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이미경(Mi Kyoung Lee),이서호(Seo Ho Lee),최근표(Geun Pyo Choi),유창연(Chang Yeon Yu),이신영,이진하(Jin Ha Lee),이현용(Hyeon Yong Lee) 한국약용작물학회 2003 한국약용작물학회지 Vol.11 No.1
The biological activities of extracts from Rosa rugosae Radix were compared. About 78% of the growth of human hepato-carcinoma and 68% of human gastric cancer cell was inhibited in adding 0.5% ㎎/ml of the extracts of Rosa rugosae Radix respectively. The growth of human breast cancer cells was also inhibited in adding 0.5㎎/ml of the extracts as well as 66% of the human cancer cells. It was proved that the growth of human normal lung cell, scored as 20% for the extracts. Overall selectivity of the extracts on several human cancer cell line was over 4, which in higher than those from the Rosa rugosae Radix. The growth of both human immune B and T cells was enhanced up to 1.2 to 1.5 times by adding the extracts, compared to the controls. The secretion of tumor necrosis factor-alpha(TNF-α) from T cell was also increased up to 61.9pg/ml in adding the ethanol extract (0.5㎎/ml). Ethanol extract also increased up to about 61.3pg/ml of interleukin-6(IL-6) from B cell.