선별검사 목적으로 시행된 관상동맥 CT의 석회수치에 따른 임상경과 관찰

정인현 ( In Hyun Jung ),김정순 ( Jeong Soon Kim ),남효정 ( Hyo Jung Nam ),김희성 ( Hee Sung Kim ),김홍규 ( Hong Kyu Kim ),박덕우 ( Duk Woo Park ),이승환 ( Seung Whan Lee ),김영학 ( Young Hak Kim ),이철환 ( Cheol Whan Lee ),김재중 대한내과학회 2010 대한내과학회지 Vol.78 No.4

목적: 최근 많은 연구에서 MDCT가 관상동맥 질환을 진단하는데 있어서 비교적 민감도와 특이도가 우수하고, 높은 음성예측도를 가진 검사로 보고되고 있다. 그러나 무증상 환자군에서 MDCT상 유의한 협착이 보일 때 어떤 환자군에서 경피적 관동맥 성형술이나 관동맥 우회로 수술을 받는가에 대한 임상경과를 관찰한 연구는 아직 없다. 이에 저자들은 선별 검사 목적으로 MDCT를 시행한 무증상 환자의 관상동맥 석회수치에 따른 임상경과를 보고자 하였으며, 선별 검사 목적의 MDCT의 무분별한 사용을 줄이기 위해 NCEP-ATP III 지침에 따라 10년 관상동맥 질환 위험도를 구분한 각 집단 중 어떤 집단에서 MDCT상 유의한 협착이 많이 관찰되는지 알아보고자 하였다. 방법: 건강검진을 목적으로 서울아산병원 건강증진센터에 방문한 845명의 의무기록과 MDCT를 후향적으로 분석하였다. MDCT상 유의한 협착은 관상동맥 내경이 50% 이상 좁아진 경우로 정의하였고, 관상동맥 질환 위험도는 NCEP-ATP III 지침에 의해 계산된 10-year risk assessment tool(http://hp2010.nhlbihin.net/atp3/riskcalc.htm)을 사용하였다. 침습적 관상동맥 조영술은 심근부하 검사가 양성이거나 심근부하 검사가 음성이라도 MDCT상 주관상동맥의 근위부에 유의한 병변이 있을 때 시행하였고, 관상동맥 재개통술 여부는 관상동맥 조영술 후 주치의의 판단에 의해 결정되었다. 결과: 총 332명(39.3%)에서 동맥경화반이 관찰되었으며 이들 가운데 60명(7.1%)은 관상동맥의 유의한 협착을 보였다. MDCT상 유의한 협착을 갖는 환자의 유병률은 NCEP-ATP III 지침에 따른 위험도에 따라 구분하였을 때, 10년 심혈관계 합병증의 위험도가 10% 이상인 군에서 의미있게 높았다. 유의한 협착을 보인 환자들 중 28명이 관상동맥 조영검사를 받았으며, 17명은 경피적 관동맥 성형술을 받았고, 3명은 관상동맥 우회로 수술을 받았다. ROC 곡선을 이용하여 MDCT상 유의한 협착을 가진 환자에서 관상동맥 재개통술(revascularization)을 시행받은 환자에 대한 CACS의 cutoff 값은 111.0 (AUC=0.87, 95% confidence interval; 0.76~0.97, sensitivity 80.0%, specificity 92.1%)이었다. 결론: 현재 선별 검사 목적의 MDCT 시행에 대하여 논란의 여지가 많은 상황에서 NCEP-ATP III 지침에 따른 위험도가 10% 미만인 군에 대하여는 관상동맥 질환에 대한 선별검사 목적으로 MDCT를 사용하는 것은 가급적 제한하는 것이 바람직할 것으로 생각된다. 또한 선별 검사 목적으로 시행된 MDCT상 유의한 협착이 관찰되고 CACS가 110 이상일 경우 경피적 관동맥 성형술이나 관상동맥 우회수술과 같은 관상동맥 재개통술을 받게 될 가능성이 의미있게 높았다. Background/Aims: In general, multidetector computed tomography (MDCT) is not recommended as a screening tool for asymptomatic individuals. However, the programs for general health evaluation at several hospitals in Korea include MDCT to detect cardiac disease. The objectives of this study were to evaluate the clinical outcomes of asymptomatic individuals according to the coronary artery calcium score (CACS) obtained from screening MDCT and to assess the eligibility of risk stratification in the NCEP-ATP III guidelines for predicting a significant stenosis on MDCT. Methods: We reviewed the medical records of 845 asymptomatic subjects (age 53±9 years, 67% men) who underwent MDCT as part of a general health evaluation at Asan Medical Center, Seoul, Korea, from January to December 2008. Results: Atherosclerotic plaques were identified in 332 (39.3%) subjects. Sixty (7.1%) individuals had significant stenosis (≥50% diameter stenosis). The prevalence of significant stenosis was higher in the group that had more than a 10% risk of coronary heart disease (CHD) at 10 years (p<0.05). Among the patients with occult coronary artery disease (CAD), 28 received coronary angiography, which resulted in 20 revascularizations (17 percutaneous interventions and three bypass surgeries) and eight medical treatments. In patients with significant narrowing, the CACS cutoff value for predicting coronary revascularization was 111.0 (AUC=0.87, 95% confidence interval; 0.76~0.97; sensitivity 80.0%, specificity 92.1%). Conclusions: According to the NCEP-ATP III guidelines, the prevalence of occult CAD on MDCT was significantly higher in the group with a 10% or higher risk for CHD at 10 years. A CACS≥110 was associated with a significantly higher rate of coronary revascularization in asymptomatic patients with significant stenosis on MDCT. (Korean J Med 78:466-476, 2010)

