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동의보감(東醫寶鑑) 중(中) 청피(靑皮)가 주약(主藥)으로 배오(配伍)된 방제(方劑)의 활용(活用)에 대한 고찰(考察)
서범석,기호필,이준서,윤용갑,Seo, Beom-Seok,Ki, Ho-Pil,Lee, Joon-Suh,Yun, Yong-Gab 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2
This report was studied 72 cases studies related to the use of Pericarpium Citri Reticulatae Virdie mainly blended prescriptions from Dongeuibogam. The following conclusion were reached through investigations on the prescriptions that use Pericarpium Citri Reticulatae Virdie as a key ingredient. Prescriptions that Pericarpium Citri Reticulatae Virdie was taken as a monarch drug are utilized for 25 therapeutic purposes, for example, abdominal mass, children disease, malaria and abdominal dropsy. In particular, 13.9% of prescriptions appear in the chapter of abdominal mass, and 12.5% of those appear in the chapter of children. Prescriptions that utilize Pericarpium Citri Reticulatae Virdie as the main ingredient are used in the treatment of abdominal mass, abdominal dropsy, scrotal hernia and malaria. Pericarpium Citri Reticulatae Virdie is used in pathogenic factors such as cold and used in pathology related to the spleen system. The dosage of Pericarpium Citri Reticulatae Virdie is 1bun(about 0.375 gram) to 4jeon(about 15 gram), however 5bun(about 1.875 gram) to 8bun(about 3 gram) has been taken the most for clinical application. Yukmisamleunghwan and Hyungbongjeonwon are the most useful base prescriptions which use the Pericarpium Citri Reticulatae Virdie as the main ingredient.
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Selenium 공급방법이 수경재배 토마토의 생장과 Se 흡수에 미치는 영향
이철규(Cheol-Kyu Lee),조경철(Kyung-Cheol Cho),이정현(Jeong-Hyun Lee),조자용(Ja-Yong Cho),서범석(Beom-Seok Seo),양원모(Won-Mo Yang) (사)한국생물환경조절학회 2005 생물환경조절학회지 Vol.14 No.4
토마토 ‘모모타로’를 공시하여 셀레늄 10㎎ㆍL?¹의 관주 및 엽면시비 등의 단용 및 혼용처리가 수경재배 토마토의 생육 및 과실 내 셀레늄 축적 함량에 미치는 영향을 구명하였다. 토마토 종자를 50공 트레이에 파종하여 70일 동안 육묘한 후 유묘를 코코피트 슬라이브를 이용한 수경재배 시스템에 정식하였다. 양액은 일본원예시험장 배양액 표준처방으로 조성하였으며, pH 5.8~6.2와 EC 2.3 ㎎ㆍL?¹ 등으로 조절하여 공급하였다. 셀레늄은 무기태 SeO₂와 sugar fatty acid ester에 킬레이트화 한 유기태 셀레늄을 10 ㎎ㆍL?¹으로 조성하여 관주, 엽면시비, 관주와 엽면시비를 병행하여 처리하였다. 초장, 엽수, 엽면적 및 엽록소 등의 토마토 생장반응은 셀레늄의 엽면시비, 그리고 엽면시비와 관주를 병행한 처리구에서 현저히 증가하였다. 과실 내 셀레늄 축적 함량은 킬레이트화 한 유기태 셀레늄을 엽면시비와 관주를 병행하여 처리한 경우에 0.302 ㎎ㆍL?¹으로 가장 높았다. 무기태와 유기태 셀레늄의 엽면시비와 관주 등의 단용 처리 보다는 혼용 처리가 전반적인 과실 생장과 체내 셀레늄 축적에 효과적이었다. 무기태 설레늄(SeO₂) 보다는 sugar fatty acid ester에 킬레이트화한 유기태 셀레늄 처리가 셀레늄을 함유한 기능성 토마토의 수경재배에 더 효과적이었다. This study was conducted to clarify the effects of supplying methods of selenium on the growth and Se uptake of hydroponically grown tomato plants. Tomato seeds (Lycopersicum esculentum Mill. cv. Momotaro T-93, Daki Seed Co.) were sown in plug tray with fifty holes, and raised for sixty days. Tomato seedlings transplanted to coco fiber slabs were supplied with the nutrient solutions adjusted to EC 2.3 dSㆍm?¹ and pH 5.8~6.2 recommended by the Japanese Horticultural Experiment Station. Selenium forms used were inorganic SeO₂ (here in after referred to Se) and organic selenium chelated with sugar fatty acid ester (here in after referred to chelated-Se). 10 ppm selenium solutions were treated to tomato plants with foliar applications, drenching, and foliar application plus drenching. Growth characteristics in terms of plant height, number of leaves, leaf area and chlorophyll content were significantly increased in the plot of foliar application of Se, and in the plot of foliar application plus drenching of chelated-Se than other plots, respectively. Transported contents of selenium into the tomato fruits were highest as 0.302 ppm in the plot of foliar application plus drenching of chelated-Se. Also, it had tended to be higher in the plot of foliar application plus drenching than in the plots of foliar application or drenching in both of Se and chelated-Se. Foliar application and drenching of organic chelated-Se were effective to produce the functional tomato fruits.
