotenone did not exert cytotoxic effect on BMMs. 1',2'-dihydrorotenone suppressed the expression of c-fos and NFATc1 as well as osteoclast-specific genes in BMMs treated with RANKL. Treatment with RANKL inhibited the expression of inhibitors of differentiation/DNA binding (Id)1, 2, and 3; however, in the presence of 1',2'-dihydrorotenone, RANKL did not suppress the expression of Id1, 2, and 3. Furthermore, 1',2'-dihydrorotenone inhibited bone resorption and considerably attenuated the erosion of trabecular bone induced by lipopolysaccharide treatment. Taken together, these results suggest that 1',2'-dihydrorotenone has the potential to be applied in therapies for bone-related diseases.

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