대학병원 응급실을 내원한 자살 시도자들의 특성

이광헌(Kwanghun Lee),원승희(Seunghee Won),김희철(Hee-Cheol Kim),이종훈(Jong Hun Lee),서완석(Wan Seok Seo),김지우(Jiwoo Kim) 대한생물치료정신의학회 2015 생물치료정신의학 Vol.21 No.2

Objectives:This study aimed to investigate the demographic and psychosocial characteristics and suicide-related clinical variables of suicide attempters and provide empirical data to establish a suicide prevention program. Methods:The subjects were 279(122 male and 157 female) suicide attempters who were admitted to the emergency centers of 4 university hospitals in a large city between June 2011 and March 2014. Their psychosocial and demographic characteristics and suicide-related clinical variables were studied through interviews, questionnaires(on suicide intention, lethality, risk, and rescue) and their electronic medical records. Results:The main findings were as follows : among subjects in their 20s, there was a significantly higher proportion of women, while among subjects older than 60 years, there was a significantly higher proportion of men. The rate of attempting suicide in autumn was significantly higher in females while that in summer was significantly higher in males. The rate of attempting suicide in the morning was significantly higher in older(≥60 years) subjects while that at night and dawn was significantly higher in subjects below 60 years. Among interpersonal relationship problems, couple relationship problems were the most common motive for suicide attempt. Depressive disorders were the most common psychiatric illness. Conclusion:This study indicates the necessity of suicide prevention measures, tailored to several psychosocial factors(place, time-of-day, season, and so on) according to age and gender, are suited to the regional characteristics. It also reveals the necessity of intervention for couple relationship problems and appropriate psychiatric treatment for depression in order to prevent suicide

상추 및 고추 중 생산단계 농약잔류허용기준 설정 연구

이지호 ( Jiho Lee ),이광헌 ( Kwanghun Lee ),김진찬 ( Jinchan Kim ),강석현 ( Seok Hyeon Kang ),심우종 ( Woo Jong Shim ) 한국환경농학회 2020 한국환경농학회 학술대회집 Vol.2020 No.-

본 연구는 시설재배 상추 및 고추 내 농약잔류량 감소추이를 확인하여 생산단계 농산물의 농약 잔류허용기준(PHRL: Pre-Harvest Residue Limit) 설정 고시(안) 마련을 위한 기초자료로 활용되어 재배과정에서의 농산물 안전성관리를 통하여 농산물 유통단계 안전관리 강화에 그 목적이 있다. 지리적으로 차이가 있는 2개 및 3개 시험포장(상추: 음성, 청주 및 전주, 고추: 진주 및 창녕)을 선정하여, 상주 중 농약 6종(Acetamiprid, Cyenopyrafen, Lufenuron, Pyraclostrobin, Pyridalyl, Teflubenzuron)과 고추 중 농약 1종(Fenazaquin)을 안전사용기준에 따라 살포한 후, 해당 농약의 최종 수확 전 살포일을 고려하여 0, 1, 2, 3, 5, 7, 10 및 14일차에 걸쳐 시료를 수확하였다. 분석법 확립을 위해 해당 공시료에 농약별 회수율 실험을 실시하였으며, 70~110%, 변이계수 10% 이하를 만족하였다. 채취한 시료는 확립된 분석법을 바탕으로 전처리 과정을 거쳐 HPLC (HPLC-MS/MS) 및 GC (GC-MS/MS)를 이용하여 정량분석을 수행하였다. 상추 및 고추 시료를 분석하여 일차별 잔류량을 확인하고, 이를 바탕으로 약제별 회귀방정식에 의한 감소상수 및 생물학적 반감기를 산출, 통계학적 방법에 근거한 신뢰성 있는 출하전 생산단계 잔류농약 허용기준(안)을 제시하고자 한다.