급성전신발진농포증 환자의 임상 및 조직학적 분석

정인순 ( In Soon Jung ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee-bum Lee ),김성진 ( Seong-jin Kim ),이승철 ( Seung-chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.10

Background: Acute generalized exanthematous pustulosis (AGEP) is typically a medication-induced acute febrile eruption. Few large-scale studies have reported clinical data regarding AGEP in Korea. Objective: This study analyzed the clinical and histopathological features of AGEP in Koreans to identify recent trends in this context. Methods: This study retrospectively reviewed 31 patients with AGEP. Age, sex, clinical features, etiologies, laboratory findings, histopathological features, and treatment outcomes were obtained from patients’ medical records and photographs. Results: The mean age of onset was 43.6 years, and the male:female ratio was 2.1:1. All patients showed non-follicular tiny pustules and erythema. Fever was reported in 13 patients and neutrophilia in 17 patients. Medications were considered the most common etiological contributors. Twenty patients showed drug-induced AGEP, and 11 of 20 patients showed antibiotic-induced AGEP. Serum C-reactive protein and lactate dehydrogenase levels increased in 93.8% and 77.8% of the patients, respectively. Histopathologically, all patients showed subcorneal or intraepidermal pustules, followed by exocytosis and neutrophilic dermal infiltrate. Twenty-five patients improved within a mean period of 7.5 days after the onset of the skin rash. The percentage of women in the drug-induced AGEP group was significantly higher than that in the non-drug-induced AGEP group. Conclusion: This report describes a large-scale study that analyzed the clinical and histopathological features of AGEP in Koreans and seems to accurately reflect the recent trends in this context. Clinically, it is important to note that the percentage of women in the drug-induced AGEP group was higher than that in groups showing other etiologies of AGEP. (Korean J Dermatol 2018;56(10):594∼602)

분화 유도된 근육줄기세포의 내막증식 억제 효과

정인목(In Mok Jung),한소리(So Rhee Han),최금희(Keum Hee Choi),권유진(Yujin Kwon),이태승(Taeseung Lee),민승기(Seung-Kee Min),박양진(Yang Jin Park),정중기(Jung Kee Chung),하종원(Jongwon Ha),김상준(Sang Joon Kim) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.79 No.6

