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징하에 응용(應用)되는 귀출파징탕과 가미귀출파징탕의 효능(效能)에 관(關)한 연구(硏究)
송석호,송병기,이경섭,Song, Seog-Ho,Song, Byoung-Key,Lee, Kyoung-Sup 대한암한의학회 1995 大韓癌韓醫學會誌 Vol.1 No.1
The present work was done to investigate the pharmacological effectiveness of Guichoolpajing-Tang and Gamiguichoolpajing-Tang. The extracted water of those two prescription were administered to experimintal animals and determined analgesic, anti-pyretic, anti-inflammatory effects and effects on intravascular coagulation, spontaneous morements of the isolated rat uterus, the uterine contracion induced by oxytocin or $PGF_{20}$, lifespan of mice implanted intraperitoneally with Sarcoma 180. The following results were obtained. 1) The extracted water of Guichoolpajing-Tang and Gamiguichoolpajing-Tang were revealed significant analgesic effect. 2) The extracted water of Guichoolpajing-Tang and Gamiguichoolpajing-Tang showed anti-pyretic effect. 3) The extracted water of Guichoolpajing-tang and Gamiguichoolpajing-Tang showed anti-inflammatory effect. Especially, the extracted water of Gamiguichoolpajing-Tang showed more significant dffect than another. 4) Concerning the degree of concentration of FDP, Gamiguichoolpajing-Tang treated groups tevealed significant decreases. 5) The extracted water of both prescriptions revealed uterus relaxation on the spontaneous movement of the isolated rat uterus and showed uterine contraction induced by oxytocin or $PDF_{2}$. Especially Guichoolpajing-Tang showed more significant effect than another. 6) The extracted water of both prescription both prescriptions showed effect on lifespan of mice implanted intraperitoneally with Sarcoma 180.
한국인에서 Transforming Growth Factor-beta1 유전자의 Codon 10/25에서의 다형성과 간경변, 간세포암과의 관계
권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),정문기 ( Jeong Mun Gi ),박동균 ( Park Dong Gyun ),김선숙 ( Kim Seon Sug ),김연석 ( Kim Yeon Seog ),구양서 ( Gu Yang Seo ),김유경 ( Kim Yu Gyeong ),최덕주 ( Choe D 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: The genetic polymorphism of transforming growth factor-beta1 (TGF-β1) at codons 10 and 25 which influences the production of TGF-β1 is related to fibrogenesis in the lung and liver. We evaluated the genetic polymorphism at codons 10 and 25 in controls and in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Methods: Blood samples were collected from controls (n=35), patients with LC (n=64), and HCC (n=49). Genomic DNA was isolated and polymerase chain reaction (PCR) was done for a segment including codons 10 and 25. The results of direct sequencing for PCR products were compared between the controls and the patients. Results: There was no genetic polymorphism at codon 25 and three types of genetic polymorphism at codon 10. The leucine homozygous genotype (CTG/CTG) at codon 10 was more common in patients with LC than the controls (p=0.01) and especially in patients with LC caused by HBV (p=0.004). The polymorphism at codons 10 in patients with HCC was similar to the controls. However, leucine homozygous genotype was more common in patients with HCC of uninodular morphology than those of massive morphology (p=0.007). Conclusions: The genetic polymorphism of TGF-β1 at codon 10 might be associated with LC and morphology of HCC. The potential usefulness of TGF-β1 genotyping needs further studies in large scale. (Korean J Gastroenterol 2003;42:212-219)
특발성 간질성 폐렴 환자에서 임상적 지표와 혈청 Angiotensin Converting Enzyme(ACE) 및 Angiotensin 2와의 관계
경선영 ( Gyeong Seon Yeong ),한혜숙 ( Han Hye Sug ),송석호 ( Song Seog Ho ),황준규 ( Hwang Jun Gyu ),임영희 ( Im Yeong Hui ),안창혁 ( An Chang Hyeog ),박계영 ( Park Gye Yeong ),박정웅 ( Park Jeong Ung ),정성환 ( Jeong Seong Hwa 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.52 No.5
봉소상 폐(Honeycomb Lung) 소견을 보인 현미경적 다발성 혈관염 2예
한혜숙 ( Han Hye Sug ),황준규 ( Hwang Jun Gyu ),정혁상 ( Jeong Hyeog Sang ),송석호 ( Song Seog Ho ),주권욱 ( Ju Gwon Ug ),박계영 ( Park Gye Yeong ),이종호 ( Lee Jong Ho ),오영하 ( O Yeong Ha ),이현주 ( Lee Hyeon Ju ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.52 No.5
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 만성 B형 간염환자에서 라미부딘 치료 중 HBeAg소실 후 재발에 관련된 인자
최창원 ( Choe Chang Won ),김경오 ( Kim Gyeong O ),권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),김선숙 ( Kim Seon Sug ),최덕주 ( Choe Deog Ju ),김주현 ( Kim Ju Hyeon ),연종은 ( Yeon Jong Eun ),변관수 ( Byeon 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
징하에 應用되는 歸朮破징湯과 加味歸朮破징湯의 效能에 關한 硏究
宋錫鎬,宋炳基,李京燮 대한한방종양학회 1995 대한한방종양학회지 Vol.1 No.1
The present work was done to investigate the pharmacological effectiveness of Guichoolpajing-Tang and Gamiguichoolpajing-Tang. The extracted water of those two prescription were administered to experimintal animals and determined analgesic, anti-pyretic, anti-inflammatory effects and effects on intravascular coagulation, spontaneous morements of the isolated rat uterus, the uterine contracion induced by oxytocin or PGF_2●, lifespan of mice implanted intraperitoneally with Sarcoma 180. The following results were obtained. 1) The extracted water of Guichoolpjing-Tang and Gamiguichoolpajing-Tang were revealed significant analgesic effect. 2) The extracted water of Guichoolpajing-Tang and Gamiguichoolpajing-tang showed antipyretic effect. 3) The extracted water of Guichoolpajing-tang and Gamiguichoolpajing-Tang showed antiinfiammatory effect. especially, the extracted water of Gamiguichoolpajing-Tang showed more significant dffect than another. 4) concerning the degree of concentration of FDP, Gamiguichoolpjing-Tang treated groups tevealed significant decreases. 5) The extracted water of both prescriptions revealed uterus relaxation on the spontaneous movement of the isolated rat uterus and showed uterine contraction induced by oxytocin or PDF_2●, Especially Guichoolpajing-Tang showed more significant effect than another. 6) The extracted water of both prescriptior both prescriptions showed effect on lifespan of mice implanted intraperitoneally with Sarcoma 180.