소면적 재배작물 삽주 중 Kresoxim-methyl의 잔류 특성

이지호(Jiho Lee),이광헌(Kwanghun Lee),김진찬(Jinchan Kim),강석현(Seok hyeon Kang),고락도(Rak do Ko),심우종(Woo Jong Shim) 한국농약과학회 2021 한국농약과학회 학술발표대회 논문집 Vol.2021 No.5

양배추 및 취나물 중 생산단계 농약잔류허용기준 설정 연구

이지호 ( Jiho Lee ),이광헌 ( Kwanghun Lee ),김진찬 ( Jinchan Kim ),주수영 ( Suyoung Ju ),심우종 ( Woo Jong Shim ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-

본 연구는 시설재배 양배추 및 취나물 내 농약잔류량 감소추이를 확인하여 생산단계 농산물의 농약 잔류허용기준(PHRL: Pre-Harvest Residue Limit) 설정 고시(안) 마련을 위한 기초자료로 활용되어 재배과정에서의 농산물 안전성관리를 통하여 농산물 유통단계 안전관리 강화에 그 목적이 있다. 지리적으로 차이가 있는 2개 시험포장(양배추: 음성 및 청주, 취나물: 태안 및 광양)을 선정하여, 양배추 중 농약 4종(Etofenprox, Lufenuron, Emamectin, Chlorfluazuron)과 취나물 중 농약 5종(Acrinathrin, Spirodiclofen, Fenazatuin, Metaflumizone, Tebufenpyrad)을 안전사용기준에 따라 살포한 후, 해당 농약의 최종 수확 전 살포일을 고려하여 양배추의 경우 0, 1, 2, 3, 5, 7, 10 및 14일, 취나물의 경우 0, 1, 2, 3, 5, 7 및 10일차에 걸쳐 시료를 수확하였다. 분석법 확립을 위해 해당 공시료에 농약별 회수율 실험을 실시하였으며, 70~110%, 변이계수 10% 이하를 만족하였다. 채취한 시료는 확립된 분석법을 바탕으로 전처리 과정을 거쳐 HPLC (HPLC-MS/MS) 및 GC(GC-MS/MS)를 이용하여 정량분석을 수행하였다. 양배추 및 취나물 시료를 분석하여 일차별 잔류량을 확인하고, 이를 바탕으로 약제별 회귀방정식에 의한 감소상수 및 생물학적 반감기를 산출, 통게학적 방법에 근거한 신뢰성 있는 출하전 생산단계 잔류농약 허용기준(안)을 제시하고자 한다.

상추 중 생산단계 농약잔류허용기준 설정 연구

이지호 ( Jiho Lee ),이광헌 ( Kwanghun Lee ),김진찬 ( Jinchan Kim ),고락도 ( Rakdo Ko ),강석현 ( Seok Hyeon Kang ),심우종 ( Woo Jong Shim ) 한국환경농학회 2021 한국환경농학회 학술대회집 Vol.2021 No.-

본 연구는 시설재배 상추 내 농약잔류량 감소추이를 확인하여 생산단계 농산물의 농약 잔류허용 기준(PHRL: Pre-Harvest Residue Limit) 설정 고시(안) 마련을 위한 기초자료로 활용되어 재배과정에서의 농산물 안전성관리를 통하여 농산물 유통단계 안전관리 강화에 그 목적이 있다. 지리적으로 차이가 있는 3개 시험포장(음성, 청주 및 전주)을 선정하여, 상추 중 농약 6종(Fluopicolide, Cyflumetofen, Trifloxystrobin, Cyazofamid, Chlorfenapyr, Thiacloprid)을 안전사용기준에 따라 살포한 후, 해당 농약의 최종 수확 전 살포일을 고려하여 0, 1, 2, 3, 5, 7 및 10 일차에 걸쳐 시료를 수확하였다. 분석법 확립을 위해 해당 공시료에 농약별 회수율 실험을 실시하였으며, 70∼110%, 변이계수 10% 이하를 만족하였다. 채취한 시료는 확립된 분석법을 바탕으로 전처리 과정을 거쳐 HPLC (HPLC-MS/MS) 및 GC (GC-MS/MS)를 이용하여 정량분석을 수행하였다. 상추 시료를 분석하여 일차별 잔류량을 확인하고, 이를 바탕으로 약제별 회귀방정식에 의한 감소상수 및 생물학적 반감기를 산출, 통계학적 방법에 근거한 신뢰성 있는 출하전 생산단계 잔류농약 허용기준(안)을 제시하고자 한다.

