양측성 육아종성 유방염의 세침흡인 세포학적 소견 - 1예 보고 -

백승삼,전석훈,홍은경,박문향,Paik, Seung-Sam,Jeon, Seok-Hoon,Hong, Eun-Kyung,Park, Moon-Hyang 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2

Granulomatous mastitis is a rare inflammatory breast lesion, usually presented with rapidly enlarging palpable mass in young parous women and can simulate carcinoma. Unnecessary surgical procedure can be avoided if the nature of the lesion were defined by fine needle aspiratio(FNA) cytology. We experienced a case of bilateral granulomatous mastitis diagnosed by FNA cytology. The patient was a 31-year-old woman with one month history of a rapidly enlarging mass in the left breast, considered clinically to be malignant. After 4 years, she presented with a palpable mass in the right breast. The FNA cytology smears contained numerous aggregates of epithelioid histiocytes admixed with Langhans' and foreign body giant cells, lymphoytes, neutrophils and apoptotic debris leading to a diagnosis of granulomatous mastitis. The subsequent lumpectomy of the left breast confirmed the diagnosis of granulomatous mastitis. The FNA cytology smears from right breast showed identical cytologic findings.

모기질세포종의 세침흡인 세포학적 소견 - 2예 보고 -

백승삼,김동훈,이효진,장세진,박문향,이중달,Paik, Seung-Sam,Kim, Dong-Hoon,Lee, How-Jin,Jang, Se-Jin,Park, Moon-Hyang,Lee, Jung-Dal 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2

Pilomatrixoma is a benign skin appendage tumor of hair matrix cell origin. The cytological appearance of this tumor may cause problems when attempting to establish a differential diagnosis with other neoplasms. Herein we report the aspiration cytology findings of two cases of pilomatrixoma. One case was diagnosed as atypical cell clusters initially and the other was diagnosed as pilomatrixoma. On cytologic examination, both cases showed clusters of tightly arranged basaloid cells with an uniform appearance, scanty cytoplasm and round hyperchromatic nuclei. There were histiocytes and multinucleated foreign body giant cells merged with the amorphous opaque orangeophilic materials of "ghost cells". The differential diagnosis with other neoplasms is discussed.

석회화 건막 섬유종 - 증례 보고 -

백승삼,장기석,김형종,노원일,이성필,이광현,Paik, Seung-Sam,Jang, Ki-Seok,Han, Hong Xiu,Kim, Hyung-Jong,Roh, Won-Il,Lee, Seong-Pil,Lee, Kwang-Hyun The Korean Musculoskeletal Tumor Society 2003 대한골관절종양학회지 Vol.9 No.2

목적: 석회화 건막 섬유종은 소아 및 청소년층에서 수장부를 가장 많이 침범하는 양성이나 공격적 성향을 띈 섬유성 종양이다. 저자들은 최근에 15세 소년의 수부에 발생한 석회화 건막 섬유종의 치료를 경험하였기에 이를 문헌 고찰과 함께 보고하고자 한다. 증례: 15세 소년이 좌수의 소지구 부위에 재발하는 종물을 주소로 내원하였으며 이 소년은 7년전에 타 병원에서 국소 마취 하에 동일 부위에 발생한 종물을 제거한 기왕력을 가지고 있었다. 종물은 단단하였으며 압통이 있었다. 단순 방사선 촬영상에는 종물 내에 다소성으로 산재된 미세 석회 침착이 보였다. 수술 소견상 종물은 주변과 명확히 구분되지 않았으며 단단하고 옅은 회색빛의 석회화를 동반한 침습성의 결절성 형태를 보였으며 가이언 관내의 척골 신경과 척골 동맥이 바로 인접하고 있었다. 수술 후 제거한 종물을 현미경적으로 관찰한 결과 종물은 많은 석회 침착이 되어 있으면서 이형성 연골양 분화를 보이는 조직이 중간 중간에 섞여 있는 빽빽한 섬유 조직의 증식으로 이루어져 있었고 주변부는 명확히 경계 지어지지 않으며 분엽상을 보이고 있었다. 결론: 이 질환에 있어서 가장 바람직한 치료법은 기능적인 면과 주요 조직을 보존할 수 있는 한도내에서 광범위 절제를 시행하는 것이며 이렇게 치료하더라도 많게는 50 %이상의 재발율이 보고되고 있는 실정이다. Calcifying aponeurotic fibroma is a benign, aggressive fibrous tumor seen in childhood or adolescence that most commonly affects the palm. We report our experience in treating calcifying aponeurotic fibroma in the hand of fifteen-year-old boy. He was presented with a recurrent mass in hypothenar area of his left hand. He had a history of local excision of the mass 7 years ago in local clinic. The palpable mass was hard, tender and movable. The simple X-ray revealed multifocally scattered microcalcifications in the mass. The excised mass showed the features of dense fibrotic soft tissue tumor with multiple small whitish calcifications. The microscopic sections showed a lobulated and a poorly circumscribed proliferation of dense fibrous tissue, containing islands of metaplastic chondroid differentiation with prominent calcification. The recommended treatment of this lesion is wide excision allowing for sparing of functional or vital structures, but high recurrence rate as this case has been reported to be more than 50 percent.

