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      • KCI등재

        꿀벌의 독에 의한 생쥐 피부의 조직병리학적 및 미세구조적 변화

        신상희,정문진,문명진,Shin, Sang-Hee,Jeong, Moon-Jin,Moon, Myung-Jin 한국현미경학회 1997 Applied microscopy Vol.27 No.2

        꿀벌(Apis mellifera)의 독에 의해 야기되는 포유동물 피부의 조직병리학적 및 미세구조적 변화와 그 수복과정을 확인하기 위하여 실험용 생쥐의 피부에 직침법으로 꿀벌의 독을 주입한 후, 회복된 시점까지 일정시간 간격으로 조직의 표본을 제작하여 광학 및 전자현미경으로 관찰하였다. 독 주입 직후의 표본에서는 표피의 상피세포와 진피의 결합조직에서 현저한 염증반응이 유도되었고, 일부세포의 괴사가 관찰되었다. 고배율의 전자현미경상에서 교원섬유의 직경이 크게 증가되었으며, 면역 단백물질로 추정되는 전자밀도가 높은 grain의 침착이 확인되었다. 이러한 조직병리현상은 독 주입 후 12시간이 경과된 조직의 표본에서 서서히 회복되는 것으로 관찰되었다. 봉침 주위 피부조직의 조직학적 및 미세구조적 변화는 수 일간 지속되었으나, 병리학적 반응은 3일 이내에 거의 거의 소멸되는 것으로 관찰되었다. 또한 생쥐 피부에 대한 꿀벌 독의 병리반응은 다른 절지동물의 독에 비하여 비교적 경미한 것으로 확인되었다. Histopathological and fine structural changes in mouse skin after injection of venoms extracted from the venom glands of the honeybee, Apis mellifera, were studied with light and electron microscopes. At this experiment the venoms were directly injected at the hairless abdominal skin of the mouse through the sting of the bee's venomous organ. Main changes appeared within one hour after injection at both epithelial and connective tissues as considerable hyperemia and angioedema, and slight edema and fibrosis. High magnified electron micrographs reveal not only increase of diameter but also deposition of electron dense grains (which seems to be an auto immunoglobulin) at the collagenous fibers characteristically. This kinds of histological and fine structural responses were diminished from 12 hour after injection, and the pathological symptoms disappeared within 3 days at most cases. So, the skin responses induced by honeybee venom seem to be not severe compare to other cases reported by other venomous arthropods.

      • 교통-대기질 연계데이터 구축 및 관리 활용방안 연구

        신상희 ( Sang Hee Shin ),고준호 ( Joon Ho Ko ),이세희 ( Se Hee Lee ),최유진 ( Yu Jin Choi ) 서울시정개발연구원 2008 연구보고서 Vol.2008 No.27

        Road vehicles have long been identified as major contributors to the urban air pollution; this can be applied to Seoul. As a consequence, Seoul Metropolitan Government has introduced various schemes to reduce traffic-related air pollution, not giving noticeable improvement of air quality. It is by no means simple and easy to evaluate the effectiveness of traffic-related policies aimed at air quality improvement due to complex and nonlinear nature of air pollutants. It can be done only from systematic analyses of traffic and air pollution monitoring data and information. Currently, both traffic and air pollution monitoring networks have been operated in Seoul with their own purposes. In this study, the existing traffic and air pollution monitoring networks were investigated if the both the monitoring systems could be linked in order to understand the relations between transport emissions and air pollutant concentrations in depth and to evaluate the effectiveness of traffic-related policies. Furthermore, effective and efficient approaches to linking traffic and air monitoring data have been sought. Main results and suggestions from this study are as follows. 1. Correlation analysis of traffic and air pollution data from existing traffic and air pollution monitoring networks Initially, the traffic monitoring network was set up to check traffic flow, while air pollution monitoring network was set up to investigate air quality over the space people reside in. Hence, the monitoring sites of the both systems are not co-located. The shortest distance between current traffic and air pollution monitoring sites is around 340m, implying a fundamental limitation in simply linking the existing traffic and air pollution monitoring network systems. With this limitation in mind, various correlation analyses between the hour-by-hour concentrations of PM10, CO and NOx (NO & NO2) and traffic volumes, collected at the existing air and traffic monitoring sites for recent three years, have been carried out. The finding is that only NOx at a few sites show statistically meaningful correlations with traffic volume during the morning hours of 6 am to 9 am. Hence, we conclude that simple correlation analyses using data from current traffic and air pollution monitoring systems may not provide a direct answer to whether a potential traffic-related policy is effective in mitigating air pollution levels. 2. Approaches to linking traffic and air pollution monitoring data Foreign cases to link traffic and air pollution monitoring data have been reviewed, revealing that in most cases long-term co-located traffic and air pollution monitoring sites have been operated to investigate the relation between traffic and air pollution. From the careful review of the cases, following suggestions are made. 1) Short-term approaches Mobile monitoring stations, equipped with devices of both air pollution and traffic monitoring, should be prepared and deployed wherever and whenever needed. The traffic monitoring items must include not only traffic speed and volume but also the vehicles` body and fuel types. Traffic information collected by vehicle type and fuel type can be used for in-depth evaluations of traffic-related measures applied to specific vehicle type or fuel type. In addition, the greenhouse gases need to be monitored, considering the increasing interest in global warming. Firstly, the long-term co-located traffic and air pollution monitoring should be introduced to identify the relation of vehicle emissions and air pollution in more details. The location and items to be monitored should be carefully investigated in advance. The monitoring location may be selected using various modeling tools so that the estimation of the possible impacts of traffic-related policies on the air quality over the area of interest can be performed. Secondly, traffic management systems with air quality monitoring feedback should be developed in the future. To make it happen, a flexible framework allowing communications between transport emissions and traffic conditions needs to be developed by introducing a system providing high time/space resolution measurements of both air pollutant concentrations and traffic conditions on a real-time basis.

