http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
골수이식 후 만성 이식편대숙주질환으로 발생한 폐쇄성 세기관지염에 의한 이차성 재발성 기흉 1례
안철민 ( Chul Min Ahn ),황상연 ( Sang Yun Hwang ),변민광 ( Min Kwang Byun ),이진형 ( Jin Hyoung Lee ),정우영 ( Wou Young Chung ),문진욱 ( Jin Wook Moon ),박무석 ( Moo Suk Park ),민유홍 ( Yoo Hong Min ),김세규 ( Se Kyu Kim ),장준 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.57 No.2
정세진 ( Se Jin Jung ),변민광 ( Min Kwang Byun ),정우영 ( Woo Young Chung ),박무석 ( Moo Suk Park ),강신명 ( Shin Myung Kang ),김혜령 ( Hae Ryoung Kim ),신동환 ( Dong Hwan Shin ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),김성규 ( 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.6
Dermatofibrosarcoma protuberans (DFPS) is a locally aggressive skin tumor with a very low incidence in the general population. This tumor has a remarkable tendency to recur, However, a metastasis is rare. We report a case of DFPS with a pulmonary metastasis in 28-year-old man. The pulmonary metastasis developed 5 years after a complete resection of the primary skin tumor. We reviewed the clinical manifestations and treatment of DFPS, and highlight the need for a long-term follow-up examination for metastases after a wide excision of these lesions. (Tuberc Respir Dis 2006; 61: 573-577)
김영삼 ( Young Sam Kim ),변민광 ( Min Kwang Byun ),정우영 ( Wou Young Jung ),정재희 ( Jae Hee Jeong ),최상봉 ( Sang Bong Choi ),강신명 ( Shin Myung Kang ),문지애 ( Ji Ae Moon ),한숙정 ( Suk Jung Han ),남정모 ( Chung Mo Nam ),박무 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.2
연구배경: 만성폐질환 환자에서 삶의 질을 측정하는 도구로서 세인트조지 호흡기 설문(St George`s Respiratory Questionnaire;SGRQ)이 개발되어 치료효과를 판정하는 측정지표로 널리 사용되고 있으나 영어권국가에서 만들어 졌기 때문에 우리나라에서 동일하게 사용하는데 제한점을 가지고 있다. 따라서 이의 정확한 적용을 위해서 언어, 기술, 개념적인 관점을 고려하여 한국어 설문지를 만들고 이들의 타당도와 신뢰도를 평가하였다. 방법: 한국판 세인트조지 호흡기 설문은 번역, 역번역, 전문가 패널의 수정을 통해 완성되었고, 세브란스병원 호흡기내과를 방문한 환자를 대상으로 하여 이 설문을 시행하였다. 신뢰도 검정은 Cronbach`s α를 구하여 측정하였고 타당도는 폐기능검사, 6분보행검사, 호흡곤란지수와 산소포화도 검사를 동시에 시행하여 설문 검사결과와의 상관관계를 알아보았다. 결과: 74명의 환자를 대상으로 시행하였으며, 남녀 비는 2.2:1, 평균연령은 63.8±10.3세였다. 이 중 천식환자는 27명(36.5%), 만성폐쇄성폐질환 환자는 39명 (52.7%)이었고, 결핵에 의한 파괴 폐환자는 8명(10.8%)이었다. Cronbach`s α 값은 증상영역, 활동영역, 영향영역 및 총 점수에서 각각 0.63, 0.87, 0.89, 0.92 이였다. 총점수와 FEV1, FVC, 6분보행거리, 산소포화도, 호흡곤란지수와 유의한 상관관계를 보였다. 결론: 한국어판 세인트조지 호흡기 설문은 만성폐질환 및 천식과 같은 만성폐질환 환자에서 신뢰도가 높았고 총점수와의 상관관계는 6분보행검사 및 산소포화도에서 높음을 알수 있었고 폐기능 검사와의 상관계수는 원저인 세인트조지 호흡기설문 및 타 국가의 번역본 호흡기설문에서와 같이 높지 않음을 알 수 있었다. 따라서 우리나라에서도 호흡기질환의 삶의 질에 대한 치료효과 판정에 활용할 수 있을 것으로 기대된다. Background: The health-related quality of life (HRQL) for patients with chronic respiratory disease has been emphasized, because chronic respiratory disease (CRD) is chronic and progressive, and it finally causes disability. HRQL instruments may be useful for monitoring patients` progress or for determining the most appropriate choice of treatment. We describe the adapting St George`s Respiratory Questionnaire (SGRQ), which is a self-administered questionnaire developed by Jones et al. (1991), into the Korean version for covering three domains of health for the patients suffering with airways disease. Method: We obtained the original SGRQ from the author after gaining permission. For adaptation, we created an expert panel and translated the original questionnaire into Korean language. The translated questionnaire was then back-translated by bilingual experts and we compared it with the original questionnaire. After correction and feasibility testing, 74 patients with chronic respiratory disease (COPD, asthma, destroyed lung) completed the Korean version of the SGRQ. The clinical status of each patients