Purpose: Although progenitor cells may contribute to intimal hyperplasia (IH) after arterial injury, positive contribution of IH is variable with type of injury or cells. This study was designed to examine whether differentiated muscle derived stem cells (MDSC) attenuate IH in rat. Methods: MDSCs were retrieved using preplate techniques from rat calf muscle and MDSCs (preplate 6th culture fraction, pp6) were exposed to VEGF (50 ng/㎖) for endothelial differentiation prior to injection. Male rats were divided into two groups (cell treated vs. control) and underwent carotid balloon injury with 2-Fr catheter. The virus containing Green fluorescent protein (GFP) gene was transfected into cells for monitoring. Cells (5×10?) were indwelled into carotid artery for 30 minutes after injury and then blood flow was restored. Arteries were harvested at various intervals (1, 2 and 4 weeks) after injury. The intima to media thickness ratio (IMTR) was calculated with morphometric analysis. Results: Endothelial surface markers such as VE-CADHERIN were strongly expressed on differentiated MDSCs. At 4 weeks after injury, IH was predominantly observed in control group compared to cell treated group. The intensity of GFP was strongly observed at 1 week and declined at 4 weeks in carotid artery wall at MDSC group. CD31(+) endothelial cells were observed at MDSC group compared to control. The mean IMTR in cell treated groups were significantly lower than control at 2 weeks (P=0.005) and 4 weeks (P≤0.001). Conclusion: Our study demonstrates that MDSCs therapy promotes re-endothelialization and leads to attenuation of IH after balloon injury in rat.

성인 피부근염 환자 52명의 임상적 분석

정인순 ( In Soon Jung ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.1

Background: Dermatomyositis is one of the idiopathic inflammatory myopathies, characterized by unique cutaneous features. Unfortunately, there is little data regarding the clinical features of dermatomyositis in Korea patients. Objective: The study aimed to analyze the clinical features of Korean patients with adult-onset dermatomyositis. Methods: A total of 52 patients from 2002 to 2016 were analyzed retrospectively. Clinical features such as sex, age, symptoms, associated connective tissue disorders and malignancy were studied using medical records. Results: The mean onset age was 43.4 years, and the male to female ratio was 1 : 1.9. Forty-two patients (80.8%) were classified as having dermatomyositis, and 8 patients (15.4%), as having amyopathic dermatomyositis. Skin rash (94.2%) was the most common clinical feature, followed by proximal muscle weakness (61.5%), itching (55.8%), arthralgia (36.5%), and muscle pain (32.7%). Among skin rashes, symmetric violaceous erythema (67.3%) was the most frequent, followed by heliotrope rash (63.5%) and Gottron’s papule (59.6%). Serum aldolase level was elevated in 77.8%, and LDH in 69.6%. The prevalence of malignancy (23.1%) was similar to that in previous studies. Cervical cancer made up 25% (3/12) of the associated malignancies, followed by ovarian cancer and lung cancer (16.7%). Ten patients (19.2%) had other accompanying connective tissue diseases. Conclusion: To date, this is the first large-scale case study that analyzed the clinical features of Korean patients with adult-onset dermatomyositis. (Korean J Dermatol 2018;56(1):24∼29)

BIPV 용 결정질 태양광 모듈 및 재료의 투과 특성에 대한 연구

정인성(Jung, In sung),이범수(Lee, Bum-Su) 한국태양에너지학회 2012 한국태양에너지학회 학술대회논문집 Vol.2012 No.11

In 21st century, the photovoltaic industry is growing almost 30% annually worldwide. Also, the technology of solar cells is shifting to the Building Integrated systems. It is the situation which is unsatisfactory about the transmittance quality of the solar cell and module which are applied windows in buildings and vehicles. Considering the BIPV market, a research on the glass-to-glass module type is described in this paper. We analyzed the transmittance of glass-to-glass module type solar cells using Ethylene Vinyl Acetate (EVA) sheet and Poly Vinyl Butyral (PVB) sheet. We found that the EVA sheet is approximately 3% better than the PVB sheet in terms of transmittance. And, we performed an experiment on each module using 16 plates and 25 plates of 6 inch wafer size solar cell. We observed that 16-plate module has about 36.5% increase in improved transmittance and about 38% reduced in efficiency.