체액도말에서의 AgNOR수의 유의성 - 반응성 중피세포와 악성세포의 감별 -

백승삼,홍은경,장세진,박문향,이중달,Paik, Seung-Sam,Hong, Eun-Kyung,Jang, Se-Jin,Park, Moon-Hyang,Lee, Jung-Dal 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2

To distinguish reactive mesothelial cells from malignant cells in body fluid, we applied silver staining of nucleolar organizer regions(AgNORs) to ethanol fixed cytologic preparations. Fifty aspirated samples of benign(22 cases) and malignant(26 cases) body fluids were studied using the one step silver staining method. Two cytologically atypical samples were also included in the study. In malignant cases the mean AgNOR count was $3.56{\pm}0.81$, while in benign cases the mean AgNOR count was $2.02{\pm}0.33$. The difference of AgNOR counts between these two groups were statistically significant(p<0.001). The mean of atypical cases was 2.91. Both were diagnosed as malignant in follow-up cytology. In malignant effusions, there is statistically significant difference in AgNOR counts between cells forming complex papillae or clusters and singly scattered cells(p<0.05), $3.29{\pm}0.95\;and\;3.83{\pm}0.55$, respectively. We concluded that AgNOR count appears to be useful as a diagnostic tool especially when the cytologic differentiation is difficult.

자궁 경부의 유리질 세포 암종의 세포학적 소견 - 3예 보고 -

전석훈,백승삼,이원미,장세진,박용욱,박문향,이중달,Jeon, Seok-Hoon,Paik, Seung-Sam,Lee, Won-Mi,Jang, Se-Jin,Park, Yong-Wook,Park, Moon-Hyang,Lee, Jung-Dal 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.2

Glassy cell carcinoma is an unusual neoplasm of the uterine cervix that accounts for $1{\sim}2%$ of all cervical malignancy. It is a rapidly progressive and biologically aggressive disease with poor response to therapy. This tumor is considered to be a poorly differentiated mixed adenosquamous carcinoma. The cytologic findings are characterized by tumor cells arranged predominantly in syncytial like aggregates and an inflammatory background. The tumor cells have moderate amounts of eosinophilic or amphophilic cytoplasm, which is often finely granular. The nuclei are relatively large and have fine chromatin with prominent eosinophilic nucleoli. Cytologically, glassy cell carcinoma is most likely to be confused with large cell nonkeratinizing squamous cell carcinoma and with atypical reparative cells. Herein, we report three cases of glassy cell carcinoma of the uterine cervix diagnosed by cervicovaginal smear and confirmed by histologic section with review of literatures.

