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속명탕(續命湯)이 C6 glial cell 보호 및 허혈성 뇌손상에 미치는 영향
안가영,최은희,김인수,강성순,이영수,홍석,전상윤,An, Ga-Yong,Choi, Eun-Hee,Kim, In-Soo,Kang, Seong-Sun,Lee, Young-Soo,Hong, Seok,Jeon, Sang-Yun 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1
Objectives : Sokmyeung-tang(SMT) has been used for treatment of CVA in traditional oriental medicine, so this study was designed to evaluate the effect of SMT's protection on brain cell damage against the oxidative stress that was affected by CVA, We also investigated the effect of motor function improvement and neurotrophic factor in ischemic cerebral damaged rats. Methods : We measured cell viability after administrating SMT, chemicals(Paraquat, SNP, rotenone, and $H_2O_2$) which cause oxidative stress, and both SMT and chemicals. We carried out neurobehavioral evaluation(Rotarod test, Beam-walking test, postural reflex test) and observed BDNF (brain-derived neurotrophic factor) expression by injecting SMT into ischemic cerebral damaged rat. Results : Through this study, we observed the following three results. First, brain cell death caused by paraquat, rotenone, and $H_2O_2$ significantly decreased with the treatment of SMT. Second, neuronal movement function in ischemic cerebral damaged rats was significantly improved by the treatment of SMT. Third, BDNF in ischemic cerebral damaged rats increased with the treatment of SMT. Conclusions : SMT protects brain cells from damage induced by oxidative stress (Paraquat, rotenone, $H_2O_2$). SMT also improves neuronal movement function and increases BDNF in ischemic cerebral damaged rats.
유풍양영탕(愈風養營湯)이 정상 흰쥐의 국소 뇌혈류량 및 평균혈압에 미치는 영향(影響)
조국령,안가영,전상윤,Cho, Gook-Ryung,An, Ga-Yong,Jeon, Sang-Yun 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.2
Objectives: The present study was carried out to investigate the effects of Yupoongyangyeong-tang(YYT) on changes of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. In addition, the author also investigated action mechanisms of YYT on changes in rCBF and MABP. Methods and Results : In this study, treatment with YYT elevated rCBF in a dose-dependent manner, but MABP levels were elevated only in the 10 mg/ml treatment group. Pre-treatment with indomethacin. an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. Pre-treatment with methylene blue, an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by YYT, too. In addition. pre-treatment with indomethacin also inhibited increase of MABP. However, pre-treatment with methylene blue did not affect MABP levels. Conclusion : These results suggest that YYT is useful to treat patients with diseases related to cerebral ischemia, because YYT can increase rCBF. In addition, the mechanisms are thought to be related to both cyclooxygenase and guanylate cyclase.
천마구등음가감(天麻鉤藤飮加減)이 고혈압 유관인자 및 SHR 병태모델에 미치는 영향
송병용,최은희,정태산,강성순,안가영,김오영,전상윤,홍석,Song, Byoung-Yong,Choi, Eun-Hee,Jung, Tae-San,Kang, Seong-Sun,An, Ga-Yong,Kim, Oh-Young,Jeon, Sang-Yun,Hong, Seok 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3
Objectives : This study was examined to investigate the effects of Cheonmagudeng-um gagam (CGG) extract on spontaneous hypertension. Methods : For the study of CGG, we divided rats into three groups. The normal group was Wister Kyoto rats (WKY). The control group was spontaneously hypertensive rats (SHR). The treatment group was SHR which were administered CGG extract (SHR-CGG). SHR-CGG were orally administered CGG extract that was diluted in distilled water at the various concentrations for 4 weeks (234.5 mg/kg) and SHR were orally administered the same dosage of plain distilled water as SHR-CGG. Then we measured anti-oxygen effects, ACE inhibitory activity, weight of heart and kidney, blood pressure, heart rate, plasma aldosterone, electrolyte, creatinine, uric acid, BUN, and observed the cortex of the cardiac muscle, kidney, and adrenal gland. Results : CGG increased DPPH scavenging activity and SOD similar activity depending on the concentration. CGG significantly decreased ROS, TNF-${\alpha}$, IL-6, IL-$1{\beta}$, heart weight, blood pressure, heart rate, aldosterone, and BUN in SHR. CGG increased ACE inhibition activity depending on the concentration. CGG inhibited the heart, kidney and adrenal gland tissue injury that is caused by hypertension. Conclusions : These results suggest that CGG is effective in treatment and prevention of hypertension.
가미통성산(加味通聖散)이 자발성 고혈압 흰쥐에 미치는 영향
최은희,임대웅,정태산,안가영,천혜선,전상윤,홍석,Choi, Eun-Hee,Lim, Dae-Woong,Jung, Tae-San,An, Ga-Yong,Chun, Hea-Sun,Jeon, Sang-Yun,Hong, Seok 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3
Objective : This study was examined to investigate the effect of Gamitongseong-san(GTS) extract on spontaneous hypertension. Methods : After administering GTS extract to SHR for 4 weeks, we measured anti-oxygen effects, weight of body, heart and kidney, blood pressure, heart rate, aldosterone, catecholamine, electrolyte, uric acid, and BUN. Results : 1. GTS increased 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity and superoxide dismutase(SOD) similar activity depending on the concentration. 2. GTS significantly decreased heart weight in spontaneously hypertensive rat. 3. GTS significantly decreased blood pressure and heart rate in SHR. 4. GTS significantly decreased aldosterone. 5. GTS significantly decreased norepinephrine and epinephrine. 6. GTS significantly decreased $K^+$. 7. GTS significantly decreased BUN. Conclusions : These results suggest that GTS may be usefully applied for the treatment of hypertension.
도인승기탕(桃仁承氣湯)을 투여한 흉요추 압박골절 치험 1례
조희근 ( Hee Guen Jo ),추민규 ( Min Kyu Chu ),박수곤 ( Soo Gon Park ),양미성 ( Mi Sung Yang ),안가영 ( Ga Yong An ),강성인 ( Seong In Kang ),이유진 ( You Jin Lee ),최진봉 ( Jin Bong Choi ) 한방재활의학과학회 2009 한방재활의학과학회지 Vol.19 No.3
Objectives: The Purpose of this study was to investigate the clinical application of traditional Korean herbal therapy to a patient with thoraco-lumbar compression fracture. Methods: The patient who had sudden low back pain, back pain and ambulation disorder due to pain caused by an accidental fall, we prescribed Doinseunggi-tang (Taorenchenqi-tang) for her with acupuncture therapy. And we adopted several scales to estimate to progress of her symptoms. Results: Soon after taking herbal medication with other treatments, the patients pain was controlled and was able to ambulation without pain. Conclusions: In this case, we assume that Doinseunggi-tang(Taorenchenqi-tang) play an important role in improvement of the patient`s symptoms. So, the present results suggest that traditional Korean herbal therapy has the positive effect to reduce the pain and shortening the period of treatment.