http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김익수(Ik Su Kim),송옥평(Ok Pyung Song),이민혁(Min Hyuk Lee),허준(Jun Huh) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.6
N/A Primary tumors of the small bowel are relatively rare. Their incidence has been estimated at 3.0 to 6.0% of all gastrointestial tumors. We retrospectively studied 19 patients with primary tumors of the small bowel that confirmed by operation at the Department Sugery of Soon Chun Hyang University Hospital for the period from Jan. 1980 to Dec. 1992. The patients' ages ranged from 5 to 84 years old and the mean age was 53 years old, The ratio of male to female was 2.8:1. The benign tumors of small bowel were leiomyoma (3 patients), adenoma (2 patients), hamartoma (1 patient) and fibrous hitiocytoma (1 patient), and the malignant tumor were lymphoma (7 patients), leiomyosarcoma (3 patients) and undifferentiated carcinoma (1 patient). The location of benign tumors were duodenum (4 patients), jejunum (3 patients), and ileum (1 patient) and the malignant tumors were ileum (6 patient), jejunum (4 patients) and duodenum(1 patient). The most common location of benign tumor was duodenum, but the malignant tumor was ileum. The symtom and sign were abdominal pain, tarry stool and melena, palpable mass, constipation, vomiting, weight loss and hematemesis. The abdominal pain was the most common symptom in the both benign and malignant tumors. The size of the tumor ranged 1 to 10 crn (mean 4 cm) in the benign tumors and 3 to 13 cm( mean 6 cm) in the malignant tumors. The diagnostic procedures performed with contrast radiography, gastrofiberscopy and colonoscopy, ultrasonography and computed tomography but the tumors were found only 47.4% preoperatively. The operative procedures of the malignant tumor were curative resection in 5 patient; and bypass procedures in 3 cases. The postoperative complications were infection, pneumonia, enterocutaneous fistula and intestinal obstruction in 4 patient. In conclusion, poor results of small bowel tumors are probably due to diagnostic delay. Thus, prompt diagnostic studies should be performed in pateint with persistent symptoms and early consideration of laparotomy may be needed for the possibility of malignancy and curative resectior.
이문수,김태윤,조규석,채만규,김성용,백무준,이상한,박경규,김창호,송옥평,조무식,Lee, Moon-Soo,Kim, Tae-Yun,Cho, Gyu-Seok,Chae-Man-Kyu,Kim, Sung-Yong,Baek-Moo-Jun,Lee, Sang-Han,Park, Kyung-Kyu,Kim, Chang-Ho,Song-Ok-Pyung,Cho, Moo-Sik 대한위암학회 2003 대한위암학회지 Vol.3 No.1
Purpose: Genomic alterations and abnormal expression of the fragile histidine triad (FHIT) gene in gastric cancer were examined to determine whether the FHIT gene is actually a frequent target for alteration during gastric carcinogenesis. Materials and Methods: To correlate DNA and RNA lesions of the FHIT gene with the effect on FHIT protein expression, in 40 gastric cancers, we investigated the FHIT gene for loss of heterozygisity (LOH), aberrant transcripts, and protein expression. Results: Allelic loss at D3S1300 was detected in 7 of 38 ($19\%$) informative cases. Aberrant transcripts were observed in 20 of 40 ($50\%$) cases. Significant reduction of FHIT protein expression was observed in 22 of 40 ($55\%$) cases. Aberrant FHIT transcription was shown to be associated with loss of FHIT protein expression. However, aberrent FHIT transcripts themselves were not associated with any clinicopathological parameters, such as age, sex, tumor site, or clinical stage. Moreover, there was no association between the presence of LOH at D3S1300 and the expression of aberrant FHIT transcripts. Conclusion: The high frequency of aberrant FHIT transcripts, the significant rate of LOH at D3S1300, and the altered expression of the FHIT protein indicate that alterations of the FHIT gene can play an important role in gastric carcinogenesis.
이문수,채만규,김태윤,조규석,김성용,백무준,정일권,박경규,김창호,송옥평,조무식,Lee, Moon-Soo,Chae, Man-Kyu,Kim, Tae-Yun,Cho, Gyu-Seok,Kim, Sung-Yong,Baek-Moo-Jun,Chung-Il-Kwon,Park, Kyung-Kyu,Kim, Chang-Ho,Song-Ok-Pyung,Cho, Moo-Sik 대한위암학회 2002 대한위암학회지 Vol.2 No.2
Purpose: Perforated gastric cancer (PGC) is rare and occurs in $1\∼4\%$ of all gastric cancers. Possible dissemination of tumor cells at the time of perforation of the gastric carcinoma has been a matter of concern. The intraoperative determination of what kind of operation should be done and how extensive the lymphnode dissection should be still remains controversial. The purpose of this study is to evaluate the factors influencing the survival and to determine the optimal treatment for PGC. Materials and Methods: A total of 42 patients were operated on for a perforated gastric carcinoma at Soonchunhyang University Chunan Hospital from 1983 to 2000. the age and the sexes of the patients, the location of perforation, the diameter of perforation, the histologic type of the tumor, the depth of wall invasion, the absence or presence of lymph node metastasis / distant metastasis, the stage of disease, the type of operation, and the outcomes were examined. Statistically significant differences were analyzed by using Fisher's exact test. Results: The stage distributions according to the UICC classification were 1 case of stage I, 6 cases of stage II, 17 cases of stage III, and 11 cases of stage IV. An emergency gastrectomy was done in 26 patients ($61.9\%$), with a 5-yr survival rate of $44\%$. The survival of patients was significantly influenced by the depth of wall invasion, the lymphnode metastasis, distant metastasis, the stage of disease, and the type of operation. Conclusions: an emergency gastrectomy is the treatment of choice for most patients with resectable PGC. Choosing more a optimistic surgical approach for potentially curative cases of PGC should be one way to increase the patient's survival rate.