이하선의 선방세포암종의 세침흡인 세포학적 소견 - 1예 보고 -

전석훈,백승삼,이원미,박문향,이중달,Jeon, Seok-Hoon,Paik, Seung-Sam,Lee, Won-Mi,Park, Moon-Hyang,Lee, Jung-Dal 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.2

We experienced a case of well-differentiated acinic cell carcinoma of the parotid gland in a 65 year-old woman, which was correctly diagnosed preoperatively by fine needle aspiration(FNA) cytology. FNA cytology smears showed clusters or sheets of monomorphic acinic cells having reticulated or finely vacuolated basophilic or acidophilic cytoplasm. The cellular population was homogeneous or slightly polymorphic, having centrally located, round nuclei with finely reticular chromatin and inconspicuous nucleoli. Herein we report this case with its histologic features and review of literatures.

위암조직에 있어 COX-2 발현이 림프관신생과 림프절 전이에 미치는 영향

전후완,백승삼,송영수,권성준,Chun, Hu-An,Paik, Seung-Sam,Song, Young-Soo,Kwon, Sung-Joon 대한위암학회 2006 대한위암학회지 Vol.6 No.4

목적: 위암 발생에서 cyclooxygenase-2 (COX-2)가 혈관신생을 유도한다는 연구보고는 많으나 COX-2와 림프관신생과의 연관성은 잘 알려져 있지 않다. 이에 위암에서 COX-2와 VEGF-C의 상관관계 및 다른 임상병리학적 인자들과 비교 분석하여 COX-2가 림프관신생 및 전이를 유도하는지 여부를 알고자 하였다. 대상 및 방법: 1995년 7월부터 2001년 6월까지 본원에서 위암으로 진단받고 수술을 시행 받은 100명의 환자를 대상으로 COX-2와 VEGF-C에 대한 면역조직화학 검사를 시행하였으며, 이 두 인자들의 상관관계 및 성별, 병기, 림프절 전이, 종양 위치, Lauren 분류법, 혈관침범등과의 관계를 비교 분석하였다. 결과: COX-2는 86%, VEGF-C는 70%에서 양성 반응을 보였다. VEGF-C와 COX-2 모두 림프절 전이와 유의한 상관관계를 보였고(P=0.033 and P=0.012) VEGF-C와 COX-2의 발현은 밀접한 상관관계를 보였다(P=0.026). 그러나 다른 인자들과는 유의한 상관관계를 보이지 않았다. 결론: 위암환자에서 COX-2 발현은 VEGF-C 발현과 유의한 상관관계가 있었고, 이 두 인자들은 모두 림프절 전이와 연관이 있었다. 이에 COX-2 발현은 VEGF-C 발현을 매개로 림프관신생에 관여한다고 할 수 있겠다. Purpose: Many previous studies have suggested that cyclooxygenase-2 (COX-2) over expression is closely related to angiogenesis. However, few have reported the relationship between COX-2 and lymphangiogenesis which is still unclear, The aim of this study was to determine the relationship between COX-2 expression and lymphangiogenetic factor, VEGF-C, in human gastric cancer and to correlate COX-2 and VEGF-C expression with other clinocopathological features to investigate whether COX-2 contributes to lymphangiogenesis and enhances lymph node metastasis. Materials and Methods: One hundred patients who underwent curative radical surgery in Hanyang University hospital from July 1998 to June 2001 were selected. The expression of COX-2 and VEGF-C were detected by using immunohistochemistry, and the relationships between these two parameters and several clinicopathological factors (gender, stage, lymph node status, tumor location, Lauren classification and angioinvasion) were determined. Results: Increased COX-2 expression was found in 86 of 100 tumor samples (86%) and in 70 of 100 tumor samples (70%) with VEGF-C. A high correlation between VEGF-C expression and lymph node metastasis was observed (P=0.033) along as well as COX-2 expression (P=0.012). Also, there was a significant correlation between COX-2 and VEGF-C expression (P=0.026), yet no correlation were found between COX-2 and VEGF-C expression and other clinicopathological parameters. Conclusion: Our study suggests that COX-2 expression contributes to lymphangiogenesis by mediating VEGF-C and finally promoting lymph node metastasis.

