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RISS 인기검색어
- 검색키워드
- 저자 : 이여광(Li Guang Li) (검색결과 3 건)
- 무료
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태현진,이여광,박병용,박영재,최은영,이영훈,안동춘,강형섭,박상열,박수현,이존화,양홍현,김인식,Tae, Hyun-Jin,Li, Li-Guang,Park, Byung-Yong,Park, Young-Jae,Choi, Eun-Young,Lee, Young-Hoon,Ahn, Dong-Choon,Kang, Hyung-Sub,Park, Sang-Youel,Park, S 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.4
Changes in the rat testis interstitium from birth to adulthood were studied using Sprague Dawley rats of 1, 7, 14, 21, 28, 40, 60, and 90 days of age to investigate Leydig cell differentiation. In addition, serum testosterone concentrations and luteinizing hormone stimulated (LH; 100 ng/ml) testosterone secretory capacity per testis in vitro were determined via radioimmunoassay. Fetal Leydig cells were present in rat testes from birth to 21 days, and they were only steroidogenic cells in the testis at days 1 and 7. The average volume of a fetal Leydig cell and the absolute volume of fetal Leydig cell per testis were similar at all ages of experimental groups except at day 21 when lower values were observed for both parameters. The number of fetal Leydig cells per testis remained constant from birth through 21 days. Adult Leydig cells were recognized at day 14 and their absolute volume and number per testis increased linearly from 14 to 90 days. The average volume of an adult Leydig cell increased significantly with age and reached maximum size by 60 days of age where the volume was nearly three times bigger than that of at day 14. Total testosterone production per testis in vitro and serum testosterone concentrations were not significantly different at day 1 compared with 7, 14, and 21 days of age. Significant increases were observed at days 40 and 60. Values at days 60 and 90 were not significantly different.
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김인식,태현진,이여광,박영재,강형섭,박상열,박수현,박영석,이영훈,안동춘,최은영,양홍현,Kim, In-Shik,Tae, Hun-Jin,Li, Li-Guang,Park, Young-Jae,Kang, Hyung-Sub,Park, Sang-Youel,Park, Soo-Hyun,Park, Young-Seok,Lee, Young-Hoon,Ahn, Dong-Choon 대한수의학회 2003 大韓獸醫學會誌 Vol.43 No.4
The present study investigated the effects of aging on Leydig cells of Sprague Dawley rats. Rats of 3, 6, 12 and 18 months of age were used. Testes of rat were fixed by whole body perfusion using a fixative containing 2.5% glutaraldehyde in cacodylate buffer, processed and embedded in epon-araldite. Using $1{\mu}m$ sections stained with methylene blue, qualitative and quantitative morphological studies were performed. Testis incubations were used to determine luteinizing hormone (LH; 100 ng/ml) stimulated testosterone secretory capacity per testis in vitro. Testosterone levels in the incubation medium, and testosterone and luteinizing hormone levels in serum of these four groups of rats were determined by radioimmunoassay. Morphological studies revealed that Leydig cells were more abundant in the testis interstitium at 6, 12 and 18 months when compared with 3 months. The volumes of Leydig cells per testis was significantly higher, at 6, 12 and 18 months of age than those at 3 months. The number of Leydig cells per testis was doubled at 6, 12 and 18 months of age compared with 3 months. The average volume of a Leydig cell was not significantly different between 3 and 6 months of age, however, at 12 and 18 months a significantly lower value was observed. LH-stimulated testosterone production per testis in vitro was reduced by 45% at 6 months of age compared with 3 months; a further significant reduction was observed at 12 and 18 months. Serum testosterone and LH levels were not significantly different between 3 and 6 months of age but at 12 and 18 months a significantly lower value was observed in both groups for these hormones. These results showed that signs of aging are apparent in Leydig cells of Sprague Dawley rats at 12 months of age.
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아프리카산 발톱개구리 이자의 초기발생과정에서 Sox9 억제가 Pdx1 발현에 미치는 영향
박병용(Byung Yong Park),이여광(Li Guang Li),최은혜(Eun-Hye Choi),정몽룡(Mong-Yong Jung),권기탁(Ki-Tak Kwon),정연호(Yeon-Ho Jeong),김종연(Jong-Youn Kim),김인식(In-Shik Kim),박병건(Byung Keon Park),이영훈(Young-Hoon Lee) 대한해부학회 2007 Anatomy & Cell Biology Vol.40 No.1
이자는 외분비샘과 내분비샘으로 구성되어 있고 신체의 항상성을 조절하는 기관이다. 발생과정 중에 이자는 앞창자 (foregut)의 등쪽과 배쪽에서 융기하여 형성되고 성장하여 하나의 기관으로 유합된다. 발생하는 이자에서 발현되는 초기 유전자의 역할을 확인하는 것은 기관의 형성과 분화를 이해하는데 매우 중요하다. 이자발생에 관여하는 유전자 중에서 Pdx1은 초기에 발현되고 이자발생에 중요하게 관여하는 것으로 알려져 있다. Sox 단백질은 다양한 발생과정을 조절하는 전사인자이고 그중 하나인 Sox9는 발생중인 이자에서 발현되지만 아직까지 그 역할은 잘 알려져 있지 않다. 본 연구에서는 Sox9의 hormone inducible inhibitory mutant를 이용하여 Sox9의 작용을 차단한 결과, 발생하는 아프리카산 발톱개구리의 이자싹(pancreatic bud)에서 Pdx1의 발현이 감소되는 것을 확인하였다. 이상의 결과로 Sox9는 아프리카산 발톱개구리 이자의 발생에 관여할 것으로 생각된다. The pancreas is a mixed exocrine and endocrine gland involved in the control of many homeostatic functions. During embryogenesis, the pancreas arises from dorsal and ventral evaginations of the foregut, which ubsequently fuse into a single organ. The characterization of early genes expressed in the developing pancreas is critical to understand its specification and differentiation. Pdx1 is one of the earliest markers of pancreatic development and a key molecule in its development. Sox proteins form a large class of transcriptional regulators implicated in the control of a variety of developmental processes. One member of this family, Sox9, is expressed in the developing pancreas, but little is known about the function of Sox9 in the developing pancreas. We further investigated Sox9 function during pancreatic development in Xenopus. Using a hormone-inducible inhibitory mutant of Sox9, we found that Pdx1 expression was reduced in the ventral pancreatic buds in Sox9-depleted embryos. We suggest that Sox9 gene expression may be involved in pancreatic development in Xenopus.
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