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위장관 ( 胃腸管 ) : 위궤양 환자에서 Omeprazole 반복 투여시 혈청 Gastrin과 Pepsinogen A치의 변화
김만우(Man Woo Kim),박찬국(Chan Gook Park),전용준(Yong Jun Jeon),신양수(Yang Su Shin),유병전(Byung Jeon Yuh),최성도(Sung Do Choi),서영환(Yong Hwan Suh),노상현(Sang Hyun Noh) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4
N/A The fasting serum gasrin and pepsinogen A levels on oral Omeprazole treatment were observed in 17 patients of gastric ulcer diagnosed by gastrofiberscopy. The fasting serum gastrin and pepsinogen A levels 1 day prior to oral omeprazole treatment, during treatment (1st, 7th, 14th day) and fo]lowing 2 weeks treatment (1st, 7th, 15th day) were monitored respectively and compared each other. The results were as follows. 1) Serum gastrin and pepsinogen A levels during and following the treatment were significantly increased compared to basal gastrin and pepsinogen A levels before treatment each (p<0.01). 2) Serum gastrin levels following the 2 weeks treatment did not change significantly compared to that during treatment. 3) The relationship between the basal serum gastrin levels before treatment and the gasrin levels during the treatment showed positive correlation (r=0.414: p<0.01).
Paraquat 투여 백서에서 Cyclophosphamide와 Dexamethasone의 치료 효과
신정철,신양수,유병전,임현성,정태흥,박찬국,오금탁,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
Paraquat (N,N'-dimethy 1-4,4'bipyrydinium : Gramoxone^(R), a widely used herbicide, is extremely toxic to all green plants and many eukaryotic organisms. In human, paraquat intoxication leads to multiple organ failure, it preferentially damages the lung, kidney and liver and may result in death. The participation of superoxide in initiating tissue damage by administration of paraquat is well known in which one electron reduction of paraquat leads to the formation of radical species which react with molecular oxygen to give superoxide. This process initiates immunological changes with the activation of neutrophilic leukocytes, which is related to further production of superoxide. In this experiment, therapeutic effects of cyclophosphamide and dexamethasone on blood cell count, malondialdehyde as a indicator of lipid peroxidation, and antioxidant enzymes levels in the lung, liver and kidney of paraquat intoxicated rats were inbestigated. The WBC count were significantly decreased by combined treatment of cyclophosphamide and dexamethasone in paraquat intoxicated rats at 3 and 5 days but RBC count were not changed. The contents of malondialdehyde were significantly decreased in the lung and Kidney by combined treatment at 10 days after paraquat intoxication. The catalase acitvities were markedly increased in the lung and liver of rats at 10 days after paraquat intoxication, and superoxide dismutase activities showed minimal changes in the lung, liver and kidney of rats by combined treatment. These results suggest that paraquat induced tissue damage in rats can be redeced by combined administration of cyclophosphamide and dexamethasone.
만성 활동성 간염에 병발한 재발성 Guillain-Barre´ 증후군 1예
임현성,신양수,김원민,최성도,정태홍,김만우,조경원,정원영 대한내과학회 1993 대한내과학회지 Vol.44 No.2
저자등은 간 생검으로 밝혀진 41세된 만성 활동성 간염환자에서 발생한 사지마비 및 호흡마비등의 증세등이 뇌척수액 소견과 전기생리학적 소견이 GBS와 부합되고, 간염의 악화-호전과 경과를 같이하는 양상을 보였기에 보고하는 바이다. Guillain-Barre syndrome complicating chronic active hepatitis is rare. In its antecedent and associated illness, various viral infections are commonly involved (esp. viral hepatitis). A classic features that allow diagnosis of GBS is ascending symmetrical weakness, areflexia, minimal sensory loss, and albuminocytological dissociation in CSF. A number of neurological complications of viral hepatitis have been reported, including hepatic coma, hemorrhages into the CNS, both subdural and intraparenchymal. encephalitis, meningitis, myelitis, isolated pyramidal tract and extrapyramidal tract dysfunction, Meniere's disease, dermatomyositis, seizures, mononeuritis, plexitis, and psychiatric disturbances. But there were no reports about GBS complicating chronic active viral hepatitis in Korea until now. We report a case of GBS complicating chronic active hepatitis in a 41-year-old male.