소풍탕이 허혈성 뇌손상 흰쥐의 인지 및 운동기능회복에 미치는 효과

추민규 ( Min Gyu Chu ),최진봉 ( Jin Bong Choi ),신미숙 ( Mi Suk Shin ),김선종 ( Sun Jong Kim ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.2

Objectives : Sopung-tang(Shufeng-tang) is a famous herbal prescription that treated ischemic brain injury. This study was designed to evaluate the effects of Sopung-tang(Shufeng-tang) on congnition and motor function recovery after ischemic brain injury in rats. Methods : Male rats were divided into 4 groups. Those rats caused ischemic brain injury by occlusion of MCA as Longa method. Control groupⅠwas per os normal saline for 7 days after ischemic brain injury. Control group Ⅱ was per os normal saline for 14 days after ischemic brain injury. Experimental groupⅠ(Ex Ⅰ) was taken with Sopung-tang(Shufeng-tang) for 7 days after ischemic brain injury. Experimental group Ⅱ(Ex Ⅱ) was taken with Sopung-tang(Shufeng-tang) for 14 days after ischemic brain injury. The author carried out neurological, cognitive motor behavior tests and histological assessment. Neurological motor behavior tests consist of limb placement test, beam-walking test and horizontal wire test. Morris water maze test was used for cognitive motor behavior test. In the histological assessment test, TTC(2,3,5-triphenylteterazolium chloride) staining, Hematoxylin & Eosin staining and immunohistochemical staining were experimented. Results : 1. In neurological motor behavior tests, motor function recovery was significantly increased in the experimental groups as compared with control groups(p<0.05). Especially Ex Ⅱ was significantly increased as compared with Ex Ⅰ(p<0.05). 2. In Morris water maze test, congnitive motor function recovery was significantly incresed in the experimental groups as compared with control groups(p<0.05). Especially Ex Ⅱ was significantly increased as compared with Ex Ⅰ(p<0.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially most immune reaction was experimented in the Ex Ⅱ. Conclusions : According to the above results, Sopung-tang(Shufeng-tang) can treat on the congnition and motor function recovery after ischemic brain injury in rats. And it is effective method in expression of BDNF in hippocampus.

하악편차 교정을 이용한 통증완화 효과에 대한 보고

김세진 ( Se Jin Kim ),추민규 ( Min Kyu Chu ),신미숙 ( Mi Suk Shin ),김선종 ( Sun Jong Kim ),최진봉 ( Jin Bong Choi ),조현정 ( Hyun Jung Jo ) 대한경락경혈학회 2007 Korean Journal of Acupuncture Vol.24 No.3

Objectives: This study was performed to evaluate the effect of occulsal plane balancing therapy on pain control without another therapy. Methods: This clinical study was carried out in 6 cases of patients which had neck and shoulder pain. In this study we treated the patients by balancing therapy of occulsal plane using paper. We measured Visual Analogue Scale(V.A.S.) for pain intensity, Range of Motion(R.O.M.) and difference of thermographic temperature between pain site and the opposite before and 15 minutes after treatment and analyzed the change of variables. Also, we analyzed the correlation among hypomovable site of neck rotaion(HS), pain site(PS) and thick site of paper(TS). Results: 1. The average of skin temperature was decreased from 0.45±0.11 to 0.24±0.13 significantly(p<0.05). 2. The average of V.A.S was decreased from 10.00±0.00 to 3.83±0.99 significantly (p<0.05). 3. In the correlation analysis among HS, PS and TS, there is negative correlation between HS and TS, but there was no statistical significance. Conclusions: In the study, the balancing therapy of occulsal plane warrants further investigation in the change of skin temperature and R.O.M. of the joint, pain control.

양혈장근건보탕(養血壯筋健步湯)과 전침의 병용치료가 손상된 척수신경 및 운동기능에 미치는 영향

설재욱 ( Jae Uk Sul ),추민규 ( Min Kyu Chu ),김선종 ( Sun Jong Kim ),최진봉 ( Jin Bong Choi ),신미숙 ( Mi Suk Shin ),김수익 ( Soo Ik Kim ) 한방재활의학과학회 2009 한방재활의학과학회지 Vol.19 No.2

Objectives: The purpose of this study was to investigate the effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang, YGKT) and electrical acupuncture treatment in spinal cord injury(SCI)-induced rats. Methods: The subjects were divided into 5 groups ; Normal, Control-no treatment after SCI, Experimental 1(Exp. 1)-taken with YGKT 500 ㎎/㎏ 0.5 ㎖ daily after SCI. Experimental 2(Exp. 2)-taken with electrical acupuncture after SCI and Experimental 3(Exp. 3)-taken with YGKT 500 ㎎/㎏ 0.5 ㎖ and electrical acupuncture after SCI. After each operation, the present author observed cytological changes, the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, EMG, hematological(AST, ALT, WBC), histological and immunological changes. Rats were tested by Motor behavior test at 1st, 3rd, 7th, 14th and 21st day. Results: 1. All the experimental groups were improved compared with control group in the motor behavior tests including Tarlov test, Basso-Beattle-Bresnahan locomotor rating scale, modified inclined plane test, open field test, grid walk test and narrow beam test. Especially Exp. 3 was significantly improved among other groups. 2. In EMG test, H and M wave were significantly increased in Exp. 3. 3. All the experimental groups were significantly decreased compared with control group in AST, ALT and WBC. 4. NGF, BDNF and Trk B of spinal cord gray matter in all the experimental groups were increased compared with control group. Especially, Exp. 3 was more effective. 5. In histological observations, muscle contraction and denaturation of gastrocnemius muscle of all the experimental groups were inhibited. Especially, those of Exp. 3 was more effective. On the observations of liver and kidney, cell atrophy and apoptosis of all the experimental groups were decreased compared with control group. Especially, those of Exp. 3 was more effective. Conclusions: It can be suggested that YGKT and electrical acupuncture may improve motor behavior, EMG, hematological, histological and immunological findings in SCI-induced rats. Especially, combination of these two treatments will be somewhat better in spinal nerve recovery and motor function improvement.

