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이정윤,Lee, Jeong-Yun 대한안면통증구강내과학회 2013 Journal of Oral Medicine and Pain Vol.38 No.1
측두하악관절 골관절염은 측두하악장애의 한 형태로 관절조직의 생리적 내성을 초과하는 기능적 부하가 지속적으로 관절에 가해졌을 때 관절연골 및 연골하 골조직의 점진적 파괴와 이차적 염증을 특징으로 하는 질환이다. 관절면에 가해지는 물리적 하중은 관절내에서 기질파괴 단백효소나 염증성 cytokine, 유리기의 활성을 증가시키고, 그에 따라 골조직의 퇴행과 재형성 사이의 균형을 깨뜨려 골조직의 흡수를 야기한다. 최근에는 물리적 하중 이 외에 비만세포에서 유래하는 adipokine이 골흡수를 증가시킨다는 보고들이 있으나 측두하악관절에 적용하기에는 아직 추가적인 연구가 필요하므로 현재로서 골관절염의 치료는 관절의 기능적 부하를 줄이고 환자의 생리적 내성을 증가시키는 방향으로 이루어져야 한다. 임상증상은 충분한 기간 정확한 술식대로 시행한 물리치료, 약물치료, 교합안정 장치치료 등의 보존적 처치와 관절강내 주사요법이나 관절세척술 및 관절경 수술과 같은 추가적인 외과적 처치에 의해 성공적으로 조절될 수 있으나, 임상증상의 개선이 골파괴의 중지와 재형성을 담보하는 것은 아니므로 임상증상의 개선 이 후에도 지속적인 골변화의 추적관찰이 필요하다. 또한, 골변화 활성 자체를 직접적으로 조절할 수 있는 활용 가능한 치료법이 없는 한, 지속적인 동기유발과 행동조절을 통해 관절에 가해지는 기능적 부하를 환자 스스로 조절할 수 있도록 끊임없이 교육하는 것이 골변화를 겪는 측두하악관절로 하여금 보다 이른 시기에 보다 유리한 정형적 안정에 도달하게 함으로써 골관절염을 보다 성공적으로 조절할 수 있는 길이라고 할 수 있다. Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a severe form of temporomandibular disorders (TMDs), presenting gradual breakdown of articular cartilage and subchondral bone by the functional load sustained to exceed the physiologic tolerance of the joint. In such a joint loaded, offensive bioactive materials such as matrix degrading proteins, cytokines, and free radicals increase in concentration to shift the tissue response in the joint to degeneration from regeneration or remodeling. Recently, it has been issued that obesity can play an offensive role in pathogenesis of OA in a metabolic way. Adipokines released by adipose cells are present at higher concentration in the arthritic joint and joints of obese individuals. However, because of conflicting data reported, further scientific study should be performed to elucidate the practical role of adipokines in pathogenesis of TMJ OA. As far as the clinical signs and symptoms of TMJ OA are not much different from those of other forms of TMD and any definitive treatment modality to control directly the bone resorptive activity is not available yet, the treatment of TMJ OA should be directed to reduce the physical load and enhance the physiologic tolerance of the joint by means of conservative treatment such as physical therapy, medication, and occlusal splint therapy for sufficient period and, if needed after that, supplementary surgical procedure such as intra-articular injection, arthrocenthesis, and arthroscopic surgery that have turned out to be effective to control OA signs and symtpoms. Enthusiastic reassurance and motivation for patients to control behaviors for themselves to reduce unnecessary functional load in daily life is very important for the joint to reach to more favorable orthopedic stability of the TMJ more quickly, guaranteeing more successful management TMJ OA.
Effects of red ginseng oil(KGC11 o) on testosterone-propionate-induced benign prostatic hyperplasia
이정윤,김소혁,김석호,김종한,배봉석,구기방,Seung Ho So,Jeongmin Lee,Yoo-Hyun Lee 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3
Benign prostatic hyperplasia (BPH) is a disease characterized by abnormal proliferation ofthe prostate, which occurs frequently in middle-aged men. In this study, we report the effect of redginseng oil (KGC11o) on BPH. Methods: The BPH-induced Sprague-Dawley rats were divided into seven groups: control, BPH, KGC11o25, 50, 100, 200, and finasteride groups. KGC11o and finasteride were administered for 8 weeks. The BPHbiomarkers, DHT, 5AR1, and 5AR2, androgen receptor, prostate-specific antigen (PSA), Bax, Bcl-2, andTGF-b were determined in the serum and prostate tissue. The cell viability after KGC11o treatment wasdetermined using BPH-1 cells, and, androgen receptor, Bax, Bcl-2, and TGF-b were confirmed by westernblotting. Results: In the in vivo study, administration of KGC11o reduced prostate weight by 18%, suppressed DHT(up to 22%) and 5AR2 (up to 12%) levels from administration of 100 mg/kg KGC11o (P < 0.05). PSA wassignificantly downregulated dose-dependently from at the concentration of 50 mg/kg KGC11o (P < 0.05). BPH-1 cell viability significantly reduced through the treatment with KGC11o. In vitro and vivo, AR, Bcl-2TGF-b levels reduced significantly but Bax was increased (P < 0.05). Conclusion: These results suggest that KGC11o may inhibit the development of BPH by significantlyreducing the levels of BPH biomarkers via 5ARI, anti-androgenic effect, and anti-proliferation effect,serving as a potential functional food for treating BPH.