      • KCI등재

        현장조사를 통한 1인당 업무공간의 적정 면적 제안

        신상희(Shin, Sang-Hee),문수영(Moon, Soo-Young) 대한건축학회 2014 대한건축학회논문집 Vol.30 No.8

        In this study, we compared and analyzed the domestic and foreign working space area standards and domestic development condition to provide the applicable optimized area of working space per person. Using field surveys combined with literature search, the layout of surveyed business facilities and the area of each space were analyzed through collected drawings and field measurements. The working space was divided into personal exclusive space (area for exclusive use) and public space. Through the survey of domestic and foreign area standards, it was found that the working space area per person of our country itself was not small. However unlike the foreign cases, the areas to be included in the public space were included in the personal exclusive space in our country. Also the field survey revealed the space provided to an individual was about 8~9㎡ in which only 2~3㎡ belonged to the personal exclusive space. Therefore, we proposed per 8.5㎡ in the optimal business facility area plan by reflecting the development condition of including various public areas in the working space area per person.

      • KCI등재

        정수처리공정에서의 입자분석 적용방안

        신상희 ( Sang Hee Shin ),전현숙 ( Hyun Sook Jeon ),이찬형 ( Chan Hyung Lee ),배기수 ( Gi Soo Bae ) 한국물환경학회 2013 한국물환경학회지 Vol.29 No.3

        The particle counter compared with the turbidimeter provides good precision and sensitivity and can get the characteristics of particulates effectively. The purpose of this study is to provide the application of particle counter in sand and activated carbon filters. The particle count by size could be more easily sense when the water quality is changed by the influent of high turbidity or algae. We could decide the optimal backwashing cycles and detect the efficiencies of filters by monitoring the total particle count of effluent in sand and activated carbon filters.

      • 3D 프린팅을 이용한 무기체계 정비지원장비 개발을 통한 운용성 향상방안

        신상희(SANG HEE.SHIN) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4

        최근 과학기술정보통신부는 국내 제조산업의 경쟁력 강화를 위해, 3D 프린터를 활용한 양산공정 개발을 지원하는 ‘2021 년 3D 프린팅 제조혁신 실증지원 사업’을 추진한다. 이전에 연구용 시제품 제작 위주로 사용된 기술을 확장해 핵심부품 생산 공정기술을 확보하고, 부품/장비 경쟁력을 강화하기 위함이다. 실제로 과학기술정보통신부는 지난 해 강도/정밀도 등 주요 성능이 최종 목표치의 80%이상 달성하며 기술의 발전을 보여주었다. 그러나 무기체계 개발에 있어서는 아직까진 3D 프린팅을 사용한 개발방식은 활성화되지 않았다. 짧아진 개발기간동안 MIL SPEC을 준용하는 무기체계의 환경조건과 품목의 안전성 보장 등 신뢰성에 대한 검증이 완전히 이루어지지 않아, 제품 개발의 실패요소를 줄이기 위하여 이 기술을 적용하는 것을 망설이게 된다. 3D 프린팅 기술을 이용한 장비 개발에 대한 장점을 활용하기 위하여 본 논문에서는 장비운용에 큰 SPEC 이 요구되지 않으며, 파손 위험 등의 영향을 덜 미치는 정비장비를 개발할 때, 3D 프린팅 기술을 이용한 장비의 운용성 향상방안을 제시하였다. 소재 변경을 통한 운용성 강화 방안과, 제작 방법을 통한 운용성 강화 방안이다. 실 예로, 안테나 차폐장치 개발을 통해 무게 감소, 비용절감 등 운용성 향상을 확인하였다. 가혹한 환경조건과 긴 수명을 요구하는 무기체계 개발에 민수의 적용하기 위해서는 기술의 발전과 많은 시험을 통한 기술의 능력을 증명해야 하는데, 3D 프린팅을 이용한 정비지원장비 개발을 통한 시행착오를 통하여 점차 무기체계에도 적용할 수 있을 거라 기대해본다. Recently, the Ministry of Science and ICT will push for a 2021 3D printing manufacturing innovation demonstration support project that supports the development of mass-production processes using 3D printers to strengthen the competitiveness of the domestic manufacturing industry. It aims to secure core parts production process technologies by expanding technologies that were previously used to produce prototypes for research purposes and strengthen competitiveness of parts/equipment. However, the development method using 3D printing technology is not applied yet in the development of weapons system development. This is because the verification of reliability, such as environmental conditions and safety guarantees of the items of the weapon system with Mil-spec, has not been completed during the shorter development period. Therefore, developers are hesitant to apply this technology to reduce the failure of development. In order to utilize the advantages of 3D printing technology, this paper proposed measures to improve the operability of equipment using 3D printing technology when developing maintenance support equipment that is not required for equipment operation and is less affected by damage risk. It is a measure to strengthen operability through material change and to strengthen operability through manufacturing methods. For example, the development of antenna shielding devices confirmed operational improvements such as weight and cost reduction. In order to apply Industry's technology to the development of weapons systems that require harsh environmental conditions and long life, it is necessary to prove the technology's ability through many tests.

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