원저 : 소음영 진폐증 환자에서의 등기류용량 (Volume of Isoflow)의 변화

오상용 ( Sang Yong Oh ),김지원 ( Jee Won Kim ),정장영 ( Chang Young Jung ),김경아 ( Kyung Ah Kim ),윤임중 ( Im Goung Yun ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.5

원저 : Quinolyl Piperazine Phosphate가 흰쥐 규폐증에 미치는 영향

임현우 ( Hyeon Woo Yim ),정장영 ( Chang Young Jung ),오상용 ( Sang Yong Oh ),김경아 ( Kyung Ah Kim ),임영 ( Young Lim ),윤임중 ( Im Goung Yun ),노영만 ( Young Man Roh ) 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.2

알코올 기인성 대퇴골두 무혈성 괴사 발생의 위험요인

장준동(Jun-Dong Chang),이상훈(Sang-Hun Lee),오상용(Sang-Yong Oh),위영훈(Young-Hoon Wi),이재성(Jae-Sung Lee) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.6

목적: 알코올 기인성 대퇴골두 무혈성괴사 환자를 대상으로 음주 습관을 포함한 생활 습관과 지방대사에 관련된 혈청 생화학적 지표들을 역학적으로 분석하여 이 질환의 발생에 영향을 미치는 위험 요인을 밝혀 보고자 한다. 대상 및 방법: 인공고관절 전치환술 후 조직학적으로 확진된 대퇴골두 무혈성괴사 환자 250명(333 고관절)을 분석하였다. 이들 중 음주 이외에 이 질환과 관련된 원인적 요인이 없었던 169명의 환자를 질환군으로 하여 성별, 나이, 직업, 교육 정도 등이 통계적으로 일치하며 무혈성 괴사가 없었던 338명을 대조군으로 하여 환자 대조 연구를 시행하였다. 음주 습관, 흡연 습관, 체중, 키, 혈청 간기능 검사 수치(AST, ALT), 총 콜레스테롤치, 체표 면적지수를 조사하여 통계적으로 분석하였다. 결과: 대퇴골두 무혈성괴사 환자에서 음주력은 42.8%에서 있었으며 음주 기간은 질환군이 평균 8.1년이었다. 1회 평균 음주량은 84.8g, 주당 음주량은 328.2g, drink-years는 4,330이었다. 비교 위험도가 유의하게 나타난 경우는 1) 음주빈도가 주당 4회 이상, 2) 1회 음주량이 90g 이상, 3) 주당 음주량 300g 이상, 4) drink-years가 6,000 이상인 경우, 5) 안주 섭취가 없었던 경우이었다. 이 외에 하루 흡연이 20개피 이상인 경우, 간수치가 정상보다 높았던 경우, 그리고 체표면적 지수가 25 이하인 경우였다. 결론: 대퇴골두 무혈성괴사의 발생에서 알코올의 섭취는 직접적인 용량-반응 관계를 보였을 뿐만 아니라 음주 습관 또한 주요 위험 요인임을 확인하였으며, 특히 1회 음주량이 많은 경우가 무혈성 괴사 발생의 중요한 요인로 작용하는 것으로 나타났다. Purpose: To assess the relationship between the osteonecrosis of the femoral head (ONFH) and the patterns of alcohol intake and evaluate the risk factors associated with alcohol-induced ONFH using an epidemiologic study. Materials and Methods: The study examined 250 patients (333 hips) with ONFH, who were diagnosed based on the findings after a total hip arthroplasty. Among them, 169 patients who were not associated with the specific etiologic factors except for a history of alcohol were selected in the case group. These patients were compared with the 338 controls, which were matched for gender, age, occupation and education. The patterns of alcohol intake, cigarette smoking, the level of the liver function test and body mass index were statistically assessed in relation to the development of ONFH. Results: The incidence of alcohol-induced ONFH was 42.8% in all ONFH patients. The average duration of alcohol ingestion was 8.1 years. The average quantity of alcohol per day, per week and drink-years were 84.8g, 328.6g and 4,330 respectively. The elevated relative odds were observed for 1) frequent drinkers (>4/week), 2) the amount of intake per day >90 g, 3) the amount of alcohol intake per week >300 g, 4) drink-year >6,000, 5) the patients had not consumed food with their drinks. A increased risk was found for smokers (>20 cigarettes/day), patients with an increased serum transaminase level and body mass index ≤25. Conclusion: Chronic alcohol intake showed significant dose-response relation in the development of ONFH. The Increased amount of alcohol per day was a more significant risk factor than the total duration of alcohol intake. The pattern of alcohol consumption is one of the risk factors associated with the development of alcohol induced ONFH.

