한우 집단 폐사를 유발한 엔도설판 중독 사례

이보람,이현경,이경현,윤순식,김미경,박중원,정선향,이명헌,배유찬,Lee, Bo-Ram,Lee, Hyun-Kyoung,Lee, Kyung-Hyun,Yoon, Soon-Seek,Kim, Meekyung,Park, Jung-Won,Jeong, Seon-Hyang,Lee, Myoung-Heon,Bae, You-Chan 대한수의학회 2013 大韓獸醫學會誌 Vol.53 No.4

Here, we report the poisoning case of 10 cows. Several distinct clinical signs such as convulsion, excessive salivation, circling, lateral recumbency, and death were observed. Necropsy and histopathological examination did not reveal any significant abnormal findings. Moreover, no bacteria or viruses were detected in tissue, blood, and feeding food. However, endosulfan was detected from the stomach contents and microbials. Our results strongly suggest that death of cows may be closely associated with endosulfan poisoning.

가스 하이드레이트 형성 원리를 이용한 SF₆ 처리 기술에 관한 연구

이보람,이현주,김신호,이주동,김양도,Lee, Bo-Ram,Lee, Hyun-Ju,Kim, Shin-Ho,Lee, Ju-Dong,Kim, Yang-Do 한국재료학회 2008 한국재료학회지 Vol.18 No.2

[ $SF_6$ ] gas has been widely used as an insulating, cleaning and covering gas due to its outstanding insulating feature and because of its inert properties. However, the global warming potential of $SF_6$ gas is extremely high relative to typical global warming gases such as $CO_2$, CFCs, and $CH_4$. For these reasons, it is necessary to separate and collect waste $SF_6$ gas. In this study, the effects of a surfactant (Tween) on the formation rate of $SF_6$ gas hydrates were investigated. The $SF_6$ gas hydrate formation rate increased with the addition of Tween and showed a nearly 6.5 times faster hydrate formation rate with an addition of 0.2 wt.% Tween compared to an addition of pure water. This is believed to be due to the increased solubility of $SF_6$ gas with the addition of the surfactant. It was also found that $SF_6$ gas hydrate in the surfactant solution showed two-stage hydrate formation rates with a formation rate that increased rapidly in the 2nd stage.

열성 경련에 대한 중의학 임상 연구 동향 - RCT를 중심으로 -

이보람,이은주,이지홍,장규태,Lee, Bo Ram,Lee, Eun Ju,Lee, Ji Hong,Chang, Gyu Tae 대한한방소아과학회 2016 대한한방소아과학회지 Vol.30 No.3

Objectives The purpose of this study is to provide clinical evidence of Korean medicine for febrile seizure by review of randomized controlled trials on the effect of TCM (traditional Chinese medicine) for febrile seizure. Methods We searched randomized controlled trials about TCM treatment of febrile seizure from the China National Knowledge Infrastructure (CNKI) (January 2008 to June 2016). The selected literatures were assessed by Jadad scale. Results 40 papers were selected from 160 studies. Analyses of selected studies indicated that the TCM treatment group has significantly higher cure rate for febrile seizure than first aid or western medicine group. The most commonly used herbs were Gardeniae Fructus (梔子), Uncariae Ramulus cum Uncis (鉤藤), Cornus Gazeliae (羚羊角), Margarita (珍珠), Scutellariae Radix (黃芩), Glycyrrhizae Radix (甘草). The most commonly used acupoints were GV26 (人中), LI4 (合谷), KI1 (湧泉), GV20 (百會). There were no serious adverse events reported from the TCM treatment group during the treatment period. Conclusions TCM has been shown as not only effective but also safe treatment on febrile seizure. This finding can be widely utilized in clinical practice and can form the basis for development of clinical practice guidelines in future.

기상학적 가뭄지수와 수문학적 가뭄지수의 비교

이보람,성장현,정은성,Lee, Bo-Ram,Sung, Jang Hyun,Chung, Eun-Sung 한국수자원학회 2015 한국수자원학회논문집 Vol.48 No.1