노인 우울증 환자에서 Aripiprazole과 Bupropion 부가요법의 효과 및 안전성 비교 : 사후분석연구

조소혜(Sohye Jo),천은진(Eunjin Cheon),이광헌(Kwanghun Lee),구본훈(Bonhoon Koo),박영우(Youngwoo Park),이종훈(Jonghun Lee),이승재(Seungjae Lee),성형모(Hyungmo Sung) 대한생물치료정신의학회 2019 생물치료정신의학 Vol.25 No.2

Objectives:The purpose of this study was to compare aripiprazole versus bupropion augmentation therapy in older adult patients with major depressive disorder unresponsive to selective serotonin reuptake inhibitors(SSRIs). Methods:This is a post-hoc analysis of a 6-week, randomized prospective open-label multi-center study in thirty older adult patients with major depressive disorder. Participants were randomized to receive aripiprazole(N=16, 2.5-10mg/day) or bupropion(N=14, 150-300mg/day) for 6 weeks. Montgomery Asberg Depression Rating Scale (MADRS), 17-item Hamilton Depression Rating scale(HAM-D17), Iowa Fatigue Scale, Drug-Induced Extrapyramidal Symptoms Scale, Psychotropic-Related Sexual Dysfunction Questionnaire scores, and Clinical Global Impression-Severity (CGI-S) were obtained at baseline and after one, two, four, and six weeks. Changes on individual items of HAM-D17 were assessed as well as on composite scales(anxiety, insomnia and drive), and on four core subscales that capture core depression symptoms. Results:There was a significantly greater decrease in MADRS scores in aripiprazole group compared to bupropion group at 4(p<0.05) and 6(p<0.05) weeks. There were significantly higher response rate at week 4(p<0.05) and 6(p<0.05) and remission rate at week 6 in aripiprazole group compared to bupropion group. Individual HAM-D17 items showing significantly greater change with adjunctive aripiprazole than bupropion: insomnia, late(ES=0.81 vs. -0.24, p=0.043), psychomotor retardation(ES=1.30 vs. 0.66, p=0.024), general somatic symptoms(ES=1.24 vs. 0.00, p=0.01). On three composite scales, adjunctive aripiprazole was significantly more effective than bupropion with respect to mean change for drive(p=0.005). Conclusion:Results of this study suggested that aripiprazole augmentation have superior efficacy in treating general and core symptoms of depression in older adult patients. Aripiprazole augmentation is associated with greater improvement in specific symptoms of depression such as psychomotor retardation, general somatic symptoms and drive.

조현병 환자에서 아미설프라이드의 치료반응과 도파민 D3 수용체 유전자다형성의 연관성

강승걸,이헌정,이승재,최태영,우정민,김지현,정성원,구본훈,이광헌,김정란,지익성,이종훈,Kang, Seung-Gul,Lee, Heon-Jeong,Lee, Seung Jae,Choi, Tae Young,Woo, Jungmin,Kim, Jihyun,Jung, Sung-Won,Koo, Bon Hoon,Lee, Kwanghun,Kim, Jeong-Lan,Chee, 대한생물정신의학회 2013 생물정신의학 Vol.20 No.3

Objectives The aim of this study is to evaluate the association between rs6280 and rs905568 genetic polymorphism of DRD3 gene and the treatment response of amisulpride. Methods After six weeks treatment of amisulpride, 125 schizophrenia patients were interviewed based on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S). The genotyping for rs6280 and rs905568 was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay. Results There was no significant difference in the frequency of genotype and allele of rs6280 between the responders and non-responders based on the total, positive, and general score of PANSS and CGI-S score. However, there was a significant association between this SNP and treatment response in the negative score of PANSS (${\chi}^2=5.23$, p = 0.022). There was no significant association between rs905568 and the response in positive, negative, general, and total PANSS score and CGI-S score. Conclusions This is the first positive association study between DRD3 gene and the treatment response of negative symptoms to amisulpride in Korean schizophrenia patients. A larger scale research on more SNP of the DRD3 gene will make a progress in the study of pharmacogenetics on the treatment response of the amisulpride.