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옥외광고 노출빈도와 응시상황이 광고회상 및 재인에 미치는 효과 전광판 광고를 활용한 에너지 절약 캠페인을 중심으로
서범석(Beom Seok Seo),부수현(Su Hyun Boo) 한국광고홍보학회 2014 한국광고홍보학보 Vol.16 No.2
본 연구는 전광판을 활용한 공익 캠페인의 효과를 검증하는 데 목적을 두었다. 구체적으로, 본 연구에서는 전광판의 노출과 주목도, 그리고 공적 매체로서의 인식이 공익 캠페인의 효과를 높일 수 있을 것으로 가정하였다. 이를 위해, 실제로 집행된 전광판 광고(전기절약 캠페인)에 대한 광고 회상 및 캠페인 참여의도를 측정하였다. 연구결과, 전광판을 통한 지각된 광고 노출 수준이 증가할수록 전체 광고 회상율이 높아지며, 전광판에 대한 주목도가 높을수록 더 많은 광고를 회상해내었다. 다음으로 타깃 광고 회상에 관한 이항 로지스틱 분석 결과, 광고 노출과 전광판 주목도가 광고 회상에 정적인 영향을 미치는 경향을 보였다. 또한 전광판에 대한 공공성 지각의 매개 효과가 검증되었다. 구체적으로 전광판의 공공성을 높게 평가할수록 공익 캠페인 효과를 증가시킨다. 더욱이, 전광판에 대한 공공성 지각은 전광판 응시빈도, 응시시간, 그리고 주목도와 높은 정적 상관관계를 보였다. 결론적으로, 전광판을 활용한 광고의 효과를 높이기 위해서 전광판에 대한 주목도를 높일 필요가 있으며, 전광판에 대한 공적 인식을 강화시킬 필요가 있다. This study focused on the effect of public campaign through the outdoor electric bulletin board. Thus, researcher assumed that the public campaign through the outdoor electric bulletin board would be effective, and this effect would be heightened by the perceived public usefulness for bulletin board. A key conclusion of this research is as follows; First of all, the more frequently participants gazed the bulletin board, the higher the rate of recall was, and the more attention they paid to it, the more advertisement they recalled. Secondly, researcher conducted a binary Logistic Regression analysis and found out that the recall of target ads(which is about electricity saving campaign) was affected by the frequency of gaze, the time of gaze, and the degree of attention. Researcher found out that the perceived public usefulness mediated the effect of bulletin board as well. In other words, the more useful people think it is to acquire public information, the more effective the target ads is. Furthermore, the perceived public usefulness showed positive correlation with the frequency of gaze, the time of gaze, and the degree of attention. In conclusion, there is need for attracting more attention from people, and also need for making bulletin board be considered public in order to heighten the effect of ads through the electric bulletin board.
