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Objectives : Samchulkunbitang (SCKBT), an oriental herbal formula, has been used in Asian countries including Korea, China and Japan to treat the chronic gastritis, gastric ulcers and gastroptosis. However, there was not report on the anti-obesity-related diseases efficacy of SCKBT. we investigated the antioxidant effects of Samchulkunbitang soft extract (SCKBTSE). We also investigated the anti-obesity-related diseases effect of SCKBT-SE, on adipogenesis in 3T3-L1 cells and PDGF-BB-induced proliferation of rat aortic Vascular smooth muscle (VSMC, A-10). Methods : Preferentially, we analyzed the component of SCKBT-SE using high performance liquid chromatography (HPLC). In vitro, We investigated the anti-oxidant properties of SCKBT-SE on the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, contents of total flavonoid and polyphenol. 3T3-L1 cells were treated with SCKBT-SE (100 to 500 ㎍/㎖) during differentiation for 8 days. The accumulation of lipid droplets was determined by Oil Red O staining. And, To investigate the A-10 cells anti-proliferative effect of SCKBT-SE, we performed MTT assays. Results : SCKBT-SE showed inhibitory activity on adipocyte differentiation at 3T3-L1 preadipocytes without affect cell toxicity. In addition, The pre-incubation of SCKBT-SE (100 ㎍/㎖) significantly inhibited proliferation of PDGF-BB-induced VSMCs. Conclusions : The SCKBT-SE according to the present invention has excellent antihyperlipidemic and antiatherogenic effects as well as an antiobesity effect, has an effect of simultaneously treating obesity, hyperlipidemia, and arteriosclerosis, and is free from side effects by containing a traditional medicine as an active ingredient, and thus can be useful as an agent for preventing or treating obesity-related diseases