쑥갓 중 metalaxyl-M과 dinotefuran 입제의 잔류 특성 및 위해성 평가

송민호 ( Min-ho Song ),유지우 ( Ji-woo Yu ),김진찬 ( Jinchan Kim ),이광헌 ( Kwanghun Lee ),고락도 ( Rakdo Ko ),금영수 ( Young-soo Keum ),이지호 ( Jiho Lee ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-

Glebionis coronaria (called crown daisy) is commonly consumed in the Republic of Korea due to its unique smell. Since the Positive List System (PLS) was enforced in the Republic of Korea, Maximum Residue Limits (MRLs) of many crops have been established. However, the pesticides available for the crown daisy are still limited. In this study, the residual characteristics of metalaxyl-M and dinotefuran in crown daisy were investigated to expand the registration of pesticides. Additionally, risk assessment was performed by using the residual concentration of pesticides and dietary intake. Two pesticides were treated in soil on two levels, and samples were collected 51 days after seeding. The analytes were extracted using acetonitrile and the QuEChERS extraction packet (MgSO4 4 g, NaCl 1 g). The mixture was centrifuged at 4,000 rpm for 5 min, and the supernatant was diluted 1:1 with acetonitrile. The results for the concentration of pesticides were obtained with a high-performance liquid chromatography-triple quadrupole mass spectrometer. The quantitative methods for analytes were validated in linearity, accuracy, and precision. Daily dietary intake was obtained from Korea national nutrition statistics 2019. The residual concentration of metalaxyl-M in crown daisy were 0.09∼0.10 mg/kg (6 kg/10 a) and 0.17∼0.19 mg/kg (12 kg/10 a), respectively. The residual concentrations of dinotefuran in the crop were 0.53∼0.75 mg/kg (3 kg/10 a) and 1.17∼1.26 mg/kg (6 kg/10 a), each. The amounts of pesticides were less than the MRL specified by the Korean Ministry of Food and Drug Safety. The Hazard Index (HI) of metalaxyl-M and dinotefuran for consumers was 0.0075% and 0.2250%, respectively. For females in the age between 50∼64, the major consumer group, the HIs of the pesticides were <3%. Considering the consumption of crown daisy, they are not concidered to be of toxicological concern.

피나물 중 Bocalid 및 Pyraclostrobin의 토양처리시 잔류특성 및 안전성 평가

유지우 ( Ji-woo Yu ),송민호 ( Min-ho Song ),김진찬 ( Jinchan Kim ),이광헌 ( Kwanghun Lee ),고락도 ( Rakdo Ko ),금영수 ( Young-soo Keum ),이지호 ( Jiho Lee ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-

Hylomecon vernalis is widely distributed in mountainous region in korea and used as folk madicine. Due to minor cultivation area, the pesticides available for Hylomecon vernalis are highly limited. This study aimed to determine residue characteristics of soil-treated boscalid and pyraclostrobin in Hylomecon vernalis and to evaluate the risks from intake of the residual pesticides in the crop. The pesticides were treated in soil with two levels, and samples were collected 57 days after seeding. The samples were extracted using the QuEChERS extraction kit (MgSO4 4 g, NaCl 1 g). The quantitative methods for boscalid and pyraclostrobin were validated using linearity, recovery, and CV (coefficient of variation). Risk assessment of pesticides was performed using Korea national nutrition statistics 2019. The residual levels of boscalid were 0.02∼0.05 mg/ kg (6 Kg/ 10a) and 0.05∼0.08 mg/kg (12 Kg/ 10a), respectively. The residual concentrations of pyraclostrobin were below the LOQ. The amounts of pesticides were less than Maximum Residue Limits specified by the Korean Ministry of Food and Drug Safety. The maximum hazard index of boscalid in chwinamul and amaranth for consumers were 0.0075% and 0.1525%, respectively and it indicates that the risk of the pesticides from the crop is considered to be low.