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림프절의 림프종의 임상적 , 병리적 소견 및 예후 인자
어완규(Wan Kyu Eo),최종수(Jong Soo Choi),김양수(Yang Soo Kim),박병채(Byung Chae Park) 대한내과학회 1995 대한내과학회지 Vol.48 No.4
N/A Objectives: A substantial number of lymphomas arise in various extranodal sites including gastrointestinal tract and Waldeyer's ring rather than in nodal structures. However, systematic studies on clinicopathological features and prognostic factors of extranodal lymphomas are still rare worldwide. Methods: One hundred and fifty-six patients with newly diagnosed extranodal lymphomas in stage I / II seen over a 10-year period at Kosin University Hospital were included. The clinical characteristics, primary sites, and pathological subtypes were evaluated, and overall five--year survival rate and prognostic factors in evaluable patients were determined. Results: 1) The male to female ratio was 1.7: 1, and median age was 48 years. 2) The primary sites were head/neck(51%), gastrointestinal tract(35%), skin(4%), bone(3%), urogenital tract(2%), retroperitoneal soft tissue(2%), and breast, peripheral nerve and spinal cord(1% each) in order. In head/neck areas, Waldeyer's ring was the most common (78%), and in gastrointestinal tract, both stomach(44%) and small intestine(31%) were common sites. 3) The most common histological subtypes were diffuse histiocytic lymphomas(60%) and diffuse poorly differentiated lymphocytic lymphomas(18%). The two subtypes constituted the major subtypes of head/neck as well as gastrointestinal tract. 4) Forty five percent of the patients were stage I, and fifty five percent were stag II. Twenty six percent had B symptoms. 5) The overall 5 year survival rate was 67.5%. The 5 year survival rate of head/neck area was 64.0 %, and that of gstrointestinal tract was 74.0%. But there was no significant difference in survival among major sites(p=0.8990). In methods, chemotherapy only, chemo-radiotherapy and radiotherapy only(p= 0.2776). And in gastroin-testinal tract, there also was no difference in survival among surgical resection with adjuvant chemotherapy, surgical resection with radiation and chemotherapy only in gastrointestinal tract(p = 0.9752). 6) In univariate analysis, age, B symptoms, sex LDH were significant prognostic factors(p=0.0007, 0.0079, 0.0137, and 0.0259 respectively). In multivariate analysis, patients with B symptoms or age over 58 years had poor prognosis(relative risks of 2.45 and 2.73 respectively). Conclusion: The most common sites were head/ neck and gastrointestinal tract in order, and diffuse histiocytic lymphoma constituted the most common histologic subtype. Presence of B symptoms or age over 58 years was poor prognostic factors. Finally, as the number of the patients in this study was not sufficient, and the method was retrospective, large prospective randomized clinical trials are required.
알러젠 제거 옻나무 추출물 투여로 삶의 질 개선과 생존기간 연장을 보인 비소세포성 폐암 환자 1례
유승민,어완규,윤성우,Yu, Seung-Min,Eo, Wan-Kyu,Yoon, Seoung-Woo 대한암한의학회 2008 大韓癌韓醫學會誌 Vol.13 No.1
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Standard treatment such as chemotherapy, radiotherapy, and surgery have many limitations in the treatment of this disease. Therefore, new molecular-targeted therapies needed and being developed. Patients with advanced NSCLC have a short life expentancy; therefore, in addition to increasing their survival, improving their quality of life (QoL) is also an important treatment goal. In this case report, we introduce NSCLC patient treated with Allergen Removed Rhus Verniciflua Stokes(aRVS). In this case, survival time incresed as traditional korean medicine using aRVS. And the general condition of the patient became better. Further case study will be needed in order to determine the effects of aRVS on NSCLC.
