Cotrel-Dubousset 척추경 나사 고정술을 이용한 불안정 흉요추 골절의 치료 : Harrington SSI 와의 비교 관찰 Comparison with Harrington SSI

이명철,석세일,신병준,이춘성 대한골절학회 1989 대한골절학회지 Vol.2 No.1

Twenty four patients with unstable dorsolumbar spine fractures were treated with C-D pedicular screw from March 1987 to Dec. 1988 in Seoul National university Hospital and 19 patients were followed-up more than 4 months, average 7.9 months, The results of these 1 9 patients were compared with those treated with Harrington SSI from Feb. 1985 to March 1987 and following conclusions are obtained. 1. The average fixation with C-D pedicular screw was 2 segments, Even the short segments fixation, C-D pedicular screw gave better correction and stability of fractures as compared with Harrington SSI. 2. Anatomical reduction with restoration of normal spinal sagital curvature was possible using C-D pedicular screw. 3. C-D pedicular screw permitted early ambulation with minumum immobilization and slight loss of correction

Sedation for Pediatric Endoscopy

이명철 대한소아소화기영양학회 2014 Pediatric gastroenterology, hepatology & nutrition Vol.17 No.1

It is more difficult to achieve cooperation when conducting endoscopy in pediatric patients than adults. As a result, the sedation for a comfortable procedure is more important in pediatric patients. The sedation, however, often in-volves risks and side effects, and their prediction and prevention should be sought in advance. Physicians should familiarize themselves to the relevant guidelines in order to make appropriate decisions and actions regarding the preparation of the sedation, patient monitoring during endoscopy, patient recovery, and hospital discharge. Furthermore, they have to understand the characteristics of the pediatric patients and different types of endoscopy. The purpose of this article is to discuss the details of sedation in pediatric endoscopy.

Comparison of Gene Coding Region Content in In vivo and In vitro Methyl- Filtration Libraries of Maize (Zea may)

이명철,Rod A Wing,백형진,주석철,은무영 한국국제농업개발학회 2007 韓國國際農業開發學會誌 Vol.19 No.3

A large fraction of maize genome consists of LTR retrotransposons that are heavily methylated and estimated over 60% of genome. In contrast, functional genes exist in hypomethylated CpG islands and intermixed with large stretches of retrotransposon and repetitive DNA. It has been hypothesized that efficient exclusion of methylated retrotransposons and repeated DNA region is one of the rapid and cost-effective approaches for comprehensive gene discovery in large genome size of maize. Three kinds of methylation-sensitive restriction enzymes, HapII, MspI and McrBC, were used to identify the restriction frequency of cytosine methylation sites in maize genome. Roughly 60% of total maize genomic DNA restricted less than 500bp by McrBC restriction enzyme, and the most of restricted small size fraction was composed retrotransposon. In order to validate the efficient construction of gene-rich shotgun library, we compare two methylation filtering methods gene-rich methyl-filtration shotgun libraries of maize were maid and characterized in vivo and in vitro methyl-filtration system. The size selected DNA fraction by Sau3A-McrBC enzyme treated was very stable and has not appeared modification in E.coli, but most insert DNA size of partially digested with Sau3A were decrease less than 500bp by bacterial methylation-modification system. In compare of retroelements portion, Approximately 44.6% of the sequences were retroelement in unmethyl-filtered library, and the most of them was Copia type, such as Prem, Opie and Ji. The portion of retroelement was drastically decrease about 25% and 20% by in vivo and in vitro filtration system, respectively.

