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The purpose of this study was to investigate health promotion behaviors and its influencing factors, self-efficacy and depression among middle-aged women. Data on 204 women between the ages of 45 and 59 were collected from June 8th, 2009 to July 10th, 2009. Structured questionnaires were used to collect data. The following instruments were used in the study after some adaption. Health promotion Lifestyle Profile which was developed by Park(1995), Kim(1996), Jung(1996), revised by Choi(2004) was used. It consisted of 6 sub-categories likewise self actualization, exercise and stress management, hygine, rest, nutrition and health responsibility. Self-efficacy which was developed by Becker, Stuifbergen & Hall(1993), The Self-Rated Abilities for Health Practices Scale revised by Choi(2004) was used. Depression which was developed by Radloff(1977), revised by Jun(1992) CES-D scale(Center for Epidemiologic Studies Depression scale) was used. The data were analyzed using SPSS 16.0 for Windows to t-test, ANOVA and Pearson's correlation. The results of this study are as follows: 1.The ones who thought they were healthy had a statically higher score than those who thought they were unhealthy in a health promoting behavior score(p=.004). 2.The ones who had higher monthly income had a statically higher score than those who had lower monthly income in a self-efficacy score(p=.019). 3.The score of depression was statically high when the ones had lower education level, lower monthly income or lower health level estimated by themselves(p=.002). 4.There was a weak correlation between health promoting behavior and depression(r=-.320, p=.000), and between depression and self-efficacy(r=-.313, p=.000). There was a strong correlation between self-efficacy and health promoting behavior(r=.766, p=.000). In conclusion, the results of this study show that the degree of self-efficacy and depression effects health promotion behavior, and suggest that self-efficacy and depression should be considered significantly to develop efficient health promoting programs.