본 연구는 기상학적 가뭄지수가 수문학적 가뭄에 대한 모사정도를 검토하였다. 기상학적 가뭄지수 중에서 강수량을 변수로 하는 SPI(Standardized Precipitation Index)와 강수량 및 증발산량을 변수로 하는 SPEI(Standardized Precipitation Evapotranspiration Index)를 이용하였고, 수문학적 가뭄 평가를 위하여 월 총 유입량과 하천수 가뭄지수인 SDI(Streamflow Drought Index)를 계산하여, 최종적으로 기상학적 가뭄지수와 수문학적 가뭄지수와의 상관정도를 분석하였다. 월별 상관계수 비교결과, 지속기간 270일에 기상학적 가뭄지수와 월 총 유입량과 상관정도가 가장 높아서 0.67로 나타났고 기상학적 가뭄지수로 SDI와의 상관정도는 0.72~0.87이었다. 연별 극한값을 비교한 결과, 월 총 유입량의 최저값과 기상학적 가뭄지수의 연관성은 거의 확인되지 않았다. 다만 SDI와 SPEI가 매우 높은 상관정도를 보였다. 기상학적 가뭄지수로 수문학적 극한가뭄에 해석하는 데에 한계가 있는 만큼 수문 가뭄해석이 목적이라면 유량자료가 직접 활용될 수 있는 가뭄지수가 필요하다. In this study, meteorological drought indices were examined to simulate hydrological drought. SPI (Standardized Precipitation Index) and SPEI (Standardized Precipitation Evapotranspiration Index) was applied to represent meteorological drought. Further, in order to evaluate the hydrological drought, monthly total inflow and SDI (Streamflow Drought Index) was computed. Finally, the correlation between meteorological and hydrological drought indices were analyzed. As a results, in monthly correlation comparison, the correlation between meteorological drought index and monthly total inflow was highest with 0.67 in duration of 270-day. In addition, a meteorological drought index were correlated 0.72 to 0.87 with SDI. In compared to the annual extremes, the relationship between meteorological drought index and minimum monthly inflow was hardly confirmed. But SDI and SPEI showed a slightly higher correlation. There are limitation that analyze extreme hydrological drought using meteorological drought index. For the evaluation of the hydrological drought, drought index which included inflow directly is required.

건강보험 청구자료를 이용한 전립선염 환자의 의료 이용 및 항생제 처방 현황

이보람,최윤정,최연송,공나영,최민선,Lee, Boram,Choi, Yoon Jung,Choi, Younsong,Kong, Nayoung,Choi, Minsun 한국임상약학회 2018 한국임상약학회지 Vol.28 No.2

Background: Prostatitis, one of the most common diseases of the prostate, is a complex disease with various clinical features. This study aims to analyze the utilization and prescribing patterns of antibiotics in Korean patients with prostatitis between 2008 and 2015. Methods: We used the National Health Insurance Database complied from the Health Insurance Review and Assessment Service (HIRA). The outcomes included the number of claims, number of patients, medical cost, and length of stay for each year. In addition, the prescribing patterns of antibiotics, including fluoroquinolone, and low-dose use of ciprofloxacin and levofloxacin were investigated. Results: The total number of patients and medical cost increased by 9.5% and 51.7% from 2008 to 2015, respectively. Most prostatitis patients were classified as chronic prostatitis patients. The prescribing proportion of antibiotics for chronic prostatitis outpatients decreased from 71.0% to 66.9% from 2008 to 2015, and fluoroquinolone accounted for more than half of the total antibiotics. Over 80% of prescription of levofloxacin and ciprofloxacin was identified to be for low-dose use. Conclusion: Most of the patients with prostatitis experienced pain relief and condition improvement after antibiotic treatment; however, chronic prostatitis and chronic pelvic pain syndrome recur easily. Therefore, active disease management and further studies are needed to enhance our understanding of effective treatment for prostatitis.

소아에서 사봉혈(四縫穴) 활용에 대한 문헌 조사

이보람,신혜진,이지홍,장규태,Lee, Boram,Shin, Hye Jin,Lee, Jihong,Chang, Gyu Tae 대한한방소아과학회 2018 대한한방소아과학회지 Vol.32 No.3

Objectives The objective of this study is to investigate the application of Sifeng point (EX-UE 10) in children and to make suggestions for domestic research and clinical application by reviewing relevant randomized controlled trials. Methods Eight electronic databases including English, Chinese, Korean databases were comprehensively searched for randomized controlled trials evaluating the effects of Sifeng point in children up to May 2, 2018. We extracted the year of publication, country, target diseases or symptoms, location of Sifeng, acupuncture method; such as acupuncture tool and depth of insertion, and frequency, number, and duration of the treatment. Results Fifty studies were included for analysis. All the included studies were conducted in China, and studies were published from 1962 to 2017. The most frequent target symptom was anorexia (46%). In addition, Sifeng point was used for digestive diseases or symptoms such as diarrhea, constipation, and mesenteric lymphadenitis, as well as respiratory diseases or symptoms such as cough, cold, acute bronchiolitis, recurrent respiratory tract infections, bronchopneumonia, and asthmatic bronchitis. Also, allergic diseases such as chronic urticaria, and other variety of symptoms such as malnutrition, fever, and iron-deficiency anemia were treated with the Sifeng point. The location of Sifeng points was inconsistent, and the most common location of the Sifeng point was the midpoint of transverse creases of the proximal interphalangeal joints of the index, middle, ring and little fingers (84.2%). The most commonly used acupuncture tool was three-edged needle (40.9%). All included studies have the method of squeezing out blood or mucus from the Sifeng points. The treatment was mostly conducted once per week (35.4%), mostly repeated for 4 times (32.6%). The most common treatment duration was 4 weeks (18.6%). Conclusions We could identify acupuncture method and various indications for the Sifeng points treatment. Based on this study, there is a need for the clinical application and related researches on the Sifeng points in children in Korea. In addition, the treatment location of Sifeng point should be standardized.

