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NO(Nitric Oxide)가 생쥐의 배 발달에 미치는 영향
민부기,김기석,이희섭,홍기연,신형도,성연경,김형민,Min, Bu-Kie,Kim, Kie-Suk,Rhee, Hee-Sub,Hong, Gi-Youn,Shin, Hyeong-Do,Sung, Yeon-Kyeong,Kim, Hyung-Min 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.2
Objective: To ananlyze the direct effect of nitric oxide (NO), generated from sodium prusside (SNP) on the embryo developments in reproductive process. Design: Ova from mouse were treated to allow fertilization in in vitro culture. And the samples of fertilized ova were alloted into five alliqutos. Each alliquot was cultured in media treated with either concentration at 0 (n=92), $25{\mu}M$ (n=84), $50{\mu}M$ (n=80), $100{\mu}M$ (n=77), $500{\mu}M$ (n=54) of SNP. Main Outcome Measure: Rates of embryonal cell cleavages, viability and cell morphology were assessed during in vitro fertilization and culture. Results: As analyse the cell cleavage at 24 hours after in vitro culture of fertilised egg in variuos NO concentration, all of egg cells of each alliquot were developed to $2\sim4$ cell stage. But the alliquot of egg cells treated with $50{\mu}M$, which were totally degenerated. And also all embryonal cells of each alliquot were developed to 8 cell stage and morula stage on culture continuosly. And the embryonal cells of each alliquot were analysed at 24 and 48 hours following the in vitro culture. The rates of cell fragmentation and fusion were $4.2{\pm}3.4%$ in control group which is not treated with NO, while experimental groups was high, as rated $23.4{\pm}6.2%$ in $25{\mu}M$, $28.2{\pm}5.7%$ in $50{\mu}M$ and $32.1{\pm}6.4%$ in $100{\mu}M$ concentration of NO. Accordingly the rate of abnormal morphology of embryonal cell in control was lower significantly than that in each alliquot of experimental groups (p<0.05). And the degenerated rates of embryonal cells were 0% in control, $17.8{\pm}6.7%$ in $25{\mu}M$, $23.6{\pm}4.7%$ in $50{\mu}M$ and $26.8{\pm}11.2%$ in $100{\mu}M$ at 8 cells and morula on culture of 48 and 72 hours. On the examination of embryonal cells developed to blastocyst through in vitro culture, the rates of degenerated cells were $16.8{\pm}7.2%$ in control, $37.5{\pm}6.2%$ in $25{\mu}M$, $73.4{\pm}4.6%$ in $50{\mu}M$, 100% in $100{\mu}M$. Conclusion: This results suggeted that the NO in any concentrations is harmful on embryos in view of morphology as well as viability of cell, and the toxicity of NO on embryo is stronger at condition in higher concentration of NO.
신형도,박형진,김홍곤,한원철 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1
Mucinous tumor are cystic tumors with loculus lined with mucin-secreting epithelium constitute approximately 8-10% of primary epithelial ovarian tumors. Of all mucinous neoplasms, 75-85% are benign. It is often reach very large size particularly with the benign counterpart being reported on occasion to have exceed 100 lbs. Malignancy develops in 5-10% of benign mucinous cysts. About 15-20% of neoplasms are bilateral. We experienced a huge ovarian mucinous tumor of 155 ㎏. measured 42 × 30 × 28 ㎝ in size, and the volume of cystic contents was about 10 L in a nulligravida 36-year-old woman. Pathologic diagnosis was moderately differentiated mucinous cystadenocarcinoma of right ovary. So, we presented with a brief review of literatures.
자궁경부에 발생한 Glassy Cell Carcinoma 1례
이봉주,신형도,김흥곤,한원철 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.1
Glassy cell carcinoma of the uterine cervix is very rare and poorly differentiated adenosquamous cell carcinoma. The histologic appearance is distinctive which is characterized by 1) cells with moderate amount of cytoplasm having a ground glass or finely granular appearance, 2) distinct cell mass that stains with eosin and periodic-acid Schiff (PAS), 3) enlarged nuclei with prominent single or multiple nucleoli. Therapy is the same as for invasive squamous cell carcinoma and adenocarcinoma but the therapeutic results were poor. We report a case of glassy cell carcinoma of the uterine cervix.