Do3 CuZnAl 합금에 있어서의 역형상기억효과

정인상,이인철,박정식,이순린 ( In Sang Chung,In Chul Lee,Jung Sig Park,Soon Lin Lee ) 한국열처리공학회 1990 熱處理工學會誌 Vol.3 No.2

Since the reverse shape memory effect(RSME) was reported in a CuZnAl alloy, further study has been done on the mechanism of this phenomenon and reported that it occurs by the bainitic transformation. But the present authors revealed in the previous work that the RSME in a B2 CuZnAl alloy is not caused by the shear process involved in the bainitic transformation and also that the RSME takes place as the remaining α`₂phase, which is two-step transformed strain induced martensite, is newly transformed into α phase. In order to provide further evidence in supporting the facts, thus, more detailed investigations have been carried out in a DO₃CuZnAl alloy.

흉부 X-Ray 검사실에서 Auto Voice Device의 유용성과 방사선사의 편의성에 관한 고찰

정인아(In-A Jung),이동희(Dong-Hee Lee),이민우(Min-Woo Lee),김순배(Sun-Bae Kim) 대한영상의학기술학회 2012 대한영상의학기술학회 논문지 Vol.2012 No.-

목적: 음성안내가 많은 흉부 X-ray 검사실에서 사용할 Auto voice device를 제작하여 장비의 유용성과 이에 따른 방사선사의 업무 편의성에 대해 알아보고자 하였다. 대상 및 방법: 2012년 01월 09일 부터 02월 24일에 걸쳐 방사선사 87명에게 검사방법과 장비사용법이 담긴 동영상을 보여준 후 연구목적과 취지를 설명하고 협조를 요청하여 설문 지를 배부하여 분석하였다. 방사선사의 일반적 특성은 성별은 남성이 58명(67.7%)으로 9 명(33.3%)인 여성의 약 2배이고, 평균연령은 36(35.89±7.90)세이며, 근무기간은 13(13.41±7.54)년, 검사건수는 300~399건이 41명(28.7%)으로 가장 많은 비중을 차지했 다. 조사결과 분석은 방사선사의 검사에 대한 일반적 견해와 개선사항과 장비의 질에 대한 견해를 파악하기 위해 빈도와 백분율을 산출하고, 검사장비도입의 효과 및 효능의 통계적 처리는 SPSS를 이용하여 일원배치 분산분석(ANOVA)을 하였다. 결과: 설문조사 결과 연령과 근무기간에 따른 Auto voice device의 유용성은 유의확률이 0.05 이상으로 모두 통계적으로 유의하지 않아 상관관계가 적은 것으로 나타났다. 그러나 검사건수에 따른 검사자의 피로도 감소는 유의확률 0.000 (p<0.01)으로 매우 유의한 결과를 얻었고, 검사건수에 따른 업무의 편의성도 유의확률 0.001 (p<0.01)으로 매우 유의하다는 결과가 나왔다. 결론: Auto voice device를 사용함으로써 업무의 편의성 증가와 목의 피로도 감소는 매우 높은 평가를 얻었다. 하지만 장비를 조작하는 시간이 추가됨에 따라서 전체적인 검사시간은 단축되지 않았고, 호흡조절도 장비를 사용하는 것과 육성을 사용하는 것을 비교하였을 때크게 다르지 않았다. 향후 개선사항들을 토대로 장비의 음질 개선과 언어의 다양화, 자막기 능을 추가하여 현재 장비의 업그레이드를 진행 중이며, 더 발전된 Auto voice device로 방사선사의 업무에 보다 더 효율을 줄 것으로 기대한다. Purpose: This study investigated usefulness of the device and its work convenience for radiologic technologist by making auto voice device used at chest X-ray lab where many voice guidance is made. Materials and Methods: The subjects are 87 radiologic technologists and they were asked to see video clip where how to use the device and method of applying to examination was introduced during the period from Jan. 9, 2012 to Feb. 24, 2012. Since then, study purpose was explained to ask for cooperation. For general characteristics of the subjects, the gender is 58 males (67.7%); 29 females (33.3%) - male is double female. Average age is 36 (35.89±7.90). Working period is 13 (13.41±7.54) years. As for number of examination by radiologic technologist, 41 radiologic technologists (28.7%) did 300-399 cases each person. To show general opinion of the subjects about examination, and opinion about improvements and quality of device, percentage was used. Effect and efficiency of using Auto voice device was analyzed using ANOVA through statistical processing by SPSS. Results: For reduction of fatigue in radiologic technologist s throat according to number of examination, p-value 0.000 (p<0.01) - this is very significant result. For work convenience according to number of examination, p-value 0.000 (p<0.01) -this is also very significant result. Conclusion: Using auto voice device brought increase of work convenience and reduction of fatigue in throat. But whole time for examination was not saved because maneuvering device requires additional time. In controlling breathing, there is no much difference between using device and human voice. It is expected that if auto voice device is improved in sound quality, variety in provided language etc. through this study results, this device would be more useful for work of radiologic technologists in the future.