소아 성장에 미치는 한방요법의 임상적 효과 및 성장 진단척도로서의 골밀도 평가

김세진 ( Se Jin Kim ),고홍개 ( Min Kyu Chu ),최진봉 ( Jin Keun Han ),추민규 ( Hong Gae Ko ),한진근 ( Mi Suk Shin ),신미숙 ( Sun Jong Kim ),김선종 ( Jin Bong Choi ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.2

Objectives : The aim of the present study was to evaluate the effect of oriental medicine therapy on the growth of children, and to assess the relation of BMD(Bone Mineral Density) and the stature growth during the period of bone growth. Methods : We measured height and weight of the children, percentile of the growth by using the growth curve, BMD and bone age by using Osteoimages Plus. We treated the children with acupuncture, herbal acupuncture, herbal medication, physical therapy. Then we measured difference of height and percentile change of the children. Results and Conclusions : 1. According to sexual type, percentile change of the growth is higher in the female. 2. According to age group, percentile change of the growth is higher in period Ⅱ(Male;11-14, Female;10-12). 3. According to treatment group, percentile change of the growth is higher in acupuncture and herbal-acupuncture, herbal-medication treated group. 4. According as BMD increases, BMI(Body Mass Index) were ascending significantly.

황구침법(黃丘鍼法)을 이용한 고혈압 환자의 혈압강하 효과에 대한 증례보고

한창현 ( Chang Hyun Han ),황치원 ( Chi Won Hwang ),신미숙 ( Min Suk Shin ),신선화 ( Seon Hwa Shin ),최선미 ( Sun Mi Choi ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.3

Objectives: The aim of the study was to investigate the antihypertensive effect of Hwang-gu Acupuncture in hypertensive patients. Methods: We measured the blood pressure of the patients who were admitted in the Oriental Medical Clinic of Brother from 25th November 2005 to 27th March 2006. We included the patients only in case of the systolic blood pressure was over 140mmHg or diastolic blood pressure was over 90mmHg, Twenty two patients were treated by Hwang-gu Acupuncture. In order to evaluate the effect of the Hwang-gu Acupuncture, the blood pressure was measured before and after Acupuncture procedure total 4 times, 10times. Results: There were a significant decrease in the systolic blood pressure and significant decrease in the diastolic blood pressure by Hwang-gu Acupuncture 4 times. The effect of Hwang-gu Acupuncture by measurement time on blood pressure were follows: In a systolic blood pressure was gradually deceased significantly from 1st to 4th but diastolic blood pressure was significantly decreased after 2nd and 4th only. Conclusions: These results suggest that Hwang-gu Acupuncture is effective in decreasing the systolic and diastolic blood pressure.

폐경 후 여성의 전단계 및 1기 고혈압에 대한 침 치료: 다기관 무작위 대조 예비연구

김정은 ( Jung Eun Kim ),최진봉 ( Jin Bong Choi ),김형준 ( Hyeong Jun Kim ),강경원 ( Kyung Won Kang ),류연 ( Yan Liu ),정희정 ( Hee Jung Jung ),이민희 ( Min Hee Lee ),신미숙 ( Mi Suk Shin ),김재홍 ( Jae Hong Kim ),최선미 ( Sun Mi 경락경혈학회 2014 Korean Journal of Acupuncture Vol.31 No.1

Objectives: This study aims to evaluate the effectiveness and safety of acupuncture and explore the appropriate number of treatment for postmenopausal women diagnosed with prehypertension and stage 1 hypertension. Methods: A 4-arm randomized open label pilot trial will be performed at 2 centers. Sixty participants will be divided into 2 treatment groups and 2 control groups. Treatment groups will receive acupuncture at 8 points(bilateral GB20, LI11, ST36, SP6) for 4 weeks(treatment group A, 10 total sessions) or 8 weeks(treatment group B, 20 total sessions), while maintaining usual care. Control groups will not receive acupuncture but will be under usual care for 16 weeks(control group C) or 20 weeks(control group D). Each patient`s living habits will be corrected and drugs that may affect blood pressure(BP) will be prohibited. Treatment group A and control group C will be evaluated at 4, 8, 12, and 16 weeks after randomization, while treatment group B and control group D will be evaluated at 4, 8, 12, 16, and 20 weeks after randomization. The major outcome variable is the magnitude of change in diastolic BP levels at 4 weeks after randomization; auxiliary outcome variables are (1) diastolic BP change at 8, 16, and 20 weeks, (2) systolic BP change, (3) BP control rate, (4) lipid profiles, and (5) high-sensitivity C-reactive protein. Patient safety will be assessed at every visit. Results and Conclusions: The study findings may help develop evidence for the effectiveness and safety of acupuncture for BP control.