관절경을 이용한 족관절의 골연골병변의 치료

이명철,성상철,강승백 대한슬관절학회 1993 대한슬관절학회지 Vol.5 No.1

Over the past few years the arthroscope has played a major role in the evaluation and treatment of the chondral and osteochondral lesions of ankle joint. But its technique is very difficult and require considerable expertise with instrument. We reviewed 10 ankles in 10 patients who underwent arthroscopic treatment of the osteochondral lesion of ankle at Seoul National University Hospital from 1986 to 1991. The mean age at the time of surgery was 30 years (reange,16 to 49 years). There were eight males and two females, All patients had history of trauma and conservative treatment under the diagnosis of ankle sprain. The mean follow-up was 2 years and 9 months (range, 1 year and 2 months to 6 years and 7 months). Preoperative diagnosis were osteochondritis dissecans in 7 ankles, loose osteochondral body in one and degenerative arthritis in two through CT or MRI. Arthroscopic diagnosis were osteochondritis dissecans with crater and loose body in 6 ankles, loose osteochondral body with no osteochondral defect in one and posttraumatic degenerative arthritis in three. Six ankles with crater and loose body were treated with arthrosopic abrasion and loose body removal. One aknle with loose osteochondral body was treated with loose body removal and 3 ankles with degenerative arthritis were treated with resection of body spur and osteochondral ridge. At last follow up, 8 ankles showed excellent and two showed good result. Postoperatively one patient complained transient dorsal numbness and there were no permanent complications. Arthroscope would play a definite role in the diagnosis and treatment of the osteochondral lesions of ankle.

갑상선기능항진증에서 좌심실용적 및 기능변화에 관한 연구

이명철,고창순 대한핵의학회 1983 핵의학 분자영상 Vol.17 No.2

The purpose of this study is to investigate the effects of thyroid hormone on the left ventricular(LV) volume and function in man with untreated hyperthyroidism and to determine the effects of successful therapy for thyrotoxicosis on the ventricular pathophysiology. In the precent study, equilibrium ralhianuclide cardiac angiography was performed and LV volume index, ejection phase indexes of LV performance, serum thyroid hormone levels and other hemodynamic parameters were measured in 28 normal subjects and 39 patients with hyperthyroidism before treatment and again every 4 weeks for the first 2 months after the initiation of effective therapy. The result obtained were as follows; 1) In the untreated hyperthyroid state heart rate, blood volume, cardiac index and stroke volume index(97±14 beats/min, 73.5±11.8 ml/kg, 6.9±1.4 l/min/m2 and 77.6±13.8 ml/m2, respectively) were increased significantly compared to those in normal control(74±12beats/min, 65.6±14.8 ml/kg, 3.8±1.2 l/min/m2 and 56.6±13.2 ml/m2 rely). (Mean±SD). 2) There was a significant increase in LV end-diastolic volume index in patients with hyperthyroidism(30.5±7.5 for hyperthyroid group compared to a normal control of 22.2±6.5;P〈0.001), whereas end-systolic volume index remained unchanged 9.6±3.6 and 8.8±3.3 respectively). 3) In patients with hyperthyroidism, LV ejection fraction was 70.0±5.6%, fractional shortening 32.9±5.1%, mean velocity of circumferential fiber shortening(mean Vcf) 1.34±0.31 circ/sec and maximum ejection rate 3.47±0.80. All the ejection phase indexes were significantly greater than those in normal control(65.2±5.7%, 28.8±3.2%, 0.88±0.37 circ/sec and 2.27±0.50, respectively; p〈0.001). 4) Effective therapy produced significant decrease in all the values of serum thyroid hormone concenrations(p〈0.001), hemodynamic parameters(p〈0.001), end-diastolic volume index(p〈0.01) and ejection phase indexes of LV contractility in patients with hyperthyroidism and after one to two months, when the patients were euthyroid, these measurements were in the rangeof normal. 5) A significant linear correlation between mean Vcf and serum thyroxine level(r=0.63. p$lt;0.001) as well as between mean Vcf and serum triiodothyronine level(r=0.62, p$lt;0.001) was found. The lesser degree of correlation was also noted between other ejection phase indexes and serum thyroid hormone concentrations. The resilts indicate that the major effects of excess thyroid hormone on the LV in human beings with hyperthyroidism are an enhancement of LV function and an increase in LV endsiastolic volume and that these effects cause predictable reversible cardiac alteration which are changed dramatically and immedately after effective therapy.