데이타 배열을 사용하는 병렬 프로그램에서 그레인 크기를 이용한 데이타 선인출 기법

정인범(In-Bum Jung),이준원(Joon-Won Lee) 한국정보과학회 2000 정보과학회논문지 : 시스템 및 이론 Vol.27 No.1

데이타 선인출 방법은 데이타 참조와 프로세서 계산의 중첩을 이용하여 주메모리 접근 지연시간을 줄여주는 효과적인 방법이다. 그러나 선인출된 데이타가 캐쉬 메모리에 있는 다른 유용한 데이타들을 대체시키거나 또한 선인출된 데이타가 사용되지 않는 무익한 선인출일 경우 프로그램의 성능은 저하된다. 이러한 현상은 향후 사용되는 데이타들에 대한 정확한 예측이 부족하므로 발생된다. 병렬 프로그램이 계산을 위하여 데이타 배열들을 사용할 때 그레인 크기는 향후 사용되는 데이타 지역의 범위를 나타내므로 데이타 선인출을 위한 유용한 정보이다. 이런 정보를 기반으로 본 논문에서는 병렬 프로그램의 그레인 크기를 이용한 새로운 데이타 선인출 방법을 제안한다. 모의시험에서 제안된 선인출 방법은 기존의 선인출 방법들보다 버스 트랜잭션을 감소시킬 뿐만 아니라 유용한 선인출의 증가로 시험된 병렬 프로그램들의 성능을 향상시킨다. The data prefetching scheme is an effective technique to reduce the main memory access latency by exploiting the overlap of processor computations with data accesses. However, if the prefetched data replicate the useful existing data in the cache memory and they are not being used in computations. performances of programs are aggravated. This phenomenon results from the lack of correct predictions for data being used in the future. When parallel programs exploit the data arrays for computations, the grain size is useful information for data prefetching scheme because it implies the range of data using in computations. Based on this information, we suggest a new data prefetching scheme exploited by the grain size of the parallel program. Simulation results show that the suggested prefetching scheme improves the performance of the simulated parallel programs due to the reduction of bus transactions as well as useful prefetching operations.

자궁근종 환자의 수술 전후 혈중 렙틴의 농도 변화

정인국 ( In Kook Jung ),김기형 ( Ki Hyung Kim ),나용진 ( Yong Jin Na ),이규섭 ( Kyu Sup Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.8

