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이동녕,문진영,오규석,이태균,최미정,이동목,남경수,Lee, Dong-Nyung,Moon, Jin-Young,Oh, Gue-Suc,Lee, Tae-Kyun,Choi, Mi-Jung,Lee, Dong-Mok,Nam, Kyung-Soo 한국생약학회 1997 생약학회지 Vol.28 No.3
Antaeum(ATE) has been used as a prescription for threatened abortion, associated with pregnancy in traditional medicine. Because gravida could be administered ATE for a long period, its administration might cause a harmful effect on fetus and gravida during the pregnancy. This study aimed to determine whether exposure to ATE caused mutagenicity or hepatotoxicity during the pregnant period. For mutagenicity test of ATE, Salmonella typhimurium and Bacillus subtilis were used as indications for DNA damage. In the Ames test, Samonella typhimurium TA98 and TA100 were used for mutagenicity testing, and the number of histidine revertants was measured. In Rec-assay, Bacillus subtilis H $17(Rec^+)$ and $M-45(Rec^-)$ strains were used to clarify the DNA damage property. In the SOS umu test, Salmonella typhimurium TA15335 containing plasmid pSK1002 was used as a tester strain, and we monitored the levels of umu operon expression by measuring the ${\beta}-galactosidase$ activity. From the tested results, ATE did not show DNA damage and mutagenicity. On the other hand, hepatotoxicity of ATE to female ICR mice was monitored by the measurements of s-GOT, s-GPT and LDH activities after oral feeding for 15 days. ATE did not show significant change of s-GOT, s-GPT and LDH activities in mice sera.
청소년들의 변증에 대한 단면조사 연구 - 2017 성남시 교의사업을 중심으로 -
이동녕,신선미,박정수,성현경,고재언,고호연,Lee, Dong-Nyung,Shin, Seon Mi,Park, Jeong-Su,Sung, Hyun Kyung,Go, Jae-Eon,Go, Ho-Yeon 대한예방한의학회 2019 대한예방한의학회지 Vol.23 No.2
Objective : This study is aimed to application possibility and status of pattern identification in middle and high school students. Method : This study was cross-sectional study. We recruited 277 students through school doctor program of Seongnam city in 2017. Male students are 66 in middle school, 32 in high school. Female students are 117 in middle school, 62 in high school. For pattern identification, we used the tool of Qui Xui Shui pattern identification in students. Students fill questionnaires in inquiry of pattern identification and Korean medicine doctor diagnosis inspection and palpation of students. Results : Among 277 students, no pattern identification were 114(41.2%). It appeared in the order of phlegm, blood deficinecy, qi deficiency, qi stagnation and qi reversal. Qi deficiency, qi stagnation, qi reversal, blood deficiency and phlegm pattern are statistically significant by gender except blood stagnation. of 277 students, 105 (37.9%) had one more pattern identification. Conclusions : This study showed possibility of Qui Xui Shui pattern for student health management. In the future, large scale follow up study will be needed to clarify the relationship of pattern identification and student's health.
한의표준임상진료지침 개발을 위한 수족냉증에 대한 한의사의 인식과 치료현황
이동녕 ( Dong-nyung Lee ),김형준 ( Hyung-jun Kim ),유준상 ( Jun-sang Yu ) 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.3
Objectives: The purpose of this study were to researched a Korean medicine doctors` recognition about coldness of hands and feet, and developing of korean medicine clinical practice guidelines (CPG) for coldness of hands and feet. Methods: We conducted a questionnaire survey targeting 399 Korean medicine doctors belonging to the Association of Korean Medicine by e-mail and analyzed the answers. Results: 1. 86.86% of the respondents agreed about the necessity of CPG for coldness of hands and feet. 2. 84.2% of respondents wanted coding of Korean Standard Classification of Diseases (KCD) on coldness of hands and feet. 3. To diagnosis a coldness of hands and feet, the respondents used a Subjective symptoms (98.5%), Infrared thermographic imaging device (DITI) (26.32%) Heart rate variablity test (HRV) (17.04%), Thermometer (9.77%), Cold stress test (2.76%) 4. Causing of coldness of hands and feet, the respondents considered a constitution or heredity (84.71%), stress (73.66%), lack of exercise (64.91%), irregular eating habits (51.63%), Cold meals (32.83%), depression (31.33%), etc. 5. Treating coldness of hands and feet, the respondents used a herbal medicine (66.85%), acupuncture (70.7%) Pharmacopuncture (23.85%) and moxibustion (60.08%) for 10.91±8.03 week. Conclusions: We researched a Korean Medicine doctors` recognition of CPG, clinical diagnosis, treatment on a coldness of hands and feet, and policy they required.
이동녕 ( Dong Nyung Lee ),이정임 ( Jeong Im Lee ),고호연 ( Ho Yeon Go ),김형준 ( Hyung Jun Kim ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.4
Objectives: The purpose of this study was to examine the relationship between cold hypersensitivity and bone mineral density. Methods: 28 outpatients who visited○○University Oriental Hospital from July 11th, 2013 to August 28th, 2013 were analyzed. Patients were subjected to thermometer, and those with thermal difference greater than 0.3 ℃ between upper arm and palm and also with more than VAS 4 of cold hypersensitivity were diagnosed with cold sensitivity. Lumba spine (L2-4) and heel bone measurement were obtained on dual energy X-ray absorptiometry (DEXA) and Quantitative Computed Tomography (QCT). Results: 1. There was statistically significant correlation between T-score of DEXA and body weight (0.522), BMI (0.643), OSTA (Osteoporosis elf-assesment Tool for Asians, 0.579), BMI, T-score and Z-score of QCT. OSTA and T-score of QCT (0.521) also had statistically significance. 2. There was no statistically significant correlation between body fat, abdominal obesity rate, degree of cold hypersensitivity, upper arm and palm’s temperature difference, palm temperature, height and Z-score, T-score of QCT or T-sore of DEXA. Conclusions: Bone mineral density was lower in women who had cold hypersensitivity of hand and feet. But there was no statistically significant correlation between bone mineral density and degree of cold hypersensitivity, upper arm and palm’s temperature difference.