단일기관에서 시행된 30년간의 신생검 결과와 임상상 분석

배홍진 ( Hong Jin Bae ),문강륜 ( Kang Ryun Moon ),김예진 ( Ye Jin Kim ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),신영태 ( Young Tai Shin ) 대한내과학회 2013 대한내과학회지 Vol.84 No.3

목적: 경피적 신생검은 사구체질환의 진단과 치료에 있어서 필수적인 검사 방법이다. 그러나 인구와 시기별에 따른 사구체 질환의 변화에 대한 대규모 연구는 많지 않다. 경피적 신생검을 시행받은 환자들에서 임상적 적응증과 조직병리 진단의 시대별 변화를 알아보고자 본 연구를 수행하였다. 방법: 1981년부터 2010년까지 충남대학교병원에서 경피적 신생검을 시행받은 15세 이상의 총 3,052명 중 의무기록 검토와 조직진단이 가능했던 2,412명을 대상으로 연령, 성별, 적응증, 신생검 결과 등에 대해서 I기(1981-1990년), II기(1991-2000년), III기(2001-2010년)로 나누어 시기별 변화를 비교 분석하였다. Background/Aims: This study evaluated the clinical characteristics of patients who underwent kidney biopsies, and the relative changes in pathological diagnosis, according to time periods over the last 30 years (1981-2010). Methods: This study included 3,051 patients who were older than 15 years and underwent kidney biopsies at Chungnam University Hospital between January 1981 and December 2010. For analysis, the patients were grouped into three time periods: I (1981-1990), II (1991-2000), and III (2001-2010). We reviewed the available medical records of 2,450 patients and analyzed the changes in their clinical characteristics over time. Results: The mean patient age was 35.9 (range 15-91) years and the male-to-female ratio was 1.3:1. The most common indication for a kidney biopsy was an asymptomatic urinary abnormality (64.2%) and the proportion with this indication increased significantly over time (p < 0.001). Primary glomerular diseases comprised 65.4% of all pathological diagnoses, followed by secondary (13.6%) and hereditary (12.5%) glomerular diseases. The proportion of primary glomerular diseases decreased significantly with time (p < 0.001), while the proportions of secondary and hereditary glomerular diseases increased correspondingly (p < 0.001). IgA nephropathy was the most common pathological diagnosis (36.7%) overall. The proportion of IgA nephropathy increased significantly with time (p < 0.001), while minimal change disease and acute post-streptococcal glomerulonephritis decreased significantly (p < 0.001 and p = 0.013, respectively). Conclusions: The results demonstrated that the clinical indications and pathological diagnoses in patients who underwent kidney biopsies changed significantly over the last 30 years. (Korean J Med 2013;84:379-388)

Co / Cu / Co / FeMn 스핀밸브의 자기저항 특성 향상 연구

김홍진(Hong Jin Kim),배준수(Jun Soo Bae),노은선(Eun Sun Noh),이택동(Taek Dong Lee),이혁모(Hyuck Mo Lee) 한국자기학회 2002 韓國磁氣學會誌 Vol.12 No.1

It was observed that exchange bias field was increased with smooth surface and better γ-FeMn formation. Sputtering conditions were varied for the control of the surface roughness and γ-FeMn formation. From the results of Cu deposition as underlayer, it was found that γ-FeMn formation was closely related with the thickness of underlayer. After heat treatment, exchange bias field was increased over three times. This improvement was likely that the crystallites of γ-FeMn were well formed. In Co/Cu/Co/FeMn spin valve structure, magnetoresistance was increased over 1.4 times through the heat treatment. This was due to the disappearance of Co/ Cu intermixed dead layer and removal of defect, and this was examined by AES analysis.

국가R&D사업에서의 연구 성과 사업화 방안에 대한 연구 : 지능형국토정보기술혁신사업의 사례 분석

배상근,홍진원,정연재,박승욱,김병국,Bae, Sang-Keun,Hong, Jin-Won,Jung, Yeun-Jae,Park, Seung-Wook,Kim, Byung-Guk 한국공간정보학회 2012 한국공간정보학회지 Vol.20 No.2

최근의 R&D는 연구 분야에 대한 핵심 알고리즘 및 기술 개발 뿐 아니라 실질적인 성과도출 및 성과를 통한 가치창출을 매우 중요시한다. 이에 따라 현재 다양한 R&D사업에서 연구 성과의 활용을 극대화하기 위해 기술사업화에 많은 노력을 기울이고 있으며, 그 일환으로 비즈니스 모델(Business Model, BM)의 개발 및 적용에 대한 연구가 활발히 진행되고 있다. 그러나 국가 주도로 이루어지는 국가R&D사업은 일반 기업에서 주도하는 민간R&D사업과는 다른 특징을 가지고 있기 때문에, 기업을 대상으로 개발된 일반적인 비즈니스 모델 방법론을 적용하기에는 어려움이 따른다. 또한 비즈니스 모델의 실제 적용을 위해 개념적으로 작성된 비즈니스 모델을 기술적인 관점으로 체계화하기 위한 기술 아키텍처 분석과정이 필요하다. 따라서 본 논문에서는 연구 성과의 활용을 향상시키기 위한 기술사업화 지원 방안으로서, 국가R&D사업의 특성에 적합한 비즈니스 모델 개발 절차와 기술 아키텍처 분석 방법론을 제시하고, 실제 적용 가능성을 검증하기 위해 국토해양부 주관 대형 국가R&D사업단인 지능형국토정보기술혁신사업단의 비즈니스 모델 개발 과정에 적용해 보았다. Recently, it is very important to create economic value as well as develop core algorithms and technologies in the field of R&D. Various R&D projects make an effort to do the technology commercialization of their results and, as part of efforts, many studies on business model(BM) are conducted to create economic benefits in using the developed technology. However, it is difficult to use the general business model methodologies, which are usually utilized for companies, to the government's research due to different processes and characteristics between them. And for the practical application of business models, it needs to systematize conceptual business models in technical perspective through technical architecture analysis. In this study, a business model development process and a technical architecture analysis for national R&D project is developed for the technology commercialization. In addition, the process is applied to Korean Land Spatialization Program (KLSP) organized by Ministry of Land, Transport and Maritime Affairs to verify the feasibility of its practical application.