목적: 자궁근종을 가진 여성과 정상 여성에서 혈중 렙틴의 농도를 비교하고, 자궁근종을 가진 여성에서 자궁적출술 전후의 혈중 렙틴 농도의 변화를 분석하여 자궁근종과 혈중 렙틴 농도사이에 어떤 연관이 있는지 알아보고자 하였다. 연구 방법: 자궁근종을 가진 32명의 여성에서 각각 수술 전날과 수술 후 5일째 혈중 렙틴 농도를 측정하고, 정상 여성에서는 본원 건강증진센터를 방문한 날에 혈중 렙틴 농도를 측정하였다. 자궁근종을 가진 여성과 정상 여성의 혈중 렙틴 농도를 비교하고, 자궁근종을 가진 여성에서는 수술 전후 혈중 렙틴 농도의 변화를 비교하였고, 이러한 변화가 자궁근종의 절제와 직접적으로 관련된 것인지 알아보기 위해 적출된 자궁 무게와 렙틴의 변화간에 피어슨 상관 분석을 시행하였다. 결과: 자궁근종을 가진 여성은 정상 여성과 비교하여 혈중 렙틴 농도가 유의하게 낮았다. 자궁근종을 가진 여성에서 수술후 혈중 렙틴의 농도는 수술 전 혈중 렙틴 농도에 비하여 유의하게 감소되었다. 수술 전후 혈중 렙틴의 농도비 (수술 전/수술 후 렙틴)와 적출 자궁 무게간에 피어슨 상관 분석을 시행한 결과 통계적으로 유의한 상관관계를 보이지 않았다. 결론: 자궁근종 환자에서 혈중 렙틴은 정상 여성보다 낮게 측정되었고, 자궁적출술 후에 혈중 렙틴의 농도는 더욱 감소하였다. 수술 후 혈중 렙틴의 농도는 술전과 비교하여 유의하게 감소하였지만, 수술 전후 혈중 렙틴의 농도비와 적출 자궁무게 간에는 직접적인 상관관계가 없는 것으로 나타났다. 이러한 혈중 렙틴의 변화는 자궁근종과 관련한 변화가 아니고 수술 후의 스트레스 및 신경내분비학적인 반응에 의한 것으로 생각된다. 결론적으로 혈중 렙틴의 농도를 자궁근종의 보존적 치료 후의 혈청 표지자로서 임상적으로 활용하기 위해서는 더 많은 연구가 필요할 것으로 사료된다. Objective: To investigate possible relationship between uterine leiomyoma and serum leptin levels, we compared serum leptin levels between women with uterine leiomyoma and women without leiomyoma, and then investigate the effects of hysterectomy on serum leptin levels. Methods: Serum leptin levels were measured before (day-1) and after (day+5) surgery for 32 women with uterine leiomyoma and were measured when they visit our health promotion center for 32 normal women. We compared serum leptin levels between two groups, and then we analyzed perioperative changes of serum leptin levels in women with uterine leiomyoma. Pearson correlation test was performed between pre-/postoperative leptin ratio and resected uterine weight to investigate whether the changes of serum leptin levels are directly related with resection of leiomyoma. Results: In women with uterine leiomyoma, serum leptin levels were lower compared with normal group (7.41±4.31ng/㎖ vs. 17.56±8.65ng/㎖) (P<0.05). Postoperative serum leptin levels were decresed than preoperative serum leptin levels (6.07±2.98ng/㎖ vs. 7.41±4.31ng/㎖) (P<0.05). Pearson correlation coefficient between pre-/postoperative leptin ratio and resected uterine weight showed no statistical significance. Conclusion: Serum leptin levels were lower in women with uterine leiomyoma. And serum leptin levels were more decreased after hysterectomy. There were significant postoperative decrease in serum leptin levels but the result between pre-/postoperative leptin ratio and resected uterine weight revealed no direct correlation. It seems that lower serum leptin levels maybe due to postoperative stress and neuroendocrinological response rather than myoma itself. In conclusion, further investigation is needed for clinical use of serum leptin levels as a serum marker after conservative treatment of uterine leiomyoma.