was evaluated concurrently with measurement of their health status. Result: The Korean version of the SGRQ was acceptable and easy to understand. Cronbach`s alpha reliability coefficient was 0.92 for the overall scale and 0.63 for the Symptoms, subscale, 0.87 for the Activity, subscale, and 0.89 for the Impacts subscales. The correlation coefficients between the overall score and the Borg scale score, oxygen saturation, and forced expiratory volume in one second (FEV1) were 0.52, -0.32 and -0.26, respectively. These results support that the Korean SGRQ was correlated with other measurements. Conclusion: The Korean SGRQ was reliable and valid for patients with chronic respiratory disease, such as COPD, asthma, and destroyed lung. The SGRQ score was well correlated with other respiratory measurements as well. Although further studies should complete the adaptation work, our results suggest that the SGRQ may be used in Korea and also for international studies involving Korean CRD patients. (Tuberc Respir Dis 2006; 61: 121-128)
미만성 거대 B형 세포 림프종 환자에서 CHOP 항암 치료와 Filgrastim 투여 후 발생한 폐쇄세기관지기질화폐렴 1례
정우영 ( Wou Young Chung ),변민광 ( Min Kwang Byun ),이진형 ( Jin Hyoung Lee ),한창훈 ( Chang Hoon Hahn ),강신명 ( Shin Myung Kang ),김진석 ( Jin Seok Kim ),조상호 ( San Ho Cho ),김영삼 ( Young Sam Kim ),김세규 ( Se Kyu Kim ),장 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.59 No.5
옥트레오타이드를 이용한 유육종증과 동반된 유미흉의 보존적 치료
정경수 ( Kyung Soo Jung ),문지애 ( Ji Ae Moon ),윤설희 ( Sul Hee Yoon ),변민광 ( Min Kwang Byun ),정우영 ( Woo Young Jung ),정재희 ( Jae Hee Jung ),최상봉 ( Sang Bong Choi ),김대준 ( Dae Joon Kim ),표주연 ( Ju Yeon Pyo ),김영삼 ( 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.2
Sarcoidosis is a multi-system granulomatous disorder of an unknown etiology and affects individuals worldwide. It is characterized pathologically by the presence of non-caseating granulomas in more than one involved organ. However, pleural involvement of sarcoidosis is rare and there are no reported cases in Korea. Traditionally, sarcoidosis has often been treated with systemic corticosteroids or cytotoxic agents. In particular, chylothorax with sarcoidosis is usually treated with corticosteroid for approximately 3~6 months, followed by repeated therapeutic thoracentesis, talc pleurodesis, dietary treatment, or thoracic duct ligation where needed. We encountered a 46 years old female patient presenting with cough, dyspnea and both hilar lymphadenopathy (stage I) on chest radiograph. The patient was diagnosed with a non-caseating granuloma, sarcoidosis by a mediastinoscopic biopsy. For one month, she had suffered from dyspnea due to right side pleural effusion, which was clearly identified as a chylothorax on thoracentesis. Corticosteroid therapy with dietary adjustment was ineffective. She was treated successfully with a subcutaneous injection of octreotide for 3 weeks and oral corticosteroid. We report a case of successful and rapid treatment of chylothorax associated with sarcoidosis using octreotide and oral corticosteroid. (Tuberc Respir Dis 2007; 62: 119-124)
신정아 ( Jung Ar Shin ),이창률 ( Chang Ryul Lee ),변민광 ( Min Kwang Byun ),장윤수 ( Yoon Soo Chang ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),안철민 ( Chul Min Ahn ),김형중 ( Hyung Jung Kim ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.4
Background: Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. Methods: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Results: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. Conclusion: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.