자연산석탄분진 및 유리규산분진 주입에 따른 흰쥐 폐에서 병리조직학적 변화

김경아 ( Kyung Ah Kim ),정장영 ( Chang Young Jung ),오상용 ( Sang Young Oh ),임현후 ( Hyeon Woo Yim ),임영 ( Young Lim ),윤임중 ( Im Goung Yun ),노영만 ( Young Man Roh ) 대한결핵 및 호흡기학회 1992 Tuberculosis and Respiratory Diseases Vol.39 No.2

메밀 보충급여가 백서의 혈당 및 혈압에 미치는 영향

최면(Myeon Choe),김종대(Jong-Dai Kim),박경숙(Kyung-Suk Park),오상용(Sang-Yong Oh),이상영(Sang-Young Lee) 한국식품영양과학회 1991 한국식품영양과학회지 Vol.20 No.4

메밀보충급여가 백서의 혈압 및 혈당에 미치는 효과를 검토 하고자 AIN-76 diet와 AIN-76 diet의 탄수화물원을 박피 메밀분으로 교체한 식이로 4주간 사육하여 성장율, 혈당, 인슐린 분비능, 혈압 등의 변화를 측정하고 고찰한 결과는 다음과 같다. 동일실험 기간동안 체중증가량 및 식이섭취량은 대조군과 메밀투여군 사이에 큰차이를 보이지 않았다. 메밀보충급여군은 혈당강하작용이 있음이 관찰 되었으며, 혈압은 유의성이 없으나 수치적으로 어느정도 감소시키는 경향을 보였다. 또한 메밀보충급여에 의해 공복 시 혈청 인슐린 수준은 낮았으며 혈당을 투여한 후 혈중의 당이 증가하면 분비되는 인슐린 양도 빠르게 증가하는 경향을 나타내었으나 유의성은 없었다. To investigate possible effects of buckwheat on blood glucose level and blood pressure, Sprague-Dawley rats were divided into two groups and fed either AIN-76 diet or modified AIN-76 diet with buckwheat flour for 4 weeks. At the end of experiment, determinations of blood pressure and blood glucose level(glucose tolerance test) were performed. In order to determine insulin levels in both fasted and glucose loaded serum, the animals in both groups were subdivided into two groups. Blood pressure was slightly decreased in the group fed buckwheat(-6mmHg) but not significantly. Glucose tolerance curve of the animal fed buckwheat flour showed clearly different pattern from that of the control group with decreasing tendency. Mobilization of serum insulin was 1.5 times faster in buckwheat group than in control group 1 hour after glucose loading. Further research is needed to find what substance(s) in buckwheat do this role.

일부 여성 특수고용 근로자의 업무상 손상 및 건강문제의 관련 요인

박우진(Woo-Jin Park),임형준(Hyoung-June Im),원종욱(Jong-Uk Won),고상백(Sang-Baek Koh),주영수(Young-Su Ju),노재훈(Jae-Hoon Roh),오상용(Sang-Yong Oh),권영준(Young-Jun Kwon),황창국(Chang-Kook Hwang),임정욱(Jung-Wook Lim) 대한직업환경의학회 2009 대한직업환경의학회지 Vol.21 No.4

전처리방법에 따른 산화에틸렌 분석법의 평가

이신영,김치년,조영봉,오상용,노재훈 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.2

The limit of detection(LOD), pooled coefficient of variation(pooled CV), desorption dffciency(DE), and stability after desorption by pre-treatments was compared and evaluated for analyzing the Ethylene oxide(EO) sampling on HBr-coated Charcoal tube, The results were as follows: 1. The EO's LOD was 2,483ug/sample when using the desorptin solvent, benzene : CS2(99:1), and 1.919ug/sample after using DMF. The result of the sample that passed DMF desorption and was derivativized was 1.301ug/sample. 2. EO's pooled CV was 0.00503 when using the solvent benzene:CS(99:1), after desorption with DMF, the result was 0.00329, and the result of those derivativized by DMF desorption was 0.00514. 3. EO's DE using the solvent benzene:CS(99:1) was 92.13%, atter desorption with DMF, it was 102.75%, and the result of those studied after being derivativized by DMF desorption was 96.47%. 4. EO's stability for the sample with the solvent benzene:CS(99:1), comparing result of next-day analysis to same-day was 96.81% after desorption was 95.69% These results were in accordance with the less than 5% given by OSHA methoc 50. In conclusion, when pre-treatment of the EO in the HBr=coated charcoal, analyzing immediately after desorption by DMF is more simple, precise, and efficient than other analyzing methods, and the stabiity of the sample 24 hours after desorption was alst established.