한국형 노인우울검사(Korean Form of Geriatric Depression Scale;KGDS) 표준화 연구

정인과(In-Kwa Jung),곽동일(Dong-Il Kwak),조숙행(Sook-Haeng Joe),이현수(Hyeon-Soo Lee) 대한노인정신의학회 1997 노인정신의학 Vol.1 No.1

본 연구는 한국형 노인우울검사(KGDS)에 대한 표준화 연구로, 예비 연구에서 제기되었던 문항 내용 및 길이, 표집의 문제를 개선하여 최종적으로 30문항을 확정한 후 신뢰도와 타당도를 검증하였다. 연구대상은 60세 이상의 노인 450명으로, 우울환자 군은 129명(남자 28명, 여자 119명)이었고 대조군은 321명(남자 276명, 여자 194)이었다. KGDS의 신뢰도를 검증한 결과, Cronbach의 계수는 .88, 반분신뢰도는 .79, GDS와의 상관은 .87로서 만족스러운 수준이었고 두 집단의 평균의 차이를 검증해본 결과 α=.001 수준에서 유의하였다(환자군 평균 17.82(10.52), 대조군 평균 10.52(5.12), t=12.07). KGDS의 구성타당도와 내적 구조를 파악하기 위해 실시한 요인분석에서는 정서적 불편감(Emotional discomfort), 비관적 사고 및 불행감(Negative thinking and Unhappiness feeling), 신체적 약화 및 기력쇠퇴(Physical weakening and decreased vitality), 인지기능 저하(Cognitive dysfunction), 사회적 관심과 활동저하(Decreased social interest and activity) 등 총 5개의 구성요인이 밝혀졌고 총 설명변량은 53.72%였다. 마지막으로 KGDS의 판별력과 최적 절단점수를 확인하기 위해 판별분석 및 민감도, 특이도의 지표를 구하여 본 결과 전체판별률은 75%이었고 최적 절단점수는 14점이 제안되었으며 고전적인 백분위점수분포를 추가적으로 고려하여 14∼18점 사이는 경계선수준 및 경도의 우울증, 19∼21점 사이는 중등도의 우울증, 22점 이상은 심도의 우울증으로 분류할수 있을 것으로 기대되었다. 결론적으로, 기존의 노인 우울검사(GDS)의 낮은 진단 변별력을 개선시키고자 새로이 만든 한국형 노인우울검사(KGDS)는 기존 검사에 비해 진단변별력이 10% 가량 향상되었을 뿐 아니라 신뢰도, 타당도도 만족스러운 수준을 보여 노인우울 진단용 검사로 유용하게 쓰일 수 있을 것으로 여겨진다. This study was aimed to standardize the Korean Geriatric Depression Scale (KGDS). In order to slove the unsatisfied discriminating power of Geriatric Depression Scale (GDS:Yesavage et al. 1983) presented in Korean studies, the authors made KGDs. The preliminary KGDS was costructed of 40 items selected from GDS, BDI, SDS, MMPI-D, CES-S and had satisfied reliability and validity, but had some problems in item contents, number of times, and sampling. Thus by correcting these problems, the authors made new KGDS of 30 item, and tested the reliability and validity of the final version of KGDS. The values of Cronbach's α and Split-half reliability were .88 and .79 respectively, and correlational coefficent with GDS was .87. The differences of means was signified at α=.001 level (patients group mean=17.82 (10.52), control group mean=10.52 (5.12), t=12.07). On factor anlaysis, 5 factors in KGDS were extracted. They were labeled Emotional discomfort (factor 1), Negative thinking and Unhappinesss feeling (factor 2), Physical weakening and decreased vitality (factor 3), Cognitive dysfunction (factor 4), Decreased social interest and activity (factor 5), which represent depressive features of the elderly in thought, emotional, cognitive, physical, social aspects. The total percentage of variance of 5 factors was 53.72%. The result of discriminatin anlaysis showed that hit ratio of KGDS was 75%, and the score of 14 was suggested as the optimal cutoff score. Additionally, by use percentile score distribution of control group (normal) subjects, each of the score of 14-18, 19-21, over 22 suggested borderline or mild depression, moderate depression, severe depression, respectively. Conclusively, the final version of KGDS not only improved diagnostic discriminatory power approxtimately 10% than GDS, but also showed satisfiable reliability and validity. So the KGDS could be a useful tool for evaluaion of elderly depression.