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서범석(Beom Seok Seo),박상협(Sang Hyub Park) 대한전산화단층기술학회 2015 대한CT영상기술학회지 Vol.17 No.1
목적 : 상행 대동맥 박리 환자의 follow up 검사에서 기존의 ECG - triggered chest pain protocol 대신 non-ECG-triggered high pitch protocol을 시행하여 대동맥 근위부와 상행 대동맥, 복부 대동맥의 영상의 질을 비교하고, 선량을 감소시키고자 하였다. 대상 및 방법 : 동맥기에서 non-ECG triggered high-pitch mode를 사용하거나(group 1, n=69), ECG-triggered chest pain mode를 사용하여(group 2, n=60) 임상적으로 바람직한 CT angiography가 시행된 129명의 환자들의 데이터를 후향적으로 평가 하였다(남자 94명, 여자 35명, 평균나이 58.9±15.4세). 흉 복부 대동맥 전체의 조영 증강 정도와 잡음을 평가하였고, 두 명의 독립된 판독자들이 대동맥 근위부에서 motion artifact 유무 및 영상의 질을 평가하였다. 장비에서 보고된 dose-length product(DLP) 값을 바탕으로 effective dose 값을 구하였다. 결과 : 근위부의 영상의 질은 aortic root에서 group1(mean±SD, 2.34±0.59)이 group 2(2.63±0.51)보다 낮았고(ρ=0.076), 상행 대동맥에서는 group 1(mean±SD, 2.98±0.93)과 group2(2.96±0.19)로 두 그룹이 비슷하였다(ρ=0.64). 영상 잡음은 ascending, descending, abdominal aorta에서 두 그룹이 모두 비슷했고, arch level에서만 group 2가 더 높았다. 두 그룹들은 모두 비슷한 양의 조영제가 사용 되었고, 모든 level에서 적절한 조영증강을 보였다(〉250 HU). 측정된 방사선량은 group 1(mean±SD, 7.6±0.94 mSv)가, group 2(33.5±9.1 mSv)보다 상당히 낮았다(ρ〈0.0001). 결론 : Non-ECG triggered high-pitch mode를 이용한 흉 복부 대동맥 영상은 ECG -triggered chest pain CT와 비교하여 충분한 조영 증강과 비슷한 수준의 aortic root의 영상을 제공하고, 방사선량을 감소시켜 준다. Purpose : We sought to compare image quality, contrast enhancement, and radiation dose in patients undergoing Non-ECG triggered high pitch helical CT or ECG-triggered chest pain CT of the thoracoabdominal aorta. Materials and methods : We retrospectively assessed data from 129 consecutive patients(94 men, 35women; mean age, 58.9±15.4[SD] years) undergoing clinically indicated CT angiography of the thoracoabdominal aorta on a dual-source scanner using either the non-ECG triggered high-pitch helical mode(group 1, n=69) or ECG-Triggered chest pain mode(group 2, n=60) during arterial phase. We assessed image noise and contrast enhancement throughout the thoracoabdominal aorta. Also two independent readers assessed image quality. Scanner-reported dose-length product values were used to estimate effective dose values. Results : Image quality at the aortic root was higher in group 2(mean±SD, 2.63±0.51) than group 1(2.34±0.59; ρ=0.076). Group 1(mean±SD, 2.98±0.93) and group 2(2.96±0.19; ρ=0.64) was similar at the ascending aorta, also similar quality for both groups noted at other levels. Group 2 scans displayed higher image noise at the aortic arch level, and both groups displayed similar image noise at all levels. The groups received a similar volume of contrast material, and acceptable contrast enhancement (〉250HU) were noted in the two groups. The estimated radiation dose was significantly lower in group 1(mean±SD, 7.6±0.94 mSv) than in group 2(33.5±9.1 mSv;ρ〈0.0001). Conclusion : Image of the thoracoabdominal aorta with non-ECG triggered high-pith CTA provides similar quality images of the aortic root and ascending aorta with sufficient contrast enhancement and decreased estimated radiation dose compared with ECG-triggered chest pain CT.
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Tabebuia impertiginosa Martius ex DC(Taheebo)의 혈소판 응집 억제활성에 관한 연구
서범석(Seo Beom-seok),고관영(Go Gwan-Young),박영현(Park Young-Hyun),박병수(Park B.S.),장성근(Chang Sung-Keun) 한국산학기술학회 2004 한국산학기술학회 학술대회 Vol.- No.-
Platelet aggregation is a complex phenomenon that probably involves several intracellular biochemical pathways. When activated, platelets change shape, aggregate and release the contents of their intracellular granules. The interactions between platelets and blood vessel walls are important in the development of thrombosis and cardiovascular diseases. When blood vessels are damaged, platelet aggregation occurs rapidly to form haemostatic plugs or arterial thrombi at the sites of vessel injury or in regions where blood flow is disturbed. These thrombi are the source of thromboembolic complications of atherosclerosis, heart attacks, stroke, and peripheral vascular disease. Therefore, the inhibition of platelet function represents a promising approach for the prevention of thrombosis. Plants constitute a rich source of bioactive chemicals such as phenolics, terpenoids and alkaloids. Plant extracts may be an alternative to currently used medicinal source because they constitute a rich source of bioactive chemicals. This study was performed to investigate the antiplatelet activity of extract of Tabebuia impetiginosa Martius ex DC (Taheebo) and find out which fractions to this activity in rabbit platelet. Taheebo was methanol extracted and solvent fractionated in to five fractions (hexane, chloroform, ethylacetate, butanol and water). And each fractions were investigated inhibitory effects on platelet aggregation induced by various agonists using washed rabbit platelets in vitro.
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