조무연,어완규,이상욱,정인철,Cho, Moo Youn,Eo, Wan Kyu,Lee, Sang Uk,Jeong, In cheol Korean Society of Life Science 1995 생명과학회지 Vol.5 No.3
To investigate genomic changes in c-myc gene by a chemical carcinogen, human lymphoblast NC-37 cells were exposed to benzo(a)pyrene(BP) and dimethylbenzanthracene(DMBA), and the c-myc gene expression was evaluated by Northern and Southern blot hybridization techniques. The results are as follows: When the genomic DNA of NC-37 cells exposed to several concentrations(1.25, 2.5 and 5ug/ml) of BP concentration. However, the c-myc gene was most significantly enhanced with 2.5ug/ml of BP. The expressions of c-myc gene in NC-37 cells was stimulated by BP and DMBA. Addition of TPA reduced the gene expression BP-treated cells, whereas it enhanced the gene expression in DMBA-treated cells. The expression of c-H-ras gene was slightly increased by treatment with BP and DMBA alone and in combination with TPA, however the magnitude of increase was not significantly different between each other. The expressions of c-myc c-H-ras genes in Burkitt's lymphoma cells were greater than those in NC-37 cells. When the DNA extracted from NC-37 cells exposed to various concentrations of BP were amplified by polymerase chain reaction using a primer set containing c-myc exon I, the amplified products were of the same size in all groups. To evaluate the BP toxicity in E.coli to which human c-myc gene-cloned pBR322 vector was inserted, Southern blot hybridization was conducted on c-myc genes digested with EcoRI/HindIII and Smal/Xbal restriction enzymes, and observing that in 2 ug/ml BP-treated cells a 3.5kb fragment was generated in addition to 1.3kb fragment which can be observed in normal cells. Direct nucleotide sequence analysis of polymerase chain reaction products showed a mutation of G$\longrightarrow$A transition at the Smal recognition site.
폐경기 여성에서 저용량 에스트로겐 대체요법으로 인한 지질대사의 변화에 관한 연구
김흥열(Heung Yeol Kim),어완규(Wan Kyu Eo) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.8
목적 : 실험대조군 연구를 통해 폐경 후 여성에서 저용량 에스트로겐의 지질 효과를 알아보고자 하였다. 연구 대상 및 방법 : 2000년 3월부터 2002년 3월까지 고신대학교 복음 병원 산부인과 외래를 방문하여 자궁의 양성 질환으로 자궁적출술을 시행 받은 여성 중 에스트로겐 제재로만 0.625 ㎎의 에스트로겐 보충요법을 1년간 시행받은 75명의 폐경여성 (1군)과 0.31 ㎎의 저용량 에스트로겐 보충요법을 1년간 시행받은 55명의 폐경여성 (2군)을 대상으로 하여 치료 시작전, 치료 6개월 후, 치료 12개월 후 혈청 지질을 측정하였다. 결과 : 1군, 2군 두군 모두 기저치에 대한 혈중 총 콜레스테롤 농도의 비는 투여기간 내내 감소하였으나 유의한 차이는 없었다. 1군, 2군 두군 모두 기저치에 대한 혈중 중성지방 콜레스테롤 농도의 비는 투여기간 내내 증가하였으나 통계적으로 유의한 차이가 없었다. 1군, 2군 두군 모두 기저치에 대한 혈중 HDL 콜레스테롤 농도의 비는 투여기간 내내 증가하였으며, 유의한 증가를 보였다 (p<0.05). 1군, 2군 두군 모두 기저치에 대한 혈중 LDL 콜레스테롤 농도의 비는 투여기간 내내 감소하였으며, 유의한 감소를 보였다 (p<0.05). 결론 : 저용량 호르몬 대체요법은 패경증상의 치료와 심혈관질환 예방에 어느 정도 안전하고 효과적인 치료방법으로 기존의 용량보다 부작용의 빈도가 낮아 치료의 순응도를 높일 수 있는 효과적일 것으로 생각한다. Objective : To evaluate the effects of low dose estrogen replacement therapy on the lipid profile in the postmenopausal women. Methods : This prospective randomized clinical trial examined the effects of low dose conjugated equine estrogen on lipid profile in 140 postmenopausal women. Treatment included 0.625 mg conjugated equine estrogen (group I, n=75), or 0.31㎎ conjugated equine estrogen (group Ⅱ, n=55) for 12 months, Lipid profile were performed at months 6 and 12 months. Results : HDL cholesterol increased significantly during the treatment in Group I and Group Ⅱ. LDL cholesterol decreased significantly during the treatment in Group I and Group Ⅱ. Total cholesterol in Group I and Group Ⅱ decreased during treatment, but not significantly. As triglyceride increased slightly during the treatment in Group I and Group Ⅱ but not significantly. Conclusion : The low dose conjugated equine estrogen is also positive changes on lipid profile.