의인성 쿠싱증후군에 대한 한방 증례 보고

이보람,강유경,정해룡,김경민,조성우,김원일,Lee, Bo Ram,Kang, You Gyung,Jeong, Hae Ryong,Kim, Kyung Min,Cho, Sung Woo,Kim, Won-Ill 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.1

Objectives : The purpose of this study is to report the improvement of a patient diagnosed as iatrogenic Cushing syndrome treated with herbal medicine. Methods : We treated a patient diagnosed as iatrogenic Cushing syndrome with s Wiryeong-tang gagam and Sinbeopbanha-tang for 10days. While being treated with herbal medicine, the patient got acupuncture treatment two times a day. Results : After treatment, weakness of lower limb and tremor got improved. Vomiting and disgusting also got better. Conclusion : Using herbal medicine may improve various symptoms of iatrogenic Cushing syndrome effectively.

특발성 저신장의 경제성 평가 연구 경향 분석: 체계적 문헌고찰

이보람,권찬영,장수빈,Lee, Boram,Kwon, Chan-Young,Jang, Soobin 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.2

Objectives We aimed to examine health-related economic analysis of available interventions on idiopathic short stature (ISS). Methods Eight studies were reviewed from English, Korean, and Chinese databases which were published up to December 24, 2020. Effectiveness, utility, and cost data were extracted from the studies and descriptive analysis of the individual studies was conducted Results Five studies were chosen. In the two economic evaluation studies, the incremental cost-effectiveness ratio (ICER) of growth hormone (GH) treatment was presented by performing cost-effectiveness analysis based on the deterministic decision tree approach for the GH and untreated group. Final adult height and direct medical costs were analyzed as effectiveness and cost outcomes. In 1 review article, an ICER of GH was presented based on systematic review on the effects of the GH treatment. In the two clinical trials, the effectiveness and cost of the 12 months Oriental medicine combination treatment were presented in comparison with the GH treatment alone. There were no literatures that provided utility data of available intervention on ISS. Conclusions The results of this study will be used as basic data for the economic analysis of Oriental medicine treatment on ISS in the future.

Predicted Mean Vote(PMV)를 이용한 겨울철 종합병원의 실내 온·열 환경의 평가

이보람,김정훈,김규상,김혜진,이기영,Lee, Boram,Kim, Jeonghoon,Kim, KyooSang,Kim, Hyejin,Lee, Kiyoung 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.6

Objectives: A hospital is a complex building that serves many different purposes. It has a major impact on patient's well-being as well as on the work efficiency of the hospital staff. Thermal comfort is one of the major factors in indoor comfort. The purpose of this study was to determine thermal comfort in various locations in a hospital. Methods: Various indoor environmental conditions in a general hospital were measured in February 2014. The predicted mean vote (PMV) and carbon dioxide ($CO_2$) concentration were measured simultaneously in the lobby, office, restaurant, and ward. Results: The ward was the most thermally comfortable location (PMV=0.44) and the lobby was the most uncomfortable (PMV = -1.39). However, the $CO_2$ concentration was the highest in the ward (896 ppm) and the lowest in the lobby (572 ppm). The average PMV value was the most comfortable in the ward and the lowest in the lobby. In contrast, for concentration of carbon dioxide, the highest average was in the ward and the lowest in the lobby. Due to air conditioner operation, during operating hours the PMV showed values close to 0 compared to the non-operating time. Correlation between PMV and $CO_2$ differed by location. Conclusion: The PMV and concentration of carbon dioxide of the hospital lobby, office, restaurant and ward varied. The relationship between PMV and carbon dioxide differed by location. Consideration of how to apply PMV and carbon dioxide is needed when evaluating indoor comfort.

약인성 간손상 환자에게 협진을 위한 한약의 추가 처방이 간수치에 미치는 영향에 대한 증례보고

이보람,김원일,Lee, Bo-Ram,Kim, Won-Il 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.1

Objective : The purpose of this study is to report that patient diagnosed as drug-induced liver injury treated with herbal and western medicine improve liver function test. Methods : We treated the patient diagnosed as drug-induced liver injury caused by antibiotics with Hepatotonics and Cheonggan-tang Gagam(淸肝湯加減). Then, We followed up the result of liver function test. After the result of liver function test improved, we diagnosed the patient with Korean medical methods, and evaluated the symptom of Cerebral infarction and liver function test treating the patient with Jihwangumja (地黃飮子). Result : After our treatment, Liver function test and symptoms of Cerebral infarction result improved. Conclusion : Use of Western medicine with herbal medicine can improved liver function test of drug-induced liver injury effectively and herbal medicine do not disturb the liver function.