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오민혁(Min Hyuck Oh),박해진(Hae-Jin Park),신미래(Mi-Rae Shin),노성수(Seong-Soo Roh) 대한약학회 2021 약학회지 Vol.65 No.4
This study aimed to examine the protective effect of the water extract from Spatholobi Caulis (SC) on rats with acute liver injury (ALI) induced by thioacetamide (TAA) and its underlying mechanism. ALI was induced by intraperitoneal injection with TAA for 3 days in a row and the rats were administered SC (100 or 200 mg/kg) 1 h 30 min prior to the TAA treatment. Myeloperoxidase (MPO) was measured in serum and malondialdehyde (MDA) was measured in serum and liver tissue, as markers related to oxidative stress. Further, inflammation-related proteins and apoptosis proteins were investigated using western blot analysis. SC treatment significantly reduced the levels of MPO and MDA. Further, SC treatment significantly reduces the mitogen-activated protein kinase (MAPK) signaling pathway, including p-JNK, p-ERK, and p-p38, and reduces the expression of pro-inflammatory signaling factors. Furthermore, it effectively decreased the expression of Bax, Cytochrome C, and Cleaved Caspase-3 in liver tissue. Taken together, SC treatment alleviate0d the severity of ALI via inhibition of inflammation through both the MAPK pathway and Matrix metalloproteinase (MMPs)-dependent apoptosis.
오민혁(Min-Hyuk Oh),백정명(Jung-Myoung Baek),이병하(Byung Ha Lee),김정훈(Jung-Hoon Kim),황성욱(Sung-Wook Hwang),원종률(Jong-Ryul Won) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.11
Economy of world has grown rapidly. This growth has increased the ownership of household electrical appliances including room air conditioners. The number of users of air conditioners is predicted to grow dramatically in the future. This paper discusses the present status of residential appliance energy efficiency standards around the world. The study found that the energy efficiency standards for room air conditioners would mitigate a significant amount of emissions in Korea.
Thioacetamide로 유발한 간손상 모델에서 계혈등(鷄血藤)의 간보호 효과
오민혁 ( Min Hyuck Oh ),신미래 ( Mi-rae Shin ),노성수 ( Seong-soo Roh ) 대한본초학회 2021 大韓本草學會誌 Vol.36 No.2
Objectives : This study was undertaken to investigate the hepatoprotective effect of Spatholobi Caulis water extract (SC) to thioacetamide (TAA)-induced acute liver injury (ALI) in rats. Methods : The rats were injected intraperitoneally with TAA (200 ㎎/㎏ body weight) and orally administered SC (100 or 200 ㎎/㎏ b.w.) daily for 3 days. Liver biomarkers were assessed by serum glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and ammonia levels. Malondialdehyde (MDA) was measured both serum and liver tissue. In addition, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, anti-oxidant, and inflammation-related proteins were investigated by western blot analysis. Histological examination further confirmed though hematoxylin and eosin stain. Results : The SC treatment reduced liver function markers like GOT and GPT and also remarkably decreased ammonia level. Moreover, the elevated MDA level in TAA-induced group was significantly reduced by SC treatment. NADPH oxidase expression associated with oxidative stress including NOX2, NOX4, and p47<sup>phox</sup> markedly inhibited by SC administration. SC treatment exerted anti-oxidant effect through the increase of anti-oxidant enzyme including superoxide dismutase (SOD), Catalase, and heme oxygenase-1 (HO-1). The protein expressions of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), IL-6, and IL-1β induced by nuclear factor-kappa B (NF-κB) activation were modulated through blocking the phosphorylation of inhibitor of nuclear factor κBα (IκB)α. SC treatment also improved histological alterations. Conclusion : These findings suggested that SC administration may be a potential candidate for the prevention or treatment of ALI.
EMTP MODELS를 이용한 전기철도 FACTS 설비의 제어 구현 연구
오민혁(Min-Hyuk Oh),이병하(Byung-Ha Lee) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7
The purpose of this paper is to compensate the voltage drop of the power system in the AC Electric Railway Systems. Reactive power compensation is often the most effective way to improve system voltage drop. The suitable modeling of the electric railway system should be applied to the EMTP. the dynamic characteristics of 3-Phase Induction Motor in Electric Railway Systems is considered for precise modeling. it is shown through EMTP simulation using EMTP MODELS that voltage drop can be compensated effectively by STATCOM.
소시호탕(小柴胡湯)이 thioacetamide로 유발된 간섬유증 동물 모델에 미치는 영향
이세희,오민혁,신미래,이지혜,노성수,Lee, Se Hui,Oh, Min Hyuck,Shin, Mi-Rae,Lee, Ji Hye,Roh, Seong-Soo 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.6
Objectives: The aim of the current study was to investigate the effect of Sosiho-tang on thioacetamide (TAA)-induced liver fibrosis in mice and to elucidate its underlying mechanisms. Methods: The mice were divided into 4 groups: Normal mice (Normal), TAA-induced control mice (Control), TAA-induced and silymarin-treated (50 mg/kg) mice (Silymarin), and TAA-induced and Sosiho-tang treated (200 mg/kg) mice (SSHT). Liver fibrosis was induced via intraperitoneal injection of TAA three times a week for 8 weeks. Silymarin and Sosiho-tang were concomitantly administered for 8 weeks. Serum and liver tissues were then collected and the anti-oxidant and inflammatory protein levels in the liver tissues were evaluated using western blotting. Results: SSHT administration significantly reduced the levels of AST, ALT, ammonia, and MPO in the serum. SSHT also significantly down-regulated liver NADPH oxidase and regulated the Nrf2/Keap1 signaling pathway. SSHT treatment downregulated the liver NF-κB levels and suppressed inflammatory cytokines. SSHT treatment also decreased bile acid-related factors, such as CYP7A1 and NTCP, and fibrosis-related factors, such as α-SMA and Collagen I. Conclusions: Taken together, these data suggest that SSHT administration suppressed the progression of liver fibrosis by activating the Nrf2/Keap1 pathway and inhibiting NF-κB.
선로 조류 유지 기법에 근거한 계통축약 및 다변수 제어기법 적용 연구
이병하(Byung-Ha Lee),오민혁(Min-Hyuk Oh),백정명(Jung-Myoung Baek) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.11
The modern enormous electric power system has made power system analysis much more complex and difficult. For effective analysis of the power system, model reduction and aggregation is required. In this paper, a new aggregation method is presented to aggregate the coherent generators in the large scale power system while matching the power flow. In order to demonstrate the effects of this aggregation method, it is applied to a small scale power system. A multi-variable control technique of H<SUB>∞</SUB> control is also applied to enhance the dynamic stability of the aggregated power system.