이정윤,김성수,김장형,송왕철,Lee Jung-Yun,Kim Sung-Su,Kim Jang-Hyung,Song Wang-Cheol 한국정보통신학회 2006 한국정보통신학회논문지 Vol.10 No.5
High-rate WPAN 은 CAT의 Time Slot 할당 스케줄링 방법을 정의 하고 있지 않다. 이에 CAT의 Time Slot 할당 스케줄링 방법 에 관한 많은 연구가 진행 중이다. 하지만 지금까지의 연구들은 Air Interface의 에러 요소의 미적용이나 특정 DEV의 기아 현상 등의 단점 등을 내포하고 있다. 이에 본 논문에서는 채널의 상태에 따른 우회 경로를 제공하여 채널 타임 할당 스케줄링 방법의 단점을 극복하는 알고리즘을 제안한다. Wireless Personal Area Networks(WAPANs) are designed for short-range ad hoc connectivity among portable devices. They have gained much attention in the industry recently. One of them, High-rate WPAN, is designed to support multimedia traffic that requires high data rates. But, High-rate WPAN standards don't specify the time slot assignment scheduling method of CAT(Channel Time Allocation). So, there has been many studies regarding time slot assignment scheduling of CAT. However, present studies involve demerits about not applying various types of errors in air interlace or having a starvation of a specific DEV(data device). In this paper, we propose algorithms about supplying the intermediate channel assignment in order to avoid these demerits. This method will help other methods that use time slot assignment scheduling of CTA.
고유벡터의 변화량에 의한 비례감쇠구조물의 변경질량 및 그 위치 해석
이정윤,Lee, Jung-Youn 한국생산제조학회 2010 한국생산제조학회지 Vol.26 No.2
In spite of a large amount of previous research, detail study on modified mass in proportional damping system is not well understood. It is common to predict structural dynamic design parameters due to the change of mass, but to predict the amount of modified mass and the location where the mass is being modified are rarely found in previous literature. Such inverse problem required detail analytical study in order to understand structural modification in proportional damping system. This paper predicts the modified mass and the modified mass location in proportional damping system using sensitivity coefficients and iterative method. The sensitivity coefficients are obtained from the change of eigenvectors due to mass modification. This method is applied to a horizontal beam and three degree of freedoms system. To validate the predicted changing mass and its location, the obtained results are compared to the reanalysis result which shows good agreement.
이정윤,김병기,Jae Weon Kim,Jung Bok Lee,Eunhyang Park,Je-Gun Joung,김성훈,Chel Hun Choi,Hee Seung Kim 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4
Objective: Management of heavily pre-treated platinum-resistant ovarian cancer remains a therapeutic challenge. Outcomes are poor with non-platinum, single-agent chemotherapy (CT); however, molecularly targeted anticancer therapies provide new options. Methods: This open-label, investigator-initiated, phase 2 umbrella trial (NCT03699449) enrolled patients with platinum-resistant ovarian cancer (at least 2 prior lines of CTand Eastern Cooperative Oncology Group 0/1) to receive combination therapy based on homologous recombination deficiency (HRD) and programmed death ligand 1 (PD-L1) status determined by archival tumour sample assessment. HRD-positive patients were randomised to either olaparib 200mg bid tablet + cediranib 30mg qd (arm 1) or olaparib 300mg bid tablet + durvalumab 1,500mg q4w (arm 2). HRD-negative patients were allocated to either durvalumab 1,500 mg q4w + pegylated liposomal doxorubicin (PLD) or topotecan or weekly paclitaxel (6 cycles; arm 3, those with PD-L1 expression) or durvalumab 1,500 mg q4w + tremelimumab 75mg q4w (4 doses) + PLD or topotecan or weekly paclitaxel (4 cycles; arm 4, those without PD-L1 expression). Arm 5 (durvalumab 1,500 mg q4w + tremelimumab 300mg [1 dose] + weekly paclitaxel [60 mg/m2 D1,8,15 q4w for 4 cycles] was initiated after arm 4 completed. The primary endpoint was objective response rate (ORR; Response Evaluation Criteria in Solid Tumours 1.1). Results: Between Dec 2018 and Oct 2020, 70 patients (median 57 years; median 3 prior treatment lines [range 2–10]) were treated (n=16, 14, 5, 18, and 17, respectively). Overall ORR was 37.1% (26/70, 95% confidence interval=25.9, 49.5); 2 achieved complete response. ORR was 50%, 42.9%, 20%, 33.3%, and 29.4%, respectively. Grade 3/4 treatment-related adverse events (TRAEs) were reported in 37.5%, 35.7%, 20%, 66.7%, and 35.3% of patients, respectively. No TRAEs leading to treatment discontinuation and no grade 5 TRAEs were observed. Conclusion: This study, the first biomarker-driven umbrella trial in platinum-resistant recurrent ovarian cancer, suggests clinical utility with biomarker-driven targeted therapy. All treatment combinations were manageable, and without unexpected toxicities.
이정윤,Lee, Jeong-Yun 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.4
This study predicts the modified structural eigenvectors and eigenvalues due to the change in the mass and stiffness of a structure by iterative calculation of the sensitivity coefficient using the original dynamic characteristics. The method is applied to examples of a cantilever and 3 degree of freedom lumped mass model by modifing the mass and stillness. The predicted dynamic characteristics are in good agreement with these from the structural reanalysis using the modified mass and stiffness.