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윤태균(Tae Gyoon Yoon),김현정(Hyun Jeong Kim),염광원(Kwang Won Yum) 대한통증학회 2002 The Korean Journal of Pain Vol.15 No.1
N/A Background: Recently, aminoglycoside antibiotics such as gentamicin, neomycin and amikacin have been known to have antinociceptive effects on several pain models in rats and mice, in addition to their antibacterial activities. However, there has been no report concerning aminoglycoside`s antinociceptive effects on neuropathic pain. The present study was undertaken to assess the antinociceptive action of amikacin and also investigate a possible antinociceptive mechanisms through the use of antagonists in an neuropathic pain models in rats. Methods: Rats were prepared with tight ligation at the left 5^th and 6^th lumbar spinal nerves (according to Kim and Chung`s neuropathic pain model). The antinociceptive effects of amikacin (1, 10, and 100mg/kg i.p.) in rats with neuropathic pain were assessed. In addition, after co-administration of naloxone(1 mg/kg i..p.) with 10 mg/kg of amikacin, the responses to mechanical stimulus were measured over two hours. Results: The antinociceptive effects shown by amikacin on neuropathic pain were significant (P <0.05), but were inhibited by co-administred nalxone in rats with mechanical allodynia. Conclusions: Amikacin showed significant antinociceptive effects in rats with neuropathic pain against mechanical allodynia. The antinociceptive effect on the mechanical stimuli was mediated through the opioid receptor.
쥐의 포르말린시험에서 척수에서의 열충격 단백질들의 발현에 관한 연구
황정태(Jeong Tae Hwang),윤태균(Tae Gyoon Yoon),김현정(Hyun Jeong Kim),염광원(Kwang Won Yum) 대한통증학회 2002 The Korean Journal of Pain Vol.15 No.1
N/A Background: Heat shock proteins (HSPs) are induced in the central nervous system by stressful stimuli are thought to assist in the maintenance of cellular integrity and viability. Recently, several lines of evidence have indicated that HSPs are related to the synaptic in the nervous system, which is related to the nociceptive stimuli induced by formalin injection into rat`s hind paw. Methods: Male Sprague-Dawley rats weighing 250-300g were subcutaneously injected with 100㎕ of fershly made 5% formalin into the right hind paw. At 1 and 24 hour(s) after formalin injection, the right and left sides of the 5^th and 6^th lumbar spinal cord were collected. HSP90, HSP 70, and HSP27 levels were examined using Western blot analysis. Results: Pain related behaviors induced by formalin were typically observed during 1 hr after formalin injection. However, at 24 hr after formalin injeciton, such pain behaviors were rarely observed. Only at 1 hr after formalin injection, HSP70 was significantly more expressed in the ipsilateral and contralateral lumbar spinal cord (P <0.05). The others did not show significant changes in HSPs levels compared to those of the control group. Conclusions: These results suggest that the overexpression of HSP70 in the lumbar spinal cord at 1 hr after formalin injection, which is associated with painful stress, may be related to the molecular mechanism of central sensitization.
일회용 주사기를 이용한 기관내튜브의 새로운 기낭 팽창법의 유용성
허진 ( Jin Huh ),윤태균 ( Tae Gyoon Yoon ),권원경 ( Won Kyoung Kwon ),주영 ( Young Joo ),김덕경 ( Duk Kyung Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.5
Background: Risk for injuries resulting from overinflated or underinflated endotracheal tube cuff warrants adequate cuff inflation technique. Thus, this study was designed to measure the actual intracuff pressures obtained by new estimation techniques. Methods: 95 adult surgical patients requiring tracheal intubation were randomized to two groups with respect to the endotracheal tube model: Portex(R) (n=55) and Euromedical(R) (n=40). After induction of anesthesia, the cuff was inflated using new estimation techniques with two different syringes: PR10 or PR20 (passive release technique using a 10-ml or 20-ml syringe, respectively). Subsequently, an aneroid manometer was used to measure the actual intracuff pressures. These inflation techniques were repeated two times. A direct cuff measurement range of 25 to 40 cmH2O was used as a reference for optimal intracuff pressure. Size 7.0 mm internal diameter (ID) tubes were used for women and size 7.5 mm ID for men. Results: 88 eligible patients were studied: Portex group (n=50) and Euromedical group (n=38). With respect to the rate of optimal cuff inflation, PR10 was significantly higher than PR20 in both groups (56% vs. 10% in Portex group; 63.2% vs. 0% in Euromedical group, respectively) (P<0.05). Conclusions: When direct intracuff measurement is not available, a new method, named "passive release technique" using a 10-ml syringe, is a useful alternative cuff inflation method. (Korean J Anesthesiol 2009;56:513~8)
