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위장관 ( 胃腸管 ) : 원발성 위악성 임파종의 임상적 관찰
이상종(Sang Jong Lee),박영철(Young Chul Park),이승세(Seung Sei Lee),정을순(Eul Soon Jung),권순호(Soon Ho Kwon),이화영(Hwa Young Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A Primary gastric lymphoma represents 1 to 6% of all gastric cancer and anatomically is the most common type of extranodal lymphoma. We present the clinicopathologic findings in 9 patients with primary gastric lymphoma between Jaunary 1984 and March 1990 in the this hospital. 1) The mean age of patients was 46.0 years with a male to female ratio 3.5:l. 2) The most common initial symptom was epigastric pain among these patients. 3) Fiberoptic gastroscopy was performed in 9 patients, who revealed ulceroinfiltrative lesion in 4 cases, ulcerative lesion in 3 cases, infiltrative lesion in 2 cases, respectively. Pathologic findings of biopsy specimens elicited gastric lymphoma in 8 cases and adenocarcinom in 1 case respectively. 4) All were non-Hodgkins lymphoma, and histologic classification by the Rappaport system was possible in all cases including 4 cases of diffuse histiocytic type, 3 cases of diffuse mixed histiocytic and lymphocytic, 2 cases of diffuse lymphocytic poorly differeatiated type respectively. 5) According to modified TMN staging system, 3 cases were stage I, 2 cases stage II, 2 cases stage III and 2 cases unknown in our series. 6) Surgical resection was done on 7 patients, of whom 5 patients received chemotherapy and 2 patients both combined chemotherapy and radiotheyapy. The 2-years survival rate of our seriea was 55.6%.
원발성 간암과 췌장암에 있어서의 αFP , TATI 및 CA 19 - 9 의 임상적 의의
이상종(Sang Jong Lee),이만호(Man Ho Lee),이승세(Seung Sei Lee),서영주(Young Joo Suh),채종찬(Jong Chan Chae),정을순(Eul Soon Jung) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A The aim of this study was to evaluate the usefulness of measuring more than two tumor markers including TATI in the diagnosis of pancreatic cancer and hepatoma. Pancreatic cancer patients (10); The range of serum CA 19-9 concentration was 55.01-231 U/ml. All of 10 (100%) had increased value (>33U/ml). Nine of 10 patients (90%) had CA 19-9 values above the cancer diagnostic cut off level (>100U/ml). Serum TATI concentration were raised (range 26.47-450 pg/,L ) in 80% (8/10) of the patients. Serum TATI concentration was above cut off level (40pg/I ) in 5 patients (50%). One patient, who had non diagnostic CA19-9 level (42.9 U/ml), had 413.47 pg/Lof serum TATI concentration. Thus when the two tumor markers (CA19-9, TATI) were used together, all of 10 pancreatic cancer patients (100%) had diagnostic cut off level. Primary hepatoma patients (22); Serum aFP value were raised in 86.36% (19/22) of the patients (range 14.26-2014 pg/ml). Six patients had value of non diagnostic range (14.26-237 pg/ml), so that 59. 09% (13/22) of the patients had a diagnostic aFP value (>400pg/ml). Serum TATI values were raised in 77.2% (17/22) of the patients. 59% (13/22) of the patients had serum TATI value above the cut off level. Of the 6 patients who had non diagnostic a FP level, three patients had serum TATI value above cut off level. When serum n FP and TATI were measured together, 81.8% (18/22) of the patients had at least one of the value above cut off level. So if the two tumor markers were used together (CA19-9 and TATI in pancreatic cancer, aFP and TATI in primary hepatoma) it might be helpful in some patients in the diagnosis of malignancy. But accounting economical and other factors, we think it needs further evaluation.
상부 위장관 질환에 있어 Campylobacter Pyloridis 에 대한 연구
이상종(Sang Jong Lee),이만호(Man Ho Lee),박영철(Young Chul Park),강진호(Jin Ho Kang),정을순(Eul Soon Jung),홍미재(Mi Jae Hong),김유경(You Kyoung Kim) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1
N/A Since the first description of an unidentified curved bicillus that was called campylobacter pyloridis and isolated from gastric mucosa by Warren and Marshall in 1983 the campylobacter pyloridis has been implicated as a bacteriologic agent for the etiology of gastritis and peptic ulcer. 171 patients with upper gastrointestinal symptoms referred to endoscopic study in our clinic between December 1987 and December 1988, 19 asymtomatic individuals were considered for study. By culture of Warthin-Starry silver stain and gram stain or both, we found that overall 73% (124/171) of patients were positive for compylobacter pyloridis. In other endoscopic groups, the following positive incidence were found: severe superficial gastritis, 76% (67/88): chronic superficial gastritis, 67 %(33/49); gastric ulcer, 81%(9/11): duodenal ulcer, 83%(5j6): gastric cancer 59%(10/17). In various histologic groups, we found the organism in 75%(81/108) of patients among severe superficial gastritis and 59%(10/17) of patients among gastric adenocarcinoma. But in the control group of 19 asymptomatic individuals, the organisms were found from only 5 cases (26%). In its antimicrobial sensitivity test, cephalosporin, chloramphenicol, erythromycin, carbenicillin, kanamycin and tetracycline have the sensitivity of 100%. Amikin, ampicillin and tobramycin were sensitive in 71% to 80% and gentamycin was sensitive in 50%, but colistin was resistant. 12 campylobacter pyloridis positive patients were treated by various therapeutic regimens for 4 weeks (ranitidines, sucralfate: colloidal bismuth substrate: antibiotics). Among the patients, the patients, the histologic improvement was in the group treated with colloidal bismuth substrate. These results support the hypothesis that campylobacter pyloridis might be etiologically related to gastritis and peptic ulcer.