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이병완,김진화,고승현,이병완,김난희,이상열,김현진,문민경,박석오,최경묵 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.5
The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel and traditional insulin analogues has also been accumulated. Following global trends, many results of clinical trials, especially concerning the clinical efficacy and safety of insulin therapy, have been published about Korean patients with T2DM. After a systematic search of recent evidence, the KDA updated and modified its clinical practice recommendations regarding the initiation, choice, and intensification of insulin and created an insulin treatment algorithm for the first time to guide physicians caring for adult Korean patients with T2DM.
이병완,이용호,박철영,이은정,이원영,김난희,최경묵,박근규,최연경,차봉수,이대호,The Korean Diabetes Association (KDA) Fatty Liver Research Group 대한당뇨병학회 2020 Diabetes and Metabolism Journal Vol.44 No.3
This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic complications compared to those without NAFLD. With regards to the evaluation of patients with T2DM and NAFLD, ultrasonography-based stepwise approaches using noninvasive biomarker models such as fibrosis-4 or the NAFLD fibrosis score as well as imaging studies such as vibration-controlled transient elastography with controlled attenuation parameter or magnetic resonance imagingproton density fat fraction are recommended. After the diagnosis of NAFLD, the stage of fibrosis needs to be assessed appropriately. For management, weight reduction achieved by lifestyle modification has proven beneficial and is recommended in combination with antidiabetic agent(s). Evidence that some antidiabetic agents improve NAFLD/NASH with fibrosis in patients with T2DM is emerging. However, there are currently no definite pharmacologic treatments for NAFLD in patients with T2DM. For specific cases, bariatric surgery may be an option if indicated.
이병완,고재현,임준호,고영호,김광주 한국정보디스플레이학회 2014 Journal of information display Vol.15 No.4
The polyethylene terephthalate (PET) substrate is one of the key materials comprising optical films, which are essential componentsin various optical devices, such as displays. The elastic properties of oriented PET were investigated via Brillouinlight scattering spectroscopy. The high-frequency longitudinal and transverse sound velocities in the hypersonic region weredetermined using a special right-angle scattering geometry, where the information of the refractive index was not included inthe calculation. When the propagation direction of the acoustic modes was changed in the plane with respect to the stretchingdirections, the longitudinal and transverse sound velocities exhibited periodic modulations, clearly revealing the acousticanisotropy of the film arising from the stretching condition.
이병완,고재현,박재훈,신동명,황윤회 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.7
The temperature dependences of the acoustic properties and the dielectric relaxation times of polydimethylsiloxane were investigated by using high-resolution Brillouin and broadband dielectric spectroscopies. The longitudinal sound velocity showed a large increase upon approaching the glass transition temperature while the acoustic absorption coefficient exhibited a maximum at 263 K. Comparison of these results with previous ultrasonic data revealed a substantial frequency dispersion of the acoustic properties of this silicone-based elastomer. The relaxation times derived from the acoustic absorption peaks were consistent with the temperature dependence of the dielectric relaxation time of the structural process, indicating a strong coupling between the acoustic waves and the segmental motions of the main chains.
이병완,강보현,강한욱,김형훈,김현진,노정현,지재환,하창영,정재훈,민용기,이명식,이문규,김광원 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.3
당뇨병은 관상동맥질환의 중요 위험인자이다. 당뇨병의 유병률의 증가와 더불어 관상동맥질환 환자에서의 당뇨병 환자 비율은 점차 증가추세에 있다. 본 연구에서 관상동맥질환의 위험인자는 당뇨병, 나이, 비만, 고혈압, 흡연 그리고 관상동맥질환의 가족력이었다. 관상동맥질환 환자에 서 당뇨병군과 정상 혈당군간에는 나이, 고혈압, 흡연, 관상동맥질환의 가족력, 고밀도지단백 콜레스테롤, 중성지방, fibrinogen, t-PA, PAI-1이 통계적 유의한 차이가 있었다. 심근경색 환자를 대상으로 시행한 연구에서 당뇨병군과 정상 혈당군간에는 흡연, 지질강하제 복용, homocysteine,t-PA, PAI-I 그리고 CRP가 유의한 차이를 보였다. 혈당조절을 잘된 환자군과 잘되지 못한 환자군의 비교에서는 요산과 고밀도지단백 콜레스테롤만이 유의한 차이를 보였다. 당뇨병 환자에서의 지질 수치 중 고밀도지단백 콜레스테롤이 관상동맥질환의 주요 예측인자이며 위험인자라고 생각된다. 당뇨병 환자에서는 특히 금연과 혈압 그리고 혈당수치를 철저히 조절해야 한다. 당뇨병이 발생한 이후 혈당조절을 잘하는 것이 관상동맥질환의 발생과 사망률을 감소시킬 수 있을 지, 그리고 당뇨병 환자에서 혈당조절 이외의 어느 인자를 교정하는 것이 관상동맥질환을 예방하는데 도움이 될지 앞으로 전향적 연구가 필요하리라 사료된다. Background: Diabetes is a very important risk factor of coronary artery disease. The prevalence of diabetes in Korea is increasing steadily. The objective of this study was to establish the prevalence and cardiovascular risk factors of diabetes in coronary artery disease in Korean type 2 diabetes. Methods: Of the patients enrolled in SMC-coronary artery angiography protocol, we investigated 1143 subjects (from Jan. 1st to Dec.31th, 2001) with suspicious coronary artery disease reflected from symptoms of chest pain, EKG and enzyme abnormalities, and thallium scan. Sociodemographic characteristics and laboratory data were investigated using retrospective analysis. Results: The prevalence of diabetes in coronary artery disease patients was 37.49 %. The risk factors of coronary artery disease were diabetes, old age, obesity, hypertension, smoking and family history of coronary artery disease in our study. Among patients with coronary artery disease, there were significant differences in age, hypertension, smoking, family history of coronary artery disease, and levels of HDL-C, triglyceride, fibrinogen, t-PA, PAI-1 between diabetic patients and normo-glycemic patients. In the comparison of patients with myocardial infarction, there were significant difference in smoking, prescription of lipid-lowering drugs, homocysteine, tPA, PAI-I, and CRP between diabetic patients and normo-glycemic patients. Only the levels of uric acid and HDL-C showed meaningful difference between diabetic patients with well-controlled blood sugar and poorly-controlled blood sugar. Conclusion: With the increase in the prevalence of diabetes, the proportion of diabetic patients in coronary artery disease has also increased. Among patients with coronary artery disease, the risk factors of coronary artery disease were age, hypertension, smoking, family history of coronary artery disease, and levels of HDL-C, triglyceride, fibrinogen, t-PA, PAI-1 in diabetic patients compared to normo-glycemic patients. Diabetic patients must stop smoking and maintain strict control of blood pressure and blood glucose level. In addition, HDL-C was very important predictive risk factor for coronary artery disease.