저용량의 스테로이드 사용이 류마토이드 관절염환자의 골밀도 및 혈청 Osteocalcin에 미치는 영향

이명철,조보연,이홍규,고창순,민헌기,이명식,김성연,송영욱 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.1

Low dose glucocorticoids are effective in the management of rheumatoid arthritis, but there remains concern about their side effects, particularly osteoporosis. To examine the effect of low dose glucocorticoids on the bone mineral density and osteoblastic activity in rheumatoid arthritis, bone mineral density (NSAID) and serum osteocalcin were measured in 26 patients treated with nonsteroidal anti inflammatory drugs and 19 patients treated with glucocorticoid (prednisolone daily dose less than 10 mg) and 145 normal controls. Bone mineral densities at the femur neck and trochanter were significantly decreased in NSAID group compared with the normal controls and those at the lumbar spine, femur neck, trochanter and Ward's triangle were significantly decreased in steroid group compared with the normal controls. However the Z values of bone mineral densities were not different between the two groups at either site. Serum osteocalcin was not decreased significantly in steroid group. These findings suggest that low dose glucocorticoid treatment in rheumatoid arthritis is not assiciated with an increased risk of osteoporosis and that low dose glucocorticoid does not inhibit osteoblastic activity. (J. Kor Soc Endocrinol 5:37~44, 1990)

한국운동재활학회지 Journal of Exercise Rehabilitation 국제화 전략

이명철 한국운동재활학회 2016 한국운동재활학회 학술대회 Vol.2016 No.05

측두엽 간질에서 F-18-FDG PET에 나타난 측두엽 내외측 부위별 대사의 차이

이명철,이동수,정준기,김현집,송호천,이상건,여정석 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.1

Purpose: We investigated the difference of glucose metabolism of medial and lateral temporal lobes of patients with temporal lobe epilepsy (TLE) utilizing quantitative comparison of regional metabolic activities using asymmetric index. Materials and Methods: We studied 19 pathologically proven mesial TLE and 25 lateral TLE patients. Lateral TLE patients were either normal on magnetic resonance imaging (cryptogenic: n=14) or had structural lesions (lesional: n=11). Asymmetric index (ASI) was calculated as [(ipsilateral-contralateral)/(ipsilateral+ contralateral)]×200. Results: ASI of medial and lateral lobes of mesial TLE was decreased (-16.4±8.3 and -12.7±5.5, respectively). In cryptogenic lateral TLE, ASI of lateral temporal lobe was decreased (-11.8±4.7), whereas that of medial temporal lobe was not decreased (-4.6±6.3). ASI of medial lobe of lesional lateral TLE was -7.3±9.1, which was significantly different from that of mesial TLE (p<0.05). Patients with lesional lateral TLE had evident metabolic d or decrease (ASI: -22±10.5) in lateral temporal lobe. While we could not find the difference of metabolic activity in lateral temporal lobes between cryptogenic lateral TLE and mesial TLE patients, the difference of metabolic activity was significant in medial temporal lobes which was revealed by ASI quantitation. Conclusion: Asymmetric decrease of metabolic activity in both medial and lateral temporal lobes indicates medial temporal epilepsy. Symmetry of metabolic activity in medial temporal lobe combined with asymmetry of that in lateral temporal lobe may give hints that the epileptogenic zone is lateral.

Doxorubicin 심근 손상에서 111In-항 Myosin 항체의 섭취

이명철,정준기,조보연,고창순 대한핵의학회 1988 핵의학 분자영상 Vol.22 No.1

머신러닝과 공통데이터모델을 활용한 국가 간암 검진 대상자의 간암 예측 모델

이명철,최경선,서혜선 한국보건사회약료경영학회 2022 한국보건사회약료경영학회지 Vol.10 No.1

BACKGROUNDS To find early liver cancer, the ministry of health and welfare has conducted surveillance targeting high-risk patients. In 2017, the incidence rate of liver cancer in surveillance was 0.9%, suggesting that a broad patient group was included in surveillance. In this study, to reduce surveillance patients, a prediction model with zero-falsenegative was developed using a machine learning. METHODS To develop the model, we used 2016 Health Insurance Review & Assessment Service-National Patients Sample utilized to the Common Data Model (CDM). This study targeted patients who did not have a severe condition of liver cancer in surveillance. The number of the target was 13,703 cases. The covariates for the model were identified by a chi-square test conducted on gender, age group, condition between a case and control group. LASSO was performed to develop the model. RESULTS Gender, age group, forty diseases were selected as a covariate. The model has an AUC of 0.745, a negative rate of 4.0%, a specificity of 4.5%, and a PPV of 11.8% with zerofalse- negative. CONCLUSION It might be possible to refine surveillance and save the budget of the National Health Insurance Service, and governments.