실험적 진폐증에서 투여약제에 따른 면역학적 병리학적 조직변화

윤임중,임현우,노영만,오상용,정장영,임영,김경아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.2

To access the effects of some drugs such as piperazine phosphare, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups. To each group, the turbid solution mixed free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally. At the begining and 5th week of experiment, piperazine phosphate(8mg/week orally), aspirin(1.5mg/day intramuscularly), azathioprine(25mg/day orally) and allopurinol(1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight. dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neurtrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B₄, tumor necrotsis factor, prostaglandin E₂were examined, and observed the pathological chages in lung tissue. The results were as follow : 1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group. 2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group. 3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group. 4. The amount of superoxide ion was frequently less in the experimental group compared with the control one. 5. The amount of hydroxyproline was significantly lower in the experimental group than in the control one. 6. The amount of leukotriene B₄was usually less in the drug administered group than in the control one. 7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one. 8. The amount of prostaglandin E₂was usually higher in each experimental group than in the control one.

1995년 국군병사에서 발생한 국내감염 말라리아 환자 87명에 대한 역학적 및 임상적 분석

강문원,임현우,오상용,임채승,김동립,서지영,안영수 대한감염학회 1996 감염 Vol.28 No.3

목적: 한국에서는 1980년대 중반이후 토착형 말라리아 발생이 없었으나, 1993년 새로이 말라리아가 발생한 후 비무장지대 부근에서 근무하는 장병에게서 말라리아환자가 지속적으로 급증하고 있다. 방법: 저자들은 반복되는 고열로 1995년도에 국군수도병원에 내원한 환자중 말라리아로 확 진된 87명의 환자를 대상으로 임상적 및 역학적자료를 분석하였다. 결과: 모든 환자에서 해외여행 경험이 없어 국내감염으로 사료되었다. 62명의 환자(71.3%)에서 증상발현시 비무장지대 근무를 하였거나 혹은 근무를 수행하고 있었다. 환자발생은 6월부터 10월까지 발생하였으며 온도상승과 함께 발생이 증가하여 무더운 8월에 가장많이 발생하였다. 말초혈액 검사상 모두가 삼일열 말라리아로 진단되었으나, 발열의 주기가 48시간을 보인 환자는 61명(70.1%)뿐이었고, 24시간은, 10명(11.4%), 불규칙 주기가 16명(18.4%)이었다. 13명에서 치료약제의 투여 없이 증상의 자연소실을 보였으며, 그중 5명에서 2∼4주후 재발되었다. 치료로 hydroxychloroquine과 primaquine을 투여하였으며, 치료후 대부분이 24시간내, 늦어도 48시간내에 발열의 증세가 소실하였다. 현재까지 재발된 환자는 없었다. 결론: 1995년 비무장지대의 서부전선에서 삼일열 말라리아가 집단 발생하였다. 경기도 파주군 및 연천군지역에 말라리아 박멸을 위하여 포괄적인 말라리아 대책이 어루어져야 할 것으로 사료된다. Background: Republic of Korea(ROK) has been free from endemic malaria since the mid-1980s, but malaria infections have been increasing steadily in the soldiers serving near the western part of Demilitarized Zone(DMZ) since its first resurgence in 1993. Methods: We analyzed epidemiologic and clinical data of 87 malaria patients seen at Capital Armed Forces General Hospital in 1995. Results: All patients had never been outside of Korea, and were thought to have contracted the disease indigenously. Many of patients (62 patients, 71.3%) had served or were serving at the DMZ at the onset of the disease. Occurrence of patients was distributed from June to October with the number of patients increasing as the weather became hot and humid peaking in August. Peripheral blood smears showed various forms of Plasmodium vivax in all patients. Fever pattern was typical in 61 cases(70.1%) with 48 hr interval, but atypical in 10 cases(11.4%) with 24 hr interval and in 16 cases(18.4%) with irregular pattern. Some patients(8 cases) even had spontaneous remission of fever before treatment and 5 cases had a history of simillar episode of fever 2 to 4 weeks before, Patients were treated with hydroxychloroquine and primaquine showing rapid clinical and hematologic responses. No relapse has been found up to the present. Conclusion: An outbreak of P. vivax malaria was found near the western part of DMZ in 1995. In order to eradicate malaria, a proper surveillance system is needed in the areas.