갑상선 유리질 소주형 선종의 세침흡인 세포학적 소견 - 1예 보고 -

김성호,백승삼,박문향,Kim, Seong-Ho,Paik, Seung-Sam,Park, Moon-Hyang 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.2

Hyalinizing trabecular adenoma is an uncommon benign thyroid tumor that is recently described in the literature. This tumor is easily confused with medullary carcinoma on surgical specimens and with papillay carcinoma on cytologic specimens. Herein we report the cytologic characteristics of a case of histologically proven hyalinizing trabecular adenoma of the thyroid gland. Cytologically, the aspirate showed trabecular or individually dispersed polygonal cells with finely stippled chromatin pattern, nuclear grooves, and eosinophilic nuclear pseudoinclusions. No colloid materials were noted in the background.

말초 신경에 발생한 신경 내 결절종: 2예 보고

김태승,조영훈,백승삼,김성재,Kim, Tai-Seung,Jo, Young-Hoon,Paik, Seung-Sam,Kim, Sung-Jae 대한근골격종양학회 2013 대한골관절종양학회지 Vol.19 No.2

말초 신경에 발생하는 결절종은 일부 보고된 바는 있으나, 발생 빈도는 드문 것으로 되어있으며 발생 부위는 비골 신경이 가장 흔한 것으로 보고되고 있다. 이외에도 요골 신경, 척골 신경, 정중 신경, 좌골 신경, 경골 신경 및 후 골간신경에 발생한 경우도 보고되고 있다. 저자들은 내측 족저 신경에 발생한 신경 내 결절종 1예와 총 비골 신경에 발생한 신경 내 결절종 1예를 신경학적 후유증 없이 치료하여 이를 보고하고자 한다. Ganglion cysts that occurred within sheaths of peripheral nerves have been documented in literatures, but it is relatively rare condition. The peroneal nerve is the most common site of involvement. Other reported sites of involvement are the radial, ulnar, median, sciatic, tibial and posterior interosseous nerves. We report a case of the intraneual ganglion cyst within peroneal nerve and another case of the intraneural ganglion cyst within a medial plantar nerve that were successfully excised without neurologic complication.

부갑상샘 암좀의 세포학적 소견 - 2예 보고 -

진윤희,김미선,백승삼,장세진,박문향,박용욱,Jin, Yun-Hee,Jin, Mi-Sheon,Paik, Seung-Sam,Jang, Se-Jin,Park, Moon-Hyang,Park, Yong-Wook 대한세포병리학회 2003 대한세포병리학회지 Vol.14 No.1

Parathyroid carcinoma is a rare disorder accounting for 0.5% to 5% of parathyroid neoplasia. Diagnosis of parathyroid carcinoma in fine needle aspiration cytology (FNAC) is difficult because ail characteristic features of parathyroid carcinoma can be recognized in parathyroid adenoma or hyperplasia. Cellular atypism cannot be used for the diagnostic criteria of parathyroid carcinoma as malignancies of most other organs. We experienced two cases of cytologic features of parathyroid carcinoma confirmed by histologic examination. The majority of tumor cells formed large cohesive clusters, although individual tumor cells were also present. The tumor cells displayed rather pleomorphic round to oval nuclei, occasional prominent nucleoli, and distinct cytoplasmic margin. Occasionally karyolysis, anuclear cells, and nonepithelial cell clusters were noted. The histologic findings showed a partially lobulated architecture, with admixture of sheets of chief cells, oxyphil cells, and occasional water clear cells. The tumor infiltrated into the thyroid parenchyme and perithyroidal soft tissue. The electron microscopic study of case 1 disclosed typical findings of parathyroid neoplasm; clusters of secretory chief cells with centrally located round to ovoid nuclei, moderately clumped heterochromatins and one or two nucleoli. The tumor cells showed conspicous interdigitation of contiguous ceil membrane and intercellular microvilli.