임상연구 : 어린이에서 후두마스크와 후두 튜브 삽입에 적절한 Propofol의 중간 유효 농도
박혜진 ( Hye Jin Park ),윤태균 ( Tae Gyoon Yoon ),김종성 ( Chong Sung Kim ),김성덕 ( Seong Deok Kim ),김희수 ( Hee Soo Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.3
Background: The median effective concentration, EC50, for the supraglottic airway (predicted plasma concentration equilibrated with the effect site at which supraglottic airway insertion is successful in 50% of patients) of propofol in children was not known. The aim of this study was to determine the EC50 with a target-controlled infusion of propofol to insert a classic laryngeal mask airway (LMA) and laryngeal tube (LT) in pediatric patients. Methods: Pediatric patients scheduled for urologic, orthopedic, or plastic surgery lasting less than 2 hr under general anesthesia were enrolled in this study. The patients were divided into two groups in a randomized, double blind manner. After applying a standard cardiorespiratory monitor, anesthesia was carried out with a target-controlled infusion (TCI) using the stelpump program. The initial target concentration of propofol was 5μg/ml, and in accordance with Dixon`s up-and-down, the propofol concentration for consecutive patients in each group was varied with increments or decrements of 0.2μg/ml based on the previous patient insertion result. Results: The EC50 of propofol required to insert a LMA and LT was 5.5 ± 0.2μg/ml and 5.6 ± 0.2μg/ml, respectively. Conclusions: The EC50 of propofol is similar for LMA and LT. (Korean J Anesthesiol 2006; 51: 330~4)
증례보고 : 체외순환 없는 관상동맥 우회술 도중 호기말이산화탄소분압에 의해 조기 발견된 파열된 폐 낭포
김성협 ( Seong Hyop Kim ),윤태균 ( Tae Gyoon Yoon ),강주은 ( Joo Eun Kang ),오충식 ( Chung Sik Oh ),김덕경 ( Duk Kyung Kim ),김태엽 ( Tae Yop Kim ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.1
Capnography is monitoring of concentration or partial pressure of CO2 in respiratory gases. It provides information about CO2 production, pulmonary perfusion, alveolar ventilation, respiratory patterns and elimination of CO2 from the anesthesia circuit and ventilator. Thus it gives us a rapid and reliable method to detect life threatening conditions such as malposition of tracheal tube, ventilatory failure, circulatory failure and defective breathing circuits. Authors experienced that change of capnogram during off pump coronary artery bypass grafting surgery helped early detecting ruptured bulla and prevented intraopertive or postoperative pneumothorax. (Korean J Anesthesiol 2009;56:83~6)
증례보고 : 모야모야병 환자에서의 심폐회로를 가동하지 않는 관상동맥우회로 이식술 중 뇌산소포화도 감시
김성협 ( Seong Hyop Kim ),김태엽 ( Tae Yop Kim ),이현하 ( Hyun Ha Lee ),윤태균 ( Tae Gyoon Yoon ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.4
We report a case using cerebral oxygen saturation (rCbO2) for off-pump coronary artery bypass graft (OPCAB) surgery in a patient with co-existing Moyamoya disease. The rCbO2 with the routine monitoring for OPCAB surgery were monitored intraoperatively. In spite of infusing nimodipine (0.2 μg/kg/min) and maintaining the end-tidal CO2 tension at 35-40 mmHg, a sudden reduction in the right-side rCbO2 from the base line value of 70-80%/78-83% (Left/Right) to 70-72%/65-70% was developed during the harvesting of the vascular graft. We increased the rate of phenylephrine infusion to increase systemic and cerebral perfusion pressure, and both rCbO2 values were elevated to 80%/70% within 3 minutes. However, the preferential reduction in the right-side rCbO2 compared with the left-side value was not corrected. While suspecting cerebral ischemia due to cerebral vascular spasm, we administered nimodipine 2 mg bolus and increased infusion rate to 0.5 μg/kg/min. Finally, the preferential rCbO2 reduction in the right-side was corrected and both rCbO2 reached 84%/91%. We concluded rCbO2 monitoring is useful for detecting an intraoperative episode of cerebral ischemia and maintaining the optimal cerebral perfusion during OPCAB surgery with Moyamoya disease. (Korean J Anesthesiol 2009;56:433~7)