NICS : A System for Service Control and Management on Intelligent Networks

공남수,배현주,김상기,임덕빈,홍진표,Gong, Nam-Su,Bae, Hyeon-Ju,Kim, Sang-Gi,Im, Deok-Bin,Hong, Jin-Pyo 한국전자통신연구원 1992 전자통신 Vol.14 No.4

Intelligent Network offers network operators significant opportunities to provide new services such as Freephone service and Credit Calling service. To realize the IN capabilities it is required to introduce several new components into the existing telecommunication network. Among them Service Control Point is regarded as a keystone node of Intelligent Network. This paper discusses the architecture design and implementation of NICS(Network Information Control System), which is a combined system of SCP and SMS. Service processing aspects are discussed in detail among the functions of NICS, and service management and test environment of service logic are presented also. The field trial of NICS which has been developed to provide Freephone Service and Credit Calling Service is scheduled at the end of 1993.

Parlay Open API 기반 개방형 서비스 설계 및 구현

나승필(Seung-Pil Na),홍진표(Jin-Pyo Hong),배현주(Hyun-Joo Bae) 한국통신학회 2004 한국통신학회 학술대회 및 강연회 Vol.2004 No.12

혈액투석치료를 받는 말기신부전 환자에서 체내 수분분포와 임상상

장원익 ( Won Ik Jang ),배홍진 ( Hong Jin Bae ),함영록 ( Young Rok Ham ),장동석 ( Dong Suk Chang ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),이강욱 ( Kang Wook Lee ),신영태 ( Young Tai Shin ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.3

Purpose: Maintenance of the normal hydration state is one of the major purposes of hemodialysis therapy in patients with end-stage renal disease. Overhydration is an important and independent predictor of mortality in patients with end-stage renal disease on regular hemodialysis. BCM (body composition monitor, FMC, Germany) reliably enables quantitative assessment of hydration status and body composition. The aims of this study were to investigate the relationship between hydration status and clinical features and the risk factors of overhydration. Methods: We measured hydration status and body composition of total 72 patients with end-stage renal disease on regular hemodialysis by BCM from June, 2009 to September, 2009. We also reviewed the clinical characteristics and laboratory findings and comorbidities retrospectively. Results: The hydration status measured by BCM was correlated well with interdialytic weight gain after 48 hours and 72 hours from last hemodialysis treatment (r=0.42 p<0.001, r=0.38 p<0.01, respectively). There was no statistically significant difference in comorbidities, age, sex, BMI, blood pressure, hypotensive episodes between the patients with overhydrated state (relative hydration status ≥20%) and control patients (relative hydration status <20%). In overhydrated patients, serum iron level was lower than control patients 48 hrs after last hemodialysis (p<0.05). Conclusion: This cross-sectional study showed that hydration status measured by BCM was correlated well with interdialytic weight gain although there was no significant clinical difference between overhydrated and control patients with end-stage renal disease on regular hemodialysis

동정맥 이식편을 통해 혈액투석치료를 받는 환자에서 발생한패혈성 폐색전증

이강욱 ( Kang Wook Lee ),권오경 ( Oh Kyung Kwon ),배홍진 ( Hong Jin Bae ),장원익 ( Won Ik Jang ),정사라 ( Sa Rah Chung ),최대은 ( Dae Eun Choi ),나기량 ( Ki Ryang Na ),신영태 ( Young Tai Shin ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.6

Purpose: Septic pulmonary embolism (SPE) is different from non-infectious thromboembolism in that it causes pulmonary arterial obstruction and inflammation by infectious emboli from various sources. There are increased risks of SPE in patients with chronic kidney disease because of decreased immunity and frequent venous puncture with the use of indwelling venous catheters or arterio-venous graft (AVG). However, SPE related with AVG infection in end-stage renal failure patient is very rare. Recently, we experienced a typical case of septic pulmonary embolism occurring in a 57-year-old man with infected AVG during hemodialysis. The patient had started hemodialysis 10 years ago due to diabetic end stage renal failure. Due to functional failure of the arterio-venous fistula, hemodialysis had been performed through an AVG on the upper left arm 3 years before admission. One week before admission, the patient complained of fever, chill, and painful swelling on the AVG site. Chest x-ray and computerized tomography showed variable sized multiple nodules and some cavity formation, suggestive of septic pulmonary embolism on both lung fields. Methicillin-resistant Staphylococcus aureus (MRSA) was identified from blood and wound culture studies. The AVG was removed along with continued use of vancomycin administration for 8 weeks. Complete clinical and radiological recovery was attained 2 months after initiation of antibiotic treatment.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.