이석권(Suk Kwon Lee),어완규(Wan Kyu Eo),최철준(Chul Joon Choi),조정휘(Chung Whee Choue),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),송정상(Jung Sang Song),배종화(Jong Hoa Bae) 대한내과학회 1990 대한내과학회지 Vol.39 No.2
N/A To access the hypothesis that left atrial enlargement as measured by echocardiography is the earliest sign of cardiac dysfunction in patients with systemic hypertension alone, we underwent M-mode echocardiography in 13 normal controls and 31 hypertensive patients who have neither quantitative evidence of left ventricular hypertrophy by noninvasive techniques, nor other causes of left atrial enlargement, such as coronary artery or valvular hart disease. The results were as follows: 1) There were no significant differences in left ventricular end-systolic and end-diastolic dimension, left ventricular mass, ejection fraction, or fractional shortening. 2) The left atrial dimension in the hypertensive patients (1.98±0.51cm) was significantly higher than normal control (3.27±0.46 cm) (p<0.05). 3) The left artial index was also higher in the hyper-tensive patients, 1.99±0.36cm/m² versus 2.42±0.39cm/m² (p<0.05), and the left atrial-to-aortic root dimension ratio was significantly higher in the hypertensive group, 1.10±0.14 versus 1.37±0.39 (p<0.05). The above results suggest that echocardiographic left atrial enlargement may be an early sign of hypertensive heart disease in patients with no other discernible causes of left atrial enlargement.
수술이 힘든 고령의 직장-S상결장암 환자에 대한 알러젠 제거 옻나무 추출물 위주의 한방치료 1례
권은미,정의홍,김경석,정현식,전성하,어완규,최원철,이상헌,Kwon, Eun-Mi,Jeong, Yee-Hong,Kim, Kyung-Suk,Jung, Hyun-Sik,Cheon, Seong-Ha,Eo, Wan-Kyu,Choi, Won-Cheol,Lee, Sang-Hun 대한암한의학회 2010 大韓癌韓醫學會誌 Vol.15 No.1
We report a case of an 85-year old man with an adenocarcinoma of the rectosigmoid colon (clinical stage II). Though tumor was resectable, the patient was considered to be inoperable because of old age and comorbidities such as asthma, diabetes and old myocardial infarction. He wanted to receive alternative care, so he was exclusively treated with standardized Allegern-removed Rhus verniciflua Stokes (aRVS) extract and other herbal medicine such as BOJUNGIKGI-TANG GAMIBANG. During 18 months, he has shown good performance status without transfusion. This report suggests that herbal treatment including standardized aRVS for rectosigmoid colon cancer could be an alternative treatment option when it is unabled to be treated by surgical resection.
김은희,서영광,김달래,고병희,전성하,어완규,최원철,이수경,Kim, Eun-Hee,Seo, Young-Kwang,Kim, Dal-Lae,Koh, Byung-Hee,Cheon, Seong-Ha,Eo, Wan-Kyu,Choi, Won-Cheol,Lee, Soo-Kyung 사상체질의학회 2007 사상체질의학회지 Vol.19 No.2
1. Objectives In this case report, We report a case of advanced non-seminomatous germ tell tumor(NSGCT) of the testis to retroperitoneal lymph node. We successfully managed with sasang medical treatment. 2. Methods We treated a man with NSGCT of testis with retroperitoneal lymph node metastasis. We evaluated pain grade by VAS(visual analogue scale). and fever grade by body temperature(by axillary thermometer) 3. Results Pain and fever were improved with the Sasang constitutional medicine. 4. Conclusions Cancer pain and fever was markedly improved by Sasang Constitutional management. Further studies are needed to evaluate the cause of the improvement.