한국 성인을 대상으로 한 미국 및 유럽 폐활량 검사 재현성 기준의 유용성
박병훈 ( Byung Hoon Park ),박무석 ( Moo Suk Park ),정우영 ( Woo Young Jung ),변민광 ( Min Kwang Byun ),박선철 ( Seon Cheol Park ),신상윤 ( Sang Yun Shin ),전한호 ( Han Ho Jeon ),정경수 ( Kyung Soo Jung ),문지애 ( Ji Ae Moon ),김 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.5
연구배경: 본 연구를 통해 2005년도 ATS/ERS 폐활량검사 지침에서 제시한 재현성 기준을 한국 성인들에게 적용할 수 있는 지와, 한국 성인들의 폐활량 검사 시 재현성에 영향을 미치는 요인들을 알아보고자 하였다. 방 법: 국민건강영양조사, COPD 코호트, 지역사회 코호트로부터 얻은 성인 4,663명의 폐활량검사 결과를 이용하여 dFVC 및 dFEV1를 계산하여 분포를 알아보고, 1994년도 ATS 지침 및 2005년도 ATS/ERS 지침을 만족하는 검사의 비율을 비교하였다. 다중회귀분석을 통해 개인적 특성 및 재현성 기준의 변화가 재현성에 영향을 미치는가를 알아보았다. 결 과: 폐활량검사를 시행한 사람들 중 95% 이상이 150ml 이내의 재현성 기준을 만족시켰다. 1994년도 ATS 지침에 따라 검사를 시행한 경우 재현성을 만족하지 않는 경우가 증가하였다. 다중회귀분석 결과 재현성에 영향을 주는 요인들은 신장, 연령, 체중, 폐쇄성폐질환 여부, 재현성 기준의 변화 등이었으나 재현성에 영향을 미치는 정도는 매우 작았다(0.5∼3.0%). 결 론: 한국인에게도 2005년도 ATS/ERS에서 제시한 재현성 기준을 적용할 수 있을 것으로 생각하며, 이를 위해서는 변경된 재현성 기준에 대한 지속적인 홍보와 검사자 들에 대한 교육 및 정도 관리가 필요하다. Background: The objective of this study was to evaluate the clinical applicability of the repeatability criteria recommended by the American Thoracic Society/European Respiratory Society (ATS/ERS) spirometry guidelines and to determine which factors affect the repeatability of spirometry in Korean adults. Methods: We reviewed the spirometry data of 4,663 Korean adults from the Korean National Health and Nutritional Examination Survey (KNHANES) Chronic Obstructive Pulmonary Disease Cohort (COPD cohort) and the Community-based Cohort Study VI-Fishing village/Islands (community cohort). We measured the anthropometric factors and differences between the highest and second-highest FVC (dFVC) and FEV1 (dFEV1) from prebronchodilator spirometry. Analyses included the distribution of dFVC and dFEV1, comparison of the values meeting the 1994 ATS repeatability criteria with the values meeting the 2005 ATS/ERS repeatability criteria, and the performance of linear regression for evaluating the influence of subject characteristics and the change of criteria on the spiro-metric variability. Results: About 95% of subjects were able to reproduce FVC and FEV1 within 150 ml. The KNHANES based on the 1994 ATS guidelines showed poorer repeatability than the COPD cohort and community cohort based on the 2005 ATS/ERS guidelines. Demographic and anthropometric factors had little effect on repeatability, explaining only 0.5 to 3%. Conclusion: We conclude that the new spirometry repeatability criteria recommended by the 2005 ATS/ERS guidelines is also applicable to Korean adults. The repeatability of spirometry depends little on individual characteristics when an experienced technician performs testing. Therefore, we suggest that sustained efforts for public awareness of new repeatability criteria, quality control of spirograms, and education of personnel are needed for reliable spirometric results. (Tuberc Respir Dis 2007;63:405-411)